{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:19:58Z","timestamp":1770502798833,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4368,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1016\/s0960-9822(01)00391-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:18:16Z","timestamp":1027617496000},"page":"1240-1250","source":"Crossref","is-referenced-by-count":100,"title":["Altering telomere structure allows telomerase to act in yeast lacking ATM kinases"],"prefix":"10.1016","volume":"11","author":[{"given":"Simon W.L","family":"Chan","sequence":"first","affiliation":[]},{"given":"Jennifer","family":"Chang","sequence":"additional","affiliation":[]},{"given":"John","family":"Prescott","sequence":"additional","affiliation":[]},{"given":"Elizabeth H","family":"Blackburn","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(01)00391-8_BIB1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.genet.34.1.331","article-title":"Telomeres and their control","volume":"34","author":"McEachern","year":"2000","journal-title":"Annu Rev Genet"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0092-8674(93)90049-V","article-title":"Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase","volume":"72","author":"Wellinger","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0960-9822(00)00450-4","article-title":"Cell cycle restriction of telomere elongation","volume":"10","author":"Marcand","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1101\/gad.12.8.1073","article-title":"The telomerase reverse transcriptase","volume":"12","author":"Nugent","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.286.5437.117","article-title":"Est1 and Cdc13 as comediators of telomerase access","volume":"286","author":"Evans","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1126\/science.7618104","article-title":"Telomerase in yeast","volume":"269","author":"Cohn","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.276.5312.561","article-title":"Reverse transcriptase motifs in the catalytic subunit of telomerase","volume":"276","author":"Lingner","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB8","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1073\/pnas.94.21.11190","article-title":"Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity","volume":"94","author":"Lingner","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/2517","article-title":"Circular chromosome formation in a fission yeast mutant defective in two ATM homologues","volume":"20","author":"Naito","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB10","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1128\/MCB.19.9.6065","article-title":"Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae","volume":"19","author":"Ritchie","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/35044005","article-title":"The DNA damage response","volume":"408","author":"Zhou","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0092-8674(95)90479-4","article-title":"TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene","volume":"82","author":"Greenwell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0092-8674(95)90480-8","article-title":"TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1","volume":"82","author":"Morrow","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ng0796-350","article-title":"Accelerated telomere shortening in ataxia telangiectasia","volume":"13","author":"Metcalfe","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB15","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1093\/emboj\/16.19.6018","article-title":"ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase","volume":"16","author":"Vaziri","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.271.5247.357","article-title":"Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways","volume":"271","author":"Sanchez","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(87)90576-9","article-title":"The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity","volume":"51","author":"Greider","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB18","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1128\/MCB.13.10.6586","article-title":"Sequence-specific DNA primer effects on telomerase polymerization activity","volume":"13","author":"Lee","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB19","doi-asserted-by":"crossref","first-page":"10712","DOI":"10.1073\/pnas.93.20.10712","article-title":"Purification of telomerase from Euplotes aediculatus","volume":"93","author":"Lingner","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB20","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/genetics\/138.4.1025","article-title":"Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae","volume":"138","author":"Liu","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/383354a0","article-title":"Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats","volume":"383","author":"Krauskopf","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB22","doi-asserted-by":"crossref","first-page":"12486","DOI":"10.1073\/pnas.95.21.12486","article-title":"Rap1 protein regulates telomere turnover in yeast","volume":"95","author":"Krauskopf","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1101\/gad.6.5.801","article-title":"A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation","volume":"6","author":"Hardy","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB24","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1101\/gad.11.6.748","article-title":"A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae","volume":"11","author":"Wotton","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB25","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1097-2765(05)00094-8","article-title":"Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process","volume":"6","author":"Teng","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1550-7408.1995.tb01537.x","article-title":"Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats","volume":"42","author":"Romero","year":"1995","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/376403a0","article-title":"Runaway telomere elongation caused by telomerase RNA gene mutations","volume":"376","author":"McEachern","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1083\/jcb.145.2.203","article-title":"Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast","volume":"145","author":"Smith","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB29","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1128\/MCB.20.8.2941-2948.2000","article-title":"Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres","volume":"20","author":"Prescott","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/genetics\/155.1.475","article-title":"The Mre11p\/Rad50p\/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast","volume":"155","author":"Ritchie","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0092-8674(00)81626-8","article-title":"The many interfaces of Mre11","volume":"95","author":"Haber","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/MCB.12.2.563","article-title":"Characterization of double-strand break-induced recombination","volume":"12","author":"Sugawara","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35007091","article-title":"ATM phosphorylates p95\/nbs1 in an S-phase checkpoint pathway","volume":"404","author":"Lim","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/35013083","article-title":"Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products","volume":"405","author":"Zhao","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB35","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1101\/gad.12.18.2956","article-title":"Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway","volume":"12","author":"Desany","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB36","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1073\/pnas.85.2.534","article-title":"Generation of telomere-length heterogeneity in Saccharomyces cerevisiae","volume":"85","author":"Shampay","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB37","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1093\/emboj\/18.12.3509","article-title":"Progressive cis-inhibition of telomerase upon telomere elongation","volume":"18","author":"Marcand","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB38","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1128\/MCB.18.9.5600","article-title":"Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo","volume":"18","author":"Bourns","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB39","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1126\/science.275.5305.1478","article-title":"Block in anaphase chromosome separation caused by a telomerase template mutation","volume":"275","author":"Kirk","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB40","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.288.5467.863","article-title":"Template boundary in a yeast telomerase specified by RNA structure","volume":"288","author":"Tzfati","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/nar\/22.2.124","article-title":"Use of a selection technique to identify the diversity of binding sites for the yeast RAP1 transcription factor","volume":"22","author":"Graham","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB42","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1128\/MCB.15.11.6128","article-title":"Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint","volume":"15","author":"Garvik","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB43","first-page":"115","article-title":"Designer deletion strains derived from Saccharomyces cerevisiae S288C","volume":"14","author":"Brachmann","year":"1998","journal-title":"Yeast"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB44","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1093\/nar\/21.14.3329","article-title":"A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae","volume":"21","author":"Baudin","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0076-6879(91)94022-5","article-title":"Targeting, disruption, replacement, and allele rescue","volume":"194","author":"Rothstein","year":"1991","journal-title":"Methods Enzymol"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00340712","article-title":"High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier","volume":"16","author":"Schiestl","year":"1989","journal-title":"Curr Genet"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB47","series-title":"Guide to Yeast Genetics and Molecular Biology","author":"Guthrie","year":"1991"},{"key":"10.1016\/S0960-9822(01)00391-8_BIB48","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1101\/gad.11.4.528","article-title":"Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro","volume":"11","author":"Prescott","year":"1997","journal-title":"Genes Dev"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982201003918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982201003918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T21:33:37Z","timestamp":1620768817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982201003918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":48,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0960982201003918"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(01)00391-8","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}