{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:16:19Z","timestamp":1779340579864,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1997,6,1]],"date-time":"1997-06-01T00:00:00Z","timestamp":865123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,6,1]],"date-time":"1997-06-01T00:00:00Z","timestamp":865123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5890,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[1997,6]]},"DOI":"10.1016\/s0960-9822(06)00188-6","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T05:30:59Z","timestamp":1081834259000},"page":"408-417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"title":["CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion"],"prefix":"10.1016","volume":"7","author":[{"given":"Tamara","family":"Roach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Slater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Koval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen Cahir","family":"McFarland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinoshin","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(06)00188-6_BIB1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","article-title":"Adhesion receptors of the immune system","volume":"346","author":"Springer","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(92)90115-S","article-title":"Integrins: Versatility, modulation, and signaling in cell adhesion","volume":"69","author":"Hynes","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.7716514","article-title":"Integrins and signal transduction pathways: the road taken","volume":"268","author":"Clark","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0955-0674(94)90097-3","article-title":"Focal adhesion kinase and associated proteins","volume":"6","author":"Schaller","year":"1994","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB5","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0960-9822(95)00272-7","article-title":"The ins and outs of receptor tyrosine phosphatases","volume":"5","author":"Fashena","year":"1995","journal-title":"Curr Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB6","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nsb1295-1043","article-title":"Protein tyrosine phosphatases take off","volume":"2","author":"Barford","year":"1996","journal-title":"Nature Struc Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.120.3.757","article-title":"Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cardherin\/\u03b2-catenin complex in cell transformed with a temperature-sensitive v-SRC gene","volume":"120","author":"Behrens","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB8","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/j.1460-2075.1992.tb05225.x","article-title":"The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions","volume":"11","author":"Volberg","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.iy.12.040194.000505","article-title":"CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development","volume":"12","author":"Trowbridge","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0092-8674(89)90504-7","article-title":"Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation","volume":"58","author":"Pingel","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0092-8674(93)90302-7","article-title":"Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice","volume":"74","author":"Kishihara","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB12","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1073\/pnas.90.4.1402","article-title":"Correlation between Src family member regulation by the protein tyrosine phosphatase, CD45, and transmembrane signaling through the T-cell receptor","volume":"90","author":"Cahir McFarland","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB13","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1002\/j.1460-2075.1992.tb05595.x","article-title":"CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx","volume":"11","author":"Shiroo","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/j.1460-2075.1993.tb05659.x","article-title":"CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck","volume":"12","author":"Sieh","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1084\/jem.174.2.447","article-title":"CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte\/macrophage colony-stimulating factor (GM-CSF), a GM-CSF\/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand)","volume":"174","author":"Broxmeyer","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB16","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.4049\/jimmunol.155.4.2175","article-title":"Cross-linking of CD45 enhances activation of the respiratory burst in response to specific stimuli in human phagocytes","volume":"155","author":"Liles","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB17","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.4049\/jimmunol.155.8.4016","article-title":"The low affinity Fc\u03b3RIIa and Fc\u03b3RIII\u03b2 on polymorphonuclear neutrophils are differentially regulated by CD45 phosphatase","volume":"155","author":"Hoffmeyer","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB18","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4049\/jimmunol.146.3.949","article-title":"Selected antibodies to leukocyte common antigen (CD45) inhibit human neutrophil chemotaxis","volume":"146","author":"Harvath","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB19","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1073\/pnas.82.19.6576","article-title":"Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells","volume":"82","author":"Maher","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB20","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.166.6.1685","article-title":"Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo","volume":"166","author":"Rosen","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB21","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1083\/jcb.126.6.1585","article-title":"The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes","volume":"126","author":"Lin","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB22","first-page":"1651","article-title":"Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases","volume":"13","author":"Hurley","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB23","doi-asserted-by":"crossref","first-page":"13594","DOI":"10.1016\/S0021-9258(17)36871-0","article-title":"CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases","volume":"269","author":"Burns","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB24","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/MCB.16.9.4996","article-title":"Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity","volume":"16","author":"D\u2019Oro","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB25","first-page":"227","article-title":"Receptor protein tyrosine phosphatases, cell adhesion and signal transduction","volume":"8","author":"Brady-Kalnay","year":"1994","journal-title":"Adv Protein Phosphatases"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/j.1460-2075.1993.tb05658.x","article-title":"p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin\u2013catenin cell adhesion system","volume":"12","author":"Hamaguchi","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1083\/jcb.130.4.977","article-title":"Receptor protein tyrosine phosphatase PTP\u03bc associates with cadherins and catenins in vivo","volume":"130","author":"Brady-Kalnay","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB28","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.4049\/jimmunol.154.7.3488","article-title":"Zymosantriggered association of tyrosine phosphoproteins and Lyn kinase with cytoskeleton in human monocytes","volume":"154","author":"Zaffran","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB29","first-page":"849","article-title":"Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region","volume":"7","author":"Lichtenberg","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB30","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1084\/jem.178.3.1017","article-title":"Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages","volume":"178","author":"English","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.172.1.347","article-title":"Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56\/ck","volume":"172","author":"Ostergaard","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(94)90334-4","article-title":"Signal transduction by lymphocyte antigen receptors","volume":"76","author":"Weiss","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/smim.1995.0032","article-title":"Positive and negative regulation of leukocyte activation by protein tyrosine phosphatases","volume":"7","author":"Thomas","year":"1995","journal-title":"Sem Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB34","doi-asserted-by":"crossref","first-page":"27987","DOI":"10.1074\/jbc.270.47.27987","article-title":"Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells","volume":"270","author":"Katagiri","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB35","first-page":"1680","article-title":"Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src","volume":"14","author":"Schaller","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB36","doi-asserted-by":"crossref","first-page":"21206","DOI":"10.1074\/jbc.270.36.21206","article-title":"Cloning and characterization of cell adhesion kinase \u03b2, a novel protein-tyrosine kinase of the focal adhesion subfamily","volume":"270","author":"Sasaki","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB37","doi-asserted-by":"crossref","first-page":"28478","DOI":"10.1016\/S0021-9258(18)46952-9","article-title":"An adhesion molecule-like protein that interacts with and is a substrate for a Drosophila receptor-linked protein tyrosine phosphatase","volume":"269","author":"Tian","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB38","first-page":"1349","article-title":"Differential tyrosine-specific phosphorylation of integrin in Rous sarcoma virus transformed cells with differing transformed phenotype","volume":"5","author":"Horvath","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB39","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.133.4.895","article-title":"Deficiency of Src family kinases p59\/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions","volume":"133","author":"Lowell","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB40","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.150.5.1886","article-title":"Macrophage activation: lipoarabinomannan (LAM) from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes of c-fos, KC, JE and TNF-\u03b1","volume":"150","author":"Roach","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(06)00188-6_BIB41","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1073\/pnas.83.21.8122","article-title":"Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacterophage T7 RNA polymerase","volume":"83","author":"Fuerst","year":"1986","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982206001886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982206001886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:57:01Z","timestamp":1760777821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982206001886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["S0960982206001886"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(06)00188-6","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[1997,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0960-9822(06)00188-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997  Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}