{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:44:08Z","timestamp":1776185048590,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5221,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[1999,4]]},"DOI":"10.1016\/s0960-9822(99)80195-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:05:09Z","timestamp":1027609509000},"page":"445-448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":577,"title":["Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum"],"prefix":"10.1016","volume":"9","author":[{"given":"Valerie A.","family":"Wallace","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(99)80195-X_BIB1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-4886(61)90055-3","article-title":"An autoradiographic analysis of histogenesis in the mouse cerebellum","volume":"4","author":"Miale","year":"1961","journal-title":"Exp Neurol"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-3806(83)90119-0","article-title":"Direct correlation between Purkinje and granule cell number in the cerebella of lurcher chimeras and wildtype mice","volume":"312","author":"Wetts","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB3","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1523\/JNEUROSCI.07-03-00829.1987","article-title":"Numerical matching during cerebellar development: quantitative analysis of granule cell death in staggerer mouse chimeras","volume":"7","author":"Herrup","year":"1987","journal-title":"J Neurosci"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/mcne.1995.1019","article-title":"Local control of granule cell generation by cerebellar Purkinje cells","volume":"6","author":"Smeyne","year":"1995","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB5","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0896-6273(00)80645-5","article-title":"Hedgehog and patched in neural development and disease","volume":"21","author":"Goodrich","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(00)81386-0","article-title":"Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity","volume":"87","author":"Ericson","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0168-9525(96)10051-2","article-title":"The world according to hedgehog","volume":"13","author":"Hammerschmidt","year":"1997","journal-title":"Trends Genet"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0092-8674(00)80325-6","article-title":"Catching a Gli-mpse of Hedgehog","volume":"90","author":"Ruiz i Altaba","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB9","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB10","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.1998.70031327.x","article-title":"Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain","volume":"70","author":"Traiffort","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj1870001","article-title":"The kinetics of antibody binding to membrane antigens in solution at the cell surface","volume":"187","author":"Mason","year":"1980","journal-title":"Biochem J"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0014-4886(69)90015-6","article-title":"Early effects of x-irradiation of the cerebellum in infant rats: decimation and reconstitution of the external granular layer","volume":"24","author":"Altman","year":"1969","journal-title":"Exp Neurol"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0092-8674(00)80074-4","article-title":"Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain","volume":"86","author":"Porter","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.274.5285.255","article-title":"Cholesterol modification of hedgehog signaling proteins in animal development","volume":"274","author":"Porter","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB15","doi-asserted-by":"crossref","first-page":"14037","DOI":"10.1074\/jbc.273.22.14037","article-title":"Identification of a palmitic acid-modified form of human Sonic hedgehog","volume":"273","author":"Pepinsky","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0896-6273(00)80682-0","article-title":"Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog","volume":"22","author":"Wechsler-Reya","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB17","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/(SICI)1096-9861(19961223)376:4<653::AID-CNE11>3.0.CO;2-N","article-title":"Neurogenesis in neonatal rat brain is regulated by peripheral injection of basic fibroblast growth factor (bFGF)","volume":"376","author":"Tao","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1097-4695(199709)33:3<289::AID-NEU7>3.0.CO;2-Y","article-title":"In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor","volume":"33","author":"Tao","year":"1997","journal-title":"J Neurobiol"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0896-6273(91)90168-Y","article-title":"Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro","volume":"6","author":"Gao","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80094-X","article-title":"The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal","volume":"86","author":"Alcedo","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/382547a0","article-title":"Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling","volume":"382","author":"van den Heuvel","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1242\/dev.124.2.363","article-title":"Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina","volume":"124","author":"Jensen","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0960-9822(99)80195-X_BIB23","unstructured":"LR Sidman, Histogenesis of mouse retina studied with thymidine-H3KG Smelser (Eds), The Structure of the Eye 487-506, Academic Press, New York."}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096098229980195X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096098229980195X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:58:37Z","timestamp":1760777917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096098229980195X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["S096098229980195X"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(99)80195-x","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0960-9822(99)80195-X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}