{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:17:17Z","timestamp":1770833837009,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[1995,8]]},"DOI":"10.1016\/s0962-8924(00)89044-3","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:48:29Z","timestamp":1027583309000},"page":"293-297","source":"Crossref","is-referenced-by-count":92,"title":["Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?"],"prefix":"10.1016","volume":"5","author":[{"given":"Woodring E.","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry W.","family":"Shay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0962-8924(00)89044-3_BIB1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/239197a0","volume":"239","author":"Watson","year":"1972","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0022-5193(73)90198-7","volume":"41","author":"Olovinikov","year":"1973","journal-title":"J. Theor. Biol."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB3","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","volume":"11","author":"Counter","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB4","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/337331a0","volume":"337","author":"Greider","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(89)90035-4","volume":"59","author":"Morin","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/hmg\/1.1.3-a","volume":"1","author":"Kipling","year":"1992","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0921-8734(91)90018-7","volume":"256","author":"Harley","year":"1991","journal-title":"Mutat. Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB9","unstructured":"WRIGHT, W.E. and SHAY, J.W. in Aging and Cell Death (Holbrook, N.J. and Martin, G.R., eds), John Wiley & Sons (in press)"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB10","first-page":"1407","volume":"8","author":"Shay","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0022-2836(92)90096-3","volume":"225","author":"Levy","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/excr.1993.1283","volume":"209","author":"Shay","year":"1993","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-4827(91)90453-2","volume":"196","author":"Shay","year":"1991","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0092-8674(93)90493-A","volume":"75","author":"Sandell","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB15","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1128\/MCB.4.9.1689","volume":"4","author":"Maltzman","year":"1984","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB16","first-page":"7491","volume":"89","author":"Kuerbitz","year":"1992"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB17","first-page":"6304","volume":"51","author":"Kastan","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/366701a0","volume":"366","author":"Xiong","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/excr.1994.1063","volume":"211","author":"Noda","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB20","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","volume":"75","author":"Harper","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB22","first-page":"3391","volume":"54","author":"Michieli","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB23","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.7863329","volume":"267","author":"Parker","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB24","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1091\/mbc.4.9.897","volume":"4","author":"Zhang","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB25","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/369574a0","volume":"369","author":"Waga","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB26","first-page":"8655","volume":"91","author":"Flores-Rozas","year":"1994"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB27","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0092-8674(90)90141-Z","volume":"63","author":"Gottschling","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB28","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1101\/gad.7.7a.1146","volume":"7","author":"Kyrion","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0168-9525(92)90232-S","volume":"8","author":"Wright","year":"1992","journal-title":"Trends Genet."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0531-5565(92)90069-C","volume":"27","author":"Wright","year":"1992","journal-title":"Exp. Gerontol."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/345456a0","volume":"345","author":"Wang","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/MCB.15.1.425","volume":"15","author":"Shay","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB33","first-page":"1","volume":"2","author":"Shay","year":"1994","journal-title":"Mol. Cell Diff."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/excr.1994.1062","volume":"211","author":"Rubel","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.959840","volume":"194","author":"Nowell","year":"1976","journal-title":"Science"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB36","first-page":"5116","volume":"72","author":"Knudson","year":"1975"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB37","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB38","series-title":"An Unsolved Problem of Biology","author":"Medawar","year":"1952"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2307\/2406060","volume":"11","author":"Williams","year":"1957","journal-title":"Evolution"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB40","series-title":"The Evolutionary Biology of Aging","author":"Rose","year":"1991"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/270301a0","volume":"270","author":"Kirkwood","year":"1977","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(00)89044-3_BIB42","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1749-6632.1992.tb38685.x","volume":"663","author":"Kirkwood","year":"1992","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB43","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0531-5565(92)90003-I","volume":"27","author":"Shay","year":"1992","journal-title":"Exp. Gerontol."},{"key":"10.1016\/S0962-8924(00)89044-3_BIB44","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0896-6273(92)90029-D","volume":"9","author":"Ma","year":"1992","journal-title":"Neuron"}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892400890443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892400890443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T03:06:21Z","timestamp":1578452781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962892400890443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["S0962892400890443"],"URL":"https:\/\/doi.org\/10.1016\/s0962-8924(00)89044-3","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[1995,8]]}}}