{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:22:00Z","timestamp":1773980520425,"version":"3.50.1"},"reference-count":75,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1016\/s0962-8924(02)00042-9","type":"journal-article","created":{"date-parts":[[2003,2,17]],"date-time":"2003-02-17T21:25:27Z","timestamp":1045517127000},"page":"79-85","source":"Crossref","is-referenced-by-count":462,"title":["Insulin\/IGF and target of rapamycin signaling: a TOR de force in growth control"],"prefix":"10.1016","volume":"13","author":[{"given":"Sean","family":"Oldham","sequence":"first","affiliation":[]},{"given":"Ernst","family":"Hafen","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0962-8924(02)00042-9_BIB1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1210\/er.22.6.818","article-title":"Distinct and overlapping functions of insulin and IGF-I receptors","volume":"22","author":"Nakae","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB3","first-page":"955","article-title":"Genetics of mouse growth","volume":"42","author":"Efstratiadis","year":"1998","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","article-title":"Signal transduction by receptors with tyrosine kinase activity","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB5","first-page":"179","article-title":"The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action","volume":"228","author":"White","year":"1998","journal-title":"Curr. Topics in Micro. and Immun."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/me.14.6.823","article-title":"Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains","volume":"14","author":"Razzini","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB7","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1128\/MCB.13.12.7418","article-title":"Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1","volume":"13","author":"Sun","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.biochem.70.1.535","article-title":"Synthesis and function of 3-phosphorylated inositol lipids","volume":"70","author":"Vanhaesebroeck","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S1471-4914(01)02161-X","article-title":"PI 3-kinase, mTOR, protein synthesis and cancer","volume":"7","author":"Vogt","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/mp.54.3.133","article-title":"IGF-I receptor signalling in transformation and differentiation","volume":"54","author":"Valentinis","year":"2001","journal-title":"Mol. Pathol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0168-9525(93)90209-Z","article-title":"The multistep nature of cancer","volume":"9","author":"Vogelstein","year":"1993","journal-title":"Trends Genet."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0959-437X(00)00123-4","article-title":"Genetic control of cell size","volume":"10","author":"Stocker","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0092-8674(00)80799-0","article-title":"Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4","volume":"97","author":"B\u00f6hni","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB15","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1074\/jbc.271.24.14610","article-title":"Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules","volume":"271","author":"Tanaka","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB16","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/j.1460-2075.1993.tb05842.x","article-title":"The SH2\/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling","volume":"12","author":"Skolnik","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1432-1033.1994.tb18983.x","article-title":"Involvement of Src-homology\/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor","volume":"223","author":"Giorgetti","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB18","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1242\/dev.129.17.4103","article-title":"The Drosophila insulin\/IGF receptor controls growth and size by modulating PtdInsP(3) levels","volume":"129","author":"Oldham","year":"2002","journal-title":"Development"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB19","doi-asserted-by":"crossref","first-page":"23346","DOI":"10.1074\/jbc.M003579200","article-title":"Characterization of Drosophila insulin receptor substrate","volume":"275","author":"Poltilove","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB20","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/MCB.16.5.2509","article-title":"The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis","volume":"16","author":"Yenush","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB21","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1002\/j.1460-2075.1996.tb01049.x","article-title":"The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth","volume":"1","author":"Leevers","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB22","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0960-9822(99)80450-3","article-title":"Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor","volume":"9","author":"Weinkove","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1534-5807(02)00117-X","article-title":"Drosophila's insulin\/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions","volume":"2","author":"Britton","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB24","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/emboj\/19.11.2537","article-title":"The conserved phosphoinositide 3-kinase pathway determines heart size in mice","volume":"19","author":"Shioi","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0962-8924(99)01519-6","article-title":"PTEN: a tumour suppressor that functions as a phospholipid phosphatase","volume":"9","author":"Maehama","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB26","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.96.8.4240","article-title":"New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase\/AKT pathway","volume":"96","author":"Cantley","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(00)80674-1","article-title":"The multiple roles of PTEN in tumor suppression","volume":"100","author":"Di Cristofano","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0968-0004(01)01958-2","article-title":"Ten years of protein kinase B signalling: a hard Akt to follow","volume":"26","author":"Brazil","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3350001","article-title":"Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation","volume":"335","author":"Coffer","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB30","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/70293","article-title":"Cell-autonomous regulation of cell and organ growth in Drosophila by Akt\/PKB","volume":"1","author":"Verdu","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB31","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1038\/sj.onc.1203739","article-title":"The conserved PI3\u2032K\/PTEN\/Akt signaling pathway regulates both cell size and survival in Drosophila","volume":"19","author":"Scanga","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB32","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1126\/science.1068094","article-title":"Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt\/PKB","volume":"295","author":"Stocker","year":"2002","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1357-4310(00)01770-6","article-title":"PI3-kinase inhibition: a target for drug development?","volume":"6","author":"Stein","year":"2000","journal-title":"Mol. Med. Today"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB34","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.1073\/pnas.191379498","article-title":"Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP\/RAFT\/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo","volume":"98","author":"Mills","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1535-6108(02)00024-7","article-title":"A matter of life and death","volume":"1","author":"Green","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0959-437X(00)00151-9","article-title":"Growth regulation by oncogenes \u2013 new insights from model organisms","volume":"11","author":"Prober","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","article-title":"TOR, a central controller of cell growth","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0092-8674(02)01009-7","article-title":"Identification of TOR signaling complexes: More TORC for the cell growth engine","volume":"111","author":"Abraham","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/0264-6021:3510001","article-title":"Amino acid regulation of gene expression","volume":"351","author":"Fafournoux","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1042\/0264-6021:3510545","article-title":"Amino-acid-dependent signal transduction","volume":"351","author":"van Sluijters","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/excr.1999.4683","article-title":"Ribosomal S6 kinase signaling and the control of translation","volume":"253","author":"Dufner","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB42","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/0955-0674(95)80064-6","article-title":"The 70kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling","volume":"7","author":"Chou","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-642-56688-2_5","article-title":"The p70 S6 kinase integrates nutrient and growth signals to control translational capacity","volume":"26","author":"Avruch","year":"2001","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB44","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1046\/j.1432-1327.2000.01719.x","article-title":"Synthesis of the translational apparatus is regulated at the translational level","volume":"267","author":"Meyuhas","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0955-0674(98)80150-6","article-title":"The mRNA 5\u2032 cap-binding protein eIF4E and control of cell growth","volume":"10","author":"Sonenberg","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0968-0004(97)01101-8","article-title":"PHAS\/4E-BPs as regulators of mRNA translation and cell proliferation","volume":"22","author":"Lawrence","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0065-2660(08)60142-X","article-title":"The Minute genes in Drosophila and their molecular functions","volume":"38","author":"Lambertsson","year":"1998","journal-title":"Adv. Genet."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB48","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1128\/MCB.22.6.1656-1663.2002","article-title":"Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth","volume":"22","author":"Lachance","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB49","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1126\/science.285.5436.2126","article-title":"Drosophila S6 kinase: a regulator of cell size","volume":"285","author":"Montagne","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB50","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/35078571","article-title":"The translational inhibitor 4E-BP is an effector of PI(3)K\/Akt signalling and cell growth in Drosophila","volume":"3","author":"Miron","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB51","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1093\/emboj\/17.22.6649","article-title":"Disruption of the p70s6k\/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase","volume":"17","author":"Shima","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB52","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1101\/gad.845700","article-title":"Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin","volume":"14","author":"Oldham","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB53","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1101\/gad.835000","article-title":"Regulation of cellular growth by the Drosophila target of rapamycin dTOR","volume":"14","author":"Zhang","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB54","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.995802","article-title":"Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1\/eIF4E","volume":"16","author":"Fingar","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB55","first-page":"E36","article-title":"Insulin signaling: lessons from the Drosophila tuberous sclerosis complex, a tumor suppressor","author":"Montagne","year":"2001","journal-title":"Sci. STKE"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB56","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1101\/gad.239102","article-title":"Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling","volume":"16","author":"Radimerski","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB57","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb847","article-title":"Tsc tumour suppressor proteins antagonize amino-acid TOR signalling","volume":"4","author":"Gao","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB58","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1073\/pnas.151033798","article-title":"A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice","volume":"98","author":"Kobayashi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB59","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1101\/gad.901101","article-title":"TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth","volume":"15","author":"Gao","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB60","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(01)00333-6","article-title":"Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size","volume":"105","author":"Potter","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB61","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","article-title":"The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation","volume":"105","author":"Tapon","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB62","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB63","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1083\/jcb.jcb.200206108","article-title":"Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent","volume":"159","author":"Jaeschke","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","article-title":"Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway","volume":"10","author":"Manning","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB65","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ncb840","article-title":"Akt regulates growth by directly phosphorylating Tsc2","volume":"4","author":"Potter","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB66","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ncb763","article-title":"dS6K-regulated cell growth is dPKB\/dPI(3)K-independent, but requires dPDK1","volume":"4","author":"Radimerski","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB67","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1101\/gad.13.22.2905","article-title":"Cellular survival: a play in three Akts","volume":"13","author":"Datta","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB68","first-page":"3504","article-title":"A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells","volume":"60","author":"Sekulic","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB69","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1242\/dev.125.11.2149","article-title":"Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms","volume":"125","author":"Britton","year":"1998","journal-title":"Development"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB70","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/gene.10139","article-title":"Inhibition of cellular growth and proliferation by dTOR overexpression in, Drosophila","volume":"34","author":"Hennig","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB71","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0960-9822(02)01091-6","article-title":"TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation","volume":"12","author":"Long","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB72","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35077225","article-title":"Oncogenic kinase signalling","volume":"411","author":"Blume-Jensen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB73","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1204091","article-title":"The rapamycin-sensitive signal transduction pathway as a target of cancer therapy","volume":"19","author":"Hidalgo","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0962-8924(02)00042-9_BIB74","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/bst0290541","article-title":"Interplay between insulin and nutrients in the regulation of translation factors","volume":"29","author":"Proud","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/S0962-8924(02)00042-9_BIB75","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.1073\/pnas.092141899","article-title":"Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene","volume":"99","author":"Menand","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892402000429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892402000429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T21:05:58Z","timestamp":1622667958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962892402000429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0962892402000429"],"URL":"https:\/\/doi.org\/10.1016\/s0962-8924(02)00042-9","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}