{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:28:54Z","timestamp":1779344934548,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1016\/s0962-8924(02)02262-6","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T03:21:59Z","timestamp":1027653719000},"page":"193-200","source":"Crossref","is-referenced-by-count":194,"title":["Protein kinase D: an intracellular traffic regulator on the move"],"prefix":"10.1016","volume":"12","author":[{"given":"Johan","family":"Van Lint","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Rykx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Vantus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Sturany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie R","family":"Vandenheede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Seufferlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0962-8924(02)02262-6_BIB1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-4889(99)00040-3","article-title":"PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu","volume":"1450","author":"Hayashi","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1074\/jbc.272.2.952","article-title":"Determination of the specific substrate sequence motifs of protein kinase C isozymes","volume":"272","author":"Nishikawa","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB3","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1074\/jbc.M008719200","article-title":"Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases","volume":"276","author":"Sturany","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB4","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1073\/pnas.91.18.8572","article-title":"Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain","volume":"91","author":"Valverde","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB5","doi-asserted-by":"crossref","first-page":"19567","DOI":"10.1074\/jbc.M001357200","article-title":"Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis","volume":"275","author":"Vertommen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1074\/jbc.273.1.410","article-title":"Protein kinase D activation by mutations within its pleckstrin homology domain","volume":"273","author":"Iglesias","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(99)00772-3","article-title":"Protein kinase D activation by deletion of its cysteine-rich motifs","volume":"454","author":"Iglesias","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-5793(98)01189-2","article-title":"Dissimilar phorbol ester binding properties of the individual cysteine-rich motifs of protein kinase D","volume":"437","author":"Iglesias","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB9","doi-asserted-by":"crossref","first-page":"24601","DOI":"10.1074\/jbc.M002964200","article-title":"Protein kinase C \u03bc is regulated by the multifunctional chaperon protein p32","volume":"275","author":"Storz","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB10","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1093\/emboj\/19.12.2935","article-title":"Spatial and temporal regulation of protein kinase D (PKD)","volume":"19","author":"Matthews","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.200110047","article-title":"Structural requirements for localization and activation of protein kinase C\u03bc (PKC\u03bc) at the Golgi compartment","volume":"156","author":"Hausser","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB12","doi-asserted-by":"crossref","first-page":"32616","DOI":"10.1074\/jbc.M101649200","article-title":"Rapid protein kinase D translocation in response to G protein-coupled receptor activation. Dependence on protein kinase C","volume":"276","author":"Rey","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0014-5793(99)01090-X","article-title":"Dynamic re-distribution of protein kinase D (PKD) as revealed by a GFP\u2013PKD fusion protein: dissociation from PKD activation","volume":"457","author":"Matthews","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB14","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1093\/emboj\/20.21.5982","article-title":"Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain","volume":"20","author":"Maeda","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB15","doi-asserted-by":"crossref","first-page":"49228","DOI":"10.1074\/jbc.M109395200","article-title":"Regulated nucleocytoplasmic transport of protein kinase D in response to G protein-coupled receptor activation","volume":"276","author":"Rey","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1126\/science.1066759","article-title":"Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane","volume":"295","author":"Baron","year":"2002","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB17","doi-asserted-by":"crossref","first-page":"27662","DOI":"10.1074\/jbc.273.42.27662","article-title":"Identification of in vivo phosphorylation sites required for protein kinase D activation","volume":"273","author":"Iglesias","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB18","doi-asserted-by":"crossref","first-page":"26543","DOI":"10.1074\/jbc.274.37.26543","article-title":"Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D\/protein kinase C\u03bc","volume":"274","author":"Matthews","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB19","doi-asserted-by":"crossref","first-page":"32606","DOI":"10.1074\/jbc.M101648200","article-title":"Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo","volume":"276","author":"Waldron","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB20","unstructured":"Brandlin, I. et al. PKC\u03b7 mediated PKC\u03bc-activation modulates ERK and JNK signal pathways. J. Biol. Chem. (in press)"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB21","doi-asserted-by":"crossref","first-page":"9224","DOI":"10.1074\/jbc.274.14.9224","article-title":"The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C","volume":"274","author":"Waldron","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(00)81092-2","article-title":"Active and inactive protein kinases: structural basis for regulation","volume":"85","author":"Johnson","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(98)00606-1","article-title":"The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases","volume":"430","author":"Johnson","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB24","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.1074\/jbc.274.14.9258","article-title":"Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins","volume":"274","author":"Hausser","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/27938","article-title":"A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity","volume":"394","author":"Tzivion","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0092-8674(00)80606-6","article-title":"G\u03b2\u03b3-mediated regulation of Golgi organization is through the direct activation of protein kinase D","volume":"98","author":"Jamora","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB27","doi-asserted-by":"crossref","first-page":"18476","DOI":"10.1074\/jbc.M002266200","article-title":"Proteolytic cleavage and activation of protein kinase C \u03bc by caspase-3 in the apoptotic response of cells to 1-\u03b2-D-arabinofuranosylcytosine and other genotoxic agents","volume":"275","author":"Endo","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB28","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1074\/jbc.270.3.1455","article-title":"Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase","volume":"270","author":"Van Lint","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB29","doi-asserted-by":"crossref","first-page":"23952","DOI":"10.1074\/jbc.272.38.23952","article-title":"Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway","volume":"272","author":"Zugaza","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB30","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1074\/jbc.273.12.7038","article-title":"Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase C\u03b3 and protein kinase C","volume":"273","author":"Van Lint","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB31","doi-asserted-by":"crossref","first-page":"20245","DOI":"10.1074\/jbc.272.32.20245","article-title":"Bryostatin 1 induces biphasic activation of protein kinase D in intact cells","volume":"272","author":"Matthews","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB32","doi-asserted-by":"crossref","first-page":"17114","DOI":"10.1074\/jbc.M908959199","article-title":"Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C","volume":"275","author":"Waldron","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1074-7613(00)80261-7","article-title":"Protein kinase C \u03bc (PKC \u03bc) associates with the B cell antigen receptor complex and regulates lymphocyte signaling","volume":"5","author":"Sidorenko","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.160.1.273","article-title":"Common and distinct signaling pathways mediate the induction of TNF-\u03b1 and IL-5 in IgE plus antigen-stimulated mast cells","volume":"160","author":"Csonga","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1432-1327.1998.2570047.x","article-title":"Protein kinase C\u03bc downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-\u03baB-dependent protective genes","volume":"257","author":"Johannes","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB36","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/cr0002801","article-title":"Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions","volume":"101","author":"Newton","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB37","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/0264-6021:3460561","article-title":"The PI3K\u2013PDK1 connection: more than just a road to PKB","volume":"346","author":"Vanhaesebroeck","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0014-5793(99)01424-6","article-title":"Bruton's tyrosine kinase (Btk) associates with protein kinase C \u03bc","volume":"461","author":"Johannes","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-5793(01)02219-0","article-title":"Protein kinase C \u03bc selectively activates the mitogen-activated protein kinase (MAPK) p42 pathway","volume":"492","author":"Hausser","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB40","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/MCB.22.3.916-926.2001","article-title":"The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins","volume":"22","author":"Wang","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB41","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1093\/emboj\/18.20.5567","article-title":"Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor","volume":"18","author":"Bagowski","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB42","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/bbrc.2001.4591","article-title":"Protein kinase D is sufficient to suppress EGF-induced c-Jun Ser 63 phosphorylation","volume":"282","author":"Hurd","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB43","doi-asserted-by":"crossref","first-page":"40048","DOI":"10.1074\/jbc.M005261200","article-title":"Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D","volume":"275","author":"Iglesias","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1097-0215(19990105)80:1<98::AID-IJC19>3.0.CO;2-D","article-title":"Protein-kinase-C\u03bc expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture","volume":"80","author":"Rennecke","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB45","doi-asserted-by":"crossref","first-page":"40298","DOI":"10.1074\/jbc.M106512200","article-title":"Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin or phorbol esters in Swiss 3T3 cells","volume":"276","author":"Zhukova","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB46","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1038\/sj.onc.1202827","article-title":"An invasion-related complex of cortactin, paxillin and PKC\u03bc associates with invadopodia at sites of extracellular matrix degradation","volume":"18","author":"Bowden","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB47","first-page":"2445","article-title":"Cis-polyunsaturated fatty acids stimulate \u03b21 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-\u03b5 and -\u03bc","volume":"61","author":"Palmantier","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0092-8674(01)00228-8","article-title":"Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network","volume":"104","author":"Liljedahl","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB49","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0092-8674(00)81713-4","article-title":"The curious status of the Golgi apparatus","volume":"95","author":"Glick","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB50","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0955-0674(98)80064-1","article-title":"The organisation of the Golgi apparatus","volume":"10","author":"Warren","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0092-8674(00)80449-3","article-title":"Regulation of Golgi structure through heterotrimeric G proteins","volume":"91","author":"Jamora","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02262-6_BIB52","doi-asserted-by":"crossref","first-page":"23126","DOI":"10.1074\/jbc.273.36.23126","article-title":"Association of protein kinase C\u03bc with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase","volume":"273","author":"Nishikawa","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-230X(08)60767-8","article-title":"Phosphoinositide 4- and 5-kinases and the cellular roles of phosphatidylinositol 4,5-bisphosphate","volume":"74","author":"Hsuan","year":"1998","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/S0962-8924(02)02262-6_BIB54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/43613","article-title":"Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid","volume":"401","author":"Schmidt","year":"1999","journal-title":"Nature"}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892402022626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892402022626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T05:09:07Z","timestamp":1681794547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962892402022626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0962892402022626"],"URL":"https:\/\/doi.org\/10.1016\/s0962-8924(02)02262-6","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}