{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T05:53:35Z","timestamp":1776578015951,"version":"3.51.2"},"reference-count":124,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1016\/s0965-1748(00)00018-7","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T02:32:40Z","timestamp":1027650760000},"page":"429-442","source":"Crossref","is-referenced-by-count":46,"title":["Mosquito immune responses and malaria transmission: lessons from insect model systems and implications for vertebrate innate immunity and vaccine development"],"prefix":"10.1016","volume":"30","author":[{"given":"Carolina","family":"Barillas-Mury","sequence":"first","affiliation":[]},{"given":"Benjamin","family":"Wizel","sequence":"additional","affiliation":[]},{"given":"Yeon","family":"Soo Han","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"5428","key":"10.1016\/S0965-1748(00)00018-7_BIB1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.285.5428.736","article-title":"Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2","volume":"285","author":"Aliprantis","year":"1999","journal-title":"Science"},{"issue":"17","key":"10.1016\/S0965-1748(00)00018-7_BIB2","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1002\/j.1460-2075.1996.tb00846.x","article-title":"Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae","volume":"15","author":"Barillas-Mury","year":"1996","journal-title":"Embo J."},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/emboj\/18.4.959","article-title":"Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection","volume":"18","author":"Barillas-Mury","year":"1999","journal-title":"Embo J."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1101\/gad.8.3.300","article-title":"Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila","volume":"8","author":"Binari","year":"1994","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/S0965-1748(00)00018-7_BIB5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(88)90099-2","article-title":"The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV","volume":"53","author":"B\u00f6hnlein","year":"1988","journal-title":"Cell"},{"issue":"5428","key":"10.1016\/S0965-1748(00)00018-7_BIB6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1126\/science.285.5428.732","article-title":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors","volume":"285","author":"Brightbill","year":"1999","journal-title":"Science"},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0965-1748(94)90033-7","article-title":"Purification of an insect defensin from the mosquito, Aedes aegypti","volume":"24","author":"Chalk","year":"1994","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/BF02258365","article-title":"Identification of immune-related protein kinases from mosquitoes (Aedes aegypti)","volume":"5","author":"Chiou","year":"1998","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/S0965-1748(00)00018-7_BIB9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0965-1748(97)00017-9","article-title":"Molecular characterization of a defensin gene from the mosquito, Aedes aegypti","volume":"27","author":"Cho","year":"1997","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0965-1748(95)00108-5","article-title":"Cloning and characterization of cDNAs encoding the antibacterial peptide, defensin A, from the mosquito, Aedes aegypti","volume":"26","author":"Cho","year":"1996","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"16","key":"10.1016\/S0965-1748(00)00018-7_BIB11","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","article-title":"Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction","volume":"274","author":"Chow","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB12","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1073\/pnas.95.7.3748","article-title":"Mariner transposition and transformation of the yellow fever mosquito, Aedes aegypti","volume":"95","author":"Coates","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"18","key":"10.1016\/S0965-1748(00)00018-7_BIB13","doi-asserted-by":"crossref","first-page":"12650","DOI":"10.1074\/jbc.274.18.12650","article-title":"Vesicular ATPase-overexpressing cells determine the distribution of malaria parasite oocysts on the midguts of mosquitoes","volume":"274","author":"Cociancich","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"4776","key":"10.1016\/S0965-1748(00)00018-7_BIB14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.3532325","article-title":"Genetic selection of a Plasmodium-refractory strain of the malaria vector Anopheles gambiae","volume":"234","author":"Collins","year":"1986","journal-title":"Science"},{"issue":"5","key":"10.1016\/S0965-1748(00)00018-7_BIB15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/00034989760888","article-title":"Progress in the map-based cloning of the Anopheles gambiae genes responsible for the encapsulation of malarial parasites","volume":"91","author":"Collins","year":"1997","journal-title":"Ann. Trop. Med. Parasitol."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0969-2126(99)80107-5","article-title":"Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA","volume":"7","author":"Cramer","year":"1999","journal-title":"Structure Fold. Des."},{"issue":"5332","key":"10.1016\/S0965-1748(00)00018-7_BIB17","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"issue":"5416","key":"10.1016\/S0965-1748(00)00018-7_BIB18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1126\/science.284.5416.951","article-title":"Requirement for type 2 NO synthase for IL-12 signaling in innate immunity","volume":"284","author":"Diefenbach","year":"1999","journal-title":"Science"},{"issue":"21","key":"10.1016\/S0965-1748(00)00018-7_BIB19","doi-asserted-by":"crossref","first-page":"11508","DOI":"10.1073\/pnas.94.21.11508","article-title":"Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites","volume":"94","author":"Dimopoulos","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"21","key":"10.1016\/S0965-1748(00)00018-7_BIB20","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1093\/emboj\/17.21.6115","article-title":"Malaria infection of the mosquito Anopheles gambiae activates immune-responsive genes during critical transition stages of the parasite life cycle","volume":"17","author":"Dimopoulos","year":"1998","journal-title":"Embo J."},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB21","doi-asserted-by":"crossref","first-page":"884","DOI":"10.4049\/jimmunol.163.2.884","article-title":"IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model","volume":"163","author":"Doolan","year":"1999","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/jmbi.1993.1392","article-title":"kappa B-like motifs regulate the induction of immune genes in Drosophila","volume":"232","author":"Engstr\u00f6m","year":"1993","journal-title":"J. Mol. Biol."},{"issue":"5258","key":"10.1016\/S0965-1748(00)00018-7_BIB23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.272.5258.50","article-title":"The instructive role of innate immunity in the acquired immune response","volume":"272","author":"Fearon","year":"1996","journal-title":"Science"},{"issue":"14","key":"10.1016\/S0965-1748(00)00018-7_BIB24","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/emboj\/17.14.3816","article-title":"Malaria circumsporozoite protein inhibits protein synthesis in mammalian cells","volume":"17","author":"Frevert","year":"1998","journal-title":"Embo J."},{"issue":"17","key":"10.1016\/S0965-1748(00)00018-7_BIB25","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1073\/pnas.92.17.7769","article-title":"Nucleotide sequence of the cDNA encoding the proenzyme of phenol oxidase A1 of Drosophila melanogaster","volume":"92","author":"Fujimoto","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0952-7915(98)80029-0","article-title":"Antimicrobial peptides of vertebrates","volume":"10","author":"Ganz","year":"1998","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0965-1748(00)00018-7_BIB27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0965-1748(99)00095-8","article-title":"Molecular characterization of five serine protease genes cloned from Anopheles gambiae hemolymph","volume":"30","author":"Gorman","year":"2000","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4269\/ajtmh.1997.56.446","article-title":"A genetic study of a melanization response to Sephadex beads in Plasmodium-refractory and -susceptible strains of Anopheles gambiae","volume":"56","author":"Gorman","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB29","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/genetics\/146.3.965","article-title":"Mapping a quantitative trait locus involved in melanotic encapsulation of foreign bodies in the malaria vector, Anopheles gambiae","volume":"146","author":"Gorman","year":"1997","journal-title":"Genetics"},{"issue":"17","key":"10.1016\/S0965-1748(00)00018-7_BIB30","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1073\/pnas.92.17.7764","article-title":"Proenzyme of Manduca sexta phenol oxidase: purification, activation, substrate specificity of the active enzyme, and molecular cloning","volume":"92","author":"Hall","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1-2","key":"10.1016\/S0965-1748(00)00018-7_BIB31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00279527","article-title":"The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus","volume":"238","author":"Hanratty","year":"1993","journal-title":"Mol. Gen. Genet."},{"issue":"12","key":"10.1016\/S0965-1748(00)00018-7_BIB32","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1002\/j.1460-2075.1995.tb07285.x","article-title":"Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects","volume":"14","author":"Harrison","year":"1995","journal-title":"Embo J."},{"issue":"5","key":"10.1016\/S0965-1748(00)00018-7_BIB33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1097-2765(00)80392-5","article-title":"Relish, a central factor in the control of humoral but not cellular immunity in Drosophila","volume":"4","author":"Hedengren","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0965-1748(00)00018-7_BIB34","series-title":"Malaria Vaccine Development","first-page":"35","article-title":"Attacking the infected hepatocyte","author":"Hoffman","year":"1996"},{"issue":"5418","key":"10.1016\/S0965-1748(00)00018-7_BIB35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.284.5418.1313","article-title":"Phylogenetic perspectives in innate immunity","volume":"284","author":"Hoffmann","year":"1999","journal-title":"Science"},{"issue":"8","key":"10.1016\/S0965-1748(00)00018-7_BIB36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0962-8924(97)01087-8","article-title":"Drosophila immunity","volume":"7","author":"Hoffmann","year":"1997","journal-title":"Trends in Cell Biology"},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB37","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)81286-6","article-title":"Marelle acts downstream of the Drosophila HOP\/JAK kinase and encodes a protein similar to the mammalian STATs","volume":"84","author":"Hou","year":"1996","journal-title":"Cell"},{"issue":"4903","key":"10.1016\/S0965-1748(00)00018-7_BIB39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.2497518","article-title":"Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression","volume":"244","author":"Hoyos","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0965-1748(00)00018-7_BIB40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)81277-5","article-title":"STATs: Signal Transducers and Activators of Transcription","volume":"84","author":"Ihle","year":"1996","journal-title":"Cell"},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB41","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0092-8674(93)90495-C","article-title":"Dif, a dorsal-related gene that mediates an immune response in Drosophila","volume":"75","author":"Ip","year":"1993","journal-title":"Cell"},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB42","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4049\/jimmunol.161.2.539","article-title":"Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response","volume":"161","author":"Janeway","year":"1998","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB43","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1073\/pnas.95.7.3743","article-title":"Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly","volume":"95","author":"Jasinskiene","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"21","key":"10.1016\/S0965-1748(00)00018-7_BIB44","doi-asserted-by":"crossref","first-page":"12220","DOI":"10.1073\/pnas.95.21.12220","article-title":"Pro-phenol oxidase activating proteinase from an insect, Manduca sexta: a bacteria-inducible protein similar to Drosophila easter","volume":"95","author":"Jiang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB45","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0965-1748(97)00045-3","article-title":"Molecular cloning of cDNAs for two pro-phenol oxidase subunits from the malaria vector, Anopheles gambiae","volume":"27","author":"Jiang","year":"1997","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"10","key":"10.1016\/S0965-1748(00)00018-7_BIB46","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0965-1748(97)00066-0","article-title":"Subunit composition of pro-phenol oxidase from Manduca sexta: molecular cloning of subunit ProPO-P1","volume":"27","author":"Jiang","year":"1997","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-1119(96)00088-1","article-title":"Analysis of a lysozyme gene from the malaria vector mosquito, Anopheles gambiae","volume":"174","author":"Kang","year":"1996","journal-title":"Gene"},{"issue":"4-5","key":"10.1016\/S0965-1748(00)00018-7_BIB48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0145-305X(99)00012-9","article-title":"Serine proteinase inhibitors in arthropod immunity","volume":"23","author":"Kanost","year":"1999","journal-title":"Dev. Comp. Immunol."},{"issue":"6587","key":"10.1016\/S0965-1748(00)00018-7_BIB49","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/382174a0","article-title":"Impaired IL-12 responses and enhanced development of Th2 cells in Stat4- deficient mice","volume":"382","author":"Kaplan","year":"1996","journal-title":"Nature"},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB50","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/j.1460-2075.1993.tb05800.x","article-title":"Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila","volume":"12","author":"Kappler","year":"1993","journal-title":"Embo J."},{"issue":"17","key":"10.1016\/S0965-1748(00)00018-7_BIB51","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1073\/pnas.92.17.7774","article-title":"Molecular cloning of insect pro-phenol oxidase: a copper-containing protein homologous to arthropod hemocyanin","volume":"92","author":"Kawabata","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/S0965-1748(00)00018-7_BIB52","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1084\/jem.188.11.2091","article-title":"Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide","volume":"188","author":"Kirschning","year":"1998","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB53","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.4049\/jimmunol.154.7.3391","article-title":"Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites","volume":"154","author":"Klotz","year":"1995","journal-title":"J. Immunol."},{"issue":"14","key":"10.1016\/S0965-1748(00)00018-7_BIB54","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1096\/fasebj.10.14.9002549","article-title":"Regulation of STAT-dependent pathways by growth factors and cytokines","volume":"10","author":"Leaman","year":"1996","journal-title":"Faseb J."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB55","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1432-1327.1998.2570615.x","article-title":"Molecular cloning of cDNA for pro-phenol\u2013oxidase-activating factor I, a serine protease is induced by lipopolysaccharide or 1,3-beta-glucan in coleopteran insect, Holotrichia diomphalia larvae","volume":"257","author":"Lee","year":"1998","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2583.1998.71047.x","article-title":"Molecular cloning and chromosomal localization of a prophenoloxidase cDNA from the malaria vector Anopheles gambiae","volume":"7","author":"Lee","year":"1998","journal-title":"Insect. Mol. Biol."},{"issue":"15","key":"10.1016\/S0965-1748(00)00018-7_BIB57","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1073\/pnas.93.15.7888","article-title":"Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori","volume":"93","author":"Lee","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0952-7915(99)80005-3","article-title":"Antimicrobial peptides in mammalian and insect host defence","volume":"11","author":"Lehrer","year":"1999","journal-title":"Curr. Opin. Immunol."},{"issue":"21","key":"10.1016\/S0965-1748(00)00018-7_BIB59","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1073\/pnas.92.21.9465","article-title":"A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense","volume":"92","author":"Lemaitre","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB60","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/j.1460-2075.1995.tb07029.x","article-title":"Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila","volume":"14","author":"Lemaitre","year":"1995","journal-title":"Embo J."},{"issue":"6","key":"10.1016\/S0965-1748(00)00018-7_BIB61","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette spatzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB62","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0092-8674(89)90833-7","article-title":"NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control","volume":"58","author":"Lenardo","year":"1989","journal-title":"Cell"},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB63","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/jmbi.1998.1705","article-title":"Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin","volume":"278","author":"Levashina","year":"1998","journal-title":"J. Mol. Biol."},{"issue":"5435","key":"10.1016\/S0965-1748(00)00018-7_BIB64","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.285.5435.1917","article-title":"Constitutive activation of toll-mediated antifungal defense in serpin-deficient drosophila","volume":"285","author":"Levashina","year":"1999","journal-title":"Science"},{"issue":"29","key":"10.1016\/S0965-1748(00)00018-7_BIB65","doi-asserted-by":"crossref","first-page":"20092","DOI":"10.1074\/jbc.274.29.20092","article-title":"Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti","volume":"274","author":"Lowenberger","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/expr.1999.4350","article-title":"Mosquito\u2013Plasmodium interactions in response to immune activation of the vector","volume":"91","author":"Lowenberger","year":"1999","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2583.1999.810107.x","article-title":"Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti","volume":"8","author":"Lowenberger","year":"1999","journal-title":"Insect Mol. Biol."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB68","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0965-1748(95)00043-U","article-title":"Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti","volume":"25","author":"Lowenberger","year":"1995","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(99)00121-3","article-title":"Gene structure and polymorphism of an invertebrate nitric oxide synthase gene","volume":"232","author":"Luckhart","year":"1999","journal-title":"Gene"},{"issue":"10","key":"10.1016\/S0965-1748(00)00018-7_BIB70","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1073\/pnas.95.10.5700","article-title":"The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide","volume":"95","author":"Luckhart","year":"1998","journal-title":"Proc. Natl. Acad. Sci., USA"},{"key":"10.1016\/S0965-1748(00)00018-7_BIB71","doi-asserted-by":"crossref","unstructured":"Ma, C., Kanost, M.R., 2000. A beta,1-3-glucan-recognition protein from an insect, Manduca sexta, agglutinates microorganisms and activates the phenoloxidase cascade. J. Biol. Chem., In press.","DOI":"10.1074\/jbc.275.11.7505"},{"issue":"12","key":"10.1016\/S0965-1748(00)00018-7_BIB72","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1093\/emboj\/18.12.3380","article-title":"A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF","volume":"18","author":"Manfruelli","year":"1999","journal-title":"Embo J."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB73","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0092-8674(93)90127-C","article-title":"A structural superfamily of growth factors containing a cystine knot motif","volume":"73","author":"McDonald","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB74","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0952-7915(97)80152-5","article-title":"Innate immunity: impact on the adaptive immune response","volume":"9","author":"Medzhitov","year":"1997","journal-title":"Curr. Opin. Immunol."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB75","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)80412-2","article-title":"Innate immunity: the virtues of a nonclonal system of recognition","volume":"91","author":"Medzhitov","year":"1997","journal-title":"Cell"},{"issue":"6640","key":"10.1016\/S0965-1748(00)00018-7_BIB76","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"issue":"12","key":"10.1016\/S0965-1748(00)00018-7_BIB77","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.4049\/jimmunol.139.12.4192","article-title":"Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures","volume":"139","author":"Mellouk","year":"1987","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB78","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1101\/gad.13.7.792","article-title":"Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor","volume":"13","author":"Meng","year":"1999","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB79","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(00)81288-X","article-title":"Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway","volume":"84","author":"Meraz","year":"1996","journal-title":"Cell"},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB80","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2583.1998.00067.x","article-title":"A lysozyme in the salivary glands of the malaria vector Anopheles darlingi","volume":"7","author":"Moreira-Ferro","year":"1998","journal-title":"Insect Mol. Biol."},{"issue":"17","key":"10.1016\/S0965-1748(00)00018-7_BIB81","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1074\/jbc.274.17.11727","article-title":"A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes","volume":"274","author":"M\u00fcller","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB82","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0952-7915(96)80103-8","article-title":"The role of hemolymph coagulation in innate immunity","volume":"8","author":"Muta","year":"1996","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB83","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/eji.1830210134","article-title":"l-Arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and\/or interleukin 6 stimulation","volume":"21","author":"Nussler","year":"1991","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB84","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/3.4.317","article-title":"TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6","volume":"3","author":"Nussler","year":"1991","journal-title":"Int. Immunol."},{"key":"10.1016\/S0965-1748(00)00018-7_BIB85","series-title":"The Insect Viruses","article-title":"RNA virus expression systems","author":"Olson","year":"1998"},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(00)80505-1","article-title":"Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?","volume":"7","author":"O'Shea","year":"1997","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB87","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/ae\/45.2.80","article-title":"Mosquito immunity and malaria parasites","volume":"45","author":"Paskewitz","year":"1999","journal-title":"American Entomologist"},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB88","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2583.1999.83124.x","article-title":"An easter-like serine protease from Anopheles gambiae exhibits changes in transcript abundance following immune challenge","volume":"8","author":"Paskewitz","year":"1999","journal-title":"Insect Mol. Biol."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB89","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0012-1606(86)90070-9","article-title":"Hopscotch, a larval\u2013pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila","volume":"118","author":"Perrimon","year":"1986","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB90","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4049\/jimmunol.148.1.197","article-title":"IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite","volume":"148","author":"Pied","year":"1992","journal-title":"J. Immunol."},{"issue":"5396","key":"10.1016\/S0965-1748(00)00018-7_BIB91","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB92","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2583.1996.tb00055.x","article-title":"Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA","volume":"5","author":"Richman","year":"1996","journal-title":"Insect Mol. Biol."},{"issue":"20","key":"10.1016\/S0965-1748(00)00018-7_BIB93","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1093\/emboj\/16.20.6114","article-title":"Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes","volume":"16","author":"Richman","year":"1997","journal-title":"Embo J."},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB94","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll","volume":"95","author":"Rock","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/S0965-1748(00)00018-7_BIB95","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1074\/jbc.274.11.7441","article-title":"Prophenoloxidase-activating enzyme of the silkworm, Bombyx mori. Purification, characterization, and cDNA cloning","volume":"274","author":"Satoh","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/S0965-1748(00)00018-7_BIB96","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF02529735","article-title":"Molecular mechanisms of endotoxin activity","volume":"164","author":"Schletter","year":"1995","journal-title":"Arch. Microbiol."},{"issue":"22","key":"10.1016\/S0965-1748(00)00018-7_BIB97","doi-asserted-by":"crossref","first-page":"10700","DOI":"10.1073\/pnas.91.22.10700","article-title":"Interleukin 12 induction of interferon gamma-dependent protection against malaria","volume":"91","author":"Sedegah","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0965-1748(00)00018-7_BIB98","first-page":"583","article-title":"Multiple immune factors interact with the immunoglobulin enhancer sequences","volume":"330","author":"Sen","year":"1986","journal-title":"Cell"},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB99","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1073\/pnas.95.7.3385","article-title":"Plasmodium gallinaceum preferentially invades vesicular ATPase-expressing cells in Aedes aegypti midgut","volume":"95","author":"Shahabuddin","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0952-7915(98)80026-5","article-title":"Role of the prophenoloxidase-activating system in invertebrate immunity","volume":"10","author":"S\u00f6derh\u00e4ll","year":"1998","journal-title":"Curr. Opin. Immunol."},{"issue":"5820","key":"10.1016\/S0965-1748(00)00018-7_BIB101","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/292246a0","article-title":"Sequence and specificity of two antibacterial proteins involved in insect immunity","volume":"292","author":"Steiner","year":"1981","journal-title":"Nature"},{"issue":"4827","key":"10.1016\/S0965-1748(00)00018-7_BIB102","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1126\/science.3118464","article-title":"Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel","volume":"238","author":"Steward","year":"1987","journal-title":"Science"},{"issue":"6","key":"10.1016\/S0965-1748(00)00018-7_BIB103","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0092-8674(89)90773-3","article-title":"Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function","volume":"59","author":"Steward","year":"1989","journal-title":"Cell"},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB104","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1006\/bbrc.1998.9150","article-title":"Peptide sequence of an antibiotic cecropin from the vector mosquito, Aedes albopictus","volume":"249","author":"Sun","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1-2","key":"10.1016\/S0965-1748(00)00018-7_BIB105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(99)00799-1","article-title":"Cloning and expression of three cecropin cDNAs from a mosquito cell line","volume":"454","author":"Sun","year":"1999","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB106","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0305-0491(92)90436-U","article-title":"Affinity purification and characterization of CIF, an insect immunoresponsive factor with NF-kappa B-like properties","volume":"103","author":"Sun","year":"1992","journal-title":"Comp. Biochem. Physiol. B"},{"issue":"6575","key":"10.1016\/S0965-1748(00)00018-7_BIB107","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/380627a0","article-title":"Essential role of Stat6 in IL-4 signalling","volume":"380","author":"Takeda","year":"1996","journal-title":"Nature"},{"issue":"4","key":"10.1016\/S0965-1748(00)00018-7_BIB108","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"issue":"1-2","key":"10.1016\/S0965-1748(00)00018-7_BIB109","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-1119(99)00098-0","article-title":"TLR6: A novel member of an expanding toll-like receptor family","volume":"231","author":"Takeuchi","year":"1999","journal-title":"Gene"},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/5504","article-title":"Endotoxin opens the Tollgates to innate immunity","volume":"5","author":"Ulevitch","year":"1999","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB111","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0952-7915(99)80004-1","article-title":"Recognition of gram-negative bacteria and endotoxin by the innate immune system","volume":"11","author":"Ulevitch","year":"1999","journal-title":"Curr. Opin. Immunol."},{"issue":"6755","key":"10.1016\/S0965-1748(00)00018-7_BIB112","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/44605","article-title":"The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens","volume":"401","author":"Underhill","year":"1999","journal-title":"Nature"},{"issue":"8","key":"10.1016\/S0965-1748(00)00018-7_BIB113","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1091\/mbc.4.8.767","article-title":"A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B","volume":"4","author":"Wasserman","year":"1993","journal-title":"Mol. Biol. Cell"},{"issue":"20","key":"10.1016\/S0965-1748(00)00018-7_BIB114","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1093\/emboj\/16.20.6120","article-title":"The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense","volume":"16","author":"Williams","year":"1997","journal-title":"Embo J."},{"issue":"6671","key":"10.1016\/S0965-1748(00)00018-7_BIB115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/32195","article-title":"Regulated nuclear import of Rel proteins in the Drosophila immune response","volume":"392","author":"Wu","year":"1998","journal-title":"Nature"},{"issue":"6","key":"10.1016\/S0965-1748(00)00018-7_BIB116","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1084\/jem.177.6.1779","article-title":"Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide","volume":"177","author":"Xie","year":"1993","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/S0965-1748(00)00018-7_BIB117","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(00)81287-8","article-title":"Identification of a Stat gene that functions in Drosophila development","volume":"84","author":"Yan","year":"1996","journal-title":"Cell"},{"issue":"6699","key":"10.1016\/S0965-1748(00)00018-7_BIB118","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/26239","article-title":"Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling","volume":"395","author":"Yang","year":"1998","journal-title":"Nature"},{"issue":"23","key":"10.1016\/S0965-1748(00)00018-7_BIB119","doi-asserted-by":"crossref","first-page":"12337","DOI":"10.1073\/pnas.94.23.12337","article-title":"Mosquito transferrin, an acute-phase protein that is up-regulated upon infection","volume":"94","author":"Yoshiga","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.163.1.1","article-title":"Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2","volume":"163","author":"Yoshimura","year":"1999","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/S0965-1748(00)00018-7_BIB121","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0965-1748(99)00036-3","article-title":"Immulectin, an inducible C-type lectin from an insect, Manduca sexta, stimulates activation of plasma prophenol oxidase","volume":"29","author":"Yu","year":"1999","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/S0965-1748(00)00018-7_BIB122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(95)01050-O","article-title":"Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain","volume":"374","author":"Zanetti","year":"1995","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/S0965-1748(00)00018-7_BIB123","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/genetics\/143.2.941","article-title":"An integrated genetic map of the African human malaria vector mosquito, Anopheles gambiae","volume":"143","author":"Zheng","year":"1996","journal-title":"Genetics"},{"issue":"5311","key":"10.1016\/S0965-1748(00)00018-7_BIB124","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.276.5311.425","article-title":"Quantitative trait loci for refractoriness of Anopheles gambiae to Plasmodium cynomolgi B","volume":"276","author":"Zheng","year":"1997","journal-title":"Science"}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174800000187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174800000187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:51:19Z","timestamp":1681692679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174800000187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":124,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0965174800000187"],"URL":"https:\/\/doi.org\/10.1016\/s0965-1748(00)00018-7","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}