{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:59:41Z","timestamp":1780484381177,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Biochemical Sciences"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1016\/s0968-0004(02)02179-5","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T20:25:18Z","timestamp":1034022318000},"page":"514-520","source":"Crossref","is-referenced-by-count":797,"title":["Evolution of protein kinase signaling from yeast to man"],"prefix":"10.1016","volume":"27","author":[{"given":"Gerard","family":"Manning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D","family":"Plowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucha","family":"Sudarsanam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0968-0004(02)02179-5_BIB1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1101\/gr.8.10.1038","article-title":"Novel families of putative protein kinases in bacteria and archaea: evolution of the \u201ceukaryotic\u201d protein kinase superfamily","volume":"8","author":"Leonard","year":"1998","journal-title":"Genome Res."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1097-2765(01)00256-8","article-title":"Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity","volume":"7","author":"Yamaguchi","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0014-5793(02)02299-8","article-title":"Elongation factor-2 kinase and its newly discovered relatives","volume":"514","author":"Ryazanov","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0968-0004(96)10068-2","article-title":"The protein kinases of budding yeast: six score and more","volume":"22","author":"Hunter","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB5","doi-asserted-by":"crossref","first-page":"13603","DOI":"10.1073\/pnas.96.24.13603","article-title":"The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms","volume":"96","author":"Plowman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","article-title":"Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB7","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1006\/jmbi.2000.5197","article-title":"Automatic clustering of orthologs and in-paralogs from pairwise species comparisons","volume":"314","author":"Remm","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature724","article-title":"The genome sequence of Schizosaccharomyces pombe","volume":"415","author":"Wood","year":"2002","journal-title":"Nature"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/nar\/28.1.77","article-title":"Integrating functional genomic information into the Saccharomyces genome database","volume":"28","author":"Ball","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/387489a0","article-title":"Evidence for a clade of nematodes, arthropods and other moulting animals","volume":"387","author":"Aguinaldo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1101\/gr.8.6.590","article-title":"Large-scale taxonomic profiling of eukaryotic model organisms: a comparison of orthologous proteins encoded by the human, fly, nematode, and yeast genomes","volume":"8","author":"Mushegian","year":"1998","journal-title":"Genome Res."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2148-2-7","article-title":"The evolutionary position of nematodes","volume":"2","author":"Blair","year":"2002","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1101\/gr.10.2.192","article-title":"The large srh family of chemoreceptor genes inCaenorhabditis nematodes reveals processes of genome evolution involving large duplications and deletions and intron gains and losses","volume":"10","author":"Robertson","year":"2000","journal-title":"Genome Res."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB14","doi-asserted-by":"crossref","unstructured":"Maglich, J.M. et al. (2001). Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol. 2, research0029.0021-0027","DOI":"10.1186\/gb-2001-2-8-research0029"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/chemse\/26.2.151","article-title":"Updating the str and srj (stl) families of chemoreceptors in Caenorhabditis nematodes reveals frequent gene movement within and between chromosomes","volume":"26","author":"Robertson","year":"2001","journal-title":"Chem. Senses"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1101\/gr208802. Article published online before print in April 2002","article-title":"Evidence suggesting that a fifth of annotated Caenorhabditis elegans genes may be pseudogenes","volume":"12","author":"Mounsey","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0960-9822(01)00524-3","article-title":"Identification of the first invertebrate interleukin JAK\/STAT receptor, the Drosophila gene domeless","volume":"11","author":"Brown","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB18","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/bies.10016","article-title":"The JAK\/STAT pathway and Drosophila development","volume":"23","author":"Luo","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0168-9525(00)02095-3","article-title":"Genes that fight infection: what the Drosophila genome says about animal immunity","volume":"16","author":"Khush","year":"2000","journal-title":"Trends Genet."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB20","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1101\/gad.909001","article-title":"NF-\u03baB signaling pathways in mammalian and insect innate immunity","volume":"15","author":"Silverman","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB21","first-page":"M57","article-title":"A new family of IKK-related kinases may function as I \u03ba B kinase kinases","volume":"1471","author":"Peters","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0959-437X(00)00118-0","article-title":"Toll signaling: the enigma variations","volume":"10","author":"Wasserman","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB23","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0960-9822(01)00241-X","article-title":"A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans","volume":"11","author":"Pujol","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB24","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/35021086","article-title":"The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells","volume":"406","author":"Coopman","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-1119(99)00373-X","article-title":"Appearance and disappearance of Syk family protein-tyrosine kinase genes during metazoan evolution","volume":"239","author":"Steele","year":"1999","journal-title":"Gene"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB26","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/PL00006508","article-title":"Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra","volume":"48","author":"Suga","year":"1999","journal-title":"J. Mol. Evol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1097-2765(00)80081-7","article-title":"The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development","volume":"1","author":"Roulier","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB28","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1128\/MCB.19.6.4405","article-title":"The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation","volume":"19","author":"Baba","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0896-6273(01)00446-9","article-title":"The transmembrane protein off-track associates with plexins and functions downstream of semaphorin signaling during axon guidance","volume":"32","author":"Winberg","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB30","first-page":"2179","article-title":"Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family","volume":"11","author":"Mossie","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/1521-1878(200101)23:1<69::AID-BIES1009>3.3.CO;2-B","article-title":"Deceiving appearances: signaling by \u201cdead\u201d and \u201cfractured\u201d receptor protein-tyrosine kinases","volume":"23","author":"Kroiher","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/1521-1878(200101)23:1<34::AID-BIES1005>3.3.CO;2-4","article-title":"Revelations of the RYK receptor","volume":"23","author":"Halford","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB33","doi-asserted-by":"crossref","first-page":"11916","DOI":"10.1074\/jbc.272.18.11916","article-title":"A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling","volume":"272","author":"Oishi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00018-002-8407-9","article-title":"The Ror receptor tyrosine kinase family","volume":"59","author":"Forrester","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB35","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0896-6273(00)80739-4","article-title":"A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals","volume":"22","author":"Zhou","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB36","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1002\/j.1460-2075.1995.tb00124.x","article-title":"Calmodulin binding to Drosophila NinaC required for termination of phototransduction","volume":"14","author":"Porter","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/(SICI)1097-0169(1996)35:4<367::AID-CM8>3.0.CO;2-3","article-title":"Role of the ninaC proteins in photoreceptor cell structure: ultrastructure of ninaC deletion mutants and binding to actin filaments","volume":"35","author":"Hicks","year":"1996","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB38","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/geno.2000.6256","article-title":"Cloning and chromosomal localization of a human class III myosin","volume":"67","author":"Dose","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB39","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1073\/pnas.021558598","article-title":"Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons","volume":"98","author":"Hahn","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB40","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1006\/bbrc.2000.3599","article-title":"A Drosophila homolog of LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization","volume":"276","author":"Ohashi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB41","doi-asserted-by":"crossref","first-page":"23092","DOI":"10.1074\/jbc.C100196200","article-title":"Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42- binding kinase \u03b1","volume":"276","author":"Sumi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/86011","article-title":"Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A- induced growth cone collapse","volume":"4","author":"Aizawa","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB43","doi-asserted-by":"crossref","first-page":"31449","DOI":"10.1074\/jbc.M102988200","article-title":"Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells","volume":"276","author":"Toshima","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB44","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1089\/104454999315150","article-title":"Drosophila center divider gene is expressed in CNS midline cells and encodes a developmentally regulated protein kinase orthologous to human TESK1","volume":"18","author":"Matthews","year":"1999","journal-title":"DNA Cell Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0960-9822(98)70227-1","article-title":"Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway","volume":"8","author":"Monnier","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB46","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/35010610","article-title":"Gli regulation by the opposing activities of fused and suppressor of fused","volume":"2","author":"Murone","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB47","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1126\/science.282.5396.2033","article-title":"The taxonomy of developmental control in Caenorhabditis elegans","volume":"282","author":"Ruvkun","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB48","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1101\/gad.10.10.1184","article-title":"The c-ros tyrosine kinase receptor controls the regionalization and differentiation of epithelial cells in the epididymis","volume":"10","author":"Sonnenberg-Riethmacher","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB49","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1073\/pnas.090102397","article-title":"Characterization of PDZ-binding kinase, a mitotic kinase","volume":"97","author":"Gaudet","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-6147(00)01676-X","article-title":"FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition","volume":"22","author":"Cross","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00502-5","article-title":"Guidance of cell migration by the Drosophila PDGF\/VEGF receptor","volume":"107","author":"Duchek","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0968-0004(02)02179-5_BIB52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1073\/pnas.96.2.523","article-title":"Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase","volume":"96","author":"Gayko","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0968-0004(02)02179-5_BIB53","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/oxfordjournals.molbev.a026346","article-title":"Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegans","volume":"17","author":"Rikke","year":"2000","journal-title":"Mol. Biol. Evol."}],"container-title":["Trends in Biochemical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968000402021795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968000402021795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T18:13:11Z","timestamp":1583777591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968000402021795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0968000402021795"],"URL":"https:\/\/doi.org\/10.1016\/s0968-0004(02)02179-5","relation":{},"ISSN":["0968-0004"],"issn-type":[{"value":"0968-0004","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}