{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T22:24:19Z","timestamp":1764714259869},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Biochemical Sciences"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1016\/s0968-0004(99)01530-3","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T01:30:23Z","timestamp":1027647023000},"page":"50-52","source":"Crossref","is-referenced-by-count":239,"title":["A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae"],"prefix":"10.1016","volume":"25","author":[{"given":"Kira S","family":"Makarova","sequence":"first","affiliation":[]},{"given":"L","family":"Aravind","sequence":"additional","affiliation":[]},{"given":"Eugene V","family":"Koonin","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0968-0004(99)01530-3_BIB1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/MR.56.4.592-621.1992","article-title":"Regulation by proteolysis: energy-dependent proteases and their targets","volume":"56","author":"Gottesman","year":"1992","journal-title":"Microbiol. Rev."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0955-0674(98)80119-1","article-title":"SCF and APC: the Yin and Yang of cell cycle regulated proteolysis","volume":"10","author":"Peters","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1369-5274(99)80025-3","article-title":"Regulation by proteolysis: developmental switches","volume":"2","author":"Gottesman","year":"1999","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(00)80753-9","article-title":"How the cyclin became a cyclin: regulated proteolysis in the cell cycle","volume":"97","author":"Koepp","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0968-0004(99)01530-3_BIB5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0076-6879(94)44034-4","article-title":"Families of cysteine peptidases","volume":"244","author":"Rawlings","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0076-6879(94)44004-2","article-title":"Families of serine peptidases","volume":"244","author":"Rawlings","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)80426-2","article-title":"Viral proteases: evolution of diverse structural motifs to optimize function","volume":"91","author":"Babe","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0968-0004(99)01530-3_BIB8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0014-5793(98)01574-9","article-title":"Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases","volume":"441","author":"Chen","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.282.5389.754","article-title":"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis","volume":"282","author":"Stephens","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0968-0004(99)01530-3_BIB10","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1128\/MCB.9.12.5726","article-title":"Sequence and structure of the Drosophila melanogaster ovarian tumor gene and generation of an antibody specific for the ovarian tumor protein","volume":"9","author":"Steinhauer","year":"1989","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/bies.950080106","article-title":"The role of the otu gene in Drosophila oogenesis","volume":"8","author":"King","year":"1988","journal-title":"BioEssays"},{"key":"10.1016\/S0968-0004(99)01530-3_BIB12","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1006\/jmbi.1999.2653","article-title":"Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches","volume":"287","author":"Aravind","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/cmb.1995.2.9","article-title":"Maximum discrimination hidden Markov models of sequence consensus","volume":"2","author":"Eddy","year":"1995","journal-title":"J. Comput. Biol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB15","doi-asserted-by":"crossref","first-page":"16671","DOI":"10.1074\/jbc.270.28.16671","article-title":"The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases","volume":"270","author":"Snijder","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/(SICI)1097-0134(19990401)35:1<70::AID-PROT7>3.0.CO;2-9","article-title":"Identification of homologous core structures","volume":"35","author":"Matsuo","year":"1999","journal-title":"Proteins"},{"key":"10.1016\/S0968-0004(99)01530-3_BIB17","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1016\/S0021-9258(18)42292-2","article-title":"The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity","volume":"267","author":"Opipari","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB18","doi-asserted-by":"crossref","first-page":"18068","DOI":"10.1074\/jbc.271.30.18068","article-title":"A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism","volume":"271","author":"Cooper","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/bj3210125","article-title":"The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development","volume":"321","author":"Callebaut","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/(SICI)1520-6408(1997)20:2<163::AID-DVG9>3.0.CO;2-5","article-title":"Nurse cell polytene chromosomes of Drosophila melanogaster otu mutants: morphological changes accompanying interallelic complementation and position effect variegation","volume":"20","author":"Mal\u2019ceva","year":"1997","journal-title":"Dev. Genet."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB21","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1242\/dev.124.7.1419","article-title":"The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes","volume":"124","author":"Keyes","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0968-0004(99)01530-3_BIB22","first-page":"1023","article-title":"Multiple alignment of biopolymer sequences, based on the search for statistically significant common segments","volume":"29","author":"Seledtsov","year":"1995","journal-title":"Mol. Biol. (Mosk)."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB23","first-page":"333","article-title":"SEALS: a system for easy analysis of lots of sequences","volume":"5","author":"Walker","year":"1997","journal-title":"Intelligent Syst. Mol. Biol."},{"key":"10.1016\/S0968-0004(99)01530-3_BIB24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/prot.340190108","article-title":"Combining evolutionary information and neural networks to predict protein secondary structure","volume":"19","author":"Rost","year":"1994","journal-title":"Proteins"}],"container-title":["Trends in Biochemical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968000499015303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968000499015303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T01:03:42Z","timestamp":1620954222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968000499015303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0968000499015303"],"URL":"https:\/\/doi.org\/10.1016\/s0968-0004(99)01530-3","relation":{},"ISSN":["0968-0004"],"issn-type":[{"value":"0968-0004","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}