{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T07:14:57Z","timestamp":1771744497057,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6560,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Structure"],"published-print":{"date-parts":[[1995,8]]},"DOI":"10.1016\/s0969-2126(01)00216-7","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T19:10:35Z","timestamp":1090609835000},"page":"815-821","source":"Crossref","is-referenced-by-count":194,"title":["The 70S Escherichia coli ribosome at 23 \u00e5 resolution: fitting the ribosomal RNA"],"prefix":"10.1016","volume":"3","author":[{"given":"Holger","family":"Stark","sequence":"first","affiliation":[]},{"given":"Florian","family":"Mueller","sequence":"additional","affiliation":[]},{"given":"Elena V","family":"Orlova","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schatz","sequence":"additional","affiliation":[]},{"given":"Prakash","family":"Dube","sequence":"additional","affiliation":[]},{"given":"Tarik","family":"Erdemir","sequence":"additional","affiliation":[]},{"given":"Friedrich","family":"Zemlin","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Brimacombe","sequence":"additional","affiliation":[]},{"given":"Marin van","family":"Heel","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0969-2126(01)00216-7_BIB1","series-title":"The Ribosome: Structure, Function and Evolution","author":"Hill","year":"1990"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0959-440X(05)80149-6","article-title":"Hollows, voids, gaps and tunnels in the ribosome","volume":"3","author":"Yonath","year":"1993","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0079-6107(82)90013-X","article-title":"Structural studies of ribosomes","volume":"40","author":"Liljas","year":"1982","journal-title":"Prog. Biophys. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0022-2836(82)90259-5","article-title":"Distribution of RNA and protein in crystalline eukaryotic ribosomes","volume":"156","author":"K\u00fchlbrandt","year":"1982","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/319693a0","article-title":"Location of exit channel for nascent protein in 80S ribosome","volume":"319","author":"Milligan","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.3576200","article-title":"A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstruction","volume":"236","author":"Yonath","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1006\/jmbi.1994.1406","article-title":"Electron cryomicroscopy of B. stearothermophilus 50S ribosomal subunits crystallized on phospholipid monolayers","volume":"239","author":"Avila-Sakar","year":"1994","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0022-2836(88)90334-8","article-title":"Positions of S2, S13, S16, S17, S19 and S21 in the 30S ribosomal subunit of Escherichia coli.","volume":"200","author":"Capel","year":"1988","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/j.1460-2075.1992.tb05060.x","article-title":"Inter-protein distances within the large ribosomal subunit from E. coli ribosomes","volume":"11","author":"May","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.bb.13.060184.001511","article-title":"Immuno electron microscopy of ribosomes","volume":"13","author":"St\u00f6ffler","year":"1984","journal-title":"Annu. Rev. Biophys. Bioeng"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0022-2836(82)90280-7","article-title":"Ribosomal subunit orientation determined in the monomeric ribosome by single and by double-labeling immune electron microscopy","volume":"161","author":"Lake","year":"1982","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB12","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0022-5193(70)90110-4","article-title":"ART and the ribosome: a preliminary report on the three-dimensional structure of individual ribosomes determined by an algebraic reconstruction technique","volume":"29","author":"Bender","year":"1970","journal-title":"J. Theor. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0022-2836(83)90066-9","article-title":"Three-dimensional reconstruction and averaging of 30S ribosomal subunits of Escherichia coli from electron micrographs","volume":"163","author":"Knauer","year":"1983","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0022-2836(83)90067-0","article-title":"Three-dimensional reconstruction and averaging of 50S ribosomal subunits of Escherichia coli from electron micrographs","volume":"163","author":"Oettl","year":"1983","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1083\/jcb.115.3.597","article-title":"Three-dimensional reconstruction of the 70S Escherichia coli ribosome in ice: the distribution of ribosomal RNA","volume":"115","author":"Frank","year":"1991","journal-title":"J. Cell Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0092-8674(94)90548-7","article-title":"Starvation in vivo for aminoacyl-tRNA increases the spatial separation between the two ribosomal subunits","volume":"79","author":"\u00d6fverstedt","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0304-3991(94)90038-8","article-title":"The ribosome at improved resolution: new techniques for merging and orientation refinements in 3D cryo-electron microscopy of biological particles","volume":"53","author":"Penczek","year":"1994","journal-title":"Ultramicroscopy"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB18","first-page":"23","article-title":"Structure analysis of ice-embedded single particles","volume":"Suppl. 6","author":"van Heel","year":"1992","journal-title":"Scanning Microsc"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/jsbi.1995.1003","article-title":"Structure of Lumbricus terrestris hemoglobin at 30 \u00e5 resolution determined using angular reconstitution","volume":"114","author":"Schatz","year":"1995","journal-title":"J. Struct. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0304-3991(87)90078-7","article-title":"Angular reconstitution: a posteriori assignment of projection directions for 3D reconstruction","volume":"21","author":"van Heel","year":"1987","journal-title":"Ultramicroscopy"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nsb0195-18","article-title":"Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel","volume":"2","author":"Serysheva","year":"1995","journal-title":"Nat. Struct. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1432-1033.1995.0365h.x","article-title":"The structure of ribosomal RNA: a three-dimensional jigsaw puzzle","volume":"230","author":"Brimacombe","year":"1995","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.bi.53.070184.001003","article-title":"Structure of ribosomal RNA","volume":"53","author":"Noller","year":"1984","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB24","series-title":"Electron Microscopy 1994, vol 1","first-page":"47","article-title":"A helium-cooled super-conducting cryo-electron microscope with field-emission gun, and first results","author":"Zemlin","year":"1994"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB25","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/j.1460-2075.1985.tb03944.x","article-title":"The characteristic views of E. coli and B. stearothermophilus 30S ribosomal subunits in the electron microscope","volume":"4","author":"van Heel","year":"1985","journal-title":"EMBO J"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB26","first-page":"114","article-title":"Classification of very large electron microscopical image data sets","volume":"82","author":"van Heel","year":"1989","journal-title":"Optik"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0304-3991(88)90006-X","article-title":"Determination of mutual orientation of identical particles from their projections by the moments methods","volume":"25","author":"Goncharov","year":"1988","journal-title":"Ultramicroscopy"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1098\/rstb.1971.0054","article-title":"Procedures for three-dimensional reconstruction of spherical viruses by Fourier synthesis from electron micrographs","volume":"261","author":"Crowther","year":"1971","journal-title":"Philos. Trans. R. Soc. Lond. B"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB29","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1364\/JOSAA.9.001749","article-title":"A posteriori determination of relative projection directions of arbitrarily oriented macromolecules","volume":"9","author":"Farrow","year":"1992","journal-title":"J. Opt. Soc. Am. A"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB30","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1073\/pnas.79.10.3111","article-title":"Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: immune mapping of the nascent chain","volume":"79","author":"Bernabeau","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB31","first-page":"in press","article-title":"Getting closer to an understanding of the three-dimensional structure of ribosomal RNA","author":"Mueller","year":"1995","journal-title":"Biochem. Cell Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB32","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1093\/nar\/20.11.2627","article-title":"How are tRNAs and mRNAs arranged in the ribosome? An attempt to correlate the stereochemistry of the tRNA\u2013mRNA interaction with constraints imposed by the ribosomal topography","volume":"20","author":"Lim","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0022-2836(85)90043-9","article-title":"Three-dimensional arrangement of the E. coli 16S ribosomal RNA","volume":"184","author":"Expert-Bezancon","year":"1985","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0022-2836(88)90383-X","article-title":"A detailed model of the three-dimensional structure of Escherichia coli 16S ribosomal RNA in situ in the 30S subunit","volume":"199","author":"Brimacombe","year":"1988","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0022-5193(88)80202-9","article-title":"Prediction of the three-dimensional structure of the E. coli ribosomal RNA","volume":"134","author":"Nagano","year":"1988","journal-title":"J. Theor. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0022-2836(88)90588-8","article-title":"Model for the three-dimensional folding of 16S ribosomal RNA","volume":"204","author":"Stern","year":"1988","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB37","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0022-2836(91)80182-T","article-title":"Computer modeling of 16S ribosomal RNA","volume":"221","author":"Hubbard","year":"1991","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/jmbi.1994.1448","article-title":"A quantitative model of the Escherichia coli 16S RNA in the 30S ribosomal subunit","volume":"240","author":"Malhotra","year":"1994","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB39","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1093\/nar\/18.15.4325","article-title":"Selective isolation and detailed analysis of intra-RNA cross-links induced in the large ribosomal subunit of E. coli: a model for the tertiary structure of the tRNA binding domain in the 23S RNA","volume":"18","author":"Mitchell","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0022-2836(91)90730-T","article-title":"Characterization and preliminary attempts for derivatization of crystals of large ribosomal subunits from Haloarcula marismortui diffracting to 3 \u00e5 resolution","volume":"222","author":"Von B\u00f6hlen","year":"1991","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0033583500004297","article-title":"Cryo-electron microscopy of vitrified specimens","volume":"21","author":"Dubochet","year":"1988","journal-title":"Q. Rev. Biophys"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.bb.15.060186.001321","article-title":"Electron microscopy of frozen hydrated biological specimens","volume":"15","author":"Chiu","year":"1986","journal-title":"Annu. Rev. Biophys"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB43","first-page":"in press","article-title":"A new generation of the IMAGIC image processing system","author":"van Heel","year":"1995","journal-title":"J. Struct. Biol"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB44","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/j.1460-2075.1993.tb05775.x","article-title":"Bacteriophage SPP1 portal protein: a DNA pump with 13-fold symmetry","volume":"12","author":"Dube","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB45","first-page":"187","article-title":"Use of multivariate statistics in analyzing the images of biological macromolecules","volume":"6","author":"van Heel","year":"1981","journal-title":"Ultramicroscopy"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB46","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1364\/JOSAA.7.000601","article-title":"Classification of image data in conjugate representation spaces","volume":"7","author":"Borland","year":"1990","journal-title":"J. Opt. Soc. Am. A"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB47","first-page":"146","article-title":"Exact filters for general geometry three-dimensional reconstruction","volume":"73","author":"Harauz","year":"1986","journal-title":"Optik"},{"key":"10.1016\/S0969-2126(01)00216-7_BIB48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jemt.1060090405","article-title":"Three-dimensional reconstruction of single particles from random and nonrandom tilt series","volume":"9","author":"Radermacher","year":"1988","journal-title":"J. Electr. Microsc. Tech"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212601002167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212601002167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T21:07:30Z","timestamp":1585861650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212601002167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["S0969212601002167"],"URL":"https:\/\/doi.org\/10.1016\/s0969-2126(01)00216-7","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[1995,8]]}}}