{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:31:26Z","timestamp":1778628686669,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2001,2,13]],"date-time":"2001-02-13T00:00:00Z","timestamp":982022400000},"content-version":"vor","delay-in-days":409,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nuclear Medicine and Biology"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1016\/s0969-8051(99)00082-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T21:28:54Z","timestamp":1027632534000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["6-[18F]fluoro-A-85380: an in vivo tracer for the nicotinic acetylcholine receptor"],"prefix":"10.1016","volume":"27","author":[{"given":"Ursula","family":"Scheffel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G","family":"Horti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei O","family":"Koren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayden T","family":"Ravert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P","family":"Banta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige A","family":"Finley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edythe D","family":"London","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F","family":"Dannals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0969-8051(99)00082-7_BIB1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1021\/jm9506884","article-title":"Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors","volume":"39","author":"Abreo","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/oxfordjournals.schbul.a033320","article-title":"Schizophrenia, sensory gating, and nicotinic receptors","volume":"24","author":"Adler","year":"1998","journal-title":"Schizophr. Bull."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0024-3205(89)90340-8","article-title":"In vivo specific binding of [3H]l-nicotine in the mouse brain","volume":"44","author":"Broussolle","year":"1989","journal-title":"Life Sci"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0024-3205(98)00514-1","article-title":"In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography","volume":"63","author":"Chefer","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0024-3205(94)00488-E","article-title":"Diversity of neuronal nicotinic acetylcholine receptor","volume":"56","author":"Decker","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/(SICI)1098-2396(199612)24:4<403::AID-SYN8>3.0.CO;2-H","article-title":"Mapping nicotinic acetylcholine receptors with PET","volume":"24","author":"Ding","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/(SICI)1099-1344(199805)41:5<451::AID-JLCR111>3.0.CO;2-R","article-title":"Synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy] pyridine, a highly potent radioligand for in vivo imaging central nicotinic acetylcholine receptors","volume":"41","author":"Dolle","year":"1998","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0091-3057(83)80023-9","article-title":"Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to cerebral cortex in rat","volume":"18","author":"Flicker","year":"1983","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0006-3223(94)00252-X","article-title":"Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia","volume":"38","author":"Freedman","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-1-4684-8047-4_28","article-title":"Nicotinic cholinergic receptors in human brain","volume":"296","author":"Giacobini","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0899-3289(18)30006-3","article-title":"Dose-related actions of nicotine on behavior and physiology","volume":"1","author":"Henningfield","year":"1989","journal-title":"J. Subst. Abuse"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/jm9706224","article-title":"Identification and initial structure-activity relationship of (R)-5-(2-azetinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, nonopioid analgesic agent acting via neuronal nicotinic acetylcholine receptors","volume":"41","author":"Holladay","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1099-1344(199604)38:4<355::AID-JLCR842>3.0.CO;2-3","article-title":"Synthesis of a radiotracer for studying nicotinic acetylcholine receptors","volume":"38","author":"Horti","year":"1996","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB14","first-page":"1260","article-title":"[18F]FPH for PET imaging of nicotinic acetylcholine receptors","volume":"38","author":"Horti","year":"1997","journal-title":"J. Nucl. Med."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1099-1344(199804)41:4<309::AID-JLCR78>3.0.CO;2-I","article-title":"Synthesis of a radiotracer for studying nicotinic acetylcholine receptors","volume":"41","author":"Horti","year":"1998","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0969-8051(98)00031-6","article-title":"2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors","volume":"25","author":"Horti","year":"1998","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB17","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1021\/jm980233p","article-title":"Synthesis and evaluation of [11C]-N-methylated analogs of epibatidine as tracers for PET studies of nicotinic acetylcholine receptors","volume":"41","author":"Horti","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0969-8051(98)00086-9","article-title":"Radiosynthesis and preliminary evaluation of 5-[123\/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine","volume":"26","author":"Horti","year":"1999","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB19","first-page":"1025","article-title":"Basal forebrain-lesioned monkeys are severely impaired in tasks of association and recognition memory","volume":"14","author":"Irle","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB20","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/jm980170a","article-title":"2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy) pyridines","volume":"41","author":"Koren","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1749-6632.1995.tb17481.x","article-title":"Acute and chronic nicotinic interactions with dopamine systems and working memory performance","volume":"757","author":"Levin","year":"1995","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3940(85)90182-X","article-title":"Autoradiographic localization of [3H]nicotine binding sites in the rat brain","volume":"53","author":"London","year":"1985","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB23","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/BF00964952","article-title":"Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer\u2019s dementia","volume":"14","author":"London","year":"1989","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00252173","article-title":"Nicotine-11C","volume":"1","author":"Maziere","year":"1976","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0969-8051(97)00120-0","article-title":"Fluoro-norchlorofluoroepibatidine (NFEP)","volume":"24","author":"Molina","year":"1997","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB26","doi-asserted-by":"crossref","unstructured":"Musachio J. L., Scheffel U., Finley P. A., Zhan Y., Mochizuki T., Wagner H. N. and Dannals R. F. (1998) 5-[I-125\/123]Iodo-3(2(S)-azetidydinylmethoxy) pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors. Life Sci. 62, PL 351\u2013357.","DOI":"10.1016\/S0024-3205(98)00180-5"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB27","series-title":"Pain and Headache, Neurotransmitters and Pain Control","first-page":"1","article-title":"Cholinergic and catecholaminergic modulation of nociceptive reactions. Interactions with opiates","author":"Pert","year":"1987"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng1095-201","article-title":"A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal nocturnal frontal lobe epilepsy","volume":"11","author":"Steinlein","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB29","first-page":"1737","article-title":"Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an epibatidine analog","volume":"38","author":"Villemagne","year":"1997","journal-title":"J. Nucl. Med."},{"key":"10.1016\/S0969-8051(99)00082-7_BIB30","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1097\/00001756-199807130-00030","article-title":"In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand","volume":"9","author":"Vaupel","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0006-8993(86)90819-X","article-title":"Nicotinic acetylcholine binding sites in Alzheimer\u2019s disease","volume":"371","author":"Whitehouse","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/S0969-8051(99)00082-7_BIB32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF02261245","article-title":"Application of carbon-11 labelled nicotine in the measurement of human cerebral blood flow and other physiological parameters","volume":"20","author":"Yokoi","year":"1993","journal-title":"Eur. J. Nucl. Med."}],"container-title":["Nuclear Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805199000827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969805199000827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T04:26:27Z","timestamp":1760847987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969805199000827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0969805199000827"],"URL":"https:\/\/doi.org\/10.1016\/s0969-8051(99)00082-7","relation":{},"ISSN":["0969-8051"],"issn-type":[{"value":"0969-8051","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"6-[18F]fluoro-A-85380: an in vivo tracer for the nicotinic acetylcholine receptor","name":"articletitle","label":"Article Title"},{"value":"Nuclear Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0969-8051(99)00082-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Elsevier Science Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}