{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:31:41Z","timestamp":1778311901363,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1016\/s1043-2760(02)00668-9","type":"journal-article","created":{"date-parts":[[2002,10,12]],"date-time":"2002-10-12T00:38:10Z","timestamp":1034383090000},"page":"331-335","source":"Crossref","is-referenced-by-count":72,"title":["Peroxisome proliferator-activated receptor-\u03b3 in macrophage lipid homeostasis"],"prefix":"10.1016","volume":"13","author":[{"given":"Chih-Hao","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1043-2760(02)00668-9_BIB1","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","article-title":"Nuclear receptors and lipid physiology: opening the X-files","volume":"294","author":"Chawla","year":"2001","journal-title":"Science"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/er.20.5.649","article-title":"Peroxisome proliferator-activated receptors: nuclear control of metabolism","volume":"20","author":"Desvergne","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1210\/rp.56.1.239","article-title":"Peroxisome proliferator-activated receptors: from genes to physiology","volume":"56","author":"Kliewer","year":"2001","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0248-4900(05)80176-5","article-title":"Positive regulation of the peroxisomal \u03b2-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)","volume":"77","author":"Dreyer","year":"1993","journal-title":"Biol. Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB5","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1073\/pnas.94.9.4312","article-title":"Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors \u03b1 and \u03b4","volume":"94","author":"Forman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB6","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1073\/pnas.94.9.4318","article-title":"Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors \u03b1 and \u03b3","volume":"94","author":"Kliewer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1210\/me.11.6.779","article-title":"Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay","volume":"11","author":"Krey","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0092-8674(95)90193-0","article-title":"15-Deoxy-\u03b412,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR\u03b3","volume":"83","author":"Forman","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0092-8674(95)90194-9","article-title":"A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor \u03b3 and promotes adipocyte differentiation","volume":"83","author":"Kliewer","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB10","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","article-title":"An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3)","volume":"270","author":"Lehmann","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1097-2765(00)80209-9","article-title":"PPAR\u03b3 is required for placental, cardiac, and adipose tissue development","volume":"4","author":"Barak","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1097-2765(00)80210-5","article-title":"PPAR\u03b3 mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance","volume":"4","author":"Kubota","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR( is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB14","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1128\/MCB.20.14.5119-5128.2000","article-title":"Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor\u03b2 (\u03b4)","volume":"20","author":"Peters","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1083\/jcb.200011148","article-title":"Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR) \u03b1- and PPAR\u03b2-mutant mice","volume":"154","author":"Michalik","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB16","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1073\/pnas.091021198","article-title":"A selective peroxisome proliferator-activated receptor \u03b4 agonist promotes reverse cholesterol transport","volume":"98","author":"Oliver","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(00)81575-5","article-title":"PPAR\u03b3 promotes monocyte\/macrophage differentiation and uptake of oxidized LDL","volume":"93","author":"Tontonoz","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81574-3","article-title":"Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR\u03b3","volume":"93","author":"Nagy","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor \u03b3 is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/35154","article-title":"PPAR\u03b3 agonists inhibit production of monocyte inflammatory cytokines","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.47.4.507","article-title":"PPAR\u03b3: adipogenic regulator and thiazolidinedione receptor","volume":"47","author":"Spiegelman","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/08830180109056722","article-title":"Regulation of lineage commitment during lymphocyte development","volume":"20","author":"Staal","year":"2001","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/08830180109056724","article-title":"Transcription factors that regulate growth and differentiation of myeloid cells","volume":"20","author":"Nagamura-Inoue","year":"2001","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB24","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.1038\/sj.onc.1204853","article-title":"Transcriptional regulation in acute promyelocytic leukemia","volume":"20","author":"Lin","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83336","article-title":"PPAR\u03b3-dependent and -independent effects on macrophage-gene expression in lipid metabolism and inflammation","volume":"7","author":"Chawla","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/83328","article-title":"The role of PPAR\u03b3 in macrophage differentiation and cholesterol uptake","volume":"7","author":"Moore","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(01)00238-0","article-title":"Atherosclerosis. The road ahead","volume":"104","author":"Glass","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00041433-200110000-00006","article-title":"Peroxisome proliferator-activated receptors in endothelial cell biology","volume":"12","author":"Plutzky","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB30","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1074\/jbc.275.7.4541","article-title":"Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) agonists. PPAR\u03b3 co-association with transcription factor NFAT","volume":"275","author":"Yang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB31","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.4049\/jimmunol.164.2.1046","article-title":"Activation of peroxisome proliferator-activated receptor \u03b3 does not inhibit IL-6 or TNF-( responses of macrophages to lipopolysaccharide in vitro or in vivo","volume":"164","author":"Thieringer","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB32","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1128\/MCB.20.5.1692-1698.2000","article-title":"Inhibition of I\u03baB kinase and I\u03baB phosphorylation by 15-deoxy-\u03b4(12,14)-prostaglandin J(2) in activated murine macrophages","volume":"20","author":"Castrillo","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/47520","article-title":"Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I\u03baB kinase","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB34","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1128\/MCB.20.13.4699-4707.2000","article-title":"Peroxisome proliferator-activated receptor \u03b3-dependent repression of the inducible nitric oxide synthase gene","volume":"20","author":"Li","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5551\/jat1994.4.1","article-title":"The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and insusceptibility to infection in Msr-knockout mice","volume":"4","author":"Suzuki","year":"1997","journal-title":"J. Atheroscler. Thromb"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB36","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI9259","article-title":"Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice","volume":"105","author":"Febbraio","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/83348","article-title":"PPAR\u03b1 and PPAR\u03b3 activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway","volume":"7","author":"Chinetti","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A PPAR\u03b3\u2013LXR\u2013ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB39","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.289.5484.1524","article-title":"Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers","volume":"289","author":"Repa","year":"2000","journal-title":"Science"},{"key":"10.1016\/S1043-2760(02)00668-9_BIB40","doi-asserted-by":"crossref","first-page":"12097","DOI":"10.1073\/pnas.200367697","article-title":"Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR\u03b1","volume":"97","author":"Venkateswaran","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB41","doi-asserted-by":"crossref","first-page":"28240","DOI":"10.1074\/jbc.M003337200","article-title":"Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor\/retinoid X receptor","volume":"275","author":"Costet","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB42","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00041433-200104000-00006","article-title":"Structure, function and regulation of the ABC1 gene product","volume":"12","author":"Schmitz","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00041433-200104000-00010","article-title":"Mouse models of atherosclerosis","volume":"12","author":"Reardon","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1172\/JCI10370","article-title":"Peroxisome proliferator-activated receptor \u03b3 ligands inhibit development of atherosclerosis in LDL receptor-deficient mice","volume":"106","author":"Li","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.ATV.21.3.365","article-title":"Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice","volume":"21","author":"Collins","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB46","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.ATV.21.3.372","article-title":"Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL","volume":"21","author":"Chen","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB47","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.041609298","article-title":"Reduction of atherosclerosis in apolipoprotein E-knockout mice by activation of the retinoid X receptor","volume":"98","author":"Claudel","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1043-2760(02)00668-9_BIB48","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1128\/MCB.21.22.7558-7568.2001","article-title":"Autoregulation of the human liver X receptor \u03b1 promoter","volume":"21","author":"Laffitte","year":"2001","journal-title":"Mol. Cell. Biol."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276002006689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276002006689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T06:38:21Z","timestamp":1622097501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276002006689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S1043276002006689"],"URL":"https:\/\/doi.org\/10.1016\/s1043-2760(02)00668-9","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}