{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:56:47Z","timestamp":1771977407864,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":6653,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[1995,12]]},"DOI":"10.1016\/s1063-4584(05)80013-5","type":"journal-article","created":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T07:23:17Z","timestamp":1129015397000},"page":"213-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":274,"title":["The role of viscosupplementation with hylan G-F 20 (Synvisc\u00ae) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone"],"prefix":"10.1016","volume":"3","author":[{"given":"Mark E.","family":"Adams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 J.","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan I.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Siminovitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Zummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1063-4584(05)80013-5_bib1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/art.1780260712","article-title":"Social and economic impacts of four musculoskeletal conditions","volume":"26","author":"Kramer","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1016\/S1063-4584(05)80013-5_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2105\/AJPH.74.6.574","article-title":"Epidemiology of musculoskeletal impairments and associated disability","volume":"74","author":"Cunningham","year":"1984","journal-title":"Am J Public Health"},{"key":"10.1016\/S1063-4584(05)80013-5_bib3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/bmj.286.6363.418","article-title":"The nature and causes of osteoarthrosis","volume":"286","author":"Gardner","year":"1983","journal-title":"BMJ"},{"key":"10.1016\/S1063-4584(05)80013-5_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0002-9343(86)90075-6","article-title":"Pathogenesis of osteoarthritis","volume":"80","author":"Howell","year":"1986","journal-title":"Am J Med"},{"key":"10.1016\/S1063-4584(05)80013-5_bib5","series-title":"Clinical concepts in regional musculoskeletal illness","first-page":"137","article-title":"Pathobiology of knee osteoarthritis: influences of medical therapy and of usage","author":"Adams","year":"1987"},{"key":"10.1016\/S1063-4584(05)80013-5_bib6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.7326\/0003-4819-116-7-598","article-title":"Knee pain is the malady\u2014not osteoarthritis","volume":"116","author":"Hadler","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/S1063-4584(05)80013-5_bib7","first-page":"3082","article-title":"Diagnosing osteoarthritis and minimizing the effects","volume":"4","author":"Adams","year":"1991","journal-title":"Medicine North Am"},{"issue":"Suppl 27","key":"10.1016\/S1063-4584(05)80013-5_bib8","first-page":"1","article-title":"Osteoarthritis: update on diagnosis and therapy","volume":"18","author":"Pelletier","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1016\/S1063-4584(05)80013-5_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1056\/NEJM199107113250203","article-title":"Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee","volume":"325","author":"Bradley","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/S1063-4584(05)80013-5_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0950-3579(05)80025-1","article-title":"Non-steroidal anti-inflammatory drugs versus simple analgesics in the treatment of arthritis","volume":"4","author":"Sanders","year":"1990","journal-title":"Bailli\u00e8re's Clin Rheumatol"},{"issue":"10","key":"10.1016\/S1063-4584(05)80013-5_bib11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7326\/0003-4819-115-10-787","article-title":"Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs","volume":"115","author":"Gabriel","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/S1063-4584(05)80013-5_bib12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3109\/00365529109025028","article-title":"Drug-related admissions to a department of medical gastroenterology. The role of self-medicated and prescribed drugs","volume":"26","author":"Hallas","year":"1991","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/S1063-4584(05)80013-5_bib13","first-page":"71","article-title":"Non-steroidal anti-inflammatory drugs: assessment of risks","volume":"8","author":"Inman","year":"1987","journal-title":"Eur J Rheumatol Inflamm"},{"key":"10.1016\/S1063-4584(05)80013-5_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0002-9343(88)90250-1","article-title":"Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis","volume":"84","author":"Bloom","year":"1988","journal-title":"Am J Med"},{"key":"10.1016\/S1063-4584(05)80013-5_bib15","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1136\/bmj.297.6655.1017","article-title":"Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine","volume":"297","author":"Ehsanullah","year":"1988","journal-title":"BMJ"},{"key":"10.1016\/S1063-4584(05)80013-5_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.7326\/0003-4819-115-3-195","article-title":"Misoprostil compared with sucralfate in the prevention of non-steroidal anti-inflammatory drug-induced gastric ulcer. A randomized, controlled trial","volume":"115","author":"Agrawal","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/S1063-4584(05)80013-5_bib17","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0140-6736(88)92892-9","article-title":"Prevention of NSAID induced gastric ulcer with misoprostil: a multicentre, double-blind, placebo-controlled trial","volume":"3","author":"Graham","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/S1063-4584(05)80013-5_bib18","series-title":"Disorders of the knee","first-page":"61","article-title":"The physical properties of synovial fluid and the special role of hyaluronic acid","author":"Balazs","year":"1981"},{"key":"10.1016\/S1063-4584(05)80013-5_bib19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/art.1780100407","article-title":"Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritic human synovial fluid","volume":"10","author":"Balazs","year":"1967","journal-title":"Arthritis Rheum"},{"issue":"Suppl 39","key":"10.1016\/S1063-4584(05)80013-5_bib20","first-page":"3","article-title":"Viscosupplementation: a new concept in the treatment of osteoarthritis","volume":"20","author":"Balazs","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/S1063-4584(05)80013-5_bib21","series-title":"Osteoarthritis current clinical and fundamental problems","first-page":"165","article-title":"The role of hyaluronic acid in arthritis and its therapeutic use","author":"Balazs","year":"1984"},{"issue":"Suppl 39","key":"10.1016\/S1063-4584(05)80013-5_bib22","first-page":"10","article-title":"Intra-articular hyaluronan injections in the treatment of osteoarthritis: state-of-the-art review","volume":"20","author":"Peyron","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/S1063-4584(05)80013-5_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0737-0806(89)80120-0","article-title":"Clinical trial comparison of intra-articular sodium hyaluronate products in the horse","volume":"9","author":"Phillips","year":"1989","journal-title":"J Equin Veter Sci"},{"key":"10.1016\/S1063-4584(05)80013-5_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00001721-199102000-00026","article-title":"Matrix engineering","volume":"2","author":"Balazs","year":"1991","journal-title":"Blood Coag Fibrin"},{"key":"10.1016\/S1063-4584(05)80013-5_bib25","series-title":"Cellulosics utilization: research and rewards in cellulosics. Proceedings of Nisshinbo International Conference on Cellulosics Utilization in the Near Future","first-page":"233","article-title":"Hyaluronan, its cross-linked derivative\u2014hylan\u2014and their medical applications","author":"Balazs","year":"1989"},{"key":"10.1016\/S1063-4584(05)80013-5_bib26","article-title":"The enhanced stability of the cross-linked hylan structure to hydroxyl (OH) radicals compared with the uncross-linked hyaluronan","author":"Saphwan","year":"1995","journal-title":"Radiat Chem Phys"},{"key":"10.1016\/S1063-4584(05)80013-5_bib27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0011-393X(05)80166-3","article-title":"Viscosupplementation of osteoarthritic knees with Hylan: a treatment schedule study","volume":"55","author":"Scale","year":"1994","journal-title":"Curr Ther Res"},{"issue":"Suppl 39","key":"10.1016\/S1063-4584(05)80013-5_bib28","first-page":"16","article-title":"An analysis of clinical studies of the use of cross-linked hyaluronan, hylan, in the treatment of osteoarthritis","volume":"20","author":"Adams","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/S1063-4584(05)80013-5_bib29","first-page":"1","article-title":"The epidemiology of chronic rheumatism","author":"Kellgren","year":"1963"},{"key":"10.1016\/S1063-4584(05)80013-5_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002508-198703010-00001","article-title":"Combined use of experimental pain and visual analogue scales in providing standardized measurement of clinical pain","volume":"3","author":"Price","year":"1987","journal-title":"Clin J Pain"},{"key":"10.1016\/S1063-4584(05)80013-5_bib31","series-title":"United States Code of Federal Regulations: obligations of clinical investigators","author":"United States Food and Drug Administration","year":"1977"},{"key":"10.1016\/S1063-4584(05)80013-5_bib32","series-title":"United States Code of Federal Regulations: obligations of sponsors and monitors","author":"United States Food and Drug Administration","year":"1978"},{"key":"10.1016\/S1063-4584(05)80013-5_bib33","series-title":"Biopharmaceutical statistics for drug development","first-page":"403","article-title":"Clinical efficacy trials with categorical data","author":"Koch","year":"1988"},{"key":"10.1016\/S1063-4584(05)80013-5_bib34","first-page":"7","article-title":"Guidelines for the clinical evaluation of anti-inflammatory and antirheumatic drugs (adults and children)","author":"Temple","year":"1988"},{"key":"10.1016\/S1063-4584(05)80013-5_bib35","series-title":"Musculoskeletal clinical metrology","author":"Bellamy","year":"1993"},{"key":"10.1016\/S1063-4584(05)80013-5_bib36","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/S1063-4584(05)80013-5_bib37","series-title":"Musculoskeletal clinical metrology","first-page":"193","article-title":"Standardized procedures for outcome measurement and parameters for calculating sample size for anti-rheumatic drug studies","author":"Bellamy","year":"1993"},{"key":"10.1016\/S1063-4584(05)80013-5_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0169-409X(91)90007-Y","article-title":"Drug delivery systems using hyaluronan and its derivatives","volume":"7","author":"Larsen","year":"1991","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/S1063-4584(05)80013-5_bib39","first-page":"497","article-title":"Musculoskeletal applications of hyaluronan and hylan. Potential uses in the foot and ankle","volume":"12","author":"Weiss","year":"1995","journal-title":"Clin Ped Med Surg"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458405800135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458405800135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:07:46Z","timestamp":1761016066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458405800135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["S1063458405800135"],"URL":"https:\/\/doi.org\/10.1016\/s1063-4584(05)80013-5","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[1995,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of viscosupplementation with hylan G-F 20 (Synvisc\u00ae) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1063-4584(05)80013-5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1995 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}