{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:29:45Z","timestamp":1770499785025,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6225,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biology"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1016\/s1074-5521(96)90149-0","type":"journal-article","created":{"date-parts":[[2003,12,9]],"date-time":"2003-12-09T06:54:27Z","timestamp":1070952867000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":142,"title":["The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin"],"prefix":"10.1016","volume":"3","author":[{"given":"Jill A.","family":"Mello","sequence":"first","affiliation":[]},{"given":"Samir","family":"Acharya","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Fishel","sequence":"additional","affiliation":[]},{"given":"John M.","family":"Essigmann","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1074-5521(96)90149-0_bib1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.7326\/0003-4819-100-5-704","article-title":"Cisplatin","volume":"100","author":"Loehrer","year":"1984","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/S1074-5521(96)90149-0_bib2","first-page":"477","article-title":"Biological processing of DNA modified by platinum compounds","volume":"38","author":"Bruhn","year":"1990","journal-title":"Prog. Inorg. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib3","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1021\/bi00285a031","article-title":"Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II)","volume":"22","author":"Eastman","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1021\/bi00324a025","article-title":"Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation","volume":"24","author":"Fichtinger-Schepman","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/jnci\/82.9.749","article-title":"Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin","volume":"82","author":"Sorenson","year":"1990","journal-title":"J. Natl Cancer Inst."},{"key":"10.1016\/S1074-5521(96)90149-0_bib6","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0021-9258(17)42175-2","article-title":"Cellular responses to cisplatin","volume":"269","author":"Chu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib7","first-page":"2307","article-title":"Isolation and characterization of human cDNA clones encoding a high mobility group \u2610 protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin","volume":"89","author":"Bruhn","year":"1992"},{"key":"10.1016\/S1074-5521(96)90149-0_bib8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1126\/science.1566071","article-title":"Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin","volume":"256","author":"Pil","year":"1992","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1126\/science.8342024","article-title":"Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin","volume":"261","author":"Brown","year":"1993","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib10","first-page":"8328","article-title":"Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)","volume":"86","author":"Toney","year":"1989"},{"key":"10.1016\/S1074-5521(96)90149-0_bib11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/j.1460-2075.1992.tb05144.x","article-title":"The DNA binding site of HMG1 protein is composed of two similar segments (HMG \u2610es), both of which have counterparts in other eukaryotic regulatory proteins","volume":"11","author":"Bianchi","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S1074-5521(96)90149-0_bib12","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1002\/j.1460-2075.1992.tb05551.x","article-title":"SRY, like HMG1, recognizes sharp angles in DNA","volume":"11","author":"Ferrari","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S1074-5521(96)90149-0_bib13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/357282a0","article-title":"HMG has DNA wrapped up","volume":"357","author":"Lilley","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S1074-5521(96)90149-0_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0301-4622(90)80007-T","article-title":"Bending studies of DNA sitespecifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-Pt(NH3)2(N3-cytosine)CI]+","volume":"35","author":"Bellon","year":"1990","journal-title":"Biophys. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib15","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1021\/bi00246a021","article-title":"DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II)","volume":"30","author":"Bellon","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib16","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1021\/bi00476a032","article-title":"Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin","volume":"29","author":"Donahue","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib17","first-page":"10394","article-title":"HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease","volume":"91","author":"Huang","year":"1994"},{"key":"10.1016\/S1074-5521(96)90149-0_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0921-8777(95)00037-2","article-title":"The HMG-domain protein lxr1 blocks excision repair of cisplatin-DNA adducts in yeast","volume":"362","author":"McA'Nulty","year":"1996","journal-title":"Mutat Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib19","first-page":"5672","article-title":"Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor)","volume":"91","author":"Treiber","year":"1994"},{"key":"10.1016\/S1074-5521(96)90149-0_bib20","first-page":"5146","article-title":"Differential cellular expression of the human MSH2 repair enzyme in small and large intestine","volume":"55","author":"Wilson","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0092-8674(93)90546-3","article-title":"The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer","volume":"75","author":"Fishel","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S1074-5521(96)90149-0_bib22","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0092-8674(93)90330-S","article-title":"Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer","volume":"75","author":"Leach","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S1074-5521(96)90149-0_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0026-895X(25)13467-6","article-title":"Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage","volume":"28","author":"Fram","year":"1985","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S1074-5521(96)90149-0_bib24","first-page":"5539","article-title":"Purified human MSH2 protein binds to DNA containing mismatched nucleotides","volume":"54","author":"Fishel","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib25","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.7973733","article-title":"Binding of mismatched microsatellite DNA sequences by the human MSH2 protein","volume":"266","author":"Fishel","year":"1994","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1101\/gad.9.2.234","article-title":"The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions","volume":"9","author":"Alani","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S1074-5521(96)90149-0_bib27","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1021\/bi00038a035","article-title":"Recognition of DNA interstrand cross-links of cis-diamminedichloroplatinum(II) and its trans isomer by DNA-binding proteins","volume":"34","author":"Ka\u0161parkov\u00e1","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib28","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.7604265","article-title":"GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells","volume":"268","author":"Palombo","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib29","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1126\/science.7604264","article-title":"Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells","volume":"268","author":"Drummond","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib30","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.7604266","article-title":"Mutations of GTBP in genetically unstable cells","volume":"268","author":"Papadopoulos","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1101\/gad.10.4.407","article-title":"Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair","volume":"10","author":"Marsischky","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S1074-5521(96)90149-0_bib32","first-page":"1292","article-title":"Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli","volume":"93","author":"Mellon","year":"1996"},{"key":"10.1016\/S1074-5521(96)90149-0_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1126\/science.272.5261.557","article-title":"Transcription-coupled repair deficiency and mutations in human mismatch repair genes","volume":"272","author":"Mellon","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1074-5521(96)90149-0_bib34","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/296868a0","article-title":"Mismatch correction at O6-methylguanine residues in E. coli DNA","volume":"296","author":"Karran","year":"1982","journal-title":"Nature"},{"key":"10.1016\/S1074-5521(96)90149-0_bib35","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/BF00352542","article-title":"N-Methyl-N\u2032-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair","volume":"184","author":"Jones","year":"1981","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/S1074-5521(96)90149-0_bib36","doi-asserted-by":"crossref","first-page":"12462","DOI":"10.1016\/S0021-9258(18)67110-8","article-title":"Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N\u2032-nitro-N-nitrosoguanidine","volume":"261","author":"Goldmacher","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib37","first-page":"6424","article-title":"An alykylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair","volume":"90","author":"Kat","year":"1993"},{"key":"10.1016\/S1074-5521(96)90149-0_bib38","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/nar\/20.12.2933","article-title":"Self-destruction and tolerance in resistance of mammalian cells to alkylation damage","volume":"20","author":"Karran","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib39","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/362652a0","article-title":"Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage","volume":"362","author":"Branch","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S1074-5521(96)90149-0_bib40","first-page":"2304","article-title":"DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines","volume":"55","author":"Branch","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib41","first-page":"2569","article-title":"A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage","volume":"55","author":"Aquilina","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib42","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1021\/bi00182a006","article-title":"DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage","volume":"33","author":"Griffin","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib43","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1016\/S0021-9258(18)82335-3","article-title":"O6-Methylguanine residues elicit DNA repair synthesis by human cell extracts","volume":"268","author":"Karran","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib44","first-page":"4484","article-title":"Mechanism of cis-diammine-dichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks","volume":"48","author":"Sorenson","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1242\/jcs.104.2.327","article-title":"Localization of the RNA polymerase I transcription factor hUBF during the cell cycle","volume":"104","author":"Roussel","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1016\/S1074-5521(96)90149-0_bib46","first-page":"235","article-title":"Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues","volume":"56","author":"Leach","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib47","article-title":"Loss of DNA mismatch repair in acquired resistance to cisplatin","author":"Aebi","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib48","first-page":"1374","article-title":"Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells","volume":"56","author":"Anthoney","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib49","first-page":"3721","article-title":"Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint","volume":"55","author":"Hawn","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib50","first-page":"6703","article-title":"Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells","volume":"48","author":"Sorenson","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib51","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0014-5793(93)80081-5","article-title":"Multiple cell cycle access to the apoptotic death programme in human neuroblastoma cells","volume":"320","author":"Piacentini","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/S1074-5521(96)90149-0_bib52","first-page":"2133","article-title":"Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes","volume":"53","author":"Evans","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib53","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/excr.1994.1035","article-title":"Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death","volume":"210","author":"Shinomiya","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S1074-5521(96)90149-0_bib54","series-title":"SEER Cancer Statistics Review: 1973\u20131990","first-page":"XXIV1","author":"Feuer","year":"1993"},{"key":"10.1016\/S1074-5521(96)90149-0_bib55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/ic50060a034","article-title":"Diethylenetriamine complexes of platinum(II) halides","volume":"7","author":"Watt","year":"1968","journal-title":"Inorg. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib56","first-page":"193","article-title":"A rapid method for the synthesis of cis[Pt(NH3)2CI2]","volume":"8","author":"Dhara","year":"1970","journal-title":"Indian J. Chem."},{"key":"10.1016\/S1074-5521(96)90149-0_bib57","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1021\/bi00291a016","article-title":"Use of antibodies to probe the stereochemistry of antitumor platinum drug binding to deoxyribonucleic acid","volume":"22","author":"Lippard","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/S1074-5521(96)90149-0_bib58","series-title":"Proteins: Structures and Molecular Properties","first-page":"367","article-title":"Interactions with other molecules","author":"Creighton","year":"1993"},{"key":"10.1016\/S1074-5521(96)90149-0_bib59","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res."}],"container-title":["Chemistry &amp; Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552196901490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552196901490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:00:33Z","timestamp":1761030033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552196901490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":59,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["S1074552196901490"],"URL":"https:\/\/doi.org\/10.1016\/s1074-5521(96)90149-0","relation":{},"ISSN":["1074-5521"],"issn-type":[{"value":"1074-5521","type":"print"}],"subject":[],"published":{"date-parts":[[1996,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1074-5521(96)90149-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Current Biology Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}