{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:48:57Z","timestamp":1779346137141,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4733,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1016\/s1074-7613(00)00017-0","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T05:15:11Z","timestamp":1082524511000},"page":"167-177","source":"Crossref","is-referenced-by-count":318,"title":["Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia"],"prefix":"10.1016","volume":"13","author":[{"given":"Adam","family":"Hart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Melet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Grossfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Tunnacliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi","family":"Favier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1074-7613(00)00017-0_BIB1","first-page":"1525","article-title":"Increased expression of the ETS-related transcription factor FLI-1\/ERGB correlates with and can induce the megakaryocytic phenotype","volume":"7","author":"Athanasiou","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB2","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1128\/MCB.14.5.3230","article-title":"DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma","volume":"14","author":"Bailly","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB3","doi-asserted-by":"crossref","first-page":"18554","DOI":"10.1074\/jbc.271.31.18554","article-title":"Analysis of the megakaryocyte glycoprotein IX promoter identifies positive and negative regulatory domains and functional GATA and Ets sites","volume":"271","author":"Bastian","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB4","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1182\/blood.V93.8.2637","article-title":"Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1","volume":"93","author":"Bastian","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1101\/gad.5.6.908","article-title":"Erythroleukemia induction by Friend murine leukemia virus","volume":"5","author":"Ben David","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB6","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1182\/blood.V85.7.1805.bloodjournal8571805","article-title":"A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet alpha-granules and chromosome 11 deletion at 11q23","volume":"85","author":"Breton-Gorius","year":"1995","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0925-4773(99)00256-7","article-title":"Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos","volume":"90","author":"Brown","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB8","first-page":"156","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomcznski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/geno.1994.1274","article-title":"A 1.8-Mb YAC contig in Xp11.23","volume":"21","author":"Coleman","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/359162a0","article-title":"Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours","volume":"359","author":"Delattre","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB11","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1038\/sj.onc.1201726","article-title":"The transcription of the intercellular adhesion molecule-1 is regulated by Ets transcription factors","volume":"16","author":"de Launoit","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB12","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1182\/blood.V87.11.4678.bloodjournal87114678","article-title":"Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes","volume":"87","author":"Deveaux","year":"1996","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB13","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/01.RES.84.10.1177","article-title":"Role of the Ets transcription factors in the regulation of the vascular-specific Tie2 gene","volume":"84","author":"Dube","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB14","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1101\/gad.8.16.1897","article-title":"Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo","volume":"8","author":"Dumont","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB15","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1182\/blood.V93.12.4256","article-title":"The glycoprotein Ib\/IX complex regulates cell proliferation","volume":"93","author":"Feng","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB16","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1074\/jbc.273.12.6750","article-title":"Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription","volume":"273","author":"Gory","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB17","unstructured":"Grossfeld, P.D., Gruber, P., and Chien, K. (1999). Molecular Basis of Cardiovascular Disease, K. Chien, ed. (Cambridge, MA: W.B. Saunders), pp. 135\u2013166."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/ijc.2910630407","article-title":"EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor","volume":"63","author":"Ida","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1096\/fasebj.13.2.377","article-title":"Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter","volume":"13","author":"Iljin","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/bbrc.1993.2045","article-title":"Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells","volume":"195","author":"Iwama","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB21","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/hmg\/9.8.1201","article-title":"Co-localisation of CCG-repeats and chromosome deletion breakpoints in Jacobsen Syndrome","volume":"9","author":"Jones","year":"2000","journal-title":"Hum. Mol. Gen."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1128\/MCB.13.1.473","article-title":"Hematopoietic commitment during embryonic stem cell differentiation in culture","volume":"13","author":"Keller","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB23","doi-asserted-by":"crossref","first-page":"17525","DOI":"10.1074\/jbc.273.28.17525","article-title":"The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity","volume":"273","author":"Kwiatkowski","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/MCB.13.1.668","article-title":"GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression","volume":"13","author":"Lemarchandel","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB25","first-page":"561","article-title":"The avian fli gene is specifically expressed during embryogenesis in a subset of neural crest cells giving rise to mesenchyme","volume":"42","author":"Mager","year":"1998","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB26","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1128\/MCB.16.6.2708","article-title":"Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia","volume":"16","author":"Melet","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB27","first-page":"909","article-title":"Whole-mount in situ hybridization reveals the expression of the Xl-Fli gene in several lineages of migrating cells in Xenopus embryos","volume":"39","author":"Meyer","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1006\/geno.1994.1120","article-title":"Structure and transcription of the human c-mpl gene (MPL)","volume":"20","author":"Mignotte","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB29","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1432-1327.1998.2580879.x","article-title":"Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression","volume":"258","author":"Minami","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB30","series-title":"Gene Targeting","article-title":"Production of completely ES cell derived fetuses","author":"Nagy","year":"1993"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB31","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1101\/gad.6.6.975","article-title":"Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif","volume":"6","author":"Nye","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB32","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1182\/blood.V86.7.2624.2624","article-title":"Identification and conditions for selective expression of megakaryocytic markers in Friend erythroleukemia cells","volume":"86","author":"Paoletti","year":"1995","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB33","first-page":"676","article-title":"Clinical and molecular characterization of patients with distal 11q deletions","volume":"56","author":"Penny","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB34","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1002\/j.1460-2075.1995.tb00276.x","article-title":"The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells","volume":"14","author":"Puri","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB35","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1242\/dev.126.20.4569","article-title":"Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development","volume":"126","author":"Puri","year":"1999","journal-title":"Development"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB36","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1182\/blood.V91.6.1934","article-title":"Myb and ets proteins are candidate regulators of c-kit expression in human hematopoietic cells","volume":"91","author":"Ratajczak","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB37","first-page":"577","article-title":"Overexpression of the Xenopus Xl-fli gene during early embryogenesis leads to anomalies in head and heart development and erythroid differentiation","volume":"40","author":"Remy","year":"1996","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB38","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1046\/j.1523-1755.1998.06701.x","article-title":"Development and differentiation of endothelium","volume":"67","author":"Risau","year":"1998","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.cb.11.110195.000445","article-title":"Vasculogenesis","volume":"11","author":"Risau","year":"1995","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB40","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.1074\/jbc.273.12.6662","article-title":"Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific Basal transcription initiation","volume":"273","author":"Ross","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB41","series-title":"Molecular Cloning","author":"Sambrook","year":"1989"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB42","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1038\/sj.onc.1201502","article-title":"Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene","volume":"15","author":"Schwachtgen","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/376062a0","article-title":"Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice","volume":"376","author":"Shalaby","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB44","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0092-8674(95)90531-6","article-title":"Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin\/MGDF in megakaryocyte development","volume":"81","author":"Shivdasani","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB45","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1093\/emboj\/16.13.3965","article-title":"A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development","volume":"16","author":"Shivdasani","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB46","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1128\/MCB.19.6.4452","article-title":"Fli-1, an Ets-related transcription factor, regulates erythropoietin- induced erythroid proliferation and differentiation","volume":"19","author":"Tamir","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB47","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1101\/gad.12.8.1176","article-title":"Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG","volume":"12","author":"Tsang","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1101\/gr.9.1.44","article-title":"Localization of Jacobsen syndrome breakpoints on a 40-Mb physical map of distal chromosome 11q","volume":"9","author":"Tunnacliffe","year":"1999","journal-title":"Genome Res."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB49","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1365-2141.1997.4273230.x","article-title":"Constitutive and inducible expression of megakaryocyte-specific genes in Friend erythroleukaemia cells","volume":"99","author":"Vannucchi","year":"1997","journal-title":"Br. J. Haematol."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB50","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1182\/blood.V93.9.2867","article-title":"Consequences of GATA-1 deficiency in megakaryocytes and platelets","volume":"93","author":"Vyas","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB51","doi-asserted-by":"crossref","first-page":"30823","DOI":"10.1074\/jbc.271.48.30823","article-title":"A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (vascular endothelial growth factor receptor 1) gene","volume":"271","author":"Wakiya","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB52","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1093\/emboj\/16.14.4374","article-title":"Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL","volume":"16","author":"Wang","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1074-7613(00)00017-0_BIB53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/365087a0","article-title":"Non-injection methods for the production of embryonic stem cell-embryo chimaeras","volume":"365","author":"Wood","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB54","first-page":"1621","article-title":"The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members","volume":"8","author":"Zhang","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S1074-7613(00)00017-0_BIB55","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1128\/MCB.15.12.6961","article-title":"An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes","volume":"15","author":"Zhang","year":"1995","journal-title":"Mol. Cell. Biol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T04:11:26Z","timestamp":1705119086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761300000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S1074761300000170"],"URL":"https:\/\/doi.org\/10.1016\/s1074-7613(00)00017-0","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}