{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:17:40Z","timestamp":1770358660749,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4977,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1016\/s1074-7613(00)80147-8","type":"journal-article","created":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T09:50:07Z","timestamp":1083405007000},"page":"733-742","source":"Crossref","is-referenced-by-count":203,"title":["Attrition of T Cell Memory"],"prefix":"10.1016","volume":"11","author":[{"given":"Liisa K","family":"Selin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meei Y","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy A","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew M","family":"Pardoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P","family":"Schneck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Santolucito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia K","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1074-7613(00)80147-8_BIB1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","article-title":"Phenotypic analysis of antigen-specific T lymphocytes","volume":"274","author":"Altman","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/355647a0","article-title":"Ham-2 corrects the class I antigen-processing defect in RMA-S cells","volume":"355","author":"Attaya","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB3","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.4049\/jimmunol.131.3.1531","article-title":"Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo","volume":"131","author":"Bukowski","year":"1983","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(00)80469-0","article-title":"Massive expansion of antigen-specific CD8+ T cells during an acute virus infection","volume":"8","author":"Butz","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB5","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.187.9.1395","article-title":"Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr Virus in vivo","volume":"187","author":"Callan","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB6","doi-asserted-by":"crossref","first-page":"6671","DOI":"10.1073\/pnas.90.14.6671","article-title":"A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations","volume":"90","author":"Dal Porto","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-065X.1997.tb01010.x","article-title":"Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections","volume":"159","author":"Doherty","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1074-7613(00)80573-7","article-title":"Virus-specific CD8+ T cells in primary and secondary influenza pneumonia","volume":"8","author":"Flynn","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB9","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1073\/pnas.95.13.7568","article-title":"Direct visualizaton of antigen-specific T cells","volume":"95","author":"Greten","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/369652a0","article-title":"Virus-specific CD8+ T-cell memory determined by clonal burst size","volume":"369","author":"Hou","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB11","doi-asserted-by":"crossref","first-page":"17829","DOI":"10.1074\/jbc.271.30.17829","article-title":"Binding of viral antigens to major histocompatibility complex class I H-2Db molecules is controlled by dominant negative elements at peptide non-anchor residues. Implications for peptide selection and presentation","volume":"271","author":"Hudrisier","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB12","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/369648a0","article-title":"Cytotoxic T-cell memory without antigen","volume":"369","author":"Lau","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB13","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1084\/jem.188.11.1993","article-title":"Analysis of the stability of T cell receptor (TCR) repertoire usage during lymphocytic choriomeningitis virus (LCMV) infection of mice","volume":"188","author":"Lin","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0167-5699(98)01299-7","article-title":"A very high level of crossreactivity is an essential feature of the T cell repertoire","volume":"19","author":"Mason","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1084\/jem.179.1.317","article-title":"The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen","volume":"179","author":"Mullbacher","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","article-title":"Counting antigen-specific CD8 T cells","volume":"8","author":"Murali-Krishna","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB17","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.176.5.1273","article-title":"Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen","volume":"176","author":"Oehen","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB18","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1128\/JVI.69.12.7423-7429.1995","article-title":"Discriminated selection among viral peptides with the appropriate anchor residues","volume":"69","author":"Oldstone","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1074-7613(00)80628-7","article-title":"Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection","volume":"9","author":"Oxenius","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB20","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1073\/pnas.90.9.4319","article-title":"The sizes of the CDR3 hypervariable regions of the murine T-cell receptor \u03b2 chains vary as a function of the recombined germ-line segments","volume":"90","author":"Pannetier","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00915477","article-title":"Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells","volume":"1","author":"Pross","year":"1981","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0952-7915(94)90140-6","article-title":"Specificity and editing (by apoptosis) of the CD8+ cytotoxic T lymphocyte response during viral infections","volume":"6","author":"Selin","year":"1994","journal-title":"Curr. Opin. Immun."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB23","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.4049\/jimmunol.158.11.5366","article-title":"Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection","volume":"158","author":"Selin","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB24","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1084\/jem.179.6.1933","article-title":"Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses","volume":"179","author":"Selin","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB25","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1084\/jem.183.6.2489","article-title":"Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections","volume":"183","author":"Selin","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB26","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1084\/jem.188.9.1705","article-title":"Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations","volume":"188","author":"Selin","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB27","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.4049\/jimmunol.140.12.4348","article-title":"In vitro selection of SV40 antigen epitope loss variants by site-specific cytotoxic T lymphocyte clones","volume":"140","author":"Tanaka","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4049\/jimmunol.161.1.367","article-title":"Stability of virus-specific CD4+ T cell frequencies from acute infection into long term memory","volume":"161","author":"Varga","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB29","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.4049\/jimmunol.161.7.3215","article-title":"Cutting edge","volume":"161","author":"Varga","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1369-5274(99)80067-8","article-title":"Immune deficiency, immune silencing, and clonal exhaustion of T cell responses during viral infections","volume":"2","author":"Welsh","year":"1999","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0042-6822(76)90060-X","article-title":"Antibody-complement interactions with purified lymphocytic choriomeningitis virus","volume":"73","author":"Welsh","year":"1976","journal-title":"Virology"},{"key":"10.1016\/S1074-7613(00)80147-8_BIB32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-065X.1997.tb01008.x","article-title":"Alpha-beta and gamma-delta T-cell networks and their roles in natural resistance to viral infections","volume":"159","author":"Welsh","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB33","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.142.5.1710","article-title":"Virus-induced polyclonal cytotoxic T lymphocyte stimulation","volume":"142","author":"Yang","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB34","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(00)80147-8_BIB35","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1084\/jem.185.9.1629","article-title":"Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response","volume":"185","author":"Zarozinski","year":"1997","journal-title":"J. Exp. Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300801478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300801478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T14:42:35Z","timestamp":1682692955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761300801478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S1074761300801478"],"URL":"https:\/\/doi.org\/10.1016\/s1074-7613(00)80147-8","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}