{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:39:37Z","timestamp":1770989977936,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4946,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1016\/s1074-7613(00)80161-2","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T17:29:16Z","timestamp":1087925356000},"page":"83-93","source":"Crossref","is-referenced-by-count":227,"title":["Dissecting the Multifactorial Causes of Immunodominance in Class I\u2013Restricted T Cell Responses to Viruses"],"prefix":"10.1016","volume":"12","author":[{"given":"Weisan","family":"Chen","sequence":"first","affiliation":[]},{"given":"Luis C.","family":"Ant\u00f3n","sequence":"additional","affiliation":[]},{"given":"Jack R.","family":"Bennink","sequence":"additional","affiliation":[]},{"given":"Jonathan W.","family":"Yewdell","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1074-7613(00)80161-2_BIB1","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.4049\/jimmunol.158.6.2535","article-title":"MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies","volume":"158","author":"Ant\u00f3n","year":"1997","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0008-8749(81)90368-3","article-title":"The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment","volume":"61","author":"Bennink","year":"1981","journal-title":"Cell Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1084\/jem.189.10.1591","article-title":"The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones","volume":"189","author":"Bousso","year":"1999","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB4","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.182.6.1703","article-title":"T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen","volume":"182","author":"Burrows","year":"1995","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1074-7613(00)80540-3","article-title":"Coordinate regulation of complex T cell populations responding to bacterial infection","volume":"8","author":"Busch","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB6","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.189.11.1757","article-title":"Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants","volume":"189","author":"Chen","year":"1999","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB7","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.4049\/jimmunol.158.9.4301","article-title":"Efficient priming of CD8+ memory T cells specific for a subdominant epitope following Sendai virus infection","volume":"158","author":"Cole","year":"1997","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB8","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4049\/jimmunol.158.4.1507","article-title":"MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL","volume":"158","author":"Deng","year":"1997","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1084\/jem.174.2.425","article-title":"Identification of naturally processed viral nonapeptides allows their quantitation in infected cells and suggests an allele-specific T cell epitope forecast","volume":"174","author":"Falk","year":"1991","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1074-7613(00)80573-7","article-title":"Virus-specific CD8+ T cells in primary and secondary influenza pneumonia","volume":"8","author":"Flynn","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB11","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1084\/jem.169.6.1993","article-title":"T cell memory. Long-term persistence of virus-specific cytotoxic T cells","volume":"169","author":"Jamieson","year":"1989","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB12","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/intimm\/9.9.1319","article-title":"Evidence for cooperation between TCR V region and junctional sequences in determining a dominant cytotoxic T lymphocyte response to herpes simplex virus glycoprotein B","volume":"9","author":"Jones","year":"1997","journal-title":"Int. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0022-1759(93)90158-4","article-title":"Detection of intracellular cytokines by flow cytometry","volume":"159","author":"Jung","year":"1993","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB14","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.187.9.1367","article-title":"A new look at T cells","volume":"187","author":"McMichael","year":"1998","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB15","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.4049\/jimmunol.154.9.4414","article-title":"Antigen processing in vivo and the elicitation of primary CTL responses","volume":"154","author":"Restifo","year":"1995","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB16","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.iy.11.040193.003501","article-title":"Dominance and crypticity of T cell antigenic determinants","volume":"11","author":"Sercarz","year":"1993","journal-title":"Annu. Rev. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1084\/jem.188.1.71","article-title":"Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection","volume":"188","author":"Sourdive","year":"1998","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB18","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.4049\/jimmunol.156.9.3308","article-title":"Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability","volume":"156","author":"van der Burg","year":"1996","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB19","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1128\/JVI.73.9.7619-7626.1999","article-title":"The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL\/6 mice is almost entirely directed against a single immunodominant determinant","volume":"73","author":"Wallace","year":"1999","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB20","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.4049\/jimmunol.160.6.2923","article-title":"Relationship among immunodominance of single CD8+ T cell epitopes, virus load, and kinetics of primary antiviral CTL response","volume":"160","author":"Weidt","year":"1998","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.immunol.17.1.51","article-title":"Immunodominance in MHC class I restricted responses","volume":"17","author":"Yewdell","year":"1999","journal-title":"Annu. Rev. Immunol"},{"key":"10.1016\/S1074-7613(00)80161-2_BIB22","first-page":"52","article-title":"MHC-restriced cytotoxic T cells","volume":"27","author":"Zinkernagel","year":"1979","journal-title":"Adv. Immunol"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300801612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300801612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T18:13:52Z","timestamp":1705169632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761300801612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S1074761300801612"],"URL":"https:\/\/doi.org\/10.1016\/s1074-7613(00)80161-2","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}