{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:00:32Z","timestamp":1776272432882,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2001,4,11]],"date-time":"2001-04-11T00:00:00Z","timestamp":986947200000},"content-version":"vor","delay-in-days":1714,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[1996,8]]},"DOI":"10.1016\/s1074-7613(00)80487-2","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T16:34:35Z","timestamp":1087490075000},"page":"103-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":510,"title":["Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP"],"prefix":"10.1016","volume":"5","author":[{"given":"Bhanu","family":"Sadasivan","sequence":"first","affiliation":[]},{"given":"Paul J","family":"Lehner","sequence":"additional","affiliation":[]},{"given":"Bodo","family":"Ortmann","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Spies","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Cresswell","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1074-7613(00)80487-2_BIB48","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.4049\/jimmunol.151.7.3407","article-title":"Intracellular transport of class I MHC molecules in antigen processing mutant cell lines","volume":"151","author":"Anderson","year":"1993","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB1","doi-asserted-by":"crossref","first-page":"9130","DOI":"10.1073\/pnas.90.19.9130","article-title":"Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I\u2013binding peptide into the endoplasmic reticulum in an ATP-dependent manner","volume":"90","author":"Androlewicz","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB2","doi-asserted-by":"crossref","first-page":"12716","DOI":"10.1073\/pnas.91.26.12716","article-title":"Characteristics of peptide and major histocompatibility complex class I\/\u03b22-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2)","volume":"91","author":"Androlewicz","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB3","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1074\/jbc.270.6.2784","article-title":"Molecular requirements for the interaction of class II MHC molecules and invariant chain with calnexin","volume":"270","author":"Arunachalam","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0968-0004(94)90205-4","article-title":"Calnexin","volume":"19","author":"Bergeron","year":"1994","journal-title":"Trends Biol. Sci"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB5","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1126\/science.257.5073.1142.a","article-title":"Immunodominant T cell epitope from signal sequence","volume":"257","author":"Buchmeier","year":"1992","journal-title":"Science"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB6","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.4049\/jimmunol.155.10.4726","article-title":"TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man","volume":"155","author":"Carreno","year":"1995","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1101\/SQB.1992.057.01.063","article-title":"Transport and expression of class I MHC glycoproteins in an antigen processing mutant cell line","volume":"57","author":"Click","year":"1992","journal-title":"Cold Spring Harbor Symp. Quant. Biol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB8","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1016\/S0021-9258(18)98391-2","article-title":"Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)","volume":"268","author":"David","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB9","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.175.6.1653","article-title":"Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both \u03b22-microglobulin and a peptide","volume":"175","author":"Degen","year":"1992","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0198-8859(84)90047-8","volume":"11","author":"DeMars","year":"1984","journal-title":"Human Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB11","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1073\/pnas.82.23.8183","article-title":"Mutations that impair a post-transcriptional step in expression of HLA-A and -B antigens","volume":"82","author":"DeMars","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/1074-7613(94)90049-3","article-title":"Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells","volume":"1","author":"Denzin","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB13","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1096\/fasebj.5.15.1743438","article-title":"Glucosidase inhibitors","volume":"5","author":"Elbein","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.iy.11.040193.002155","article-title":"The biochemistry and cell biology of antigen processing and presentation","volume":"11","author":"Germain","year":"1993","journal-title":"Annu. Rev. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/357375a0","article-title":"Proteolysis, proteasomes and antigen presentation","volume":"357","author":"Goldberg","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.270.5233.105","article-title":"Dependence of peptide binding by MHC class I molecules on their interaction with TAP","volume":"270","author":"Grandea","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB17","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.4049\/jimmunol.153.12.5525","article-title":"Novel allele-specific, post translational reduction in HLA class I surface expression in a mutant human B cell line","volume":"153","author":"Greenwood","year":"1994","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0955-0674(95)80009-3","article-title":"Quality control in the secretory pathway","volume":"7","author":"Hammond","year":"1995","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1073\/pnas.91.3.913","article-title":"Role of N-linked oligosaccharide recognition, glucoside trimming and calnexin in glycoprotein folding and quality control","volume":"91","author":"Hammond","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB20","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1126\/science.1546329","article-title":"HLA-A2.1-associated peptides from a mutant cell line","volume":"255","author":"Henderson","year":"1992","journal-title":"Science"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB21","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1073\/pnas.89.10.4734","article-title":"Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatability complex antigens during their assembly","volume":"89","author":"Hochstenbach","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB22","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.4049\/jimmunol.151.5.2572","article-title":"Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling","volume":"151","author":"Huczko","year":"1993","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF00404692","article-title":"An epitope common to HLA class I and class II antigens, immunoglobulin light chains and \u03b22-microglobulin","volume":"25","author":"Lutz","year":"1987","journal-title":"Immunogenetics"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0014-5793(94)00908-2","article-title":"Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells","volume":"351","author":"Meyer","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB25","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1074\/jbc.270.9.4741","article-title":"Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase","volume":"270","author":"Nauseef","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB26","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.4049\/jimmunol.156.9.3196","article-title":"Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing","volume":"156","author":"Neisig","year":"1996","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.181.1.327","article-title":"Species-specific differences in chaperone interaction of human and mouse histocompatibility complex class I molecules","volume":"181","author":"Noessner","year":"1995","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB28","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0092-8674(77)90176-3","article-title":"High resolution two dimensional electrophoresis of basic as well as acidic proteins","volume":"12","author":"O'Farrell","year":"1977","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB29","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/368864a0","article-title":"MHC class I\/\u03b22-microglobulin complexes associate with TAP transporters before peptide binding","volume":"368","author":"Ortmann","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4049\/jimmunol.123.1.342","article-title":"Use of monoclonal antibody (w6\/32) in structural studies of HLA-A, B, C antigens","volume":"123","author":"Parham","year":"1979","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1074-7613(00)80416-1","article-title":"A point mutation in the HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL","volume":"4","author":"Peace-Brewer","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB32","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1091\/mbc.6.9.1173","article-title":"Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins","volume":"6","author":"Peterson","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB33","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.4049\/jimmunol.128.6.2804","article-title":"A monoclonal antibody directed against the HLA-Bw6 epitope","volume":"128","author":"Radka","year":"1982","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1101\/SQB.1995.060.01.031","article-title":"Assembly, peptide loading and transport of MHC class I molecules in a calnexin negative cell line","volume":"60","author":"Sadasivan","year":"1995","journal-title":"Cold Spring Harbor Symp. Quant. Biol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4049\/jimmunol.155.1.143","article-title":"MHC class I expression and transport in a calnexin-deficient cell line","volume":"155","author":"Scott","year":"1995","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB36","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1242\/jcs.107.10.2705","article-title":"Retention and retrieval","volume":"107","author":"Sonnichsen","year":"1994","journal-title":"J. Cell Sci"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB37","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1073\/pnas.86.7.2361","article-title":"Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes","volume":"86","author":"Storkus","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB38","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1084\/jem.180.6.2163","article-title":"An unstable \u03b22-microglobulin","volume":"180","author":"Sugita","year":"1994","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB39","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.8191286","article-title":"Interaction of MHC class I molecules with the transporter associated with antigen processing","volume":"264","author":"Suh","year":"1994","journal-title":"Science"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB40","doi-asserted-by":"crossref","first-page":"19638","DOI":"10.1074\/jbc.270.33.19638","article-title":"Calnexin influences folding of human class I histocompatibility proteins but not their assembly with \u03b22-microglobulin","volume":"270","author":"Tector","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(90)90366-M","article-title":"Assembly of MHC class I molecules analyzed in vitro","volume":"62","author":"Townsend","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/scel.1993.1007","article-title":"The transporters associated with antigen processing","volume":"4","author":"Townsend","year":"1993","journal-title":"Sem. Cell Biol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB43","doi-asserted-by":"crossref","first-page":"20298","DOI":"10.1074\/jbc.270.35.20298","article-title":"Chaperone function of calreticulin when expressed in the endoplasmic reticulum as the membrane-anchored and soluble forms","volume":"270","author":"Wada","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB44","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1074\/jbc.270.9.4697","article-title":"The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins","volume":"270","author":"Ware","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB45","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/356443a0","article-title":"HLA-A2 molecules in an antigen processing mutant cell contain signal sequence\u2013derived peptides","volume":"356","author":"Wei","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0952-7915(95)80032-8","article-title":"Molecular chaperones in antigen presentation","volume":"7","author":"Williams","year":"1995","journal-title":"Curr. Opin. Immunol"},{"key":"10.1016\/S1074-7613(00)80487-2_BIB47","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1074\/jbc.270.8.3944","article-title":"Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules","volume":"270","author":"Zhang","year":"1995","journal-title":"J. Biol. Chem"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300804872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300804872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:47:32Z","timestamp":1761032852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761300804872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["S1074761300804872"],"URL":"https:\/\/doi.org\/10.1016\/s1074-7613(00)80487-2","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[1996,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1074-7613(00)80487-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}