{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:10:06Z","timestamp":1780132206404,"version":"3.54.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5433,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[1998,9]]},"DOI":"10.1016\/s1074-7613(00)80623-8","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T12:29:10Z","timestamp":1086956950000},"page":"405-411","source":"Crossref","is-referenced-by-count":466,"title":["Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals"],"prefix":"10.1016","volume":"9","author":[{"given":"Robert G","family":"Caldwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna B","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S1074-7613(00)80623-8_BIB1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1074-7613(00)80622-6","article-title":"EBV persistence in memory B cells in vivo","volume":"9","author":"Babcock","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB2","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1073\/pnas.94.17.9337","article-title":"Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells","volume":"94","author":"Braeuninger","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB3","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1128\/JVI.66.8.5161-5167.1992","article-title":"An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases","volume":"66","author":"Burkhardt","year":"1992","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB4","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1128\/JVI.69.6.3752-3758.1995","article-title":"A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1","volume":"69","author":"Chen","year":"1995","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/378303a0","article-title":"Syk tyrosine kinase required for mouse viability and B-cell development","volume":"378","author":"Cheng","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB6","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1073\/pnas.82.9.2731","article-title":"Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene","volume":"82","author":"Dush","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/j.1460-2075.1991.tb07954.x","article-title":"Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin","volume":"10","author":"Era","year":"1991","journal-title":"EMBO J"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB8","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1128\/JVI.70.9.6216-6226.1996","article-title":"Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction","volume":"70","author":"Fruehling","year":"1996","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/viro.1997.8690","article-title":"The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction","volume":"235","author":"Fruehling","year":"1997","journal-title":"Virology"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB10","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1073\/pnas.85.22.8693","article-title":"Eradication of Epstein-Barr virus by allogeneic bone marrow transplantation","volume":"85","author":"Gratama","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0092-8674(85)80069-6","article-title":"Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements","volume":"41","author":"Grosschedl","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB12","series-title":"Manipulating the Mouse Embryo","author":"Hogan","year":"1994"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB13","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.184.4.1495","article-title":"Hodgkin and Reed-Sternberg cells in Hodgkin\u2019s disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells","volume":"184","author":"Kanzler","year":"1996","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/309369a0","article-title":"Epstein-Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements","volume":"309","author":"Katamine","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB15","unstructured":"Kieff, E. (1996). Epstein-Barr virus and its replication. In Fundamental Virology, B.N. Fields, D.M. Knipe, and P.M. Howley, eds. (Lippincott-Raven), pp. 1109\u20131162."},{"key":"10.1016\/S1074-7613(00)80623-8_BIB16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/350423a0","article-title":"A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin \u03bc chain gene","volume":"350","author":"Kitamura","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0092-8674(00)80373-6","article-title":"In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death","volume":"90","author":"Lam","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB18","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0140-6736(91)90203-2","article-title":"Circulating Epstein-Barr virus-carrying B cells in acute malaria","volume":"337","author":"Lam","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ijc.2910390411","article-title":"Characterization of EBV-carrying B-cell populations in healthy seropositive individuals with regard to density, release of transforming virus and spontaneous outgrowth","volume":"39","author":"Lewin","year":"1987","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB20","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1128\/JVI.64.5.2319-2326.1990","article-title":"A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1","volume":"64","author":"Longnecker","year":"1990","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0966-842X(96)81504-6","article-title":"Regulation of Epstein-Barr virus latency by latent membrane protein 2","volume":"4","author":"Longnecker","year":"1996","journal-title":"Trends Microbiol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB22","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1128\/JVI.65.7.3681-3692.1991","article-title":"An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase","volume":"65","author":"Longnecker","year":"1991","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB23","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1128\/JVI.66.11.6461-6469.1992","article-title":"The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential","volume":"66","author":"Longnecker","year":"1992","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB24","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1128\/JVI.67.4.2006-2013.1993","article-title":"The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro","volume":"67","author":"Longnecker","year":"1993","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB25","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1128\/JVI.67.8.5068-5074.1993","article-title":"Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B","volume":"67","author":"Longnecker","year":"1993","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB26","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/JVI.67.1.606-609.1993","article-title":"Marker rescue of a transformation-negative Epstein-Barr virus recombinant from an infected Burkitt lymphoma cell line","volume":"67","author":"Marchini","year":"1993","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB27","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1128\/JVI.67.6.3087-3094.1993","article-title":"Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes","volume":"67","author":"Miller","year":"1993","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB28","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1073\/pnas.91.2.772","article-title":"An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking","volume":"91","author":"Miller","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1074-7613(95)80040-9","article-title":"Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases","volume":"2","author":"Miller","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0092-8674(95)90513-8","article-title":"A novel form of Epstein-Barr virus latency in normal B cells in vivo","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB31","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1128\/JVI.71.7.4882-4891.1997","article-title":"Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell","volume":"71","author":"Miyashita","year":"1997","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB32","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","author":"Mombaerts","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB33","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1128\/JVI.66.6.3715-3724.1992","article-title":"Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes","volume":"66","author":"Qu","year":"1992","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB34","unstructured":"Rickinson, A.B., and Kieff, E. (1996). Epstein-Barr virus. In Fields Virology, B.N. Fields, D.M. Knipe, and P.M. Howley, eds. (Philadelphia, PA: Lippincott-Raven), pp. 2397\u20132446."},{"key":"10.1016\/S1074-7613(00)80623-8_BIB35","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/0092-8674(91)90032-T","article-title":"Molecular and cellular origins of B lymphocyte diversity","volume":"66","author":"Rolink","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB36","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0092-8674(89)90951-3","article-title":"Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription","volume":"58","author":"Schlissel","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.173.3.711","article-title":"Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription","volume":"173","author":"Schlissel","year":"1991","journal-title":"J. Exp. Med"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB38","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB39","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1101\/gad.8.9.1030","article-title":"Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice","volume":"8","author":"Spanopoulou","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB40","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.4049\/jimmunol.154.11.5862","article-title":"Regulation of early T cell development by the engagement of TCR-\u03b2 complex expressed on fetal thymocytes from TCR-\u03b2-transgenic scid mice","volume":"154","author":"Takahama","year":"1995","journal-title":"J. Immunol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB41","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1128\/JVI.68.11.7374-7385.1994","article-title":"Epstein-Barr virus latency in blood mononuclear cells","volume":"68","author":"Tierney","year":"1994","journal-title":"J. Virol"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/378298a0","article-title":"Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk","volume":"378","author":"Turner","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ijc.2910350107","article-title":"A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals","volume":"35","author":"Yao","year":"1985","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ijc.2910430115","article-title":"Epstein-Barr virus-infected B cells persist in the circulation of acyclovir-treated virus carriers","volume":"43","author":"Yao","year":"1989","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1074-7613(00)80623-8_BIB45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ijc.2910480217","article-title":"Spontaneous outgrowth of Epstein-Barr virus-positive B-cell lines from circulating human B cells of different buoyant densities","volume":"48","author":"Yao","year":"1991","journal-title":"Int. J. Cancer"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300806238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761300806238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T20:59:20Z","timestamp":1682715560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761300806238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["S1074761300806238"],"URL":"https:\/\/doi.org\/10.1016\/s1074-7613(00)80623-8","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}