{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:58:38Z","timestamp":1789901918339,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3669,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1016\/s1074-7613(03)00176-6","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T05:15:11Z","timestamp":1082524511000},"page":"83-94","source":"Crossref","is-referenced-by-count":208,"title":["GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4\/CD8 Differentiation"],"prefix":"10.1016","volume":"19","author":[{"given":"Gabriela","family":"Hern\u00e1ndez-Hoyos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele K.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen V.","family":"Rothenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Alberola-Ila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S1074-7613(03)00176-6_BIB1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0092-8674(02)00689-X","article-title":"An invitation to T and more","volume":"109","author":"Allman","year":"2002","journal-title":"Cell Suppl."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/dbio.2002.0674","article-title":"Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3","volume":"246","author":"Anderson","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1074-7613(02)00277-7","article-title":"Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage","volume":"16","author":"Anderson","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1084\/jem.190.11.1605","article-title":"Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47","volume":"190","author":"Bain","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/84273","article-title":"Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade","volume":"2","author":"Bain","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-065X.1998.tb01239.x","article-title":"Molecular requirements for lineage commitment in the thymus-antibody-mediated receptor engagements reveal a central role for lck in lineage decisions","volume":"165","author":"Basson","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB8","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.4049\/jimmunol.169.4.1713","article-title":"Thymocyte development in early growth response gene 1-deficient mice","volume":"169","author":"Bettini","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1046-2023(02)00023-3","article-title":"Analysis of gene function in somatic mammalian cells using small interfering RNAs","volume":"26","author":"Elbashir","year":"2002","journal-title":"Methods"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB10","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1242\/dev.120.9.2673","article-title":"Embryonic expression and cloning of the murine GATA-3 gene","volume":"120","author":"George","year":"1994","journal-title":"Development"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri798","article-title":"T-cell development and the CD4-CD8 lineage decision","volume":"2","author":"Germain","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.184.3.1137","article-title":"Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus","volume":"184","author":"Hattori","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB13","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.167.9.4957","article-title":"Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage","volume":"167","author":"Hayashi","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB14","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.186.9.1597","article-title":"Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3","volume":"186","author":"Heemskerk","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB15","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1912::AID-IMMU1912>3.0.CO;2-D","article-title":"Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus","volume":"29","author":"Hendriks","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1084-9521(02)00180-5","article-title":"A Notch so simple influence on T cell development","volume":"14","author":"Hern\u00e1ndez-Hoyos","year":"2003","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80184-3","article-title":"Lck activity controls CD4\/CD8 T cell lineage commitment","volume":"12","author":"Hern\u00e1ndez-Hoyos","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB18","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/S0092-8674(02)00705-5","article-title":"Transcription","volume":"109","author":"Ho","year":"2002","journal-title":"Cell Suppl."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB19","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/j.1460-2075.1991.tb08059.x","article-title":"Human GATA-3","volume":"10","author":"Ho","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB20","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/eji.1830260918","article-title":"Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture","volume":"26","author":"Iwata","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1084\/jem.176.3.845","article-title":"Studies on T cell maturation on defined thymic stromal cell populations in vitro","volume":"176","author":"Jenkinson","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.immunol.17.1.149","article-title":"Transcriptional regulation of T lymphocyte development and function","volume":"17","author":"Kuo","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.192.1.105","article-title":"GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells","volume":"192","author":"Lee","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1074-7613(00)80205-8","article-title":"Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes","volume":"12","author":"Legname","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1074-7613(00)80185-5","article-title":"ROG, repressor of GATA, regulates the expression of cytokine genes","volume":"12","author":"Miaw","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.18.1.451","article-title":"Signaling and transcription in T helper development","volume":"18","author":"Murphy","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB27","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1128\/JVI.70.8.5701-5705.1996","article-title":"The pCL vector system","volume":"70","author":"Naviaux","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4049\/jimmunol.167.2.715","article-title":"Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice","volume":"167","author":"Nawijn","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB29","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80671-8","article-title":"Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism","volume":"9","author":"Ouyang","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng0995-40","article-title":"Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis","volume":"11","author":"Pandolfi","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/342559a0","article-title":"Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen","volume":"342","author":"Pircher","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1074-7613(00)80352-0","article-title":"Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner","volume":"6","author":"Sebzda","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.185.4.731","article-title":"Induction of the early growth response (Egr) family of transcription factors during thymic selection","volume":"185","author":"Shao","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0952-7915(02)00323-0","article-title":"New perspectives on a developmental dilemma","volume":"14","author":"Singer","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB35","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1074\/jbc.270.4.1515","article-title":"GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancers","volume":"270","author":"Smith","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB36","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.4049\/jimmunol.167.8.4468","article-title":"Enforced expression of GATA-3 severely reduces human thymic cellularity","volume":"167","author":"Taghon","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB37","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.4049\/jimmunol.169.8.4103","article-title":"Cutting edge","volume":"169","author":"Takemoto","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0092-8674(02)01111-X","article-title":"Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development","volume":"111","author":"Taniuchi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/384474a0","article-title":"Transcription factor GATA-3 is required for development of the T-cell lineage","volume":"384","author":"Ting","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1074-7613(00)80103-X","article-title":"Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death","volume":"11","author":"Van Parijs","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ni767","article-title":"Tox","volume":"3","author":"Wilkinson","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB42","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1093\/emboj\/19.17.4676","article-title":"Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs","volume":"19","author":"Yamagata","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S1074-7613(03)00176-6_BIB43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/35006664","article-title":"The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate","volume":"404","author":"Yasutomo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB44","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1073\/pnas.092143499","article-title":"RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells","volume":"99","author":"Yu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1074-7613(03)00176-6_BIB45","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1074-7613(00)80122-3","article-title":"Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3","volume":"11","author":"Zhang","year":"1999","journal-title":"Immunity"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761303001766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761303001766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T04:10:58Z","timestamp":1705119058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761303001766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S1074761303001766"],"URL":"https:\/\/doi.org\/10.1016\/s1074-7613(03)00176-6","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}