{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:07:54Z","timestamp":1758816474339},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"vor","delay-in-days":2780,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Itch sensation can be inhibited by simultaneously applied cutaneous pain at the same skin site via a central mechanism. Deep muscle pain is often associated with sensory changes in the corresponding dermatome. We investigated whether experimentally induced muscle pain has any influence on histamine\u2010induced itch and vice versa in a double blind placebo\u2010controlled study. Experiments were performed in 18 healthy subjects. In nine individuals control iontophoresis of histamine into the forearm produced a distinct itch sensation. Another nine individuals participated in an additional experiment in which histamine and saline were iontophoresed on the forearm in a randomized double\u2010blinded two\u2010way crossover design after intramuscular injection of capsaicin into the ipsilateral brachioradial muscle. Capsaicin\u2010induced muscle pain reduced itch sensation significantly. In contrast, capsaicin\u2010induced muscle pain increased significantly after cutaneous histamine application compared to muscle pain after iontophoresis of saline (placebo). These novel data indicate that muscle pain inhibits itch and histamine increases muscle pain. A bi\u2010directional interaction between cutaneous histamine\u2010sensitive afferents and nociceptive muscle afferents via central mechanisms is suggested.<\/jats:p>","DOI":"10.1016\/s1090-3801(03)00099-5","type":"journal-article","created":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T01:10:28Z","timestamp":1063329028000},"page":"179-185","source":"Crossref","is-referenced-by-count":13,"title":["Interaction between histamine\u2010induced itch and experimental muscle pain"],"prefix":"10.1002","volume":"8","author":[{"given":"G.","family":"Wasner","sequence":"first","affiliation":[]},{"given":"K.","family":"Schwarz","sequence":"additional","affiliation":[]},{"given":"J.","family":"Schattschneider","sequence":"additional","affiliation":[]},{"given":"A.","family":"Binder","sequence":"additional","affiliation":[]},{"given":"T.S.","family":"Jensen","sequence":"additional","affiliation":[]},{"given":"R.","family":"Baron","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/82924"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990229970357"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200111160-00020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.5.923"},{"key":"e_1_2_6_6_1","first-page":"377","article-title":"Experiments relation to the itch sensation\u2014its peripheral mechanism, and central pathways","volume":"3","author":"Bickford M.J.","year":"1937","journal-title":"Clin. Sci."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990229970366"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102414"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1300\/J094v05n01_04"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12284051"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03083-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(82)90005-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019068"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(97)90035-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)03339-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2684163"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/82956"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-08003.1997"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00274-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00156-5"},{"key":"e_1_2_6_21_1","volume-title":"Myofascial pain and dysfunction. The trigger point manual","author":"Travell J.G.","year":"1982"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/mr.2000.3777"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00080-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10170"},{"key":"e_1_2_6_25_1","first-page":"S9","article-title":"Stimulation histaminsensibler C\u2010Fasern im Areal der Capsaicin\u2010induzierten Allodynie","volume":"13","author":"Wasner G.","year":"1999","journal-title":"Schmerz"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00231-6"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS1090-3801(03)00099-5","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S1090-3801%2803%2900099-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:24:42Z","timestamp":1697232282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/S1090-3801%2803%2900099-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1016\/S1090-3801(03)00099-5"],"URL":"https:\/\/doi.org\/10.1016\/s1090-3801(03)00099-5","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}