{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:17:18Z","timestamp":1773911838382,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5403,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1016\/s1097-2765(00)80141-0","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T10:59:08Z","timestamp":1087988348000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":207,"title":["Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity"],"prefix":"10.1016","volume":"2","author":[{"given":"Joel D","family":"Leverson","sequence":"first","affiliation":[]},{"given":"P\u00e4ivi J","family":"Koskinen","sequence":"additional","affiliation":[]},{"given":"Frank C","family":"Orrico","sequence":"additional","affiliation":[]},{"given":"Eeva-Marja","family":"Rainio","sequence":"additional","affiliation":[]},{"given":"Katriina J","family":"Jalkanen","sequence":"additional","affiliation":[]},{"given":"Ajeeta B","family":"Dash","sequence":"additional","affiliation":[]},{"given":"Robert N","family":"Eisenman","sequence":"additional","affiliation":[]},{"given":"Scott A","family":"Ness","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(00)80141-0_BIB1","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1073\/pnas.86.22.8857","article-title":"The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias","volume":"86","author":"Amson","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB2","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.1073\/pnas.92.14.6429","article-title":"Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain","volume":"92","author":"Aziz","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1101\/gad.8.7.770","article-title":"Dominant interfering alleles define a role for c-Myb in T-cell development","volume":"8","author":"Badiani","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB4","first-page":"2205","article-title":"T-cell lymphomas in v-Myb transgenic mice","volume":"13","author":"Badiani","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0092-8674(91)90636-D","article-title":"Molecular themes in oncogenesis","volume":"64","author":"Bishop","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1101\/gad.6.4.545","article-title":"Serum-, TPA-, and Ras-induced expression from Ap-1\/Ets-driven promoters requires Raf-1 kinase","volume":"6","author":"Bruder","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0092-8674(84)90309-X","article-title":"Murine leukemia virus-induced T-cell lymphomagenesis","volume":"37","author":"Cuypers","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB8","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1101\/gad.10.15.1858","article-title":"The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb","volume":"10","author":"Dash","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB9","doi-asserted-by":"crossref","first-page":"17615","DOI":"10.1016\/S0021-9258(19)77880-6","article-title":"Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines","volume":"263","author":"Dautry","year":"1988","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/jvi.36.1.50-61.1980","article-title":"Molecular cloning and characterization of avian sarcoma virus circular DNA molecules","volume":"36","author":"DeLorbe","year":"1980","journal-title":"J. Virol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/nar\/12.1Part1.387","article-title":"A comprehensive set of sequence analysis programs for the VAX","volume":"12","author":"Devereux","year":"1984","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB12","first-page":"7334","article-title":"Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo","volume":"13","author":"Dini","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB13","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1101\/gad.6.12b.2524","article-title":"Carboxy-terminal elements of c-Myb negatively regulate transcriptional activation in cis and in trans","volume":"6","author":"Dubendorff","year":"1992","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB14","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1101\/gad.7.4.555","article-title":"The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit","volume":"7","author":"Durfee","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB15","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/0003-9861(92)90454-5","article-title":"Characterization of the proto-oncogene pim-1","volume":"298","author":"Friedmann","year":"1992","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB16","doi-asserted-by":"crossref","first-page":"R353","DOI":"10.1016\/S0960-9822(98)70220-9","article-title":"Leukemogenesis","volume":"8","author":"Graf","year":"1998","journal-title":"Curr. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0092-8674(93)90303-8","article-title":"Self-renewal and differentiation of normal avian erythroid progenitor cells","volume":"74","author":"Hayman","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB18","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1128\/MCB.18.5.2729","article-title":"c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation","volume":"18","author":"Hedge","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB19","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1128\/MCB.15.7.3813","article-title":"Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system","volume":"15","author":"Hollenberg","year":"1995","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB20","doi-asserted-by":"crossref","first-page":"14018","DOI":"10.1016\/S0021-9258(18)92804-8","article-title":"Recombinant human pim-1 protein exhibits serine\/threonine kinase activity","volume":"266","author":"Hoover","year":"1991","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(92)90361-F","article-title":"Activation of the MAP kinase pathway by the protein kinase raf","volume":"71","author":"Howe","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0092-8674(00)80906-X","article-title":"Prolyl isomerases and nuclear function","volume":"92","author":"Hunter","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB23","doi-asserted-by":"crossref","first-page":"11176","DOI":"10.1074\/jbc.272.17.11176","article-title":"Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain","volume":"272","author":"Joneja","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB24","first-page":"29","article-title":"Retroviral insertional mutagenesis as a strategy to identify cancer genes","volume":"1287","author":"Jonkers","year":"1996","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0092-8674(84)90384-2","article-title":"Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene","volume":"37","author":"Klempnauer","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB26","first-page":"1099","article-title":"Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1\/P2 promoters","volume":"8","author":"Kohlhuber","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0092-8674(00)80401-8","article-title":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation","volume":"91","author":"Kowenz-Leutz","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB28","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/310592a0","article-title":"Expression of c-myc changes during differentiation of mouse erythroleukaemia cells","volume":"310","author":"Lachman","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1097-2765(00)80021-0","article-title":"Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanism","volume":"1","author":"Leverson","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/abbi.1996.0251","article-title":"Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1","volume":"330","author":"Liang","year":"1996","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB31","first-page":"727","article-title":"Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related","volume":"7","author":"Lilly","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/344517a0","article-title":"Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation","volume":"344","author":"L\u00fcscher","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB33","first-page":"1680","article-title":"The human Pim-1 gene is selectively transcribed in different hemato-lymphoid cell lines in spite of a G + C-rich housekeeping promoter","volume":"10","author":"Meeker","year":"1990","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB34","doi-asserted-by":"crossref","first-page":"10734","DOI":"10.1073\/pnas.90.22.10734","article-title":"Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr\/lpr mice","volume":"90","author":"Moroy","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0092-8674(91)90099-K","article-title":"A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis","volume":"65","author":"Mucenski","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0014-5793(95)01386-5","article-title":"Thrombopoietin induces activation of at least two distinct signaling pathways","volume":"377","author":"Nagata","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB37","first-page":"F123","article-title":"The myb oncoprotein","volume":"1288","author":"Ness","year":"1996","journal-title":"BBA Rev. Cancer"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0092-8674(87)90008-0","article-title":"v-myb dominance over v-myc in doubly transformed chick myelomonocytic cells","volume":"51","author":"Ness","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB39","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0092-8674(89)90767-8","article-title":"The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene","volume":"59","author":"Ness","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB40","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1101\/gad.7.5.749","article-title":"Myb and NF-M","volume":"7","author":"Ness","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB41","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1128\/MCB.15.11.5966","article-title":"Casein kinase II phosphorylation site mutations in c-Myb affect DNA binding and transcriptional cooperativity with NF-M","volume":"15","author":"Oelgeschl\u00e4ger","year":"1995","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB42","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1002\/j.1460-2075.1996.tb00637.x","article-title":"Interaction of the co-activator CBP with Myb proteins","volume":"15","author":"Oelgeschl\u00e4ger","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB43","doi-asserted-by":"crossref","first-page":"12350","DOI":"10.1074\/jbc.272.19.12350","article-title":"The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells","volume":"272","author":"Sakai","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/j.1460-2075.1991.tb07994.x","article-title":"The pim-1 oncogene encodes two related protein-serine\/threonine kinases by alternative initiation at AUG and CUG","volume":"10","author":"Saris","year":"1991","journal-title":"EMBO J"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB45","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1523-1747.ep12324482","article-title":"Differentiation-associated expression of the proto-oncogene pim-1 in cultured human keratinocytes","volume":"105","author":"Stewart","year":"1995","journal-title":"J. Invest. Dermat"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB46","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1128\/MCB.18.2.989","article-title":"Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb","volume":"18","author":"Tavner","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB47","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1128\/MCB.15.9.4735","article-title":"The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE","volume":"15","author":"Tong","year":"1995","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80141-0_BIB48","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1093\/nar\/20.12.3183","article-title":"Characterization of the testes-specific pim-1 transcript in rat","volume":"20","author":"Wingett","year":"1992","journal-title":"Nucleic Acids Res"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276500801410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276500801410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:58:44Z","timestamp":1761091124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276500801410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S1097276500801410"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(00)80141-0","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1097-2765(00)80141-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}