{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:27:28Z","timestamp":1770478048600,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5191,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1016\/s1097-2765(00)80351-2","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T12:29:33Z","timestamp":1083673773000},"page":"579-591","source":"Crossref","is-referenced-by-count":277,"title":["Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53"],"prefix":"10.1016","volume":"3","author":[{"given":"Yanping","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Yue","family":"Xiong","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(00)80351-2_BIB1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1128\/MCB.18.2.1084","article-title":"The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein","volume":"18","author":"Alcalay","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/25867","article-title":"p14ARF links the tumor suppressors RB and p53","volume":"395","author":"Bates","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB3","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1101\/gad.12.15.2434","article-title":"E1A signaling to p53 involves the p19ARF tumor suppressor","volume":"12","author":"de Stanchina","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0092-8674(94)90340-9","article-title":"A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein","volume":"76","author":"Dyck","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF03401664","article-title":"The CDK2A (p16) gene and human cancer","volume":"3","author":"Foulkes","year":"1997","journal-title":"Mol. Med"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB6","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.1128\/MCB.18.12.7288","article-title":"Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6","volume":"18","author":"Freedman","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1097-2765(00)80140-9","article-title":"p300\/MDM2 complexes participate in MDM2-mediated p53 degradation","volume":"2","author":"Grossman","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Haupt","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1097-2765(00)80309-3","article-title":"RB regulates the stability and the apoptotic function of p53 via MDM2","volume":"3","author":"Hsieh","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.8153634","article-title":"A cell cycle regulator potentially involved in genesis of many tumor types","volume":"264","author":"Kamb","year":"1994","journal-title":"Science"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)80452-3","article-title":"Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19 ARF","volume":"91","author":"Kamijo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB12","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.95.14.8292","article-title":"Functional and physical interaction of the ARF tumor suppressor with p53 and MDM2","volume":"95","author":"Kamijo","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/375506a0","article-title":"Tumor-derived p16 alleles encoding proteins defective in cell-cycle inhibition","volume":"375","author":"Koh","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/387299a0","article-title":"Regulation of p53 stability by Mdm2","volume":"387","author":"Kubbutat","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB15","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1073\/pnas.95.9.4991","article-title":"Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body","volume":"95","author":"Lamorte","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/368753a0","article-title":"Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers","volume":"368","author":"Nobori","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/25870","article-title":"p19ARF links the tumor suppressor p53 and Ras","volume":"395","author":"Palmero","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0092-8674(00)81400-2","article-title":"The INK4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2\u2019s inhibition of p53","volume":"92","author":"Pomerantz","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(00)81774-2","article-title":"Signaling to p53","volume":"95","author":"Prives","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(95)90214-7","article-title":"Alterative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest","volume":"83","author":"Quelle","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB22","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1073\/pnas.94.2.669","article-title":"Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16 INK4a but not by the alternative reading frame protein p19 ARF","volume":"94","author":"Quelle","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB23","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/emboj\/17.2.554","article-title":"Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein","volume":"17","author":"Roth","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB24","first-page":"F115","article-title":"The p16INK4a\/CDK2A tumor suppresor and its relatives","volume":"1378","author":"Ruas","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB25","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB26","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1101\/gad.12.19.2984","article-title":"Tumor surveillance via the ARF-p53 pathway","volume":"12","author":"Sherr","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage\u2013induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB28","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/emboj\/18.6.1660","article-title":"A leucine-rich export signal in the p53 tetramerization domain","volume":"18","author":"Stommel","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB29","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1093\/emboj\/17.17.5001","article-title":"The alternative product from the human CDK2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2","volume":"17","author":"Stott","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0092-8674(94)90341-7","article-title":"Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells","volume":"76","author":"Weis","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/375694a0","article-title":"Interaction between the retinoblastima protein and the oncoprotein MDM2","volume":"375","author":"Xiao","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0092-8674(00)81401-4","article-title":"ARF promotes MDM2 degradation and stabilizes p53","volume":"92","author":"Zhang","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80351-2_BIB33","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1101\/gad.12.15.2424","article-title":"Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization","volume":"12","author":"Zindy","year":"1998","journal-title":"Genes Dev"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276500803512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276500803512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T01:49:56Z","timestamp":1585792196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276500803512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S1097276500803512"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(00)80351-2","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}