{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:26:22Z","timestamp":1774992382726,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5007,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1016\/s1097-2765(00)80383-4","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T13:29:16Z","timestamp":1087910956000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":293,"title":["Acetylation of MyoD Directed by PCAF Is Necessary for the Execution of the Muscle Program"],"prefix":"10.1016","volume":"4","author":[{"given":"Vittorio","family":"Sartorelli","sequence":"first","affiliation":[]},{"given":"Pier Lorenzo","family":"Puri","sequence":"additional","affiliation":[]},{"given":"Yasuo","family":"Hamamori","sequence":"additional","affiliation":[]},{"given":"Vasily","family":"Ogryzko","sequence":"additional","affiliation":[]},{"given":"Gene","family":"Chung","sequence":"additional","affiliation":[]},{"given":"Yoshihiro","family":"Nakatani","sequence":"additional","affiliation":[]},{"given":"Jean Y.J.","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Larry","family":"Kedes","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(00)80383-4_BIB1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1990.tb42359.x","article-title":"Id","volume":"599","author":"Benezra","year":"1990","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/25166","article-title":"Regulation of activity of the transcription factor GATA-1 by acetylation","volume":"396","author":"Boyes","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/35404","article-title":"Retinoblastoma protein recruits histone deacetylase to repress transcription","volume":"391","author":"Brehm","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0959-437X(96)80048-7","article-title":"Special HATs for special occasions","volume":"6","author":"Brownell","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0092-8674(00)81063-6","article-title":"Tetrahymena histone acetyltransferase A","volume":"84","author":"Brownell","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)80516-4","article-title":"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P\/CAF and CBP\/p300","volume":"90","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB8","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1128\/MCB.18.9.5355","article-title":"A human RNA polymerase II complex containing factors that modify chromatin structure","volume":"18","author":"Cho","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB9","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1101\/gad.10.19.2478","article-title":"Interaction and functional collaboration of p300\/CBP and bHLH proteins in muscle and B-cell differentiation","volume":"10","author":"Eckner","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1101\/gad.11.4.436","article-title":"Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin","volume":"11","author":"Gerber","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/38664","article-title":"Histone acetylation in chromatin structure and transcription","volume":"389","author":"Grunstein","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(00)80521-8","article-title":"Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain","volume":"90","author":"Gu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90110-C","article-title":"Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation","volume":"72","author":"Gu","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB14","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1126\/science.7863327","article-title":"Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD","volume":"267","author":"Halevy","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0092-8674(00)80553-X","article-title":"Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A","volume":"96","author":"Hamamori","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB16","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1002\/j.1460-2075.1988.tb02956.x","article-title":"A direct link between core histone acetylation and transcriptionally active chromatin","volume":"7","author":"Hebbes","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB17","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1128\/MCB.18.9.5478","article-title":"Intramolecular regulation of MyoD activation domain conformation and function","volume":"18","author":"Huang","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB18","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1128\/MCB.19.5.3496","article-title":"CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites","volume":"19","author":"Hung","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0960-9822(06)00296-X","article-title":"Acetylation of general transcription factors by histone acetyltransferases","volume":"7","author":"Imhof","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0003-2697(83)90308-1","article-title":"Use of endoproteinase Lys-C from Lysobacter enzymogenes in protein sequence analysis","volume":"134","author":"Jekel","year":"1983","journal-title":"Anal. Biochem."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB21","first-page":"5123","article-title":"Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin","volume":"12","author":"Johnston","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.279.5351.703","article-title":"Transcription factor-specific requirements for coactivators and their acetyltransferase functions","volume":"279","author":"Korzus","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB23","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0092-8674(89)90935-5","article-title":"MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer","volume":"58","author":"Lassar","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(91)90620-E","article-title":"Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12\/E47-like proteins in vivo","volume":"66","author":"Lassar","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0092-8674(93)90051-Q","article-title":"A positive role for histone acetylation in transcription factor access to nucleosomal DNA","volume":"72","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB26","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0092-8674(05)80066-2","article-title":"FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains","volume":"71","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB27","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1128\/MCB.19.2.1202","article-title":"p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage","volume":"19","author":"Liu","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 \u00c5 resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0092-8674(00)80940-X","article-title":"Rb interacts with histone deacetylase to repress transcription","volume":"92","author":"Luo","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB30","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(94)90159-7","article-title":"Crystal structure of MyoD bHLH domain-DNA complex","volume":"77","author":"Ma","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB31","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0092-8674(00)81821-8","article-title":"The TAF(II)250 subunit of TFIID has histone acetyltransferase activity","volume":"87","author":"Mizzen","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(00)80145-8","article-title":"Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome","volume":"2","author":"Munshi","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB33","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0092-8674(89)90434-0","article-title":"Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence","volume":"58","author":"Murre","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB34","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0092-8674(00)80376-1","article-title":"RNA helicase A mediates association of CBP with RNA polymerase II","volume":"90","author":"Nakajima","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.135.2.441","article-title":"Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle","volume":"135","author":"Novitch","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB36","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0092-8674(00)81219-2","article-title":"Histone-like TAFs within the PCAF histone acetylase complex","volume":"94","author":"Ogryzko","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.8.1.1","article-title":"bHLH factors in muscle development","volume":"8","author":"Olson","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/emboj\/16.2.369","article-title":"p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription","volume":"16","author":"Puri","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1097-2765(00)80005-2","article-title":"Differential roles of p300 and PCAF acetyltransferases in muscle differentiation","volume":"1","author":"Puri","year":"1997","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB41","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.12.18.2831","article-title":"DNA damage activates p53 through a phosphorylation-acetylation cascade","volume":"12","author":"Sakaguchi","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB42","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1101\/gad.4.10.1811","article-title":"Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1","volume":"4","author":"Sartorelli","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB43","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1128\/MCB.17.2.1010","article-title":"Molecular mechanisms of myogenic coactivation by p300","volume":"17","author":"Sartorelli","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/bbrc.1997.6255","article-title":"Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells","volume":"232","author":"Siavoshian","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB45","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1128\/MCB.16.12.7043","article-title":"Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation","volume":"16","author":"Skapek","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB46","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/38304","article-title":"Steroid receptor coactivator-1 is a histone acetyltransferase","volume":"389","author":"Spencer","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB47","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1101\/gad.12.5.599","article-title":"Histone acetylation and transcriptional regulatory mechanisms","volume":"12","author":"Struhl","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB48","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1073\/pnas.92.10.4646","article-title":"Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently","volume":"92","author":"Vandromme","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB49","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1126\/science.1846704","article-title":"The myoD gene family","volume":"251","author":"Weintraub","year":"1991","journal-title":"Science"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB50","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0092-8674(00)81059-4","article-title":"Targeting chromatin disruption","volume":"84","author":"Wolffe","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB51","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"A p300\/CBP-associated factor that competes with the adenoviral oncoprotein E1A","volume":"382","author":"Yang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(00)80383-4_BIB52","doi-asserted-by":"crossref","first-page":"9009","DOI":"10.1074\/jbc.271.15.9009","article-title":"Human p300 protein is a coactivator for the transcription factor MyoD","volume":"271","author":"Yuan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB53","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1101\/gad.10.23.3051","article-title":"pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis","volume":"10","author":"Zacksenhaus","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(00)80383-4_BIB54","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/emboj\/18.4.926","article-title":"Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4","volume":"18","author":"Zhang","year":"1999","journal-title":"EMBO J."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276500803834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276500803834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:01:12Z","timestamp":1761091272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276500803834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S1097276500803834"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(00)80383-4","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetylation of MyoD Directed by PCAF Is Necessary for the Execution of the Muscle Program","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1097-2765(00)80383-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}