{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:50:04Z","timestamp":1779353404985,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4337,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006264","name":"RIKEN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1016\/s1097-2765(01)00341-0","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T06:53:02Z","timestamp":1081579982000},"page":"613-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":879,"title":["A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death"],"prefix":"10.1016","volume":"8","author":[{"given":"Yasuyuki","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Takio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(01)00341-0_BIB1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0962-8924(99)01646-3","article-title":"An emerging blueprint for apoptosis in Drosophila","volume":"9","author":"Abrams","year":"1999","journal-title":"Trends. Cell Biol."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/35022514","article-title":"Structural and biochemical basis of apoptotic activation by Smac\/DIABLO","volume":"406","author":"Chai","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1101\/gad.13.3.239","article-title":"IAP family proteins\u2014suppressors of apoptosis","volume":"13","author":"Deveraux","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/40901","article-title":"X-linked IAP is a direct inhibitor of cell-death proteases","volume":"388","author":"Deveraux","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB5","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1093\/emboj\/17.8.2215","article-title":"IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases","volume":"17","author":"Deveraux","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB6","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1093\/emboj\/18.19.5242","article-title":"Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases","volume":"18","author":"Deveraux","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0092-8674(00)00008-8","article-title":"Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition","volume":"102","author":"Du","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB8","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1002\/j.1460-2075.1996.tb00629.x","article-title":"A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors","volume":"15","author":"Duckett","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB9","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1074\/jbc.275.4.2581","article-title":"Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia","volume":"275","author":"Faccio","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3390001","article-title":"The protein disulphide-isomerase family","volume":"339","author":"Ferrari","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB11","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1046\/j.1432-1327.2000.01589.x","article-title":"Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response","volume":"267","author":"Gray","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/35080103","article-title":"OPINIONXIAP, the guardian angel","volume":"2","author":"Holcik","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB14","doi-asserted-by":"crossref","first-page":"34406","DOI":"10.1074\/jbc.273.51.34406","article-title":"Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage","volume":"273","author":"Hu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","article-title":"Programmed cell death in animal development","volume":"88","author":"Jacobson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0003-2697(90)90227-Z","article-title":"Production and separation of peptides from proteins stained with Coomassie brilliant blue R-250 after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis","volume":"191","author":"Kawasaki","year":"1990","journal-title":"Anal. Biochem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.cdd.4400526","article-title":"Caspase-independent programmed cell death with necrotic morphology","volume":"6","author":"Kitanaka","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB19","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1093\/nar\/16.21.10053","article-title":"Sequence analysis and regulation of the htrA gene of Escherichia coli","volume":"16","author":"Lipinska","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB20","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1128\/jb.172.4.1791-1797.1990","article-title":"The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase","volume":"172","author":"Lipinska","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0005-2744(81)90106-6","article-title":"Studies on a new proteolytic enzyme from A chromobacter lyticus M497\u20131. I. Purification and some enzymatic properties","volume":"660","author":"Masaki","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0962-8924(99)01609-8","article-title":"An exegesis of IAPs","volume":"9","author":"Miller","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1083\/jcb.153.1.221","article-title":"The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity","volume":"153","author":"Roberts","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB24","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1093\/emboj\/16.23.6914","article-title":"The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases","volume":"16","author":"Roy","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/prep.2000.1240","article-title":"Expression, purification, and functional analysis of the human serine protease HtrA2","volume":"19","author":"Savopoulos","year":"2000","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB26","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0006-291X(05)80245-1","article-title":"Protease Do is essential for survival of Escherichia coli at high temperatures","volume":"176","author":"Seol","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB27","doi-asserted-by":"crossref","first-page":"14376","DOI":"10.1073\/pnas.97.26.14376","article-title":"An alternative, nonapoptotic form of programmed cell death","volume":"97","author":"Sperandio","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0092-8674(00)80743-6","article-title":"A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein","volume":"97","author":"Spiess","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/35065125","article-title":"A conserved XIAP-interaction motif in caspase-9 and Smac\/DIABLO regulates caspase activity and apoptosis","volume":"410","author":"Srinivasula","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB30","doi-asserted-by":"crossref","first-page":"33777","DOI":"10.1074\/jbc.M006226200","article-title":"NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP","volume":"275","author":"Sun","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB31","doi-asserted-by":"crossref","first-page":"27058","DOI":"10.1074\/jbc.M102415200","article-title":"X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes","volume":"276","author":"Suzuki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB32","doi-asserted-by":"crossref","first-page":"8662","DOI":"10.1073\/pnas.161506698","article-title":"Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death","volume":"98","author":"Suzuki","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB33","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.1074\/jbc.273.14.7787","article-title":"A single BIR domain of XIAP sufficient for inhibiting caspases","volume":"273","author":"Takahashi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB34","first-page":"5315","article-title":"IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs","volume":"58","author":"Tamm","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/S1097-2765(01)00341-0_BIB35","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.7878464","article-title":"Apoptosis in the pathogenesis and treatment of disease","volume":"267","author":"Thompson","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB36","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00341-0_BIB37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(00)00009-X","article-title":"Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins","volume":"102","author":"Verhagen","year":"2000","journal-title":"Cell"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276501003410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276501003410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:04Z","timestamp":1761091204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276501003410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S1097276501003410"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(01)00341-0","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1000787.17574","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1000787.38260","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1000787.15208","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1000787.19055","asserted-by":"object"}]},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1097-2765(01)00341-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}