{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:45:45Z","timestamp":1770500745214,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4246,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1016\/s1097-2765(01)00421-x","type":"journal-article","created":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T18:21:09Z","timestamp":1082398869000},"page":"1277-1289","source":"Crossref","is-referenced-by-count":248,"title":["Crystal Structure of a Phosphorylated Smad2"],"prefix":"10.1016","volume":"8","author":[{"given":"Jia-Wei","family":"Wu","sequence":"first","affiliation":[]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Jijie","family":"Chai","sequence":"additional","affiliation":[]},{"given":"Joan","family":"Seoane","sequence":"additional","affiliation":[]},{"given":"Morgan","family":"Huse","sequence":"additional","affiliation":[]},{"given":"Carey","family":"Li","sequence":"additional","affiliation":[]},{"given":"Daniel J.","family":"Rigotti","sequence":"additional","affiliation":[]},{"given":"Saw","family":"Kyin","sequence":"additional","affiliation":[]},{"given":"Tom W.","family":"Muir","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Fairman","sequence":"additional","affiliation":[]},{"given":"Joan","family":"Massagu\u00e9","sequence":"additional","affiliation":[]},{"given":"Yigong","family":"Shi","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(01)00421-X_BIB1","doi-asserted-by":"crossref","first-page":"27678","DOI":"10.1074\/jbc.272.44.27678","article-title":"T\u03b2RI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling","volume":"272","author":"Abdollah","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/28101","article-title":"Three-dimensional structure of the Stat3\u03b2 homodimer bound to DNA","volume":"394","author":"Becker","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB3","first-page":"905","article-title":"Crystallography and NMR system","volume":"54","author":"Brunger","year":"1998","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB4","doi-asserted-by":"crossref","first-page":"33637","DOI":"10.1074\/jbc.274.47.33637","article-title":"Smad4\/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-\u03b2 antiproliferative responses in colon cancer cells","volume":"274","author":"Calonge","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/84995","article-title":"The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization","volume":"8","author":"Chacko","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(01)00272-0","article-title":"Structural basis of caspase-7 inhibiton by XIAP","volume":"104","author":"Chai","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0092-8674(00)81443-9","article-title":"Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA","volume":"93","author":"Chen","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB8","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1101\/gad.12.14.2144","article-title":"Determinants of specificity in the TGF-\u03b2 signal transduction","volume":"12","author":"Chen","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB9","doi-asserted-by":"crossref","first-page":"R247","DOI":"10.1016\/S1074-5521(99)80109-4","article-title":"Peptide ligation and its application to protein engineering","volume":"6","author":"Cotton","year":"1999","journal-title":"Chem. Biol."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB10","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)80128-2","article-title":"MADR2 maps to 18q21 and encodes a TGF\u03b2-regulated MAD-related protein that is functionally mutated in colorectal carcinoma","volume":"86","author":"Eppert","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB12","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1093\/emboj\/16.13.3912","article-title":"A kinase subdomain of transforming growth factor-\u03b2 (TGF-\u03b2) type I receptor determines the TGF-\u03b2 intracellular signaling specificity","volume":"16","author":"Feng","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.271.5247.350","article-title":"DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1","volume":"271","author":"Hahn","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-\u03b2 signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80555-3","article-title":"Crystal structure of the cytoplasmic domain of the type I TGF\u03b2 receptor in complex with FKBP12","volume":"96","author":"Huse","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S1097-2765(01)00332-X","article-title":"The TGF\u03b2 receptor activation process","volume":"8","author":"Huse","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB17","doi-asserted-by":"crossref","first-page":"40710","DOI":"10.1074\/jbc.M005799200","article-title":"Distinct oligomeric states of SMAD proteins in the TGF-\u03b2 pathway","volume":"275","author":"Jayaraman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB19","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1093\/emboj\/17.14.4056","article-title":"Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine\/threonine kinase receptors","volume":"17","author":"Kawabata","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB20","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","article-title":"Molscript","volume":"24","author":"Klaulis","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB21","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1101\/gad.11.8.984","article-title":"The TGF-\u03b2 family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase","volume":"11","author":"Kretzschmar","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.biophys.26.1.259","article-title":"Modular peptide recognition domains in eukaryotic signaling","volume":"26","author":"Kuriyan","year":"1997","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB23","series-title":"Analytical Ultracentrifugation in Biochemistry and Polymer Science","article-title":"Computer-aided interpretation of analytical sedimentation data for proteins","author":"Laue","year":"1992"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/emboj\/17.4.996","article-title":"The L3 loop","volume":"17","author":"Lo","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0092-8674(00)81817-6","article-title":"MADR2 is a substrate of the TGF\u03b2 receptor and its phosphorylation is required for nuclear accumulation and signaling","volume":"87","author":"Macias-Silva","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-\u03b2 signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1101\/gad.14.6.627","article-title":"Controlling TGF-\u03b2 signaling","volume":"14","author":"Massague","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB28","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1038\/sj.onc.1202642","article-title":"Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis","volume":"18","author":"Miyaki","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1107\/S0108767393007597","article-title":"AMoRe and automated package for molecular replacement","volume":"50","author":"Navaza","year":"1994","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/prot.340110407","article-title":"Protein folding and association","volume":"11","author":"Nicholls","year":"1991","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB32","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0969-2126(00)88340-9","article-title":"Crystal structure of a transcriptionally active Smad4 fragment","volume":"7","author":"Qin","year":"1999","journal-title":"Structure"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB33","series-title":"Peptide Growth Factors and Their Receptors","article-title":"The transforming growth factor-\u03b2s","author":"Roberts","year":"1990"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB35","first-page":"2527","article-title":"DPC4 gene in various tumor types","volume":"56","author":"Schutte","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/40431","article-title":"A structural basis for mutational inactivation of the tumour suppressor Smad4","volume":"388","author":"Shi","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/1521-1878(200103)23:3<223::AID-BIES1032>3.0.CO;2-U","article-title":"Structural insights on Smad function in TGF\u03b2 signaling","volume":"23","author":"Shi","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB38","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0959-440X(97)80146-7","article-title":"Structures of Src-family tyrosine kinases","volume":"7","author":"Sicheri","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/385602a0","article-title":"Crystal structure of the Src-family tyrosine kinase Hck","volume":"385","author":"Sicheri","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB40","doi-asserted-by":"crossref","first-page":"28107","DOI":"10.1074\/jbc.272.44.28107","article-title":"Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-\u03b2 signaling","volume":"272","author":"Souchelnytskyi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)81701-8","article-title":"SARA, a FYVE domain protein that recruits Smad2 to the TGF\u03b2 receptor","volume":"95","author":"Tsukazaki","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB42","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/j.1460-2075.1995.tb07214.x","article-title":"GS domain mutations that constitutively activate T\u03b2R-I, the downstream signaling component in the TGF-\u03b2 receptor complex","volume":"14","author":"Wieser","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB43","first-page":"367","article-title":"Formation and activation by phosphorylation of activin receptor complexes","volume":"10","author":"Willis","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1359-6101(99)00024-6","article-title":"The Smad pathway","volume":"11","author":"Wrana","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/370341a0","article-title":"Mechanism of activation of the TGF-\u03b2 receptor","volume":"370","author":"Wrana","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.287.5450.92","article-title":"Structural basis of Smad2 recognition by the Smad anchor for receptor activation","volume":"287","author":"Wu","year":"2000","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00421-X_BIB47","doi-asserted-by":"crossref","first-page":"20688","DOI":"10.1074\/jbc.M100174200","article-title":"Formation of a stable heterodimer between Smad2 and Smad4","volume":"276","author":"Wu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB48","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/35010529","article-title":"Smad2 nuclear import function masked by SARA and unmasked by TGF\u03b2-dependent phosphorylation","volume":"2","author":"Xu","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(01)00421-X_BIB49","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/385595a0","article-title":"Three-dimensional structure of the tyrosine kinase c-Src","volume":"385","author":"Xu","year":"1997","journal-title":"Nature"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109727650100421X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109727650100421X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:25:50Z","timestamp":1682677550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109727650100421X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S109727650100421X"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(01)00421-x","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}