{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:48:49Z","timestamp":1778647729290,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1016\/s1097-2765(01)00430-0","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T02:04:48Z","timestamp":1082513088000},"page":"133-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-\u03b2-Mediated Induction of the CDK Inhibitor p15Ink4B"],"prefix":"10.1016","volume":"9","author":[{"given":"Xin-Hua","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Yun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(01)00430-0_BIB1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/108729000421420","article-title":"A combination treatment of c-myc antisense DNA with all-trans-retinoic acid inhibits cell proliferation by downregulating c-myc expression in small cell lung cancer","volume":"10","author":"Akie","year":"2000","journal-title":"Antisense Nucleic Acid Drug Dev."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB2","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1073\/pnas.92.8.3239","article-title":"Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of TGF\u03b21","volume":"92","author":"Alexandrow","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB3","first-page":"4351","article-title":"Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma","volume":"56","author":"Barrett","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB4","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of TGF\u03b2 in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB5","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1128\/MCB.21.4.1121-1131.2001","article-title":"Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene","volume":"21","author":"Chang","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB6","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1073\/pnas.98.3.992","article-title":"Inaugural article","volume":"98","author":"Chen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1440-1746.2001.02361.x","article-title":"Molecular therapy with recombinant antisense c-myc adenovirus for human gastric carcinoma cells in vitro and in vivo","volume":"16","author":"Chen","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB8","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1038\/sj.onc.1202747","article-title":"Myc-mediated transformation","volume":"18","author":"Claassen","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB9","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1073\/pnas.150006697","article-title":"A role for transcriptional repression of p21CIP1 by c-Myc in overcoming TGF\u03b2-induced cell-cycle arrest","volume":"97","author":"Claassen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB10","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1038\/sj.onc.1202748","article-title":"The Myc oncoprotein","volume":"18","author":"Cole","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1124\/mol.57.3.485","article-title":"Inhibition of c-myc expression in cells by targeting an RNA-protein interaction using antisense oligonucleotides","volume":"57","author":"Coulis","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MCB.19.1.1","article-title":"c-Myc target genes involved in cell growth, apoptosis, and metabolism","volume":"19","author":"Dang","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB13","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1073\/pnas.92.12.5545","article-title":"TGF\u03b2 induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism","volume":"92","author":"Datto","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB14","first-page":"F105","article-title":"TGF-\u03b2 receptor signaling","volume":"1333","author":"Derynck","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB16","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1128\/MCB.19.8.5504","article-title":"Histone deacetylase 1 can repress transcription by binding to Sp1","volume":"19","author":"Doetzlhofer","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)80128-2","article-title":"MADR2 maps to 18q21 and encodes a TGF\u03b2-regulated MAD-related protein that is functionally mutated in colorectal carcinoma","volume":"86","author":"Eppert","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB18","doi-asserted-by":"crossref","first-page":"24237","DOI":"10.1074\/jbc.270.41.24237","article-title":"TGF-\u03b2-induced down-regulation of cyclin A expression requires a functional TGF-\u03b2 receptor complex. Characterization of chimeric and truncated type I and type II receptors","volume":"270","author":"Feng","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB19","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1101\/gad.12.14.2153","article-title":"The tumor suppressor Smad4\/DPC4 and transcriptional adaptor CBP\/p300 are coactivators for Smad3 in TGF-\u03b2-induced transcriptional activation","volume":"12","author":"Feng","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB20","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1093\/emboj\/19.19.5178","article-title":"Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-\u03b2","volume":"19","author":"Feng","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB21","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1073\/pnas.081074898","article-title":"Myc represses the p21 promoter and interacts with Sp1\/Sp3","volume":"98","author":"Gartel","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90498-F","article-title":"Cdi1, a human G1 and S phase protein phosphatase that associates with CDK2","volume":"75","author":"Gyuris","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.271.5247.350","article-title":"DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1","volume":"271","author":"Hahn","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15ink4B is a potential effector of TGF-\u03b2-induced cell cycle arrest","volume":"371","author":"Hannon","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/387417a0","article-title":"Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-\u03b2 in cells lacking the CDK inhibitor p15","volume":"387","author":"Iavarone","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1359-6101(99)00039-8","article-title":"Molecular mechanisms of inactivation of TGF-\u03b2 receptors during carcinogenesis","volume":"11","author":"Kim","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB28","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1074\/jbc.270.10.4971","article-title":"Potential role of WAF1\/Cip1\/p21 as a mediator of TGF-\u03b2 cytoinhibitory effect","volume":"270","author":"Li","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB29","doi-asserted-by":"crossref","first-page":"26750","DOI":"10.1074\/jbc.270.45.26750","article-title":"TGF-\u03b2 activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site","volume":"270","author":"Li","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB30","first-page":"M13","article-title":"TGF-\u03b2 receptors and DNA repair genes, coupled targets in a pathway of human colon carcinogenesis","volume":"1470","author":"Markowitz","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1101\/gad.14.6.627","article-title":"Controlling TGF-\u03b2 signaling","volume":"14","author":"Massagu\u00e9","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB32","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/emboj\/19.8.1745","article-title":"Transcriptional control by the TGF-\u03b2\/Smad signaling system","volume":"19","author":"Massagu\u00e9","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)00121-5","article-title":"TGF-\u03b2 signaling in growth control, cancer, and heritable disorders","volume":"103","author":"Massagu\u00e9","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB34","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1073\/pnas.95.12.6733","article-title":"Regulation of the human p21\/WAF1\/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members","volume":"95","author":"Moustakas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB35","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1038\/sj.onc.1202746","article-title":"MYC oncogenes and human neoplastic disease","volume":"18","author":"Nesbit","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB36","doi-asserted-by":"crossref","first-page":"29244","DOI":"10.1074\/jbc.M909467199","article-title":"Role of Smad proteins and transcription factor Sp1 in p21WAF1\/Cip1 regulation by TGF-\u03b2","volume":"275","author":"Pardali","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB37","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1096\/fasebj.13.15.2105","article-title":"Specificity, diversity, and regulation in TGF-\u03b2 superfamily signaling","volume":"13","author":"Piek","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB38","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1101\/gad.9.15.1831","article-title":"Kip\/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-\u03b2","volume":"9","author":"Reynisd\u00f3ttir","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB39","doi-asserted-by":"crossref","first-page":"35053","DOI":"10.1074\/jbc.274.49.35053","article-title":"TGF-\u03b2-mediated p15INK4B induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines","volume":"274","author":"Rich","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB40","first-page":"2578","article-title":"Frequency of Smad gene mutations in human cancers","volume":"57","author":"Riggins","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB41","series-title":"The Transforming Growth Factor-\u03b2s","article-title":"Peptide growth factors and their receptors","author":"Roberts","year":"1990"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB42","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1038\/sj.onc.1202725","article-title":"New Myc-interacting proteins","volume":"18","author":"Sakamuro","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB43","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1128\/MCB.17.5.2458","article-title":"TGF-\u03b2 stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells","volume":"17","author":"Sandhu","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB44","first-page":"2527","article-title":"DPC4 gene in various tumor types","volume":"56","author":"Schutte","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB45","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/35070086","article-title":"TGF-\u03b2 influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b","volume":"3","author":"Seoane","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB46","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/35070076","article-title":"Repression of p15INK4b expression by Myc through association with Miz-1","volume":"3","author":"Staller","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jnci\/88.7.391","article-title":"Antitumor effects of antisense phosphorothioate c-myc oligodeoxynucleotides","volume":"88","author":"Stein","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB48","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1126\/science.282.5397.2270","article-title":"p53-independent role of MDM2 in TGF-\u03b2 resistance","volume":"282","author":"Sun","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1097-2765(01)00430-0_BIB49","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1128\/MCB.19.9.5913","article-title":"Myc downregulation by TGF-\u03b2 required for activation of the p15 G1 arrest pathway","volume":"19","author":"Warner","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1359-6101(99)00024-6","article-title":"The Smad pathway","volume":"11","author":"Wrana","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/S1097-2765(01)00430-0_BIB51","first-page":"4952","article-title":"Early gene responses to TGF-\u03b2 in cells lacking growth-suppressive RB function","volume":"11","author":"Zentella","year":"1991","journal-title":"Mol. Cell. Biol."}],"updated-by":[{"DOI":"10.1016\/j.molcel.2016.03.026","type":"addendum","label":"Addendum","source":"publisher","updated":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000}},{"DOI":"10.1016\/j.molcel.2016.08.027","type":"addendum","label":"Addendum","source":"publisher","updated":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000}}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276501004300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276501004300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:01:04Z","timestamp":1761091264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276501004300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S1097276501004300"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(01)00430-0","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-\u03b2-Mediated Induction of the CDK Inhibitor p15Ink4B","name":"articletitle","label":"Article Title"},{"value":"Molecular Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1097-2765(01)00430-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}