{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:59:17Z","timestamp":1775743157741,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":4187,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1016\/s1097-2765(02)00467-7","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T06:04:48Z","timestamp":1082527488000},"page":"481-491","source":"Crossref","is-referenced-by-count":256,"title":["Human Origin Recognition Complex Large Subunit Is Degraded by Ubiquitin-Mediated Proteolysis after Initiation of DNA Replication"],"prefix":"10.1016","volume":"9","author":[{"given":"Juan","family":"M\u00e9ndez","sequence":"first","affiliation":[]},{"given":"X.Helena","family":"Zou-Yang","sequence":"additional","affiliation":[]},{"given":"So-Young","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Masumi","family":"Hidaka","sequence":"additional","affiliation":[]},{"given":"William P.","family":"Tansey","sequence":"additional","affiliation":[]},{"given":"Bruce","family":"Stillman","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(02)00467-7_BIB1","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1093\/emboj\/17.10.2961","article-title":"Cell cycle modulation of protein-DNA interactions at a human replication origin","volume":"17","author":"Abdurashidova","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0092-8674(01)80009-X","article-title":"Components and dynamics of DNA replication complexes in S. cerevisiae","volume":"91","author":"Aparicio","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB3","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/emboj\/18.9.2435","article-title":"E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila","volume":"18","author":"Asano","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0092-8674(95)90096-9","article-title":"The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing","volume":"83","author":"Bell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/12013","article-title":"SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27","volume":"1","author":"Carrano","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB6","first-page":"643","article-title":"The control of mammalian DNA replication","volume":"104","author":"Cimbora","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB7","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1242\/jcs.113.11.1929","article-title":"Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process","volume":"113","author":"Coverley","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB8","doi-asserted-by":"crossref","first-page":"34983","DOI":"10.1074\/jbc.M006069200","article-title":"Identification and characterization of the human ORC6 homolog","volume":"275","author":"Dhar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB9","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1097-2765(00)80227-0","article-title":"The spatial position and replication timing of chromosomal domains are both established in early G1 phase","volume":"4","author":"Dimitrova","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.cellbio.13.1.293","article-title":"Initiation of DNA replication in eukaryotic cells","volume":"13","author":"Dutta","year":"1997","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB11","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB12","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1083\/jcb.152.6.1267","article-title":"Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication","volume":"152","author":"Furstenthal","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/35087026","article-title":"Triggering ubiquitination of a CDK inhibitor at origins of DNA replication","volume":"3","author":"Furstenthal","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB14","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1126\/science.270.5242.1667","article-title":"Conserved initiator proteins in eukaryotes","volume":"270","author":"Gavin","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.1061724","article-title":"Making sense of eukaryotic DNA replication origins","volume":"294","author":"Gilbert","year":"2001","journal-title":"Science"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB16","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1073\/pnas.081474898","article-title":"Skp2 is oncogenic and overexpressed in human cancers","volume":"98","author":"Gstaiger","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1083\/jcb.140.2.271","article-title":"Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2","volume":"140","author":"Hua","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB19","doi-asserted-by":"crossref","first-page":"23027","DOI":"10.1074\/jbc.274.33.23027","article-title":"Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein","volume":"274","author":"Iizuka","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/geno.1997.5003","article-title":"Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5","volume":"46","author":"Ishiai","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB21","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1073\/pnas.96.11.6193","article-title":"Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6","volume":"96","author":"Jiang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(91)90236-R","article-title":"Identification of cellular proteins that can interact specifically with the T\/E1A-binding region of the retinoblastoma gene product","volume":"64","author":"Kaelin","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1146\/annurev.biochem.69.1.829","article-title":"Regulation of chromosome replication","volume":"69","author":"Kelly","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.1065203","article-title":"Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase","volume":"294","author":"Koepp","year":"2001","journal-title":"Science"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB25","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.1074\/jbc.M009473200","article-title":"The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells","volume":"276","author":"Kreitz","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB26","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1101\/gad.11.24.3375","article-title":"Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants","volume":"11","author":"Liang","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1097-2765(00)00062-9","article-title":"Structure and function of Cdc6\/Cdc18","volume":"6","author":"Liu","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB28","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/35007104","article-title":"XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis","volume":"404","author":"Maiorano","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/8984","article-title":"Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation","volume":"1","author":"Marti","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB30","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0092-8674(00)81209-X","article-title":"Geminin, an inhibitor of DNA replication, is degraded during mitosis","volume":"93","author":"McGarry","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB31","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1128\/MCB.20.22.8602-8612.2000","article-title":"Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle","volume":"20","author":"M\u00e9ndez","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB32","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1101\/gad.14.13.1631","article-title":"Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro","volume":"14","author":"Mizushima","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB33","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/emboj\/19.9.2069","article-title":"Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication","volume":"19","author":"Nakayama","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB34","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1093\/emboj\/19.11.2728","article-title":"Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals","volume":"19","author":"Natale","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1101\/gr.9.1.27","article-title":"Aaa+","volume":"9","author":"Neuwald","year":"1999","journal-title":"Genome Res."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB36","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/35082600","article-title":"Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms","volume":"411","author":"Nguyen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/35007110","article-title":"The Cdt1 protein is required to license DNA for replication in fission yeast","volume":"404","author":"Nishitani","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB38","doi-asserted-by":"crossref","first-page":"44905","DOI":"10.1074\/jbc.M105406200","article-title":"The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase","volume":"276","author":"Nishitani","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB39","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1128\/MCB.16.12.6977","article-title":"Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor","volume":"16","author":"Ohtani","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB40","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1093\/emboj\/20.15.4263","article-title":"Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle","volume":"20","author":"Okuno","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB41","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1093\/emboj\/20.17.4836","article-title":"Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis","volume":"20","author":"Perkins","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB42","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/emboj\/18.2.396","article-title":"Phosphorylation of mammalian CDC6 by cyclin A\/CDK2 regulates its subcellular localization","volume":"18","author":"Petersen","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB43","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1101\/gad.832500","article-title":"Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1","volume":"14","author":"Petersen","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB44","doi-asserted-by":"crossref","first-page":"28247","DOI":"10.1074\/jbc.272.45.28247","article-title":"Identification of HsORC4, a member of the human origin of replication recognition complex","volume":"272","author":"Quintana","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB45","doi-asserted-by":"crossref","first-page":"27137","DOI":"10.1074\/jbc.273.42.27137","article-title":"ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases","volume":"273","author":"Quintana","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB46","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1242\/jcs.112.12.2011","article-title":"Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins","volume":"112","author":"Rowles","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB47","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/MCB.18.5.2758","article-title":"Human CDC6\/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase","volume":"18","author":"Saha","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB48","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/emboj\/18.3.717","article-title":"Destruction of Myc by ubiquitin-mediated proteolysis","volume":"18","author":"Salghetti","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB49","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.1062079","article-title":"Regulation of transcriptional activation domain function by ubiquitin","volume":"293","author":"Salghetti","year":"2001","journal-title":"Science"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB50","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.274.5293.1659","article-title":"Cell cycle control of DNA replication","volume":"274","author":"Stillman","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB51","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35095076","article-title":"Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line","volume":"413","author":"Strohmaier","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1083\/jcb.139.1.13","article-title":"Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles","volume":"139","author":"Su","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/12027","article-title":"p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells","volume":"1","author":"Sutterluty","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB54","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1074\/jbc.275.8.5904","article-title":"Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures","volume":"275","author":"Tatsumi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB55","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(94)90502-9","article-title":"Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain","volume":"78","author":"Treier","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB56","doi-asserted-by":"crossref","first-page":"32421","DOI":"10.1074\/jbc.273.49.32421","article-title":"The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p","volume":"273","author":"Tugal","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB57","doi-asserted-by":"crossref","first-page":"26666","DOI":"10.1074\/jbc.M102493200","article-title":"Assembly of the human origin recognition complex","volume":"276","author":"Vashee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB58","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1073\/pnas.94.1.142","article-title":"A human protein related to yeast Cdc6p","volume":"94","author":"Williams","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB59","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1126\/science.290.5500.2309","article-title":"Inhibition of eukaryotic DNA replication by geminin binding to Cdt1","volume":"290","author":"Wohlschlegel","year":"2000","journal-title":"Science"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB60","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1073\/pnas.95.7.3603","article-title":"Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells","volume":"95","author":"Yan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(02)00467-7_BIB61","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1093\/emboj\/20.17.4648","article-title":"Expression of Cdc18\/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication","volume":"20","author":"Yanow","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(02)00467-7_BIB62","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(95)90271-6","article-title":"p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase","volume":"82","author":"Zhang","year":"1995","journal-title":"Cell"}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276502004677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276502004677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T11:56:22Z","timestamp":1682682982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276502004677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S1097276502004677"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(02)00467-7","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}