{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:41:04Z","timestamp":1776415264665,"version":"3.51.2"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3485,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Cell"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/s1097-2765(03)00482-9","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T10:20:36Z","timestamp":1080642036000},"page":"33-43","source":"Crossref","is-referenced-by-count":311,"title":["Selective Recognition of Acetylated Histones by Bromodomain Proteins Visualized in Living Cells"],"prefix":"10.1016","volume":"13","author":[{"given":"Tomohiko","family":"Kanno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Kyoo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Lenardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Ozato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1097-2765(03)00482-9_BIB1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(02)01077-2","article-title":"Deciphering the transcriptional histone acetylation code for a human gene","volume":"111","author":"Agalioti","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1097-2765(02)00542-7","article-title":"The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly","volume":"9","author":"Ahmad","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S1097-2765(02)00497-5","article-title":"Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin","volume":"9","author":"An","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-3","article-title":"Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein","volume":"44","author":"Chan","year":"2001","journal-title":"Cytometry"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1091\/mbc.01-10-0523","article-title":"TBP dynamics in living human cells","volume":"13","author":"Chen","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ncb733","article-title":"Association of human TFIID-promoter complexes with silenced mitotic chromatin in vivo","volume":"4","author":"Christova","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB7","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1128\/MCB.15.7.3685","article-title":"Bdf1, a yeast chromosomal protein required for sporulation","volume":"15","author":"Chua","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB8","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/viro.1999.9999","article-title":"The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells","volume":"264","author":"Cotter","year":"1999","journal-title":"Virology"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1101\/gad.10.3.261","article-title":"A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator","volume":"10","author":"Denis","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB10","first-page":"417","article-title":"Ring3 kinase transactivates promoters of cell cycle regulatory genes through E2F","volume":"11","author":"Denis","year":"2000","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB11","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/MCB.20.17.6537-6549.2000","article-title":"A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G2-to-M transition","volume":"20","author":"Dey","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB12","doi-asserted-by":"crossref","first-page":"8758","DOI":"10.1073\/pnas.1433065100","article-title":"The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis","volume":"100","author":"Dey","year":"2003","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/20974","article-title":"Structure and ligand of a histone acetyltransferase bromodomain","volume":"399","author":"Dhalluin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0968-0004(97)01045-1","article-title":"Mitotic repression of the transcriptional machinery","volume":"22","author":"Gottesfeld","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0092-8674(02)01005-X","article-title":"Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes","volume":"111","author":"Hassan","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB16","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1101\/gad.931401","article-title":"Histone H3 specific acetyltransferases are essential for cell cycle progression","volume":"15","author":"Howe","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S1097-2765(02)00496-3","article-title":"Visualization of interactions among bZip and Rel family proteins in living cells using bimolecular fluorescence complementation","volume":"9","author":"Hu","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB18","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1126\/science.288.5470.1422","article-title":"Structure and function of a human TAFII250 double bromodomain module","volume":"288","author":"Jacobson","year":"2000","journal-title":"Science"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0968-0004(97)01042-6","article-title":"The bromodomain revisited","volume":"22","author":"Jeanmougin","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB20","doi-asserted-by":"crossref","first-page":"8538","DOI":"10.1073\/pnas.95.15.8538","article-title":"Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways","volume":"95","author":"Jiang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB21","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1083\/jcb.153.7.1341","article-title":"Kinetics of core histones in living human cells","volume":"153","author":"Kimura","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB22","doi-asserted-by":"crossref","first-page":"38307","DOI":"10.1074\/jbc.M100290200","article-title":"Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin","volume":"276","author":"Kruhlak","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1097-2765(03)00035-2","article-title":"Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries","volume":"11","author":"Ladurner","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB24","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/35048603","article-title":"Rapid exchange of histone H1.1 on chromatin in living human cells","volume":"408","author":"Lever","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1097-2765(03)00033-9","article-title":"Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation","volume":"11","author":"Matangkasombut","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB26","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0092-8674(00)81821-8","article-title":"The TAFII250 subunit of TFIID has histone acetyltransferase activity","volume":"87","author":"Mizzen","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0076-6879(99)04041-0","article-title":"Histone acetyltransferases","volume":"304","author":"Mizzen","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB28","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1002\/j.1460-2075.1996.tb00705.x","article-title":"The hbrm and BRG-1 proteins, components of the human SNF\/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis","volume":"15","author":"Muchardt","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1097-2765(02)00483-5","article-title":"Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain","volume":"9","author":"Mujtaba","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB30","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1093\/emboj\/19.22.6141","article-title":"The structural basis of the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p","volume":"19","author":"Owen","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","author":"Roth","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB32","series-title":"Current Protocols in Molecular Biology","article-title":"Isolation of histones and nucleosome cores from mammalian cells","author":"Schnitzler","year":"2000"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB33","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1101\/gad.10.19.2389","article-title":"Mitotic regulation of TFIID","volume":"10","author":"Segil","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB34","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1126\/science.288.5475.2354","article-title":"Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations","volume":"288","author":"Siegel","year":"2000","journal-title":"Science"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB35","doi-asserted-by":"crossref","unstructured":"Siegel, R.M., Chan, F.K., Zacharias, D.A., Swofford, R., Holmes, K.L., Tsien, R.Y., and Lenardo, M.J. (2000b). Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Science's STKE, http:\/\/stke.sciencemag.org\/cgi\/content\/full\/OC_sigtrans;12000\/38\/pl1.","DOI":"10.1126\/stke.2000.38.pl1"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB36","doi-asserted-by":"crossref","first-page":"16454","DOI":"10.1073\/pnas.182424999","article-title":"Heritable chromatin structure","volume":"99","author":"Smith","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(02)01080-2","article-title":"Cellular memory and the histone code","volume":"111","author":"Turner","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1097-2765(03)00482-9_BIB39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1432-1033.1989.tb14530.x","article-title":"Specific antibodies reveal ordered and cell-cycle-related use of histone-H4 acetylation sites in mammalian cells","volume":"179","author":"Turner","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0014-5793(89)80947-0","article-title":"Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies","volume":"253","author":"Turner","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1016\/S1097-2765(03)00482-9_BIB41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0014-5793(01)03309-9","article-title":"Bromodomain","volume":"513","author":"Zeng","year":"2002","journal-title":"FEBS Lett."}],"container-title":["Molecular Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276503004829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097276503004829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T09:08:18Z","timestamp":1623748098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097276503004829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S1097276503004829"],"URL":"https:\/\/doi.org\/10.1016\/s1097-2765(03)00482-9","relation":{},"ISSN":["1097-2765"],"issn-type":[{"value":"1097-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}