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U.S.A."},{"issue":"2","key":"10.1016\/S1357-2725(99)00043-6_BIB84","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.122.2.473","article-title":"Adhesive ligand binding to integrin alpha\\rm IIb\u03b23 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK","volume":"122","author":"Huang","year":"1993","journal-title":"J. Cell Biol."},{"issue":"28","key":"10.1016\/S1357-2725(99)00043-6_BIB85","doi-asserted-by":"crossref","first-page":"20701","DOI":"10.1016\/S0021-9258(19)36834-6","article-title":"Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated \u03b12 \u03b21 integrin activation in T-lymphoblastic cells","volume":"268","author":"Kapron-Bras","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB86","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.121.3.673","article-title":"Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown","volume":"121","author":"McNamee","year":"1993","journal-title":"J. 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Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB90","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0955-0674(95)80117-0","article-title":"A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression","volume":"7","author":"Roskelley","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB91","doi-asserted-by":"crossref","first-page":"9034","DOI":"10.1073\/pnas.89.19.9034","article-title":"Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction","volume":"89","author":"Yurochko","year":"1992","journal-title":"Proc. Natl. Acad. Sci. 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Biol. Chem."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB100","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.7527156","article-title":"Association of insulin receptor substrate-1 with integrins","volume":"266","author":"Vuori","year":"1994","journal-title":"Science"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB101","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1093\/emboj\/16.18.5600","article-title":"\u03b1v\u03b23 integrin associates with activated insulin and PDGF receptors and potentiates the biological activity of PDGF","volume":"16","author":"Schneller","year":"1997","journal-title":"The EMBO Journal"},{"issue":"6part 2","key":"10.1016\/S1357-2725(99)00043-6_BIB102","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1083\/jcb.131.6.1857","article-title":"The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho\/rac GTPases","volume":"131","author":"Hotchin","year":"1995","journal-title":"J. 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Chem."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB106","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/316273a0","article-title":"Isolation of a new human oncogene from a diffuse B-cell lymphoma","volume":"316","author":"Eva","year":"1985","journal-title":"Nature"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB107","first-page":"621","article-title":"Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products","volume":"9","author":"Toksoz","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB108","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/j.1460-2075.1996.tb00539.x","article-title":"The small GTP-bnding protein Rho binds to and activates a 160\u00a0kDa Ser\/Thr protein kinase homologous to myotonic dystrophy kinase","volume":"15","author":"Ishizaki","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB109","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1126\/science.271.5249.645","article-title":"Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho","volume":"271","author":"Watanabe","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB110","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1126\/science.7846531","article-title":"Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function","volume":"267","author":"Miyamoto","year":"1995","journal-title":"Science"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB111","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1083\/jcb.135.6.1633","article-title":"Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors","volume":"135","author":"Miyamoto","year":"1996","journal-title":"J. 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Cell Biol."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB115","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1083\/jcb.111.6.2785","article-title":"Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins","volume":"111","author":"Brown","year":"1990","journal-title":"J. Cell. Bio."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB116","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1083\/jcb.123.2.485","article-title":"Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in \u03b1v\u03b23-dependent ligand binding","volume":"123","author":"Lindberg","year":"1993","journal-title":"J. Cell. 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Med."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB119","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1073\/pnas.92.9.3978","article-title":"Transendothelial migration of neutrophils involves integrin-associated protein (CD47)","volume":"92","author":"Cooper","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB120","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1126\/science.274.5288.795","article-title":"Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice","volume":"274","author":"Lindberg","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB121","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1091\/mbc.7.2.193","article-title":"Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins)","volume":"7","author":"Berditchevski","year":"1996","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB122","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1074\/jbc.272.5.2595","article-title":"A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase","volume":"272","author":"Berditchevski","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB123","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/0167-5699(94)90222-4","article-title":"The ins and outs of the transmembrane 4 superfamily","volume":"15","author":"Wright","year":"1994","journal-title":"Immunol. 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Chem."},{"issue":"11","key":"10.1016\/S1357-2725(99)00043-6_BIB126","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1073\/pnas.89.11.5192","article-title":"pp125FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions","volume":"89","author":"Schaller","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB127","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bies.950170309","article-title":"Signal transduction through integrins: a central role for focal adhesion kinase?","volume":"17","author":"Richardson","year":"1995","journal-title":"BioEssays"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB128","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1091\/mbc.7.8.1209","article-title":"Inhibition of focal adhesion kinase (FAK) signalling in focal adhesions decreases cell motility and proliferation","volume":"7","author":"Gilmore","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1357-2725(99)00043-6_BIB129","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0962-8924(97)01127-6","article-title":"Focal adhesion assembly","volume":"7","author":"Burridge","year":"1997","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB130","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/377539a0","article-title":"Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice","volume":"377","author":"Ilic","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1357-2725(99)00043-6_BIB131","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0955-0674(94)90097-3","article-title":"Focal adhesion kinase and associated proteins","volume":"6","author":"Schaller","year":"1994","journal-title":"Curr. Opin. 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