{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:27:03Z","timestamp":1765700823606},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Chemical Biology"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1016\/s1367-5931(00)00171-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T19:46:18Z","timestamp":1027626378000},"page":"78-85","source":"Crossref","is-referenced-by-count":46,"title":["SNPing in the human genome"],"prefix":"10.1016","volume":"5","author":[{"given":"Christopher S","family":"Carlson","sequence":"first","affiliation":[]},{"given":"Tera L","family":"Newman","sequence":"additional","affiliation":[]},{"given":"Deborah A","family":"Nickerson","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1367-5931(00)00171-X_BIB1","doi-asserted-by":"crossref","unstructured":"Collins FS: Positional cloning moves from perditional to traditional. Nat Genet 1995, 9:347-350. [Published erratum appears in Nat Genet 1995, 11:104.]","DOI":"10.1038\/ng0495-347"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/35015718","article-title":"Searching for genetic determinants in the new millennium","volume":"405","author":"Risch","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/9642","article-title":"Prospects for whole-genome linkage disequilibrium mapping of common disease genes","volume":"22","author":"Kruglyak","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/77100","article-title":"Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28","volume":"25","author":"Taillon-Miller","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/77091","article-title":"The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes","volume":"25","author":"Eaves","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/79876","article-title":"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus","volume":"26","author":"Horikawa","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB7","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1086\/321186","article-title":"Localization of a small genomic region associated with elevated ACE","volume":"67","author":"Zhu","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/geno.1996.0019","article-title":"Increasing the information content of STS-based genome maps: identifying polymorphisms in mapped STSs","volume":"31","author":"Kwok","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB9","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.280.5366.1077","article-title":"Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome","volume":"280","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1086\/302448","article-title":"Sequence diversity in 36 candidate genes for cardiovascular disorders","volume":"65","author":"Cambien","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/10297","article-title":"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis","volume":"22","author":"Halushka","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1101\/gr.8.7.748","article-title":"Overlapping genomic sequences: a treasure trove of single-nucleotide polymorphisms","volume":"8","author":"Taillon-Miller","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1101\/gr.9.2.167","article-title":"Mining SNPs from EST databases","volume":"9","author":"Picoult-Newberg","year":"1999","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/70570","article-title":"A general approach to single-nucleotide polymorphism discovery","volume":"23","author":"Marth","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB15","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1101\/gr.9.11.1087","article-title":"Identification of candidate coding region single nucleotide polymorphisms in 165 human genes using assembled expressed sequence tags","volume":"9","author":"Garg","year":"1999","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/6851","article-title":"Reliable identification of large numbers of candidate SNPs from public EST data","volume":"21","author":"Buetow","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1101\/gr.8.3.175","article-title":"Base-calling of automated sequencer traces using Phred. I. Accuracy assessment","volume":"8","author":"Ewing","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gr.8.3.175","article-title":"Base-calling of automated sequencer traces using Phred. II. Error probabilities","volume":"8","author":"Ewing","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB19","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1101\/gr.10.8.1259","article-title":"Expression-based genetic\/physical maps of single-nucleotide polymorphisms identified by the cancer genome anatomy project","volume":"10","author":"Clifford","year":"2000","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/(SICI)1098-1004(1998)12:4<221::AID-HUMU1>3.0.CO;2-I","article-title":"Single nucleotide polymorphism hunting in cyberspace","volume":"12","author":"Gu","year":"1998","journal-title":"Hum Mutat"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/79981","article-title":"Genome-wide analysis of single-nucleotide polymorphisms in human expressed sequences","volume":"26","author":"Irizarry","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB22","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1073\/pnas.96.14.7871","article-title":"Single-nucleotide polymorphisms can cause different structural folds of mRNA","volume":"96","author":"Shen","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/35035083","article-title":"An SNP map of the human genome generated by reduced representation shotgun sequencing","volume":"407","author":"Altshuler","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/10290","article-title":"Characterization of single-nucleotide polymorphisms in coding regions of human genes","volume":"22","author":"Cargill","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/geno.1994.1469","article-title":"Comparative analysis of human DNA variations by fluorescence-based sequencing of PCR products","volume":"23","author":"Kwok","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB26","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1093\/nar\/25.14.2745","article-title":"PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing","volume":"25","author":"Nickerson","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB27","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/nar\/26.4.967","article-title":"Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome","volume":"26","author":"Rieder","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB28","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.274.5287.610","article-title":"Accessing genetic information with high-density DNA arrays","volume":"274","author":"Chee","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1296-441","article-title":"Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis","volume":"14","author":"Hacia","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.7.10.996","article-title":"Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography [letter]","volume":"7","author":"Underhill","year":"1997","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1073\/pnas.86.1.232","article-title":"Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes","volume":"86","author":"Sheffield","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB32","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1073\/pnas.85.12.4397","article-title":"Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations","volume":"85","author":"Cotton","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1073\/pnas.92.1.87","article-title":"Screening for mutations by enzyme mismatch cleavage with T4 endonuclease VII","volume":"92","author":"Youil","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/mcpr.1996.0085","article-title":"Detection of mutations in human genes by a new rapid method: cleavage fragment length polymorphism analysis (CFLPA)","volume":"11","author":"Rossetti","year":"1997","journal-title":"Mol Cell Probes"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB35","doi-asserted-by":"crossref","first-page":"E69","DOI":"10.1093\/nar\/28.12.e69","article-title":"Position and degree of mismatches and the mobility of DNA heteroduplexes","volume":"28","author":"Upchurch","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB36","first-page":"314","article-title":"Construction of a genetic linkage map in man using restriction fragment length polymorphisms","volume":"32","author":"Botstein","year":"1980","journal-title":"Am J Hum Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/324163a0","article-title":"Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes","volume":"324","author":"Saiki","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB38","doi-asserted-by":"crossref","first-page":"6230","DOI":"10.1073\/pnas.86.16.6230","article-title":"Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes","volume":"86","author":"Saiki","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1050-3862(98)00018-7","article-title":"Multiplex detection of single-nucleotide variations using molecular beacons","volume":"14","author":"Marras","year":"1999","journal-title":"Genet Anal"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB40","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1093\/nar\/22.20.4167","article-title":"Genetic bit analysis: a solid phase method for typing single nucleotide polymorphisms","volume":"22","author":"Nikiforov","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-1004(1999)13:1<1::AID-HUMU1>3.0.CO;2-I","article-title":"From gels to chips: \u2018minisequencing\u2019 primer extension for analysis of point mutations and single nucleotide polymorphisms","volume":"13","author":"Syvanen","year":"1999","journal-title":"Hum Mutat"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB42","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/nar\/17.7.2503","article-title":"Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)","volume":"17","author":"Newton","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB43","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0025-6196(12)65378-6","article-title":"A novel method for detecting point mutations or polymorphisms and its application to population screening for carriers of phenylketonuria","volume":"64","author":"Sommer","year":"1989","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1097-0320(20000201)39:2<131::AID-CYTO6>3.0.CO;2-U","article-title":"Multiplexed single nucleotide polymorphism genotyping by oligonucleotide ligation and flow cytometry","volume":"39","author":"Iannone","year":"2000","journal-title":"Cytometry"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1050-3862(98)00016-3","article-title":"Homogeneous genotyping assays for single nucleotide polymorphisms with fluorescence resonance energy transfer detection","volume":"14","author":"Chen","year":"1999","journal-title":"Genet Anal"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/7044","article-title":"Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes","volume":"17","author":"Lyamichev","year":"1999","journal-title":"Nat Biotechnol"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1050-3862(98)00019-9","article-title":"Allelic discrimination using fluorogenic probes and the 5\u2032 nuclease assay","volume":"14","author":"Livak","year":"1999","journal-title":"Genet Anal"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/mcpr.1995.0027","article-title":"Fluorescence-based DNA minisequence analysis for detection of known single-base changes in genomic DNA","volume":"9","author":"Kobayashi","year":"1995","journal-title":"Mol Cell Probes"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB49","doi-asserted-by":"crossref","unstructured":"Grossman PD, Bloch W, Brinson E, Chang CC, Eggerding FA, Fung S, Iovannisci DM, Woo S, Winn-Deen ES, Iovannisci DA: High-density multiplex detection of nucleic acid sequences: oligonucleotide ligation assay and sequence-coded separation. Nucleic Acids Res 1994, 22:4527-4534. [Published erratum appears in Nucleic Acids Res 1998, 26:5539.]","DOI":"10.1093\/nar\/22.21.4527"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB50","unstructured":"Iwahana H, Yoshimoto K, Mizusawa N, Kudo E, Itakura M: Multiple fluorescence-based PCR-SSCP analysis. BioTechniques , 1994, 16:296-297, 3000-295."},{"key":"10.1016\/S1367-5931(00)00171-X_BIB51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gr.9.1.72","article-title":"Single-tube genotyping without oligonucleotide probes","volume":"9","author":"Germer","year":"1999","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB52","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1101\/gr.10.2.258","article-title":"High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR","volume":"10","author":"Germer","year":"2000","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1101\/gr.8.5.549","article-title":"A homogeneous, ligase-mediated DNA diagnostic test","volume":"8","author":"Chen","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB54","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/clinchem\/42.9.1391","article-title":"Multiplex, fluorescent, solid-phase minisequencing for efficient screening of DNA sequence variation","volume":"42","author":"Pastinen","year":"1996","journal-title":"Clin Chem"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB55","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1101\/gr.10.6.853","article-title":"Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays","volume":"10","author":"Fan","year":"2000","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB56","doi-asserted-by":"crossref","first-page":"12164","DOI":"10.1073\/pnas.210394597","article-title":"SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping","volume":"97","author":"Hirschhorn","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB57","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1101\/gr.10.4.549","article-title":"A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension","volume":"10","author":"Chen","year":"2000","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/geno.2000.6218","article-title":"Flow cytometry-based minisequencing: a new platform for high-throughput single-nucleotide polymorphism scoring","volume":"66","author":"Cai","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB59","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/clinchem\/46.9.1498","article-title":"Application of the luminex LabMAP in rapid screening for mutations in the cystic fibrosis transmembrane conductance regulator gene: a pilot study","volume":"46","author":"Dunbar","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB60","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1086\/515512","article-title":"Association mapping of disease loci, by use of a pooled DNA genomic screen","volume":"61","author":"Barcellos","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB61","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1101\/gr.8.12.1273","article-title":"The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling","volume":"8","author":"Risch","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB62","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2144\/00293rr05","article-title":"Quantitative approach to single-nucleotide polymorphism analysis using MALDI-TOF mass spectrometry","volume":"29","author":"Ross","year":"2000","journal-title":"BioTechniques"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB63","doi-asserted-by":"crossref","unstructured":"Hoogendoorn B, Norton N, Kirov G, Williams N, Hamshere M, Spurlock G, Austin J, Stephens M, Buckland P, Owen M: Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Hum Genet 2000, in press.","DOI":"10.1007\/s004390000397"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB64","doi-asserted-by":"crossref","unstructured":"Sasaki T, Tahira T, Suzuki A, Higasa K, Kukita Y, Baba S, Hayashi K: Precise estimation of allele frequencies of single-nucleotide polymorphisms by a quantitative SSCP analysis of pooled DNA. Am J Hum Genet 2000, 68: in press.","DOI":"10.1086\/316928"},{"key":"10.1016\/S1367-5931(00)00171-X_BIB65","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.97.19.10483","article-title":"Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness","volume":"97","author":"Drysdale","year":"2000","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Current Opinion in Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S136759310000171X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S136759310000171X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T19:53:51Z","timestamp":1681329231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S136759310000171X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S136759310000171X"],"URL":"https:\/\/doi.org\/10.1016\/s1367-5931(00)00171-x","relation":{},"ISSN":["1367-5931"],"issn-type":[{"value":"1367-5931","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}