{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:10:08Z","timestamp":1764688208534},"reference-count":184,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Oncology"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1016\/s1368-8375(00)00023-3","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:09:16Z","timestamp":1027606156000},"page":"404-413","source":"Crossref","is-referenced-by-count":53,"title":["Genetic aberrations in oral or head and neck squamous cell carcinoma 3: clinico-pathological applications"],"prefix":"10.1016","volume":"36","author":[{"given":"C.","family":"Scully","sequence":"first","affiliation":[]},{"given":"J.K.","family":"Field","sequence":"additional","affiliation":[]},{"given":"H.","family":"Tanzawa","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1368-8375(00)00023-3_BIB1","doi-asserted-by":"crossref","unstructured":"Scully C, Field J.K, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN), 1 Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncology 2000;36:256\u201363.","DOI":"10.1016\/S1368-8375(00)00007-5"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB2","doi-asserted-by":"crossref","unstructured":"Scully C, Field J.K, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN), 2 Chromosomal aberrations. Oral Oncology 2000;36:311\u201327.","DOI":"10.1016\/S1368-8375(00)00021-X"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00001622-199505000-00007","article-title":"Molecular genetics of head and neck cancer","volume":"7","author":"Sidransky","year":"1995","journal-title":"Current Opinion in Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0889-8588(05)70092-7","article-title":"Predictive factors in head and neck cancer","volume":"13","author":"Bradford","year":"1999","journal-title":"Hematol Oncol Clin North Amer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB5","doi-asserted-by":"crossref","first-page":"9871","DOI":"10.1073\/pnas.91.21.9871","article-title":"Microsatellite alterations as clonal markers in the detection of human cancers","volume":"91","author":"Mao","year":"1994","journal-title":"Proc Natl Acad Sci."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00049484","article-title":"Molecular staging of head and neck squamous carcinoma","volume":"15","author":"Brennan","year":"1996","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1600-0714.1993.tb01066.x","article-title":"Tissue markers of potentially malignant oral epithelial lesions","volume":"22","author":"Scully","year":"1993","journal-title":"Journal of Oral Pathology and Medicine"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00049487","article-title":"Molecular and cellular biomarkers for field cancerization and multistep process in head and neck tumorigenesis","volume":"15","author":"Papadimitrakopoulou","year":"1996","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00001622-199709030-00006","article-title":"Biomarkers in head and neck carcinoma","volume":"9","author":"Oh","year":"1997","journal-title":"Current Opinion in Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0140-6736(92)91122-O","article-title":"Overexpression of the p53 gene in head and neck cancer, linked with heavy smoking and drinking","volume":"339","author":"Field","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/path.1711660411","article-title":"Assessment of p53 protein expression in normal, benign and malignant oral mucosa","volume":"166","author":"Ogden","year":"1992","journal-title":"J Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB12","first-page":"387","article-title":"Abnormalities in the p53 gene in tumors and cell lines of human squamous cell carcinomas of the head and neck","volume":"33","author":"Smith","year":"1992","journal-title":"Proc Am Assoc Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/carcin\/17.4.733","article-title":"Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use","volume":"17","author":"Lazarus","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB14","first-page":"197","article-title":"P53 expression and mutations in squamous cell carcinoma of the head and neck: expression correlates with the patients use of tobacco and alcohol","volume":"18","author":"Field","year":"1994","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB15","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1056\/NEJM199503163321104","article-title":"Association between cigarette smoking and mutation of the p53 gene in squamous cell carcinoma of the head and neck","volume":"332","author":"Brennan","year":"1995","journal-title":"New Engl J Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ijc.2910600406","article-title":"A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users","volume":"60","author":"Lazarus","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB17","first-page":"915","article-title":"Nuclear DNA content and p53 immunostaining in oral squamous cell carcinoma\u00a0\u2014 an analysis of a consecutive 10 year material","volume":"5","author":"Hogmo","year":"1994","journal-title":"Int J Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/ijc.2910560608","article-title":"p53 gene mutations in oropharyngeal carcinomas: a comparison of solitary and multiple primary tumors and lymph-node metastases","volume":"56","author":"Zariwala","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB19","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/1097-0142(19950401)75:7<1657::AID-CNCR2820750716>3.0.CO;2-G","article-title":"p53 expression in multicentric squamous cell carcinoma and surrounding squamous epithelium of the upper aerodigestive tract","volume":"75","author":"Nakanishi","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/ijc.2910600625","article-title":"Analysis of the p53 gene in relation to tobacco and alcohol in cancers of the upper aero-digestive tract","volume":"60","author":"Franceschi","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0964-1955(93)90049-K","article-title":"Relationship of tobacco\/alcohol use to p53 expression in patients with lingual squamous cell carcinomas","volume":"29B","author":"Matthews","year":"1993","journal-title":"Oral Oncols Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0714.1996.tb00192.x","article-title":"Overexpression of p53 protein in squamous cell carcinoma of buccal mucosa and tongue in Taiwan: an immunohistochemical and clinicopathological study","volume":"25","author":"Yan","year":"1996","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/(SICI)1096-9896(199903)187:4<469::AID-PATH262>3.0.CO;2-3","article-title":"P53 overexpression in oral mucosa in relation to smoking","volume":"187","author":"Van Oijen","year":"1999","journal-title":"J Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB24","first-page":"321","article-title":"Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis","volume":"54","author":"Shin","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB25","first-page":"4189","article-title":"Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors","volume":"53","author":"Nees","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.onc.1200812","article-title":"Field cancerisation and polyclonal p53 mutation in the upper areodigestive tract","volume":"14","author":"Waridel","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB27","first-page":"4070","article-title":"P53 mutations in squamous cell carcinoma of the head and neck predominate in a subgroup of former and present smokers with a low frequency of genetic instability","volume":"57","author":"Liloglou","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archotol.1997.01900050051006","article-title":"Absence of p53 mutations in squamous carcinomas of the tongue in nonsmoking and nondrinking patients younger than 40 years","volume":"123","author":"Sorensen","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB29","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/bjc.1995.483","article-title":"Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival","volume":"72","author":"Field","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/(SICI)1097-0215(19980821)79:4<370::AID-IJC11>3.0.CO;2-9","article-title":"Prognostic significance of p53 protein over-expression in betel and tobacco related oral oncogenesis","volume":"79","author":"Kaur","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<839::AID-IJC7>3.0.CO;2-V","article-title":"Characteristics of mutations in the p53 gene of oral squamous-cell carcinomas associated with betel-quid chewing in Sri Lanka","volume":"77","author":"Chiba","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ijc.2910580305","article-title":"Overexpression of p53 protein in betel- and tobacco-related human oral dysplasia and squamous cell carcinoma in India","volume":"58","author":"Kaur","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0714.1998.tb02097.x","article-title":"p53 aberrations in oral submucous fibrosis and oral squamous cell carcinoma detected by immunocytochemistry and PCR-SSCP","volume":"27","author":"Trivedy","year":"1998","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<527::AID-IJC4>3.0.CO;2-2","article-title":"Mutations of the p53 gene in oral squamous cell carcinomas from Sudanese dippers of nitrosamine-rich Toombak and non-snuff-dippers from the Sudan and Scandinavia","volume":"81","author":"Ibrahim","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB35","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0030-6665(20)30927-0","article-title":"Hereditary and environmental factors associated with risk and progression of head and neck cancer","volume":"25","author":"Trizna","year":"1992","journal-title":"Otolaryngol Clin North Amer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1200\/JCO.1998.16.3.1197","article-title":"Role of the p16 tumor suppressor gene in cancer","volume":"16","author":"Liggett","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB37","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/(SICI)1097-0215(19971114)73:4<531::AID-IJC13>3.0.CO;2-C","article-title":"CDKN2A mutation in a non-FAMM kindred with cancers at multiple sites results in a functionally abnormal protein","volume":"73","author":"Sun","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB38","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/jnci\/88.20.1489","article-title":"Familial tumor syndrome associated with a germline non-functional p16 allele","volume":"88","author":"Yarbrough","year":"1996","journal-title":"JNCI"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB39","doi-asserted-by":"crossref","unstructured":"Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, et al. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer; an updated review. Gastroenterology 1993;104;1535\u201349","DOI":"10.1016\/0016-5085(93)90368-M"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB40","doi-asserted-by":"crossref","unstructured":"Cairns P, Sidransky D. Molecular methods for the diagnosis of cancer. Boichim Biophys Acta 1999;1423:C11\u2013C18.","DOI":"10.1016\/S0304-419X(99)00006-2"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/000348949510400701","article-title":"Potential early markers of carcinogenesis in the mucosa of the head and neck using exfoliative cytology","volume":"104","author":"Welkoborsky","year":"1995","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1368-8375(98)00119-5","article-title":"Loss of heterozygosity of p53 gene of oral cancer detected by exfoliative cytology","volume":"35","author":"Huang","year":"1999","journal-title":"Oral Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9610(05)80092-3","article-title":"Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas","volume":"168","author":"Boyle","year":"1994","journal-title":"The American Journal of Surgery"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB44","first-page":"5258","article-title":"The use of exfoliative cell samples to map clonal genetic alterations in the epithelium of high-risk patients","volume":"57","author":"Rosin","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB45","first-page":"2690","article-title":"Genetic alterations is bronchial lavage as a potential marker for individuals with a high risk of developing lung cancer","volume":"59","author":"Field","year":"1999","journal-title":"Cancer Research"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB46","first-page":"2385","article-title":"Analysis of p53 antibody response in patients with squamous cell carcinomas of the head and neck","volume":"16","author":"Lavieille","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB47","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/jnci\/88.17.1228","article-title":"Analysis of p53 serum antibodies in patients with head and neck squamous cell carcinoma","volume":"88","author":"Bourhis","year":"1996","journal-title":"J Natl Cancer Inst."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB48","first-page":"3183","article-title":"p53 auto-antibodies in the sera of patients with oral squamous cell carcinoma","volume":"17","author":"Friedrich","year":"1997","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB49","first-page":"2873","article-title":"Head and neck cancer and p53-immunogenicity","volume":"17","author":"Maass","year":"1997","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB50","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<390::AID-IJC23>3.0.CO;2-9","article-title":"p53 antibodies in the saliva of patients with squamous cell carcinoma of the oral cavity","volume":"78","author":"Tavassoli","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB51","first-page":"5720","article-title":"Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients","volume":"56","author":"Califano","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB52","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJM199502163320704","article-title":"Molecular assessment of histopathological staging in squamous cell carcinoma of the head and neck","volume":"332","author":"Brennan","year":"1995","journal-title":"New Engl J Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB53","first-page":"1785","article-title":"Expression of p53 in premalignant and malignant squamous epithelium","volume":"6","author":"Gusterson","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB54","first-page":"4477","article-title":"The incidence of p53 mutations increases with progression of head and neck cancer","volume":"53","author":"Boyle","year":"1993","journal-title":"Cancer Research"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1600-0714.1992.tb01028.x","article-title":"Expression of the tumor suppressor gene p53 mutant nuclear phosphoprotein in oral carcinoma and potentially malignant oral lesions","volume":"21","author":"Warnakulasuriya","year":"1992","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB56","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1600-0714.1994.tb00053.x","article-title":"Association of overexpression of p53 oncoprotein with the state of cell proliferation in oral carcinoma","volume":"23","author":"Warnakulasuriya","year":"1994","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0901-5027(05)80517-X","article-title":"p53 and Ki67 expression in preneoplastic and neoplastic lesions of the oral mucosa","volume":"22","author":"Girod","year":"1993","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB58","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1093\/carcin\/15.10.2269","article-title":"p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium","volume":"15","author":"Sauter","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB59","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0964-1955(94)90066-3","article-title":"The presence of p53 protein in relation to Ki-67 as cellular proliferation marker in head and neck squamous cell carcinoma and adjacent dysplastic mucosa","volume":"30B","author":"Slootweg","year":"1994","journal-title":"Oral Oncol. Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB60","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0194-5998(94)70564-X","article-title":"Accumulation of the p53 tumor-suppressor gene product in oral leukoplakia","volume":"111","author":"Wood","year":"1994","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0714.1995.tb01124.x","article-title":"p53 protein expression in sequential biopsies of oral dysplasias and in situ carcinomas","volume":"24","author":"Regezi","year":"1995","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB62","first-page":"205","article-title":"Overexpression of p53 is an early event in the tumorigenesis of oral squamous cell carcinomas","volume":"15","author":"Shintani","year":"1995","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB63","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/(SICI)1096-9896(199604)178:4<415::AID-PATH548>3.0.CO;2-1","article-title":"P53 gene alterations and p53 protein in oral epithelial dysplasia and squamous cell carcinoma","volume":"178","author":"Kusama","year":"1996","journal-title":"J Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB64","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1042\/bst0250315","article-title":"Detection of p53 mutations in oral cancer samples using a sensitive PCR-based method","volume":"25","author":"Steingrimsdottir","year":"1997","journal-title":"Trans Biochem Soc."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB65","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/(SICI)1096-9896(199804)184:4<360::AID-PATH1263>3.0.CO;2-H","article-title":"P53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma","volume":"184","author":"Cruz","year":"1998","journal-title":"J Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB66","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<180::AID-PATH847>3.0.CO;2-L","article-title":"Overexpression of p53 in normal oral mucosa of oral cancer patients does not necessarily predict further malignant disease","volume":"182","author":"Ogden","year":"1997","journal-title":"J Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB67","first-page":"3645","article-title":"Preneoplastic oral lesions; the clinical value of image cytometry DNA analysis, p53 and p21\/WAF1 expression","volume":"18","author":"Hogmo","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB68","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nm0696-682","article-title":"Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment","volume":"2","author":"Mao","year":"1996","journal-title":"Nature Medicine"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<113::AID-HED3>3.0.CO;2-5","article-title":"9p21 deletion correlates with recurrence in head and neck cancer","volume":"20","author":"Lydiatt","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB70","first-page":"1156","article-title":"Frequent loss of chromosome 9p21-22 early in head and neck cancer progression","volume":"54","author":"Van der Reit","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB71","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/bjc.1996.142","article-title":"Frequent gene deletions in potentialy malignant oral lesions","volume":"73","author":"Emilion","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB72","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.bjc.6690505","article-title":"Role of p16\/MTS1, cyclin D1 and Rb in primary oral cancer and oral cancer cell lines","volume":"80","author":"Sartor","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB73","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0714.1999.tb02017.x","article-title":"Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan","volume":"28","author":"Kuo","year":"1999","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB74","first-page":"2421","article-title":"Genomic instability in squamous cell carcinoma of the head and neck","volume":"16","author":"Field","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB75","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/bjc.1998.644","article-title":"Microsatellite instability in squamous cell carcinoma of the head and neck related to field cancerisation phenomena","volume":"78","author":"Piccinin","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB76","first-page":"1228","article-title":"Allelic imbalance on chromosome 3p in oral dysplastic lesions: an early event in oral carcinogenesis","volume":"56","author":"Roz","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB77","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archotol.1996.01890170031007","article-title":"Definition of a tumor suppressor gene locus on the short arm of chromosome 3 in squamous cell carcinoma of the head and neck by means of microsatellite markers","volume":"122","author":"Rowley","year":"1996","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB78","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ijc.2910640509","article-title":"Microsatellite instability in oral cancer","volume":"64","author":"Ishwad","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0215(19960220)69:1<1::AID-IJC1>3.0.CO;2-8","article-title":"Loss of heterozygosity of the short arm of chromosomes 3 and 9 in oral cancer","volume":"69","author":"Ishwad","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB80","first-page":"543","article-title":"Allele loss on chromosome 3 in squamous cell carcinoma of the head and neck correlates with poor clinical prognostic indicators","volume":"4","author":"Field","year":"1994","journal-title":"International Journal of Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB81","first-page":"6484","article-title":"Deletion mapping on the short arm chromosome 3 in squamous cell carcinoma of the oral cavity","volume":"54","author":"Wu","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB82","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/bjc.1996.62","article-title":"LOH at 3p correlates with a poor survival in oral squamous cell carcinoma","volume":"73","author":"Partridge","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB83","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/sj.bjc.6690290","article-title":"The prognostic significance of allelic imbalance at key chromosomal loci in oral cancer","volume":"79","author":"Partridge","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB84","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/carcin\/15.12.2683","article-title":"MTSI\/CDK41 is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma","volume":"15","author":"Yeudall","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB85","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/00016489950181837","article-title":"P16 mutation frequency and clinical correlation in head and neck cancer","volume":"119","author":"Danahey","year":"1999","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB86","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0002-9610(99)80337-7","article-title":"TP53 mutations in upper aerodigestive squamous cell carciomas from a group of Brazilian patients","volume":"170","author":"Nagai","year":"1995","journal-title":"Am J Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB87","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ijc.2910570403","article-title":"Correlation between p53 gene expression and tumor-cell proliferation in oropharyngeal cancer","volume":"57","author":"Bourhis","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB88","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/ijc.2910550507","article-title":"Intratumoral microvessel density and p53 protein: correlation with metastasis in head and neck squamous cells carcinoma","volume":"55","author":"Gasparini","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB89","first-page":"431","article-title":"p53 Over-expression in end stage squamous cell carcinomas of the head and neck: correlates with a very poor clinical outcome","volume":"3","author":"Field","year":"1993","journal-title":"Int J Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB90","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0964-1955(94)90011-6","article-title":"Prognostic significance of p53 protein accumulation in early stage t1 oral cavity cancer","volume":"30B","author":"Gluckman","year":"1994","journal-title":"Oral Oncol, Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB91","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/jnci\/88.8.519","article-title":"P53 expression: predicting recurrence and second primary tumors in head and neck squamous cell carcinoma","volume":"88","author":"Shin","year":"1996","journal-title":"J Natl Cancer Inst."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB92","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/bjc.1993.238","article-title":"Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines","volume":"67","author":"Burns","year":"1993","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB93","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00019606-199406000-00004","article-title":"Overexpression of p53 protein in squamous cell carcinomas of head and neck without apparent gene mutations","volume":"3","author":"Xu","year":"1994","journal-title":"Diagnostic Molecular Pathology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB94","first-page":"1389","article-title":"Improved immunohistochemical detection of p53 protein in paraffin-embedded tissues reveals elevated levels in most head and neck and lung carcinomas: correlation of clinicopathological parameters","volume":"12","author":"Pavelic","year":"1992","journal-title":"Anticancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB95","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000227223","article-title":"Immunohistochemical detection of p53 oncoprotein in human oral squamous cell carcinomas and leukoplakias: comparison with proliferating cell nuclear antigen staining and correlation with clinicopathological findings","volume":"50","author":"Nishioka","year":"1993","journal-title":"Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB96","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/00016489509139324","article-title":"Immunohistochemical detection of p53 protein in preneoplastic lesions and squamous cell carcinoma of the head and neck","volume":"115","author":"Lavieille","year":"1995","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB97","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9610(05)80727-5","article-title":"p53 Over-expression correlates with increased survival in patients with squamous carcinoma of the tongue base","volume":"164","author":"Sauter","year":"1992","journal-title":"Am J Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB98","first-page":"379","article-title":"Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors","volume":"17","author":"Gapany","year":"1993","journal-title":"Cancer Detect Prevent"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB99","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/019459989411100405","article-title":"Tumor angiogenesis, the p53 antigen and cervical metastasis in squamous cell carcinoma of the tongue","volume":"111","author":"Leedy","year":"1994","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0304-3835(94)90415-4","article-title":"Association of p53 expression with cytokinetics and HPV capsid antigen prevalence in oral carcinomas","volume":"87","author":"Mukhopadhyay","year":"1994","journal-title":"Cancer Lett."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB101","first-page":"270","article-title":"Die expression der tumorsuppressor-gene p53 und Rb bei patienten mit plattenepithelkarzinomen im Kopf\/Halsbereich","volume":"42","author":"Schipper","year":"1994","journal-title":"HNO"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB102","first-page":"1217","article-title":"High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent, protein overexpression in normal epithelium and in early non-invasive lesions","volume":"10","author":"Ahomadegbe","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB103","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/1097-0142(19950101)75:1<87::AID-CNCR2820750115>3.0.CO;2-V","article-title":"p53 expression and cell proliferation in squamous cell carcinomas of the head and neck","volume":"75","author":"Nylander","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB104","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/bjc.1995.159","article-title":"p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck","volume":"71","author":"Nylander","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s004280050270","article-title":"The influence of p53 and associated factors on the outcome of patients with oral squamous cell carcinoma","volume":"433","author":"Stoll","year":"1998","journal-title":"Virchows Arch"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB106","first-page":"279","article-title":"p53 genotyping- an effective concept for molecular testing of head and neck cancer?","volume":"4","author":"Dahse","year":"1999","journal-title":"Int J Mol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB107","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s004320050188","article-title":"Clinical implications of screening p53 gene mutations in head and neck squamous cell carcinomas","volume":"124","author":"Ma","year":"1998","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB108","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/bjc.1998.632","article-title":"p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma","volume":"78","author":"Mineta","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB109","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/archotol.1994.01880270003001","article-title":"Immunohistochemical detection, of c-myc protein in head and neck tumors","volume":"120","author":"Gapany","year":"1994","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB110","first-page":"535","article-title":"Allelic imbalance on the long arm of chromosome 5 in oral squamous cell carcinoma","volume":"10","author":"Wang","year":"1997","journal-title":"Int J Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB111","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1097-0215(19980821)79:4<312::AID-IJC2>3.0.CO;2-Y","article-title":"Allelic loss of chromosome 13q14.3 in human oral cancer; correlation with lymph node metastasis","volume":"79","author":"Ogawara","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB112","first-page":"557","article-title":"Cervical metastases of head and neck squamous cell carcinoma correlate with loss of heterozygosity on chromosome 16q","volume":"14","author":"Wang","year":"1999","journal-title":"Int J Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB113","first-page":"1","article-title":"Preliminary study of 18q loss of heterozygosity and poor survival in patients with stage III head and neck cancer","volume":"11","author":"Pearlstein","year":"1997","journal-title":"On-Line Interact J Otolaryngol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB114","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/(SICI)1098-2264(199804)21:4<333::AID-GCC7>3.0.CO;2-#","article-title":"Loss of 18q predicts poor survival of patients with squamous cell carcinoma of the head and neck","volume":"21","author":"Pearlstein","year":"1998","journal-title":"Genes, Chromosomes, Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB115","first-page":"1287","article-title":"Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer","volume":"11","author":"Watanabe","year":"1997","journal-title":"Int J Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB116","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1368-8375(98)00092-X","article-title":"MDM2\/p53 co-expression in oral premalignant and malignant lesions: potential prognostic implications","volume":"35","author":"Agarwal","year":"1999","journal-title":"Oral Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB117","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1368-8375(98)00083-9","article-title":"Expression of p21\/waf1 in oral squamous cell carcinomas- correlation with p53 and mdm2 and cellular proliferation index","volume":"35","author":"Ng","year":"1999","journal-title":"Oral Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB118","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1097\/00005537-199908000-00029","article-title":"Prognostic significance of p27 expression on carcinoma of the oral cavity and oropharynx","volume":"109","author":"Venkatesan","year":"1999","journal-title":"Laryngoscope"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB119","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2447::AID-CNCR7>3.0.CO;2-A","article-title":"Reduced expression of cyclin-dependent kinase inhibitor p27 is an indicator of malignant behavior in oral squamous cell carcinoma","volume":"83","author":"Kudo","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB120","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5<1011::AID-CNCR1>3.0.CO;2-0","article-title":"Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma","volume":"85","author":"Mineta","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB121","first-page":"5997","article-title":"Frequent p53 mutations in head and neck cancer","volume":"52","author":"Somers","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB122","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0030-6665(20)30925-7","article-title":"Genetic alterations in head and neck cancer","volume":"25","author":"Somers","year":"1992","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB123","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0964-1955(94)90062-0","article-title":"Frequent amplification of 11q13 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinomas","volume":"30B","author":"Muller","year":"1994","journal-title":"Oral Oncol Eur, J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB124","first-page":"439","article-title":"D11S287, a purative oncogene in chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BDL-1","volume":"6","author":"Lammie","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB125","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0959-8049(05)80194-7","article-title":"Unexpected PRAD-1 amplification in multiple simultaneous localizations of squamous cell carcinoma of the head and neck","volume":"29","author":"Klijanienko","year":"1993","journal-title":"Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB126","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1001\/archotol.1993.01880230084013","article-title":"Chromosome 11Q13 amplification in head and neck squamous cell carcinoma","volume":"119","author":"Williams","year":"1993","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB127","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/1097-0142(19940701)74:1<152::AID-CNCR2820740124>3.0.CO;2-K","article-title":"PRAD-1 (CCND1)\/Cyclin D1 Oncogene amplification in primary head and neck squamous cell carcinoma","volume":"74","author":"Callender","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB128","first-page":"469","article-title":"Expression of cyclin D1 in squamous cell carcinomas of the head and neck","volume":"5","author":"Lucas","year":"1994","journal-title":"International Journal of Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB129","first-page":"309","article-title":"Chromosome 11q13 gene amplifications in head and neck squamous cell carcinomas: relation with lymph node invasion","volume":"5","author":"Parise","year":"1994","journal-title":"Int J Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB130","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/(SICI)1097-0215(19971219)74:6<576::AID-IJC3>3.0.CO;2-R","article-title":"Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma","volume":"74","author":"Kyomoto","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB131","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archotol.1997.01900050045005","article-title":"Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck","volume":"123","author":"Michalides","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB132","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/0046-8177(95)90197-3","article-title":"Cyclin D1 (PRAD1, CCND1) and glutathione-S-Transferase \u03c0 gene expression in head and neck squamous cell carcinoma","volume":"26","author":"Gaffey","year":"1995","journal-title":"Hum Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB133","first-page":"1609","article-title":"Chromosome 11q13 gene amplification in oral and oropharyngeal carcinomas; no correlation with subclinical lymph node invasion and disease recurrence","volume":"3","author":"Fortin","year":"1997","journal-title":"Clin Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB134","first-page":"168","article-title":"Low levels of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma","volume":"18","author":"Field","year":"1992","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/hed.2880130209","article-title":"Characterization quantification and potential clinical value of epidermal growth factor receptor in head and neck squamous cell carcinomas","volume":"13","author":"Santini","year":"1991","journal-title":"Head Neck"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB136","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0964-1955(92)90043-Z","article-title":"Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer","volume":"28B","author":"Saranath","year":"1992","journal-title":"Oral Oncol Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB137","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0964-1955(93)90047-I","article-title":"EGFR and PCNA expression in oral squamous cell carcinomas\u00a0\u2014 a valuable tool in estimating the patient's prognosis","volume":"29B","author":"Storkel","year":"1993","journal-title":"Oral Oncol Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB138","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/jnci\/90.11.824","article-title":"Levels of TGF-\u03b1 and EGFR protein in head and neck squamous cell carcinoma and patient survival","volume":"90","author":"Rubin Grandis","year":"1998","journal-title":"JNCI"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB139","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1368-8375(99)00069-X","article-title":"Clinical relevance of erbB-1 and-2 oncogenes in oral carcinomas","volume":"36","author":"Werkmeister","year":"2000","journal-title":"Oral Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1368-8375(98)00055-4","article-title":"Correlations of bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas","volume":"35","author":"Yao","year":"1999","journal-title":"Oral Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB141","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0046-8177(98)90244-1","article-title":"Overexpression of cyclin-D1, bcl-2, and bax proteins, proliferating cell nuclear antigen (PCNA) and DNA-ploidy in squamous cell carcinoma of the oral cavity","volume":"29","author":"Staibano","year":"1998","journal-title":"Hum Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB142","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3835(99)00055-5","article-title":"Decreased expression of Bax is correlated with poor prognosis in oral and oropharyngeal carcinoma","volume":"140","author":"Ito","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB143","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/(SICI)1097-0142(19990915)86:6<913::AID-CNCR4>3.0.CO;2-A","article-title":"The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue","volume":"86","author":"Xie","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB144","first-page":"1463","article-title":"Elevated expression of the c-myc oncoprotein correlates with poor prognosis in head and neck squamous-cell carcinoman","volume":"4","author":"Field","year":"1989","journal-title":"Oncogene"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1368-8375(99)00067-6","article-title":"c-Abl expression in oral squamous cell carcinoma","volume":"36","author":"Yanagawa","year":"2000","journal-title":"Oral Oncology"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB146","first-page":"747","article-title":"The NM23 gene and its expression in oral squamous cell carcinoma","volume":"6","author":"LoMuzio","year":"1999","journal-title":"Oncology Rep"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB147","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/archotol.125.9.949","article-title":"Variable genetic alterations and survival in head and neck cancer","volume":"125","author":"Gleich","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB148","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.2565047","article-title":"Allelotype of colorectal carcinomas","volume":"244","author":"Vogelstein","year":"1989","journal-title":"Science"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB149","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/jnci\/90.20.1545","article-title":"Pgenotype and genotype of advanced premalignant lesions after chemopreventive therapy","volume":"90","author":"Mao","year":"1998","journal-title":"JNCI"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB150","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM199505253322103","article-title":"Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin","volume":"332","author":"Lotan","year":"1995","journal-title":"New Engl J Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB151","first-page":"3667","article-title":"p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines","volume":"53","author":"Brachman","year":"1993","journal-title":"Cancer Research"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB152","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.3109\/00016489609137854","article-title":"Increased radiosensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma","volume":"116","author":"Pekkola-Heino","year":"1996","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB153","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0344-0338(98)80084-8","article-title":"Expression of p53 and p21 proteins in oral squamous cell carcinoma: correlation with lymph node metastasis and response to chemoradiotherapy","volume":"194","author":"Tatemoto","year":"1998","journal-title":"Pathol Res Pract"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB154","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0046-8177(99)90041-2","article-title":"Immunohistochemical detection of p53 protein accumulation in head and neck cancer: correlation with p53 gene alterations","volume":"30","author":"Taylor","year":"1999","journal-title":"Hum Pathol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB155","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1600-0714.1999.tb02058.x","article-title":"Local tumor recurrence or emergence of a new primary lesion? A molecular analysis","volume":"28","author":"Zhang","year":"1999","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB156","first-page":"2003","article-title":"Synchronous oral carcinomas: independent or common clonal origin?","volume":"58","author":"Scholes","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB157","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/jnci\/91.7.599","article-title":"Unknown primary head and neck squamous cell carcinoma; molecular identification of the site of origin","volume":"91","author":"Califano","year":"1999","journal-title":"JNCI"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB158","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/jnci\/90.13.972","article-title":"Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma","volume":"90","author":"Leong","year":"1998","journal-title":"JNCI"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB159","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0964-1955(94)90083-3","article-title":"Gene therapy\u00a0\u2014 its potential in the management of oral cancer","volume":"30B","author":"Shillitoe","year":"1994","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1368-8375(98)00002-5","article-title":"Gene therapy for oral cancer: recent progress in research","volume":"34","author":"Shillitoe","year":"1998","journal-title":"Oral Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB161","first-page":"105","article-title":"Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration","volume":"2","author":"Clayman","year":"1995","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB162","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archotol.125.8.856","article-title":"Retargetting to EGFR enhances adenovirus infection efficiency of squamous cell carcinoma","volume":"125","author":"Blackwell","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB163","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1089\/10430349950017608","article-title":"Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207)","volume":"10","author":"Carew","year":"1999","journal-title":"Hum Gene Ther."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB164","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0002-9610(98)00231-1","article-title":"Efficient gene transfer to human squamous cell carcinomas by herpes simplex virus type 1 amplicon vectors","volume":"176","author":"Carew","year":"1998","journal-title":"Am J Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB165","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1097\/00005537-199711000-00012","article-title":"Optimizing suicide gene therapy for head and neck cancer","volume":"107","author":"Sewell","year":"1997","journal-title":"Laryngoscope"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB166","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/000348949610500713","article-title":"Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas","volume":"105","author":"Goebel","year":"1996","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB167","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1001\/archotol.1997.01900120048007","article-title":"Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer","volume":"123","author":"Sewell","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB168","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00005537-199903000-00009","article-title":"Limitations of adenovirus-mediated interleukin-2 gene therapy for oral cancer","volume":"109","author":"O'Malley","year":"1999","journal-title":"Laryngoscope"},{"issue":"56","key":"10.1016\/S1368-8375(00)00023-3_BIB169","first-page":"1737","article-title":"Combination gene therapy for oral cancer in a murine model","volume":"15","author":"O'Malley","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB170","first-page":"3662","article-title":"Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus","volume":"54","author":"Liu","year":"1994","journal-title":"Cancer Research"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB171","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0959-8049(95)00611-7","article-title":"Transfection of wild-type TP53 induced differentiation in human gingival carcinoma cells","volume":"32A","author":"Takahashi","year":"1996","journal-title":"Eur J Cancer"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB172","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archotol.1996.01890170025006","article-title":"Gene therapy for head and neck cancer","volume":"122","author":"Clayman","year":"1996","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB173","first-page":"189","article-title":"Effect of p53 gene transfer on the cell proliferation and cell cycle progression in a human oral cancer cell line with p53 mutation","volume":"23","author":"Lee","year":"1998","journal-title":"Int J Oral Biol."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB174","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/archotol.1997.01900050055007","article-title":"Restoration of the G1 checkpoint and the apoptotic pathway mediated by wild-type p53 sensitises squamous cell carcinoma of the head and neck to radiotherapy","volume":"123","author":"Chang","year":"1997","journal-title":"Arch Orolaryngol Head Neck Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB175","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1368-8375(97)00083-3","article-title":"p21(WAF1\/Cip1) retards the growth of human squamous cell carcinomas in vivo","volume":"34","author":"Cardinali","year":"1998","journal-title":"Oral Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB176","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1200\/JCO.1998.16.6.2221","article-title":"Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma","volume":"16","author":"Clayman","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB177","first-page":"4119","article-title":"P16 and p16\u03b2 are potent growth suppressors of head and neck squamous carcinoma cells in vitro","volume":"56","author":"Liggett","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB178","first-page":"1997","article-title":"Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer","volume":"11","author":"Uzawa","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB179","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/hum.1997.8.5-585","article-title":"Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells","volume":"20","author":"Liu","year":"1997","journal-title":"Hum Gene Ther."},{"key":"10.1016\/S1368-8375(00)00023-3_BIB180","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5357\/koubyou.64.52","article-title":"Growth suppression of squamous cell carcinoma cell lines by PKCs\u00a0\u2014 possible application to gene therapy","volume":"64","author":"Fujii","year":"1997","journal-title":"Kokubyo Gakkai Zasshi"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB181","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.cgt.7700007","article-title":"Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines","volume":"6","author":"Liu","year":"1999","journal-title":"Cancer Gene Therapy"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB182","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0278-2391(97)90495-X","article-title":"The molecular biology of oral carcinogenesis; toward a tumor progression model","volume":"55","author":"Todd","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB183","first-page":"1489","article-title":"Evidence of multi-step oncogenesis of oral squamous cell carcinoma","volume":"5","author":"Imai","year":"1998","journal-title":"Oncology Reports"},{"key":"10.1016\/S1368-8375(00)00023-3_BIB184","first-page":"5","article-title":"Genetic aberrations in squamous cell carcinoma of the head and neck (SCCHN), with reference to oral carcinoma (Review)","volume":"10","author":"Scully","year":"1997","journal-title":"Int J Oncol"}],"container-title":["Oral Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368837500000233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368837500000233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T22:58:40Z","timestamp":1620341920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368837500000233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":184,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S1368837500000233"],"URL":"https:\/\/doi.org\/10.1016\/s1368-8375(00)00023-3","relation":{},"ISSN":["1368-8375"],"issn-type":[{"value":"1368-8375","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}