{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T08:27:18Z","timestamp":1775896038338,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2003,12,12]],"date-time":"2003-12-12T00:00:00Z","timestamp":1071187200000},"content-version":"vor","delay-in-days":1655,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Plant Biology"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1016\/s1369-5266(99)80042-9","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T12:15:20Z","timestamp":1047644120000},"page":"244-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Zeroing in on zinc uptake in yeast and plants"],"prefix":"10.1016","volume":"2","author":[{"given":"Mary Lou","family":"Guerinot","sequence":"first","affiliation":[]},{"given":"David","family":"Eidet","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1369-5266(99)80042-9_bib1","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1126\/science.282.5396.2018","article-title":"Zinc fingers in Caenorhabditis elegans: finding families and probing pathways","volume":"282","author":"Clarke","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1369-5266(99)80042-9_bib2","author":"Marschner","year":"1995"},{"key":"10.1016\/S1369-5266(99)80042-9_bib3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.271.5252.1081","article-title":"The galvanization of biology: a growing appreciation for the roles of zinc","volume":"271","author":"Berg","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1369-5266(99)80042-9_bib4_1","doi-asserted-by":"crossref","first-page":"488S","DOI":"10.1093\/ajcn\/68.2.488S","article-title":"Plant breeding: a long term strategy for the control of zinc deficiency in vulnerable populations","volume":"68","author":"Ruel","year":"1998","journal-title":"Amer J Clin Nutr"},{"key":"10.1016\/S1369-5266(99)80042-9_bib5_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.nutr.18.1.441","article-title":"The molecular biology of metal ion transport in Saccharomyces cerevisiae","volume":"18","author":"Eide","year":"1998","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/S1369-5266(99)80042-9_bib6","first-page":"2454","article-title":"The yeast ZRT1 gene encodes the zinc transporter of a high affinity uptake system induced by zinc limitation","volume":"93","author":"Zhao","year":"1996"},{"key":"10.1016\/S1369-5266(99)80042-9_bib7","doi-asserted-by":"crossref","first-page":"23203","DOI":"10.1074\/jbc.271.38.23203","article-title":"The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae","volume":"271","author":"Zhao","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S1369-5266(99)80042-9_bib8_1","doi-asserted-by":"crossref","first-page":"28617","DOI":"10.1074\/jbc.273.44.28617","article-title":"Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation","volume":"273","author":"Gitan","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S1369-5266(99)80042-9_bib9","first-page":"5624","article-title":"A novel iron-regulated metal transporter from plants identified by functional expression in yeast","volume":"93","author":"Eide","year":"1996"},{"key":"10.1016\/S1369-5266(99)80042-9_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1026438615520","article-title":"The IRT1 protein from Arabidopsis thaliana is a metal transporter with broad specificity","volume":"40","author":"Korshunova","year":"1999","journal-title":"Plant Mol Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002329900442","article-title":"Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins","volume":"166","author":"Eng","year":"1998","journal-title":"J Membr Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib12_1","first-page":"7220","article-title":"Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency","volume":"95","author":"Grotz","year":"1998"},{"key":"10.1016\/S1369-5266(99)80042-9_bib13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1104\/pp.101.2.619","article-title":"Growth and nutrient uptake by barley (Hordeum vulg\u00e4re L. cv. Herta): studies using an N-(2-hydroxyethy)ethylenedinitrilotriacetic acid-buffered nutrient solution technique. I. Zinc ion requirements","volume":"101","author":"Norvell","year":"1993","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib14","first-page":"307","article-title":"Biosynthesis of a 34-kDa polypeptide in the root-cell plasma membrane of a Zn-efficient wheat genotype increases upon Zn deficiency","volume":"24","author":"Rengel","year":"1997","journal-title":"Aust J Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib15","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/BF00020461","article-title":"The macrophage specific membrane protein Nramp controlling natural resistance in mice has homologues expressed in the root systems of plants","volume":"29","author":"Belouchi","year":"1995","journal-title":"Plant Mol Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib16","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1023\/A:1005723304911","article-title":"Cloning and characterization of the OsNramp family from Oryza sativa, a new family of membrane proteins possibly implicated in the transport of metal ions","volume":"33","author":"Belouchi","year":"1997","journal-title":"Plant Mol Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib17","first-page":"10089","article-title":"Nramp defines a family of membrane proteins","volume":"92","author":"Cellier","year":"1995"},{"key":"10.1016\/S1369-5266(99)80042-9_bib18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal-ion transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1369-5266(99)80042-9_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ng0897-383","article-title":"Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene","volume":"16","author":"Fleming","year":"1997","journal-title":"Nature Genet"},{"key":"10.1016\/S1369-5266(99)80042-9_bib20","first-page":"1148","article-title":"Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport","volume":"95","author":"Fleming","year":"1998"},{"key":"10.1016\/S1369-5266(99)80042-9_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01904169409364706","article-title":"Effect of zinc and iron deficiency on phytosiderophore release in wheat genotypes differing in zinc efficiency","volume":"17","author":"Cakmak","year":"1994","journal-title":"J Plant Nutr"},{"key":"10.1016\/S1369-5266(99)80042-9_bib22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1399-3054.1994.tb08841.x","article-title":"Is the release of phytosiderophores in zinc-deficient wheat plants a response to impaired iron utilization?","volume":"92","author":"Walter","year":"1994","journal-title":"Physiol Plantarum"},{"key":"10.1016\/S1369-5266(99)80042-9_bib23_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1146\/annurev.arplant.49.1.669","article-title":"Molecular biology of cation transport in plants","volume":"49","author":"Fox","year":"1998","journal-title":"Annu Rev Plant Physiol Plant Mol Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0176-1617(98)80260-5","article-title":"Uptake of zinc and iron by wheat genotypes differing in tolerance to zinc deficiency","volume":"152","author":"Rengel","year":"1998","journal-title":"J Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib25","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1104\/pp.111.4.1119","article-title":"Roots of iron-efficient maize also absorb phytosiderophore-chelated zinc","volume":"111","author":"von Wiren","year":"1996","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib26","first-page":"81","article-title":"Terrestrial higher plants which hyperaccumulate metallic elements \u2014a review of their distribution, ecology and phytochemistry","volume":"1","author":"Baker","year":"1989","journal-title":"Biorecovery"},{"key":"10.1016\/S1369-5266(99)80042-9_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1360-1385(98)01283-7","article-title":"Phytomining Trends","volume":"3","author":"Brooks","year":"1998","journal-title":"Plant Sci"},{"key":"10.1016\/S1369-5266(99)80042-9_bib28_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev.arplant.49.1.643","article-title":"Phytoremediation","volume":"49","author":"Salt","year":"1998","journal-title":"Annu Rev Plant Physiol Plant Mol Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib29","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1104\/pp.112.4.1715","article-title":"Physiological characterization of root Zn2+ absorption and translocation to shoots in Zn hyperaccumulator and nonaccumulator species of Thlaspi","volume":"112","author":"Lasat","year":"1996","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib30","article-title":"Cloning and characterization of a heavy metal transporter (ZNT1) from the Zn\/Cd hyperaccumulator Thlaspi caerulescens","author":"Pence","year":"1998","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib31_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1104\/pp.118.3.875","article-title":"Altered Zn compartmentation in the root symplasm and stimulated Zn absorption into the leaf as mechanisms involved in Zn hyperaccumulation in Thlaspi caerulescens","volume":"118","author":"Lasat","year":"1998","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib32","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1046\/j.1365-3040.1997.d01-134.x","article-title":"Uptake and transport of zinc in the hyperaccumutator Thlaspi caerulescens and the nonhyperaccumulator Thlaspi ochroleucum","volume":"20","author":"Shen","year":"1997","journal-title":"Plant Cell Environ"},{"key":"10.1016\/S1369-5266(99)80042-9_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1104\/pp.119.1.305","article-title":"Cellular compartmentation of zinc in leaves of the hyperaccumulator Thlaspi caerulescens","volume":"119","author":"K\u00fcpper","year":"1999","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/S0176-1617(98)80064-3","article-title":"Evidence for an important role of the tonoplast in the mechanism of naturally selected zinc tolerance in Silene vulgaris","author":"Verkleij","year":"1998","journal-title":"J Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib35","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1128\/MCB.17.9.5044","article-title":"Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae","volume":"17","author":"Zhao","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib36","doi-asserted-by":"crossref","first-page":"28713","DOI":"10.1074\/jbc.273.44.28713","article-title":"Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements","volume":"273","author":"Zhao","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S1369-5266(99)80042-9_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00261172","article-title":"Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae","volume":"219","author":"Kamizono","year":"1989","journal-title":"Mol Gen Genet"},{"key":"10.1016\/S1369-5266(99)80042-9_bib38","first-page":"3678","article-title":"COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae","volume":"12","author":"Conklin","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib39","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00285458","article-title":"Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae","volume":"244","author":"Conklin","year":"1994","journal-title":"Mol Gen Genet"},{"key":"10.1016\/S1369-5266(99)80042-9_bib40","doi-asserted-by":"crossref","first-page":"22181","DOI":"10.1074\/jbc.273.35.22181","article-title":"Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity","volume":"273","author":"Li","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S1369-5266(99)80042-9_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002329900192","article-title":"A novel family of ubiquitous heavy metal ion transport proteins","volume":"156","author":"Paulsen","year":"1997","journal-title":"J Membr Biol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib42","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1128\/jb.174.24.8102-8110.1992","article-title":"CzcR and CzcD, gene products affecting regulation of resistance to cobalt, zinc and cadmium (czc system) in Alcaligenes eutrophus","volume":"174","author":"Nies","year":"1992","journal-title":"J Bacteriol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/jn\/128.4.667","article-title":"Mammalian zinc transporters","volume":"128","author":"McMahon","year":"1998","journal-title":"J Nutr"},{"key":"10.1016\/S1369-5266(99)80042-9_bib44","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/j.1460-2075.1995.tb07042.x","article-title":"Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc","volume":"14","author":"Palmiter","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S1369-5266(99)80042-9_bib45","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/j.1460-2075.1996.tb00527.x","article-title":"ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration","volume":"15","author":"Palmiter","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S1369-5266(99)80042-9_bib46","first-page":"14934","article-title":"ZnT-3, a putative transporter of zinc into synaptic vesicles","volume":"93","author":"Palmiter","year":"1996"},{"key":"10.1016\/S1369-5266(99)80042-9_bib47","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ng1197-292","article-title":"A novel gene involved in zinc transport is deficient in the lethal milk mouse","volume":"17","author":"Huang","year":"1997","journal-title":"Nature Genetics"},{"key":"10.1016\/S1369-5266(99)80042-9_bib48_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1104\/pp.119.3.1047","article-title":"Overexpression of a zinc transporter gene from Arabidopsis can lead to enhanced zinc resistance and zinc accumulation","volume":"119","author":"van der Zaal","year":"1999","journal-title":"Plant Physiol"},{"key":"10.1016\/S1369-5266(99)80042-9_bib49","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1023\/A:1006184519697","article-title":"Zinc finger proteins: the classic zinc finger emerges in contemporary plant science","volume":"39","author":"Takatsuji","year":"1999","journal-title":"Plant Mol Biol"}],"container-title":["Current Opinion in Plant Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369526699800429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369526699800429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:23:30Z","timestamp":1761283410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369526699800429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S1369526699800429"],"URL":"https:\/\/doi.org\/10.1016\/s1369-5266(99)80042-9","relation":{},"ISSN":["1369-5266"],"issn-type":[{"value":"1369-5266","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zeroing in on zinc uptake in yeast and plants","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Plant Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1369-5266(99)80042-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}