{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:07:45Z","timestamp":1770991665881,"version":"3.50.1"},"reference-count":220,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecular Engineering"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1016\/s1389-0344(01)00101-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:10:05Z","timestamp":1027599005000},"page":"69-85","source":"Crossref","is-referenced-by-count":256,"title":["Recent developments in adjuvants for vaccines against infectious diseases"],"prefix":"10.1016","volume":"18","author":[{"given":"Derek T.","family":"O'Hagan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Lee","family":"MacKichan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manmohan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1389-0344(01)00101-0_BIB1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJM199907223410410","volume":"341","author":"Seder","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.282.5388.476","volume":"282","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB3","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0140-6736(97)09440-3","volume":"351","author":"Calarota","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.97.2.811","volume":"97","author":"Singh","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nm0498-397","volume":"4","author":"Schneider","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/35046108","volume":"408","author":"Sullivan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.1058915","volume":"292","author":"Amara","year":"2001","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB8","first-page":"1","volume":"38","author":"Ramon","year":"1924","journal-title":"Ann. Inst. Pasteur"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB9","series-title":"Vaccine Design: The Subunit and Adjuvant Approach","first-page":"141","article-title":"A compendium of vaccine adjuvants and excipients","author":"Vogel","year":"1995"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0169-409X(98)00008-8","volume":"32","author":"Gupta","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB11","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0264-410X(97)00288-0","volume":"16","author":"Relyveld","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB12","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0264-410X(96)00073-4","volume":"14","author":"Gupta","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/IAI.69.2.1151-1159.2001","volume":"69","author":"Ulanova","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB14","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0264-410X(00)00394-7","volume":"19","author":"Shi","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB15","series-title":"New Generation Vaccines","first-page":"173","article-title":"Adjuvants for the future","author":"Edelman","year":"1997"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB16","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0264-410X(00)00372-8","volume":"19","author":"Moingeon","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.1997.tb00969.x","volume":"156","author":"Zinkernagel","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/smim.1998.0142","volume":"10","author":"Janeway","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB19","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/35021228","volume":"406","author":"Aderem","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB20","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/15200","volume":"5","author":"Gallucci","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB21","doi-asserted-by":"crossref","first-page":"14\u2008590","DOI":"10.1073\/pnas.260497597","volume":"97","author":"Shi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/32183","volume":"392","author":"Albert","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB23","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1126\/science.169.3950.1042","volume":"169","author":"Bretscher","year":"1970","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB24","unstructured":"Janeway CA, Jr. 1989;54 Pt 1 AD-Section of Immunology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510: pp. 1\u201313."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)80412-2","volume":"91","author":"Medzhitov","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB26","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/smim.1998.0143","volume":"10","author":"Matzinger","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB28","doi-asserted-by":"crossref","first-page":"14\u2008590","DOI":"10.1073\/pnas.260497597","volume":"97","author":"Shi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/40967","volume":"388","author":"Fearon","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.272.5258.50","volume":"272","author":"Fearon","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB31","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.162.7.3942","volume":"162","author":"Yip","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1084\/jem.185.2.317","volume":"185","author":"Winzler","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB33","series-title":"Vaccine Design: The Subunit and Adjuvant Approach","first-page":"495","article-title":"Monophosphoryl lipid A as an adjuvant: past experiences and new directions","author":"Ulrich","year":"1995"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB34","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0952-7915(99)80066-1","volume":"11","author":"Reis e Sousa","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB35","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.184.4.1413","volume":"184","author":"De Smedt","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB36","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/42030","volume":"388","author":"Cella","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB37","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.188.11.2175","volume":"188","author":"Rescigno","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB38","first-page":"200","volume":"20","author":"Rescigno","year":"1999","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB39","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.4049\/jimmunol.162.5.2569","volume":"162","author":"Verhasselt","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB40","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1101\/gad.5.5.797","volume":"5","author":"Schneider","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/smim.1998.0136","volume":"10","author":"Medzhitov","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB42","doi-asserted-by":"crossref","first-page":"14\u2008614","DOI":"10.1073\/pnas.94.26.14614","volume":"94","author":"Lemaitre","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1073\/pnas.95.2.429","volume":"95","author":"Medzhitov","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB44","first-page":"291","volume":"15","author":"Qureshi","year":"1999","journal-title":"Inflamm. Res."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB45","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB46","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","volume":"189","author":"Shimazu","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","volume":"25","author":"Arbour","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/jlb.60.1.8","volume":"60","author":"Sweet","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB49","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4049\/jimmunol.164.2.558","volume":"164","author":"Ohashi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB50","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1126\/science.285.5428.732","volume":"285","author":"Brightbill","year":"1999","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB51","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.285.5428.736","volume":"285","author":"Aliprantis","year":"1999","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB52","doi-asserted-by":"crossref","first-page":"13\u2008766","DOI":"10.1073\/pnas.250476497","volume":"97","author":"Ozinsky","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB53","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.163.7.3920","volume":"163","author":"Means","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB54","doi-asserted-by":"crossref","first-page":"14\u2008459","DOI":"10.1073\/pnas.96.25.14459","volume":"96","author":"Underhill","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB55","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1084\/jem.166.5.1229","volume":"166","author":"Cherwinski","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB56","first-page":"A49","volume":"12","author":"Mosmann","year":"1991","journal-title":"Immunol"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB57","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-5699(91)90120-I","volume":"12","author":"Romagnani","year":"1991","journal-title":"Immunol Today"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB58","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.3107127","volume":"236","author":"Snapper","year":"1987","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB59","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.283.5405.1124","volume":"283","author":"Bottomly","year":"1999","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB60","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0923-2494(92)80058-S","volume":"143","author":"Gustafson","year":"1992","journal-title":"Res Immunol"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-1-4615-1823-5_21","volume":"6","author":"Ulrich","year":"1995","journal-title":"Pharm Biotechnol"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB62","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/intimm\/12.6.807","volume":"12","author":"De Becker","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB63","series-title":"Vaccine Adjuvants: Preparation Methods and Research Protocols","first-page":"273","article-title":"MPLr immunostimulant: adjuvant formulations","author":"Ulrich","year":"2000"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB64","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0264-410X(97)00254-5","volume":"16","author":"Thoelen","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB65","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1021\/jm990222b","volume":"42","author":"Johnson","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB66","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1128\/IAI.65.9.3520-3528.1997","volume":"65","author":"Sasaki","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB67","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1128\/IAI.68.10.5509-5516.2000","volume":"68","author":"Childers","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB68","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.4049\/jimmunol.147.6.1759","volume":"147","author":"Messina","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB69","unstructured":"Tokunaga T, Yamamoto H, Shimada S, Abe H, Fukuda T, Fujisawa Y, Furutani Y, Yano O, Kataoka T, Sudo T. 1984;72:955\u2013962."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB70","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB71","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0168-9525(87)90294-0","volume":"3","author":"Bird","year":"1987","journal-title":"Trends Genet."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB72","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.4049\/jimmunol.161.6.3042","volume":"161","author":"Jakob","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB73","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB74","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<2045::AID-IMMU2045>3.0.CO;2-8","volume":"28","author":"Sparwasser","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB75","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4049\/jimmunol.160.2.870","volume":"160","author":"Davis","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB76","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.187.7.1145","volume":"187","author":"Sun","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB77","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.4049\/jimmunol.161.9.4463","volume":"161","author":"McCluskie","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB78","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0264-410X(98)80122-9","volume":"16","author":"Moldoveanu","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB79","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0264-410X(98)00151-0","volume":"17","author":"Klinman","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB80","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.4049\/jimmunol.161.12.7054","volume":"161","author":"Broide","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB81","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.164.3.1617","volume":"164","author":"Hartmann","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0952-7915(99)00048-5","volume":"12","author":"Krieg","year":"2000","journal-title":"Curr. Opin. In Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB83","first-page":"1","volume":"13","author":"Kensil","year":"1996","journal-title":"Crit Rev Ther Drug Carr Sys"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB84","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/0264-410X(95)00077-E","volume":"13","author":"Soltysik","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB85","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/196953a0","volume":"196","author":"Glaueri","year":"1962","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB86","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1517\/13543784.7.9.1475","volume":"7","author":"Kensil","year":"1998","journal-title":"Exp. Opin. Invest. Drugs"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB87","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1089\/aid.1997.13.1163","volume":"13","author":"Keefer","year":"1997","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB88","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/S0264-410X(00)00415-1","volume":"19","author":"Evans","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB89","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1128\/JVI.72.6.4931-4939.1998","volume":"72","author":"Sasaki","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB90","series-title":"Vaccine Design: The Subunit and Adjuvant Approach","first-page":"645","article-title":"Cytokines as immunological adjuvants","author":"Heath","year":"1995"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB91","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/(SICI)1096-9098(199806)68:2<122::AID-JSO10>3.0.CO;2-4","volume":"68","author":"Salgaller","year":"1998","journal-title":"J Surg Oncol"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB92","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0022-1759(86)90402-3","volume":"95","author":"Allison","year":"1986","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB93","series-title":"Vaccine Adjuvants: Preparation Methods and Research Protocols","first-page":"49","article-title":"Freund's adjuvants","author":"Lindblad","year":"2000"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB94","series-title":"Vaccine Design: The Subunit and Adjuvant Approach","first-page":"277","article-title":"MF59: design and evaluation of a safe and potent adjuvant for human vaccines","author":"Ott","year":"1995"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB95","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/S0264-410X(97)00115-1","volume":"15","author":"Cataldo","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB96","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0264-410X(95)00240-2","volume":"14","author":"Higgins","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB97","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1357-4310(96)10058-7","volume":"3","author":"O'Hagan","year":"1997","journal-title":"Mol. Med. Today"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB98","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/infdis\/174.6.1168","volume":"174","author":"Traquina","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB99","doi-asserted-by":"crossref","unstructured":"Menegon T, Baldo V, Bonello C, Dalla CD, Di Tommaso A, Trivello R. 1999;15:573\u2013576.","DOI":"10.1023\/A:1007594911541"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB100","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1016\/S0264-410X(99)00138-3","volume":"17","author":"De Donato","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB101","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0264-410X(99)00088-2","volume":"17","author":"Heineman","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB102","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/IAI.65.5.1710-1715.1997","volume":"65","author":"Granoff","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB103","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/cimm.1998.1283","volume":"186","author":"Dupuis","year":"1998","journal-title":"Cell Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB104","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jlb.67.2.226","volume":"67","author":"Hamilton","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB105","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1086\/315022","volume":"180","author":"Pass","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB106","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0264-410X(99)00421-1","volume":"18","author":"Nitayaphan","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB107","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/infdis\/170.5.1288","volume":"170","author":"Kahn","year":"1994","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB108","doi-asserted-by":"crossref","first-page":"889","DOI":"10.7326\/0003-4819-122-12-199506150-00001","volume":"122","author":"Langenberg","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB109","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1086\/319215","volume":"32","author":"Cunningham","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB110","doi-asserted-by":"crossref","unstructured":"The AIDS Vaccine Evaluation Group OZZ protocol. J Infect Dis 2001;183:563\u2013570.","DOI":"10.1086\/318523"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB111","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/S0264-410X(97)00076-5","volume":"15","author":"Ling","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB112","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1056\/NEJM199701093360202","volume":"336","author":"Stoute","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB113","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0264-410X(99)00388-6","volume":"18","author":"McCormack","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB114","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0264-410X(96)00150-8","volume":"15","author":"Lawrence","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0304-4157(92)90004-T","volume":"1113","author":"Alving","year":"1992","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB116","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0167-5699(90)90034-7","volume":"11","author":"Gregoriadis","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB117","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0264-410X(97)00015-7","volume":"15","author":"Ambrosch","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB118","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0169-409X(98)00014-3","volume":"32","author":"Gould-Fogerite","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB119","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/S0264-410X(00)00386-8","volume":"19","author":"Guy","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB120","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0168-3659(96)01459-9","volume":"42","author":"Chen","year":"1996","journal-title":"J. Controlled Release"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB121","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0169-409X(98)00013-1","volume":"32","author":"Barr","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"Part 4","key":"10.1016\/S1389-0344(01)00101-0_BIB122","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1099\/0022-1317-78-4-757","volume":"78","author":"Rimmelzwaan","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB123","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/viro.1999.9765","volume":"259","author":"Ennis","year":"1999","journal-title":"Virology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB124","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.4049\/jimmunol.162.9.5536","volume":"162","author":"Smith","year":"1999","journal-title":"J. Immunol."},{"issue":"Part 2","key":"10.1016\/S1389-0344(01)00101-0_BIB125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/icb.1990.18","volume":"68","author":"Emery","year":"1990","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB126","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1128\/JVI.73.4.3292-3300.1999","volume":"73","author":"Verschoor","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB127","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.4049\/jimmunol.166.5.3589","volume":"166","author":"Polakos","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB128","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1016\/S0264-410X(00)00497-7","volume":"19","author":"Sjolander","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB129","series-title":"Options for the Control of Influenza III","first-page":"661","article-title":"IscomT adjuvant\u2014a promising adjuvant for influenza virus vaccines","author":"Bates","year":"1996"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB130","series-title":"Vaccine Adjuvants: Preparation Methods and Research Protocols","first-page":"239","article-title":"The ISCOM\u2122 technology","author":"Lovgren-Bengtsson","year":"2000"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB131","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.4049\/jimmunol.161.8.4000","volume":"161","author":"Brewer","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB132","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0264-410X(98)00250-3","volume":"17","author":"Tsunoda","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB133","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0264-410X(96)00099-0","volume":"14","author":"Nixon","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB134","doi-asserted-by":"crossref","unstructured":"Okada H, Toguchi H. 1995;12:1\u201399.","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v12.i1.10"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB135","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nbt0298-153","volume":"16","author":"Putney","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB136","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1128\/IAI.59.9.2978-2986.1991","volume":"59","author":"Eldridge","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB137","first-page":"239","volume":"73","author":"O'Hagan","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB138","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/0264-410X(91)90295-H","volume":"9","author":"O'Hagan","year":"1991","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB139","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0264-410X(93)90387-D","volume":"11","author":"O'Hagan","year":"1993","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB140","first-page":"661","volume":"81","author":"Maloy","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB141","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/0264-410X(95)00184-3","volume":"13","author":"Moore","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB142","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nm0398-365","volume":"4","author":"Hedley","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB143","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1023\/A:1011053931523","volume":"18","author":"Briones","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB144","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1038\/sj.gt.3301347","volume":"7","author":"Denis-Mize","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0168-3659(00)00226-1","volume":"67","author":"Kazzaz","year":"2000","journal-title":"J. Control Release"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB146","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/S0264-410X(99)00522-8","volume":"18","author":"O'Hagan","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB147","series-title":"New Generation Vaccines","first-page":"215","article-title":"Prospects for the development of new and improved vaccines through the use of microencapsulation technology","author":"O'Hagan","year":"1997"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB148","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0169-409X(98)00012-X","volume":"32","author":"O'Hagan","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB149","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0169-409X(98)00011-8","volume":"32","author":"Newman","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB150","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0264-410X(97)00149-7","volume":"16","author":"Payne","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB151","unstructured":"Lang J. Clinical trials for adjuvant evaluation. London: Management Forum, 1999."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB152","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/298347a0","volume":"298","author":"Valenzuela","year":"1982","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB153","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1128\/JVI.69.10.5929-5934.1995","volume":"69","author":"Schirmbeck","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB154","series-title":"Vaccine Adjuvants: Preparation Methods and Research Protocols","first-page":"197","article-title":"Virus-like particles as vaccine adjuvants","author":"Gilbert","year":"2000"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB155","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/nbt1197-1280","volume":"15","author":"Gilbert","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB156","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.4049\/jimmunol.157.6.2521","volume":"157","author":"Klavinskis","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB157","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/00002030-199310000-00003","volume":"7","author":"Martin","year":"1993","journal-title":"Aids"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB158","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0140-6736(05)79439-3","volume":"351","author":"Levine","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB159","first-page":"164","volume":"76","author":"Challacombe","year":"1992","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0264-410X(96)00159-4","volume":"15","author":"Challacombe","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB161","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0168-3659(90)90133-E","volume":"11","author":"Eldridge","year":"1990","journal-title":"J. Controlled Release"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB162","series-title":"Novel Delivery Systems for Oral Vaccines","first-page":"175","article-title":"Microparticles as oral vaccines","author":"O'Hagan","year":"1994"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB163","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0264-410X(94)00008-B","volume":"13","author":"Cahill","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB164","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/IAI.64.2.489-494.1996","volume":"64","author":"Jones","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB165","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1128\/IAI.63.4.1195-1200.1995","volume":"63","author":"Shahin","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB166","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/S0264-410X(00)00433-3","volume":"19","author":"Conway","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB167","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nm1096-1116","volume":"2","author":"Whittum-Hudson","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB168","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1128\/IAI.65.3.853-857.1997","volume":"65","author":"Allaoui-Attarki","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB169","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.8493576","volume":"260","author":"Marx","year":"1993","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB170","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1128\/IAI.63.8.2880-2885.1995","volume":"63","author":"Tseng","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB171","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1046\/j.1365-2567.1998.00441.x","volume":"93","author":"Ugozzoli","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB172","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0264-410X(96)00266-6","volume":"15","author":"Jones","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB173","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/386410a0","volume":"386","author":"Mathiowitz","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB174","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1021\/js9801687","volume":"88","author":"Ando","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB175","unstructured":"O'Hagan DT. 1996;189 (Part 3):477\u2013482."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB176","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0169-409X(98)00045-3","volume":"34","author":"O'Hagan","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB177","series-title":"Mucosal Immunology","first-page":"759","article-title":"Antigen delivery systems: nonliving microparticles, liposomes, cochleates, and ISCOMS","author":"Michalek","year":"1999"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB178","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1128\/IAI.63.5.1617-1623.1995","volume":"63","author":"Dickinson","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB179","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1073\/pnas.92.5.1644","volume":"92","author":"Douce","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB180","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1128\/IAI.65.7.2821-2828.1997","volume":"65","author":"Douce","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB181","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1128\/IAI.64.3.974-979.1996","volume":"64","author":"Di Tommaso","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB182","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1128\/IAI.65.1.331-334.1997","volume":"65","author":"Giannelli","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB183","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1084\/jem.187.7.1123","volume":"187","author":"Giuliani","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB184","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0264-410X(97)00153-9","volume":"16","author":"Marchetti","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB185","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1128\/IAI.67.9.4400-4406.1999","volume":"67","author":"Douce","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB186","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nm0598-607","volume":"4","author":"Tacket","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB187","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/81153","volume":"18","author":"Richter","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB188","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0167-5699(99)01523-6","volume":"20","author":"Rappuoli","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB189","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1046\/j.1365-2567.2000.00090.x","volume":"101","author":"Neidleman","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB190","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1365-2567.1996.d01-790.x","volume":"89","author":"Partidos","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB191","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.4049\/jimmunol.163.12.6502","volume":"163","author":"Simmons","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB192","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1128\/IAI.67.8.4276-4279.1999","volume":"67","author":"Barackman","year":"1999","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/S1389-0344(01)00101-0_BIB193","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1086\/317923","volume":"183","author":"Ugozzoli","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB194","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0168-3659(00)00330-8","volume":"70","author":"Singh","year":"2001","journal-title":"J Controlled Release"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB195","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.1128\/JVI.73.9.7780-7786.1999","volume":"73","author":"Gluck","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB196","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1086\/315337","volume":"181","author":"Gluck","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB197","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.4049\/jimmunol.162.12.7015","volume":"162","author":"Yamamoto","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB198","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1126\/science.283.5402.680","volume":"283","author":"Viola","year":"1999","journal-title":"Science"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB199","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/1521-4141(2000)30:8<2394::AID-IMMU2394>3.0.CO;2-Y","volume":"30","author":"Gagliardi","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB200","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/36014","volume":"391","author":"Glenn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB201","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/82225","volume":"6","author":"Glenn","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB202","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/80538","volume":"6","author":"Chen","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB203","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2567.2001.01157.x","volume":"102","author":"Lavelle","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB204","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0140-6736(94)92581-X","volume":"343","author":"Straus","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB205","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1749-6632.1993.tb44016.x","volume":"690","author":"Longenecker","year":"1993","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB206","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm0198-043","volume":"4","author":"Agrawal","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB207","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/IAI.65.12.4996-5002.1997","volume":"65","author":"Ghiara","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB208","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0167-5699(97)01053-0","volume":"18","author":"Weiner","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB209","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1128\/IAI.65.10.4288-4298.1997","volume":"65","author":"Giannasca","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB210","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1023\/A:1016030202104","volume":"13","author":"Chen","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB211","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0264-410X(97)00222-3","volume":"16","author":"Foster","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB212","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1023\/A:1012153011884","volume":"14","author":"Hussain","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB213","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2567.1997.00307.x","volume":"92","author":"Toda","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB214","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.4049\/jimmunol.158.8.3936","volume":"158","author":"Agren","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB215","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.4049\/jimmunol.162.4.2432","volume":"162","author":"Agren","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB216","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.4049\/jimmunol.164.12.6276","volume":"164","author":"Agren","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/S1389-0344(01)00101-0_BIB217","doi-asserted-by":"crossref","first-page":"12\u2008059","DOI":"10.1073\/pnas.94.22.12059","volume":"94","author":"Goletz","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB218","doi-asserted-by":"crossref","unstructured":"Singh M, et al. Pharm Res 2001;18(10):in press.","DOI":"10.1023\/A:1012269226066"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB219","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0140-6736(00)05066-2","volume":"357","author":"Nicholson","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/S1389-0344(01)00101-0_BIB220","unstructured":"O'Hagan DT, et al. J Virol 2001; in press."}],"container-title":["Biomolecular Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389034401001010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389034401001010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T21:29:46Z","timestamp":1680902986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389034401001010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":220,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S1389034401001010"],"URL":"https:\/\/doi.org\/10.1016\/s1389-0344(01)00101-0","relation":{},"ISSN":["1389-0344"],"issn-type":[{"value":"1389-0344","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}