{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:49:10Z","timestamp":1761580150712},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1016\/s1471-4906(03)00241-2","type":"journal-article","created":{"date-parts":[[2003,9,3]],"date-time":"2003-09-03T18:40:32Z","timestamp":1062614432000},"page":"522-524","source":"Crossref","is-referenced-by-count":75,"title":["Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1"],"prefix":"10.1016","volume":"24","author":[{"given":"Frank M.","family":"Raaphorst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1471-4906(03)00241-2_BIB1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","article-title":"Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells","volume":"423","author":"Park","year":"2003","journal-title":"Nature"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature01572","article-title":"Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells","volume":"423","author":"Lessard","year":"2003","journal-title":"Nature"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB3","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S1471-4906(01)02082-8","article-title":"Polycomb-group genes as regulators of mammalian lymphopoiesis","volume":"22","author":"Raaphorst","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB4","first-page":"15","article-title":"Epigenetics: unforeseen regulators in cancer","volume":"1552","author":"Muyrers-Chen","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/scdb.1999.0304","article-title":"Cellular memory of transcriptional states by Polycomb-group proteins","volume":"10","author":"Jacobs","year":"1999","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4781(99)00130-X","article-title":"Polycomb group protein complexes: do different complexes regulate distinct target genes?","volume":"1447","author":"Satijn","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(03)00157-0","article-title":"Polycomb, epigenomes, and control of cell identity","volume":"112","author":"Orlando","year":"2003","journal-title":"Cell"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB8","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1182\/blood.V99.2.488","article-title":"Differential gene expression profiling of adult murine hematopoietic stem cells","volume":"99","author":"Park","year":"2002","journal-title":"Blood"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB9","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1182\/blood.V91.4.1216","article-title":"Stage-specific expression of polycomb group genes in human bone marrow cells","volume":"91","author":"Lessard","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1101\/gad.8.7.757","article-title":"Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene","volume":"8","author":"van der Lugt","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/16476","article-title":"The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus","volume":"397","author":"Jacobs","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB14","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1093\/emboj\/17.13.3714","article-title":"Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b","volume":"17","author":"Kroon","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1074-7613(00)80516-6","article-title":"The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors","volume":"7","author":"Akasaka","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0301-472X(00)00620-2","article-title":"Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage","volume":"29","author":"Tokimasa","year":"2001","journal-title":"Exp. Hematol."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(01)00182-0","article-title":"Regulation of Th2 cell differentiation by mel-18, a mammalian Polycomb group gene","volume":"15","author":"Kimura","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ni876","article-title":"Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement","volume":"4","author":"Su","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB19","first-page":"4736","article-title":"The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells","volume":"62","author":"Dimri","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0002-9440(10)64583-X","article-title":"Coexpression of BMI-1 and EZH2 polycomb group genes in Reed\u2013Sternberg cells of Hodgkin's disease","volume":"157","author":"Raaphorst","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/S1471-4906(03)00241-2_BIB21","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1182\/blood.V97.12.3896","article-title":"Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma","volume":"97","author":"van Kemenade","year":"2001","journal-title":"Blood"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB22","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nature01075","article-title":"The polycomb group protein EZH2 is involved in progression of prostate cancer","volume":"419","author":"Varambally","year":"2002","journal-title":"Nature"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1054\/bjoc.2001.1791","article-title":"The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression","volume":"84","author":"Vonlanthen","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S1471-4906(03)00241-2_BIB24","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al Hajj","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490603002412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490603002412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T10:14:50Z","timestamp":1585131290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490603002412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S1471490603002412"],"URL":"https:\/\/doi.org\/10.1016\/s1471-4906(03)00241-2","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}