{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:18:13Z","timestamp":1772507893154,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4003,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1016\/s1535-6108(02)00094-6","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T13:11:47Z","timestamp":1034082707000},"page":"149-155","source":"Crossref","is-referenced-by-count":193,"title":["Telomere dysfunction provokes regional amplification and deletion in cancer genomes"],"prefix":"10.1016","volume":"2","author":[{"given":"R\u00f3n\u00e1n C","family":"O'Hagan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S","family":"Maser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramya","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E","family":"Artandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald A","family":"DePinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1535-6108(02)00094-6_BIB1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/gcc.2870080212","article-title":"Mapping of the 19p13 breakpoint in an ovarian carcinoma between the INSR and TCF3 loci","volume":"8","author":"Aman","year":"1993","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1954.1","article-title":"The age distribution of cancer and a multi-stage theory of carcinogensis","volume":"8","author":"Armitage","year":"1954","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35020592","article-title":"Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice","volume":"406","author":"Artandi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0165-4608(92)90113-M","article-title":"Possibly identical marker chromosome der(16)t(?13;16)(?q13or14;q22) in a squamous cell carcinoma of the skin and larynx","volume":"58","author":"Atkin","year":"1992","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0300-9084(99)80048-0","article-title":"Oxidative DNA damage processing in nuclear and mitochondrial DNA","volume":"81","author":"Bohr","year":"1999","journal-title":"Biochimie"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB6","doi-asserted-by":"crossref","unstructured":"Bohr, V., Anson, R.M., Mazur, S., and Dianov, G. (1998). Oxidative DNA damage processing and changes with aging. Toxicol. Lett. 102\u2013103, 47\u201352.","DOI":"10.1016\/S0378-4274(98)00280-X"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB7","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1128\/MCB.16.7.3765","article-title":"Telomerase activation in mouse mammary tumors","volume":"16","author":"Broccoli","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/10428199809057556","article-title":"The unexplored 5q13 locus","volume":"30","author":"Castro","year":"1998","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB9","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1182\/blood.V95.6.2138","article-title":"Deletions of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms","volume":"95","author":"Castro","year":"2000","journal-title":"Blood"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB10","first-page":"2533","article-title":"Telomerase activity associated with acquisition of malignancy in human colorectal cancer","volume":"55","author":"Chadeneau","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB11","doi-asserted-by":"crossref","first-page":"30423","DOI":"10.1074\/jbc.M101194200","article-title":"Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1\/S progression of the cell cycle","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0092-8674(00)80762-X","article-title":"p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis","volume":"97","author":"Chin","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB13","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","article-title":"Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity","volume":"11","author":"Counter","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB14","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1038\/sj.onc.1204645","article-title":"Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2","volume":"20","author":"Dang","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/35041694","article-title":"The age of cancer","volume":"408","author":"DePinho","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB16","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1126\/science.274.5293.1664","article-title":"Cell cycle checkpoints","volume":"274","author":"Elledge","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB17","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1182\/blood.V88.6.2259.bloodjournal8862259","article-title":"Translocations and deletions of 5q13.1 in myelodysplasia and acute myelogenous leukemia","volume":"88","author":"Fairman","year":"1996","journal-title":"Blood"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB18","first-page":"369","article-title":"Chromosomal markers associated with metastasis in two colon cancer cell lines established from the same patient","volume":"15","author":"Gagos","year":"1995","journal-title":"Anticancer Res."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB19","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1101\/gad.981602","article-title":"Activation of Wnt signaling bypasses the requirement for RTK\/Ras signaling during the C. elegans vulval induction","volume":"16","author":"Gleason","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0165-4608(95)00340-1","article-title":"A new translocation, t(5;21)(q13;q22) in acute myelogenous leukemia","volume":"88","author":"Gogineni","year":"1996","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB21","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/346866a0","article-title":"Telomere reduction in human colorectal carcinoma and with ageing","volume":"346","author":"Hastie","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ng771","article-title":"Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas","volume":"29","author":"Hodgson","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3346\/jkms.2002.17.1.29","article-title":"Coexpression of MUC1 with p53 or MUC2 correlates with Lymph Node Metastasis in Colorectal Carcinomas","volume":"17","author":"Jang","year":"2002","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0165-4608(93)90205-Z","article-title":"Cytogenetic studies of epithelial ovarian carcinoma","volume":"71","author":"Jenkins","year":"1993","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB25","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0960-9822(00)80123-2","article-title":"The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts","volume":"9","author":"Karanjawala","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0960-9822(02)00684-X","article-title":"Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants","volume":"12","author":"Karanjawala","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB27","first-page":"234","article-title":"Recurrent cytogenetic aberrations in human ovarian carcinomas","volume":"19","author":"Kiechle-Schwarz","year":"1995","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0165-1110(92)90010-7","article-title":"A branching process model of gene amplification following chromosome breakage","volume":"276","author":"Kimmel","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/347400a0","article-title":"Hypervariable ultra-long telomeres in mice","volume":"347","author":"Kipling","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB30","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0165-4608(99)00226-5","article-title":"Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines","volume":"119","author":"Larramendy","year":"2000","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB31","doi-asserted-by":"crossref","first-page":"12331","DOI":"10.1073\/pnas.231485898","article-title":"How do tumors make ends meet?","volume":"98","author":"Lengauer","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB32","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1128\/MCB.22.13.4836-4850.2002","article-title":"Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells","volume":"22","author":"Lo","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB33","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/(SICI)1097-0215(19991022)84:5<516::AID-IJC12>3.0.CO;2-Y","article-title":"Genetic changes associated with telomerase activity in breast cancer","volume":"84","author":"Loveday","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB34","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1128\/MCB.21.17.6017-6030.2001","article-title":"Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability","volume":"21","author":"Lu","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB35","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1126\/science.1066326","article-title":"KLF6, a candidate tumor suppressor gene mutated in prostate cancer","volume":"294","author":"Narla","year":"2001","journal-title":"Science"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB36","first-page":"221","article-title":"Cell cycle checkpoints, chromosome stability and the progression of cancer","volume":"10","author":"Nojima","year":"1997","journal-title":"Hum. Cell"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB37","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S1097-2765(01)00408-7","article-title":"DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency","volume":"8","author":"O'Driscoll","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.18388\/abp.1998_4248","article-title":"Oxidative DNA base modifications as factors in carcinogenesis","volume":"45","author":"Olinski","year":"1998","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB39","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1038\/sj.onc.1203006","article-title":"17q21-q25 aberrations in breast cancer","volume":"18","author":"Orsetti","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/emboj\/17.1.325","article-title":"Interstitial deleteions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome","volume":"17","author":"Pipiras","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB41","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1073\/pnas.92.11.4818","article-title":"Developmental and tissue-specific regulation of mouse telomerase and telomere length","volume":"92","author":"Prowse","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB42","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/1097-0215(20000520)89:3<305::AID-IJC15>3.0.CO;2-8","article-title":"Patterns of chromosomal imbalances in invasive breast cancer","volume":"89","author":"Richard","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/88871","article-title":"Telomere dysfunction and evolution of intestinal carcinoma in mice and humans","volume":"28","author":"Rudolph","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB44","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1038\/sj.onc.1204566","article-title":"Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer","volume":"20","author":"Scherl-Mostageer","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0165-4608(88)90018-0","article-title":"Familial fragile 8q22 involved as a cancer breakpoint in cells of a large bowel tumor","volume":"31","author":"Shabtai","year":"1988","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB46","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S1097-2765(01)00425-7","article-title":"Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions","volume":"8","author":"Sharpless","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB47","first-page":"3884","article-title":"Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma","volume":"60","author":"Shen","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB48","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/nar\/28.15.2969","article-title":"Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif","volume":"28","author":"Shie","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB49","first-page":"4169","article-title":"Whole genome amplification and high-throughput allelotyping identified five distinct deletion regions on chromosomes 5 and 6 in microdissected early-stage ovarian tumors","volume":"61","author":"Wang","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0959-437X(00)00161-1","article-title":"Mitotic checkpoints","volume":"11","author":"Wassmann","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB51","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1101\/gad.5.2.160","article-title":"A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration","volume":"5","author":"Windle","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00094-6_BIB52","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/gcc.2870070308","article-title":"Clonal cytogenetic evolution in a squamous cell carcinoma of the skin from a xeroderma pigmentosum patient","volume":"7","author":"Worsham","year":"1993","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/S1535-6108(02)00094-6_BIB53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/72799","article-title":"A genome-wide survey of RAS transformation targets","volume":"24","author":"Zuber","year":"2000","journal-title":"Nat. Genet."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610802000946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610802000946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T18:24:01Z","timestamp":1583519041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610802000946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S1535610802000946"],"URL":"https:\/\/doi.org\/10.1016\/s1535-6108(02)00094-6","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}