{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:48:00Z","timestamp":1781898480643,"version":"3.54.5"},"reference-count":114,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4003,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1016\/s1535-6108(02)00102-2","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T13:11:47Z","timestamp":1034082707000},"page":"103-112","source":"Crossref","is-referenced-by-count":1293,"title":["The RB and p53 pathways in cancer"],"prefix":"10.1016","volume":"2","author":[{"given":"Charles J","family":"Sherr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S1535-6108(02)00102-2_BIB1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice","volume":"318","author":"Adams","year":"1985","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB2","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1073\/pnas.93.24.13742","article-title":"Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts","volume":"93","author":"Alcorta","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB3","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1074\/jbc.M108867200","article-title":"p21(Cip1) promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export","volume":"277","author":"Alt","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1172\/JCI6926","article-title":"Safety and antitumor activity of recombinant soluble Apo2 ligand","volume":"104","author":"Ashkenazi","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB5","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1128\/MCB.21.6.2144-2153.2001","article-title":"Dual inactivation of RB and p53 pathways in RAS-induced melanomas","volume":"21","author":"Bardeesy","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ijc.2910570311","article-title":"Cyclin D1 protein expression and function in human breast cancer","volume":"57","author":"Bartkova","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/25867","article-title":"p14ARF links the tumour suppressors RB and p53","volume":"395","author":"Bates","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB8","doi-asserted-by":"crossref","first-page":"25863","DOI":"10.1074\/jbc.272.41.25863","article-title":"Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4","volume":"272","author":"Blain","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB9","first-page":"2141","article-title":"Identification of novel mdm2 binding peptides by phage display","volume":"13","author":"Bottger","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0960-9822(06)00374-5","article-title":"Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo","volume":"7","author":"Bottger","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1006154900130","article-title":"Prognostic implications of expression of the cell cycle inhibitior protein p27Kip1","volume":"52","author":"Cariou","year":"1998","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm0297-227","article-title":"Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer","volume":"3","author":"Catzavelos","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB13","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.96.8.4325","article-title":"Selective killing of transformed cells by cyclin\/cyclin-dependent kinase 2 antagonists","volume":"96","author":"Chen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB14","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/emboj\/18.6.1571","article-title":"The p21Cip1 and p27Kip1 CDK \u201cinhibitors\u201d are essential activators of cyclin D-dependent kinases in murine fibroblasts","volume":"18","author":"Cheng","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB15","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1101\/gad.11.21.2822","article-title":"Cooperative effects of INK4a and ras in melanoma susceptibility in vivo","volume":"11","author":"Chin","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB16","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1101\/gad.847700","article-title":"Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions","volume":"14","author":"Dannenberg","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB17","doi-asserted-by":"crossref","first-page":"7245","DOI":"10.1073\/pnas.94.14.7245","article-title":"Distinct roles for E2F proteins in cell growth control and apoptosis","volume":"94","author":"DeGregori","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB18","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1101\/gad.12.15.2434","article-title":"E1A signaling to p53 involves the p19ARF tumor suppressor","volume":"12","author":"de Stanchina","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB19","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1128\/JVI.74.13.6147-6155.2000","article-title":"Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein","volume":"74","author":"Doronin","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB20","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/S1471-4914(02)02305-5","article-title":"STI571 (Gleevec) as a paradigm for cancer therapy","volume":"8","author":"Druker","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB21","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1101\/gad.12.15.2245","article-title":"The regulation of E2F by pRB-family proteins","volume":"12","author":"Dyson","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB22","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1101\/gad.13.20.2658","article-title":"Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis","volume":"13","author":"Eischen","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB23","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1101\/gad.9.19.2364","article-title":"Mice lacking cyclin D1 are small and show defects in eye and mammary gland development","volume":"9","author":"Fantl","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB24","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1128\/MCB.22.10.3497-3508.2002","article-title":"Oncogenic ras and p53 cooperate to induce cellular senescence","volume":"22","author":"Ferbeyre","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB25","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1126\/science.286.5449.2507","article-title":"Pharmacological rescue of mutant p53 conformation and function","volume":"286","author":"Foster","year":"1999","journal-title":"Science"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB26","doi-asserted-by":"crossref","first-page":"16617","DOI":"10.1074\/jbc.M008867200","article-title":"Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6","volume":"276","author":"Fry","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.onc.1203251","article-title":"A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo","volume":"19","author":"Fueyo","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB28","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1101\/gad.12.19.2973","article-title":"The complexity of p53 modulation: emerging patterns from divergent signals","volume":"12","author":"Giaccia","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.281.5376.533","article-title":"Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors","volume":"281","author":"Gray","year":"1988","journal-title":"Science"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrc795","article-title":"Modeling the molecular circuitry of cancer","volume":"2","author":"Hahn","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB32","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/MCB.16.3.859","article-title":"Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence","volume":"16","author":"Hara","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB33","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1101\/gad.813200","article-title":"The Rb\/E2F pathway: expanding roles and emerging paradigms","volume":"14","author":"Harbour","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB34","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1101\/gad.5.12b.2375","article-title":"p53 alteration is a common event in the spontaneous immortalization of primary BALB\/c murine embryo fibroblasts","volume":"5","author":"Harvey","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB35","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S1471-4914(02)02307-9","article-title":"Unraveling the complexities of the Raf\/MAP kinase pathway for pharmacological intervention","volume":"8","author":"Herrera","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/9035","article-title":"Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases","volume":"1","author":"Hoessel","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB37","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1101\/gad.12.23.3644","article-title":"Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes","volume":"12","author":"Holland","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev.genet.30.1.603","article-title":"Tumor suppressor gene mutations in mice","volume":"30","author":"Jacks","year":"1996","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/16476","article-title":"The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus","volume":"397","author":"Jacobs","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB40","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1101\/gad.13.20.2678","article-title":"Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc induced apoptosis via INK4a\/ARF","volume":"13","author":"Jacobs","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/81583","article-title":"Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers","volume":"26","author":"Jacobs","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/365349a0","article-title":"Expression of transcription factor E2F1 induces quiescent cells to enter S phase","volume":"365","author":"Johnson","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1535-6108(02)00060-0","article-title":"Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents","volume":"1","author":"Johnson","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","article-title":"Apoptosis: a link between cancer genetics and chemotherapy","volume":"108","author":"Johnstone","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03402141","article-title":"Mdm2: the ups and downs","volume":"5","author":"Juven-Gershon","year":"1999","journal-title":"Mol. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ng0994-22","article-title":"Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus","volume":"8","author":"Kamb","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB47","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)80452-3","article-title":"Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF","volume":"91","author":"Kamijo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB48","first-page":"2217","article-title":"Tumor spectrum in ARF-deficient mice","volume":"59","author":"Kamijo","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB49","first-page":"2464","article-title":"Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled ATM function","volume":"59","author":"Kamijo","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB50","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1073\/pnas.97.7.3266","article-title":"Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion","volume":"97","author":"Khan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB51","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/78638","article-title":"A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer","volume":"6","author":"Khuri","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB52","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.285.5434.1733","article-title":"A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy","volume":"285","author":"Komarov","year":"1999","journal-title":"Science"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/35092584","article-title":"Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice","volume":"413","author":"Krimpenfort","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB54","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1101\/gad.11.7.847","article-title":"New functional activities for the p21 family of CDK inhibitors","volume":"11","author":"LaBaer","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB55","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S1471-4914(02)02309-2","article-title":"Therapeutic exploitation of the p53 pathway","volume":"8","author":"Lane","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB56","first-page":"1833","article-title":"Selective induction of E2F1 in response to DNA damage mediated by ATM-dependent phosphorylation","volume":"15","author":"Lin","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB58","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1038\/sj.onc.1203244","article-title":"The retinoblastoma gene family in differentiation and development","volume":"18","author":"Lipinski","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB59","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ng891","article-title":"Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry","volume":"31","author":"Lomazzi","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB60","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1101\/gad.13.17.2207","article-title":"Twist is a potential oncogene that inhibits apoptosis","volume":"13","author":"Maestro","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB61","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0955-0674(99)00044-7","article-title":"How do small GTPase signal transduction pathways regulate cell cycle entry?","volume":"11","author":"Marshall","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB62","doi-asserted-by":"crossref","first-page":"11598","DOI":"10.1073\/pnas.181181198","article-title":"A phosphotidylinositol 3-kinase\/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus","volume":"96","author":"Mayo","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB63","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/35101008","article-title":"Cancer gene therapy: fringe or cutting edge?","volume":"1","author":"McCormick","year":"2001","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB64","first-page":"3145","article-title":"The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways","volume":"61","author":"Modestou","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB65","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1128\/MCB.22.7.2204-2219.2002","article-title":"ErbB2\/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells","volume":"22","author":"Muraoka","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB66","first-page":"2267","article-title":"Rate-limiting effects of cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol","volume":"62","author":"Nahta","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB67","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1200\/JCO.2001.19.2.289","article-title":"Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer","volume":"19","author":"Nemunaitis","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB68","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/hmg\/10.7.699","article-title":"The Rb\/E2F pathway and cancer","volume":"10","author":"Nevins","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB69","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.1069861","article-title":"A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in Go cells","volume":"296","author":"Ogawa","year":"2002","journal-title":"Science"},{"issue":"this issue","key":"10.1016\/S1535-6108(02)00102-2_BIB70","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1535-6108(02)00094-6","article-title":"Telomere dysfunction provokes regional amplification and deletion in cancer genomes","volume":"2","author":"O'Hagan","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB71","first-page":"73","article-title":"Cyclin D-dependent kinases. INK4 inhibitors and cancer","volume":"1602","author":"Ortega","year":"2002","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB72","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1038\/sj.onc.1202880","article-title":"Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras","volume":"18","author":"Pantoja","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB73","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1006\/jmbi.1999.2640","article-title":"Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors","volume":"287","author":"Pavletich","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB74","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nm0297-222","article-title":"Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients","volume":"3","author":"Porter","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB75","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1073\/pnas.91.23.10918","article-title":"Deregulated transcription factor E2F\u20131 expression leads to S-phase entry and p53-mediated apoptosis","volume":"91","author":"Qin","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB76","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(95)90214-7","article-title":"Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest","volume":"83","author":"Quelle","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB77","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1101\/gad.859201","article-title":"Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions","volume":"15","author":"Ramirez","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB78","doi-asserted-by":"crossref","first-page":"9654","DOI":"10.1073\/pnas.171217498","article-title":"Differential effects of p19Arf and p16Ink4a loss on senescence of murine bone marrow-derived pre-B cells and macrophages","volume":"98","author":"Randle","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB79","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1101\/gad.969202","article-title":"E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1\/mSin3B corepressor complex","volume":"16","author":"Rayman","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB80","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0092-8674(00)00123-9","article-title":"Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF","volume":"103","author":"Ries","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB81","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1128\/MCB.22.15.5308-5318.2002","article-title":"E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis","volume":"22","author":"Rogoff","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB82","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1038\/sj.onc.1202998","article-title":"The INK4 family of cell cycle inhibitors in cancer","volume":"18","author":"Roussel","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB83","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1535-6108(02)00085-5","article-title":"E2F transcriptional repressor complexes are critical downstream targets of p19ARF\/p53-induced proliferative arrest","volume":"2","author":"Rowland","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB84","first-page":"F115","article-title":"The p16INK4a\/CDKN2A tumor suppressor and its relatives","volume":"1378","author":"Ruas","year":"1998","journal-title":"BBA Rev. Cancer"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB85","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/MCB.22.5.1360-1368.2002","article-title":"ARF differentially modulates apoptosis induced by E2F1 and Myc","volume":"22","author":"Russell","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB86","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1101\/gad.843200","article-title":"Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization","volume":"14","author":"Sage","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB87","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/S1471-4914(02)02308-0","article-title":"Complexities in the development of cyclin-dependent kinase inhibitor drugs","volume":"8","author":"Sausville","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB88","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1101\/gad.13.20.2670","article-title":"INK4a\/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53","volume":"13","author":"Schmitt","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB89","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0092-8674(02)00734-1","article-title":"A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy","volume":"109","author":"Schmitt","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB90","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1200\/JCO.1997.15.11.3301","article-title":"Role of the retinoblastoma protein in the pathogenesis of human cancer","volume":"15","author":"Sellers","year":"1997","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB91","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1101\/gad.12.1.95","article-title":"Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth","volume":"12","author":"Sellers","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB92","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0092-8674(00)81079-X","article-title":"Role of the INK4a locus in tumor suppression and cell mortality","volume":"85","author":"Serrano","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB93","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB94","doi-asserted-by":"crossref","first-page":"8166","DOI":"10.1128\/MCB.14.12.8166","article-title":"Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis","volume":"14","author":"Shan","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB95","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35092592","article-title":"Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis","volume":"413","author":"Sharpless","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB96","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1101\/gad.11.11.1464","article-title":"Cyclin E-CDK2 is a regulator of p27Kip1","volume":"11","author":"Sheaff","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB97","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sherr","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB98","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/35096061","article-title":"The INK4a\/ARF network in tumour suppression","volume":"2","author":"Sherr","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB99","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0092-8674(00)00046-5","article-title":"Cellular senescence: mitotic clock or culture shock","volume":"102","author":"Sherr","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB100","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: positive and negative regulators of G1-phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB101","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0092-8674(95)90034-9","article-title":"Cyclin D1 provides a link between development and oncogenesis in the retina and breast","volume":"82","author":"Sicinski","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB102","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jnci\/93.6.436","article-title":"Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4","volume":"93","author":"Soni","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB103","first-page":"135","article-title":"Formation of p27-CDK complexes during the human mitotic cell cycle","volume":"7","author":"Soos","year":"1996","journal-title":"Cell Growth Diff."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB104","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1097-2765(01)00327-6","article-title":"The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation","volume":"8","author":"Thomas","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB105","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1128\/MCB.22.1.370-377.2002","article-title":"p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo","volume":"22","author":"Tolbert","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB106","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/med.1021","article-title":"Cyclin-dependent kinase inhibitors for treating cancer","volume":"21","author":"Toogood","year":"2001","journal-title":"Med. Res. Rev."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrm714","article-title":"Sibling rivalry in the E2F family","volume":"3","author":"Trimarchi","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB108","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0960-9822(01)00659-5","article-title":"ARF is not required for apoptosis in Rb mutant mouse embryos","volume":"12","author":"Tsai","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB109","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1093\/emboj\/16.17.5334","article-title":"Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1","volume":"16","author":"Vlach","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB110","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/369669a0","article-title":"Mammary hyperplasia carcinoma in MMTV-cyclin D1 transgenic mice","volume":"369","author":"Wang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB111","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/78592","article-title":"Telomere dynamics in cancer progression prevention: fundamental differences in human mouse telomere biology","volume":"6","author":"Wright","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/S1535-6108(02)00102-2_BIB112","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/35082500","article-title":"Specific protection against breast cancers by cyclin D1 ablation","volume":"411","author":"Yu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB113","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.onc.1201178","article-title":"Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging","volume":"15","author":"Zindy","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(02)00102-2_BIB114","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1101\/gad.12.15.2424","article-title":"Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization","volume":"12","author":"Zindy","year":"1998","journal-title":"Genes Dev."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610802001022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610802001022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T18:23:54Z","timestamp":1583519034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610802001022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":114,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S1535610802001022"],"URL":"https:\/\/doi.org\/10.1016\/s1535-6108(02)00102-2","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}