{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:13:51Z","timestamp":1775618031209,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3791,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1016\/s1535-6108(03)00047-3","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T09:27:06Z","timestamp":1081934826000},"page":"273-283","source":"Crossref","is-referenced-by-count":112,"title":["Haploinsufficiency at the Nkx3.1 locus"],"prefix":"10.1016","volume":"3","author":[{"given":"Jeffrey A","family":"Magee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarki A","family":"Abdulkadir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Milbrandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1535-6108(03)00047-3_BIB1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1128\/MCB.22.5.1495-1503.2002","article-title":"Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia","volume":"22","author":"Abdulkadir","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/pros.2990120106","article-title":"Immunohistochemical distribution of the three predominant secretory proteins in the parenchyma of hyperplastic and neoplastic prostate glands","volume":"12","author":"Abrahamsson","year":"1988","journal-title":"Prostate"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB3","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1101\/gad.13.8.966","article-title":"Roles for Nkx3.1 in prostate development and cancer","volume":"13","author":"Bhatia-Gaur","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB4","doi-asserted-by":"crossref","first-page":"31779","DOI":"10.1074\/jbc.271.50.31779","article-title":"Prostate-specific and androgen-dependent expression of a novel homeobox gene","volume":"271","author":"Bieberich","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB5","first-page":"3869","article-title":"Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer","volume":"53","author":"Bova","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB6","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1038\/sj.onc.1203653","article-title":"Accommodating haploinsufficient tumor suppressor genes in Knudson's model","volume":"19","author":"Cook","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB7","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1073\/pnas.88.11.5006","article-title":"Genetic basis for p53 overexpression in human breast cancer","volume":"88","author":"Davidoff","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/pros.2990110304","article-title":"Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement","volume":"11","author":"English","year":"1987","journal-title":"Prostate"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/24179","article-title":"The murine gene p27Kip1 is haplo-insufficient for tumour suppression","volume":"396","author":"Fero","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/(SICI)1521-1878(200004)22:4<381::AID-BIES8>3.0.CO;2-E","article-title":"To be or not to be active","volume":"22","author":"Fiering","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/geno.1997.4715","article-title":"A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer","volume":"43","author":"He","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB13","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1101\/gad.929901","article-title":"Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas","volume":"15","author":"Inoue","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB14","series-title":"Benign Prostatic Hyperplasia Volume II","article-title":"Control of cell proliferation and cell death in the normal and neoplasic prostate","author":"Isaacs","year":"1987"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/1097-0045(20000601)43:4<255::AID-PROS4>3.0.CO;2-M","article-title":"Isolation and characterization of mouse probasin","volume":"43","author":"Johnson","year":"2000","journal-title":"Prostate"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB16","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1073\/pnas.042688999","article-title":"Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis","volume":"99","author":"Kim","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB17","first-page":"1437","article-title":"Hereditary cancer, oncogenes, and antioncogenes","volume":"45","author":"Knudson","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB18","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/j.1460-2075.1990.tb07472.x","article-title":"The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates","volume":"9","author":"Ko","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB19","first-page":"5390","article-title":"Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer","volume":"55","author":"Macoska","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/349254a0","article-title":"Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18)","volume":"349","author":"McDonnell","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(89)90174-8","article-title":"bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation","volume":"57","author":"McDonnell","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB22","first-page":"1206","article-title":"Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias","volume":"55","author":"Pietenpol","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB23","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1101\/gad.949001","article-title":"Haplo-insufficiency? Let me count the ways","volume":"15","author":"Quon","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/mc.2940070303","article-title":"How many mutations are required for tumorigenesis? Implications from human cancer data","volume":"7","author":"Renan","year":"1993","journal-title":"Mol. Carcinog."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB25","first-page":"407","article-title":"Mutation rate of normal and malignant human lymphocytes","volume":"47","author":"Seshadri","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB26","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1177\/44.11.8918908","article-title":"Double immunofluorescent staining using two unconjugated primary antisera raised in the same species","volume":"44","author":"Shindler","year":"1996","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB27","doi-asserted-by":"crossref","first-page":"38524","DOI":"10.1074\/jbc.M005220200","article-title":"EGR1 target genes in prostate carcinoma cells identified by microarray analysis","volume":"275","author":"Svaren","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/(SICI)1097-0045(19980501)35:2<109::AID-PROS4>3.0.CO;2-E","article-title":"Cellular expression of beta-microseminoprotein (beta-MSP) mRNA and its protein in untreated prostate cancer","volume":"35","author":"Tsurusaki","year":"1998","journal-title":"Prostate"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB29","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1535-6108(03)00047-3_BIB30","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0012-1606(89)90276-5","article-title":"The initiation of hepatocyte-specific gene expression within embryonic hepatocytes is a stochastic event","volume":"136","author":"van Roon","year":"1989","journal-title":"Dev. Biol."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB31","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/emboj\/17.16.4657","article-title":"Retention of wild-type p53 in tumors from p53 heterozygous mice","volume":"17","author":"Venkatachalam","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S1535-6108(03)00047-3_BIB32","first-page":"4455","article-title":"Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers","volume":"57","author":"Voeller","year":"1997","journal-title":"Cancer Res."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610803000473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610803000473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:04:51Z","timestamp":1585699491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610803000473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["S1535610803000473"],"URL":"https:\/\/doi.org\/10.1016\/s1535-6108(03)00047-3","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}