{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:00:36Z","timestamp":1761843636870,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":6370,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"European Hematology Association\u2014Jos\u00e9 Carreras Foundation"},{"DOI":"10.13039\/501100022300","name":"Institut des Hautes Etudes Scientifiques","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022300","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institut de Recherches Interdisciplinaires"},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale"},{"name":"R\u00e9gion Nord"},{"name":"French Ministry of Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Novel microarray technologies such as the AB1700 platform from Applied Biosystems promise significant increases in the signal dynamic range and a higher sensitivity for weakly expressed transcripts. We have compared a representative set of AB1700 data with a similarly representative Affymetrix HG-U133A dataset. The AB1700 design extends the signal dynamic detection range at the lower bound by one order of magnitude. The lognormal signal distribution profiles of these high-sensitivity data need to be represented by two independent distributions. The additional second distribution covers those transcripts that would have gone undetected using the Affymetrix technology. The signal-dependent variance distribution in the AB1700 data is a non-trivial function of signal intensity, describable using a composite function. The drastically different structure of these high-sensitivity transcriptome profiles requires adaptation or even redevelopment of the standard microarray analysis methods. Based on the statistical properties, we have derived a signal variance distribution model for AB1700 data that is necessary for such development. Interestingly, the dual lognormal distribution observed in the AB1700 data reflects two fundamentally different biologic mechanisms of transcription initiation.<\/jats:p>","DOI":"10.1016\/s1672-0229(07)60002-3","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T05:36:27Z","timestamp":1180071387000},"page":"212-229","source":"Crossref","is-referenced-by-count":23,"title":["High-Sensitivity Transcriptome Data Structure and Implications for Analysis and Biologic Interpretation"],"prefix":"10.1093","volume":"4","author":[{"given":"Sebastian","family":"Noth","sequence":"first","affiliation":[{"name":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Brysbaert","sequence":"additional","affiliation":[{"name":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois-Xavier","family":"Pellay","sequence":"additional","affiliation":[{"name":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arndt","family":"Benecke","sequence":"additional","affiliation":[{"name":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,5,23]]},"reference":[{"key":"2024051008215517500_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/86730","article-title":"Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer","volume":"19","author":"Hughes","year":"2001","journal-title":"Nat. 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