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We conducted a study of the current availability and other features of primary bioinformatics web resources (such as software tools and databases). The majority (95%) of the examined bioinformatics web resources were found running on UNIX\/Linux operating systems, and the most widely used web server was found to be Apache (or Apache-related products). Of the overall 1,130 Uniform Resource Locators (URLs) examined, 91% were highly available (more than 90% of the time), while only 4% showed low accessibility (less than 50% of the time) during the survey. Furthermore, the most common URL failure modes are presented and analyzed.<\/jats:p>","DOI":"10.1016\/s1672-0229(07)60017-5","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T14:12:54Z","timestamp":1182003174000},"page":"70-76","source":"Crossref","is-referenced-by-count":9,"title":["A Survey of the Availability of Primary Bioinformatics Web Resources"],"prefix":"10.1093","volume":"5","author":[{"given":"Trias","family":"Thireou","sequence":"first","affiliation":[{"name":"Biomedical Informatics Unit, Foundation for Biomedical Research of the Academy of Athens , Athens, 11527 , Greece"},{"name":"Institute of Computer Science, Foundation for Research and Technology\u2013Hellas , Heraklion, Crete, 71110 , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Spyrou","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Unit, Foundation for Biomedical Research of the Academy of Athens , Athens, 11527 , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Atlamazoglou","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Unit, Foundation for Biomedical Research of the Academy of Athens , Athens, 11527 , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,6,15]]},"reference":[{"key":"2024051008244390200_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/21987","article-title":"Accessibility of information on the web","volume":"400","author":"Lawrence","year":"1999","journal-title":"Nature"},{"key":"2024051008244390200_bib2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/bib\/5.3.300","article-title":"Bioinformatics software resources","volume":"5","author":"Gilbert","year":"2004","journal-title":"Brief. 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