{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:34:18Z","timestamp":1773660858541,"version":"3.50.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":5004,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"DBT","award":["BT\/PR7507\/BID\/07\/201\/2006"],"award-info":[{"award-number":["BT\/PR7507\/BID\/07\/201\/2006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Influenza A virus (H1N1), a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission. Some strains of H5N1 subtype are highly virulent because NS1 protein inhibits antiviral interferon \u03b1\/\u03b2 production. Another protein NS2 mediates export of viral ribonucleoprotein from nucleus to the cytoplasm through export signal. In this paper, we have studied structure-function relationships of these proteins of H1N1 subtype and have determined the cause of their pathogenicity. Our results showed that non-conservative mutations slightly stabilized or destabilized structural domains of NS1 or NS1-dsRNA complex, hence slightly increased or decreased the function of NS1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus. NS2 protein of different strains carried non-conservative mutations in different domains, resulting in slight loss of function. These mutations slightly decreased the pathogenicity of the virus. Thus, the results confirm the structure-function relationships of these viral proteins.<\/jats:p>","DOI":"10.1016\/s1672-0229(10)60021-6","type":"journal-article","created":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T11:07:03Z","timestamp":1287745623000},"page":"190-199","source":"Crossref","is-referenced-by-count":9,"title":["Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype"],"prefix":"10.1093","volume":"8","author":[{"given":"Parveen","family":"Salahuddin","sequence":"first","affiliation":[{"name":"Distributed Information Sub-Centre, Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh, 202002 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Distributed Information Sub-Centre, Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh, 202002 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"key":"2024051409225588300_bib1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature08157","article-title":"Emergence and pandemic potential of swine-origin H1N1 influenza virus","volume":"459","author":"Neumann","year":"2009","journal-title":"Nature"},{"key":"2024051409225588300_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-1135(00)00164-4","article-title":"The epidemiology and evolution of influenza viruses in pigs","volume":"74","author":"Brown","year":"2000","journal-title":"Vet. Microbiol."},{"key":"2024051409225588300_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0168-1702(02)00027-8","article-title":"The emergence of novel swine influenza viruses in North America","volume":"85","author":"Olsen","year":"2002","journal-title":"Virus Res."},{"key":"2024051409225588300_bib4","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1128\/JVI.74.18.8243-8251.2000","article-title":"Evolution of swine H3N2 influenza viruses in the Unites States","volume":"74","author":"Webby","year":"2000","journal-title":"J. Virol."},{"key":"2024051409225588300_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3949\/ccjm.76a.05009","article-title":"Update on 2009 pandemic influenza A (H1N1) virus","volume":"76","author":"Gordon","year":"2009","journal-title":"Cleve. Clin. J. 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USA"},{"key":"2024051409225588300_bib15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1099\/0022-1317-78-5-1059","article-title":"Binding of the influenza virus NS1 protein to model genome RNAs","volume":"78","author":"Hatada","year":"1997","journal-title":"J. Gen. Virol."},{"key":"2024051409225588300_bib16","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1093\/nar\/25.21.4271","article-title":"The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation","volume":"25","author":"Marion","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2024051409225588300_bib17","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1099\/0022-1317-78-10-2447","article-title":"Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo","volume":"78","author":"Marion","year":"1997","journal-title":"J. Gen. 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Sin."},{"key":"2024051409225588300_bib21","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1099\/vir.0.2008\/004606-0","article-title":"The multifunctional NS1 protein of influenza A viruses","volume":"89","author":"Hale","year":"2008","journal-title":"J. Gen. Virol."},{"key":"2024051409225588300_bib22","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1128\/jvi.68.4.2433-2441.1994","article-title":"Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA","volume":"68","author":"Qian","year":"1994","journal-title":"J. Virol."},{"key":"2024051409225588300_bib23","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1128\/MCB.20.17.6259-6268.2000","article-title":"Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus","volume":"20","author":"Aragon","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"2024051409225588300_bib24","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1099\/vir.0.19487-0","article-title":"PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes","volume":"84","author":"Burgui","year":"2003","journal-title":"J. Gen. Virol."},{"key":"2024051409225588300_bib25","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1093\/nar\/27.11.2241","article-title":"Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro","volume":"27","author":"Falcon","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"2024051409225588300_bib26","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S1097-2765(00)80099-4","article-title":"Influenza virus NS1 protein interacts with the cellular 30\u2009kDa subunit of CPSF and inhibits 3\u2032 end formation of cellular pre-mRNAs","volume":"1","author":"Nemeroff","year":"1998","journal-title":"Mol. 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Virol."},{"key":"2024051409225588300_bib28","first-page":"948","article-title":"An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure","volume":"1","author":"Qian","year":"1995","journal-title":"RNA"},{"key":"2024051409225588300_bib29","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/j.1460-2075.1994.tb06310.x","article-title":"Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport","volume":"13","author":"Fortes","year":"1994","journal-title":"EMBO J."},{"key":"2024051409225588300_bib30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1099\/0022-1317-76-4-1001","article-title":"Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components","volume":"76","author":"Fortes","year":"1995","journal-title":"J. Gen. 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Virol."},{"key":"2024051409225588300_bib37","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nm757","article-title":"Lethal H5N1 influenza viruses escape host anti-viral cytokine responses","volume":"8","author":"Seo","year":"2002","journal-title":"Nat. Med."},{"key":"2024051409225588300_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01319232","article-title":"NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells","volume":"116","author":"Richardson","year":"1991","journal-title":"Arch. Virol."},{"key":"2024051409225588300_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/emboj\/17.1.288","article-title":"The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins","volume":"17","author":"O\u2019Neill","year":"1998","journal-title":"EMBO J."},{"key":"2024051409225588300_bib40","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1093\/emboj\/19.24.6751","article-title":"Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1","volume":"19","author":"Neumann","year":"2000","journal-title":"EMBO J."},{"key":"2024051409225588300_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0065-3527(05)64012-2","article-title":"Influenza virus assembly and budding at the viral budzone","volume":"64","author":"Schmitt","year":"2005","journal-title":"Adv. Virus. Res."},{"key":"2024051409225588300_bib42","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1099\/vir.0.009639-0","article-title":"NS2\/NEP protein regulates transcription and replication of the influenza virus RNA genome","volume":"90","author":"Robb","year":"2009","journal-title":"J. Gen. Virol."},{"key":"2024051409225588300_bib43","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1128\/jvi.54.3.833-843.1985","article-title":"Expression on influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eukaryotic cells","volume":"54","author":"Greenspan","year":"1985","journal-title":"J. Virol."},{"key":"2024051409225588300_bib44","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/BF01322693","article-title":"Expression and analysis of the NS2 protein of influenza A virus","volume":"140","author":"Ward","year":"1995","journal-title":"Arch. Virol."},{"key":"2024051409225588300_bib45","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1093\/emboj\/cdg449","article-title":"Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP\/NS2)","volume":"22","author":"Akarsu","year":"2003","journal-title":"EMBO J."},{"key":"2024051409225588300_bib46","doi-asserted-by":"crossref","first-page":"13257","DOI":"10.1128\/JVI.77.24.13257-13266.2003","article-title":"A recombinant influenza A virus expressing an RNA-binding defective NS1 protein induces high levels of beta interferon and is attenuated in mice","volume":"77","author":"Donelan","year":"2003","journal-title":"J. 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