{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:35:02Z","timestamp":1740144902989,"version":"3.37.3"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":4909,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30871348","30700470"],"award-info":[{"award-number":["30871348","30700470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ10303"],"award-info":[{"award-number":["GJJ10303"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Laboratory Specific Fund","award":["2060204"],"award-info":[{"award-number":["2060204"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Population genomic approaches, which take advantages of high-throughput genotyping, are powerful yet costly methods to scan for selective sweeps. DNA-pooling strategies have been widely used for association studies because it is a cost-effective alternative to large-scale individual genotyping. Here, we performed an SNP-MaP (single nucleotide polymorphism microarrays and pooling) analysis using samples from Eurasia to evaluate the efficiency of pooling strategy in genome-wide scans for selection. By conducting simulations of allelotype data, we first demonstrated that the boxplot with average heterozygosity (HET) is a promising method to detect strong selective sweeps with a moderate level of pooling error. Based on this, we used a sliding window analysis of HET to detect the large contiguous regions (LCRs) putatively under selective sweeps from Eurasia datasets. This survey identified 63 LCRs in a European population. These signals were further supported by the integrated haplotype score (iHS) test using HapMap II data. We also confirmed the European-specific signatures of positive selection from several previously identified genes (KEL, TRPV5, TRPV6, EPHB6). In summary, our results not only revealed the high credibility of SNP-MaP strategy in scanning for selective sweeps, but also provided an insight into the population differentiation.<\/jats:p>","DOI":"10.1016\/s1672-0229(10)60027-7","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T04:31:43Z","timestamp":1299558703000},"page":"256-261","source":"Crossref","is-referenced-by-count":1,"title":["Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy"],"prefix":"10.1093","volume":"8","author":[{"given":"Libin","family":"Deng","sequence":"first","affiliation":[{"name":"Faculty of Basic Medical Science, Nanchang University , Nanchang 330006 , China"},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"},{"name":"The Institute of Translational Medicine, Nanchang University , Nanchang 330006 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Tang","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Science, Nanchang University , Nanchang 330006 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"},{"name":"Graduate University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiari","family":"Lin","sequence":"additional","affiliation":[{"name":"The Institute of Translational Medicine, Nanchang University , Nanchang 330006 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"Lai","sequence":"additional","affiliation":[{"name":"The Institute of Translational Medicine, Nanchang University , Nanchang 330006 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuoqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Science, Nanchang University , Nanchang 330006 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dake","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,3,5]]},"reference":[{"key":"2024051008273608400_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1479-7364-2-2-113","article-title":"Genome-wide scans for loci under selection in humans","volume":"2","author":"Ronald","year":"2005","journal-title":"Hum. 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