{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:02:11Z","timestamp":1715385731612},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1-2","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":4788,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"Esplorazione del Sistema Solare","award":["I\/015\/07\/0"],"award-info":[{"award-number":["I\/015\/07\/0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In recent developments in chemistry and genetic engineering, the humble researcher dealing with the origin of life finds her(him)self in a grey area of tackling something that even does not yet have a clear definition agreed upon. A series of chemical steps is described to be considered as the life\u2013nonlife transition, if one adheres to the minimalistic definition: life is self-reproduction with variations. The fully artificial RNA system chosen for the exploration corresponds sequence-wise to the reconstructed initial triplet repeats, presumably corresponding to the earliest protein-coding molecules. The demonstrated occurrence of the mismatches (variations) in otherwise complementary syntheses (\u201cself-reproduction\u201d), in this RNA system, opens an experimental and conceptual perspective to explore the origin of life (and its definition), on the apparent edge of the origin.<\/jats:p>","DOI":"10.1016\/s1672-0229(11)60002-8","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T11:55:37Z","timestamp":1308916537000},"page":"7-14","source":"Crossref","is-referenced-by-count":11,"title":["On the Observable Transition to Living Matter"],"prefix":"10.1093","volume":"9","author":[{"given":"Samanta","family":"Pino","sequence":"first","affiliation":[{"name":"Charles Darwin Department of Biology and Biotechnology, Sapienza University of Roma , Roma, 00185 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward N.","family":"Trifonov","sequence":"additional","affiliation":[{"name":"Genome Diversity Center, Institute of Evolution, University of Haifa , Haifa, 31905 , Israel"},{"name":"Division of Functional Genomics and Proteomics, Faculty of Science, Masaryk University , Brno, 61137 , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Charles Darwin Department of Biology and Biotechnology, Sapienza University of Roma , Roma, 00185 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"2024051008282058000_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1093669","article-title":"Evolution. 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