{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:15:10Z","timestamp":1774988110385,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1-2","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":4788,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2007\u20134410"],"award-info":[{"award-number":["2007\u20134410"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stable isotopes of most important biological elements, such as C, H, N and O, affect living organisms. In rapidly growing species, deuterium and to a lesser extent other heavy isotopes reduce the growth rate. At least for deuterium it is known that its depletion also negatively impacts the speed of biological processes. As a rule, living organisms \u201cresist\u201d changes in their isotopic environment, preferring natural isotopic abundances. This preference could be due to evolutionary optimization; an additional effect could be due to the presence of the \u201cisotopic resonance\u201d. The isotopic resonance phenomenon has been linked to the choice of earliest amino acids, and thus affected the evolution of genetic code. To test the isotopic resonance hypothesis, literature data were analyzed against quantitative and qualitative predictions of the hypothesis. Four studies provided five independent datasets, each in very good quantitative agreement with the predictions. Thus, the isotopic resonance hypothesis is no longer simply plausible; it can now be deemed likely. Additional testing is needed, however, before full acceptance of this hypothesis.<\/jats:p>","DOI":"10.1016\/s1672-0229(11)60003-x","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T11:56:30Z","timestamp":1308916590000},"page":"15-20","source":"Crossref","is-referenced-by-count":23,"title":["Role of Stable Isotopes in Life\u2014Testing Isotopic Resonance Hypothesis"],"prefix":"10.1093","volume":"9","author":[{"given":"Roman A.","family":"Zubarev","sequence":"first","affiliation":[{"name":"Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute , Stockholm, SE-17 177 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"2024051008283262900_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1021\/ac00253a037","article-title":"Isotopic distributions in mass spectra of large molecules","volume":"55","author":"Yergey","year":"1983","journal-title":"Anal. Chem."},{"key":"2024051008283262900_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1103\/PhysRev.39.164","article-title":"A hydrogen isotope of mass 2","volume":"39","author":"Urey","year":"1932","journal-title":"Phys. Rev."},{"key":"2024051008283262900_bib3","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1007\/PL00014267","article-title":"Safety of stable isotope use","volume":"156","author":"Koletzko","year":"1997","journal-title":"Eur. J. Pediatr."},{"key":"2024051008283262900_bib4","first-page":"641","article-title":"Some observations on biological effects of deuterium, with special reference to effects on neoplastic processes","volume":"18","author":"Katz","year":"1957","journal-title":"J. Natl. Cancer Inst."},{"key":"2024051008283262900_bib5","first-page":"286","volume-title":"Isotope Effects in Chemical Reactions","author":"Katz","year":"1971"},{"key":"2024051008283262900_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1152\/ajplegacy.1961.201.2.357","article-title":"Physiological effects of deuterium on dogs","volume":"201","author":"Czajka","year":"1961","journal-title":"Am. J. Physiol."},{"key":"2024051008283262900_bib7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1152\/ajplegacy.1962.203.5.907","article-title":"Course of deuteration and some physiological effects of deuterium in mice","volume":"203","author":"Katz","year":"1962","journal-title":"Am. J. Physiol."},{"key":"2024051008283262900_bib8","first-page":"627","article-title":"Plasma cholesterol synthesis using deuterated water in humans: effects of short-term food restriction","volume":"111","author":"Jones","year":"1988","journal-title":"J. Lab. Clin. Med."},{"key":"2024051008283262900_bib9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0304-4165(67)90191-2","article-title":"A living organism of unusual isotopic composition. Sequential and cumulative replacement of stable isotopes in Chlorella vulgaris","volume":"141","author":"Uphaus","year":"1967","journal-title":"Biochim. Biophys. Acta"},{"key":"2024051008283262900_bib10","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1126\/science.151.3715.1187","article-title":"Deuterated organisms: cultivation and uses","volume":"151","author":"Katz","year":"1966","journal-title":"Science"},{"key":"2024051008283262900_bib11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1073\/pnas.46.6.777","article-title":"Anomalous growth of microorganisms produced by changes in isotopes in their environment","volume":"46","author":"Borek","year":"1960","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024051008283262900_bib12","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/bit.260140511","article-title":"Kinetic studies of C. pyrenoidosa using 94% 13C CO2","volume":"14","author":"Fowler","year":"1972","journal-title":"Biotechnol. Bioengineer."},{"key":"2024051008283262900_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0005-2744(69)90365-9","article-title":"Purification and characterization of fully deuterated enzymes","volume":"191","author":"Rokop","year":"1969","journal-title":"Biochim. Biophys. Acta"},{"key":"2024051008283262900_bib14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1046\/j.1365-2672.2003.01866.x","article-title":"Improved methods of cultivation and production of deuteriated proteins from E. coli strains grown on fully deuteriated minimal medium","volume":"94","author":"Paliy","year":"2003","journal-title":"J. Appl. Microbiol."},{"key":"2024051008283262900_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0024-3205(73)90068-4","article-title":"Substantial replacement of mammalian body carbon with carbon-13","volume":"13","author":"Gregg","year":"1973","journal-title":"Life Sci."},{"key":"2024051008283262900_bib16","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/j.1552-4604.1986.tb03544.x","article-title":"Stable isotopes: origins and safety","volume":"26","author":"Klein","year":"1986","journal-title":"J. Clin. Pharmacol."},{"key":"2024051008283262900_bib17","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1128\/AEM.02906-06","article-title":"Stable isotope ratios and forensic analysis of microorganisms","volume":"73","author":"Kreuzer-Martin","year":"2007","journal-title":"Appl. Envir. Microbiol."},{"key":"2024051008283262900_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1469-185X.2008.00064.x","article-title":"Isotopic ecology: ten years after a call for more laboratory experiments","volume":"84","author":"del Rio","year":"2009","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"2024051008283262900_bib19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1139\/Z08-012","article-title":"Caution on isotopic model use for analyses of consumer diet","volume":"86","author":"Caut","year":"2008","journal-title":"Canadian J. Zool."},{"key":"2024051008283262900_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ecocom.2004.07.001","article-title":"Application of thermodynamic principles in ecology","volume":"1","author":"J\u00f8rgensen","year":"2004","journal-title":"Ecol. Complex."},{"key":"2024051008283262900_bib21","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1128\/jb.178.15.4530-4539.1996","article-title":"Temperature-dependent growth kinetics of Escherichia coli ML 30 in glucose-limited continuous culture","volume":"178","author":"Kovarova","year":"1996","journal-title":"J. Bacteriol."},{"key":"2024051008283262900_bib22","first-page":"3407","article-title":"Effects of heavy water (D2O) on human pancreatic tumor cells","volume":"25","author":"Hartmann","year":"2005","journal-title":"Anticancer Res."},{"key":"2024051008283262900_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(93)81479-J","article-title":"Naturally occurring deuterium is essential for the normal growth rate of cells","volume":"317","author":"Somlyai","year":"1993","journal-title":"FEBS Lett."},{"key":"2024051008283262900_bib24","first-page":"190","article-title":"Early life relict feature in peptide mass distribution","volume":"5","author":"Zubarev","year":"2010","journal-title":"Cent. Eur. J. Biol."},{"key":"2024051008283262900_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ajpa.21222","article-title":"Tissue isotopic enrichment associated with growth depression in a pig: implications for archaeology and ecology","volume":"141","author":"Warinner","year":"2010","journal-title":"Am. J. Phys. Antropology"},{"key":"2024051008283262900_bib26","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/rcm.2424","article-title":"The role of stable isotopes in human identification: a longitudinal study into the variability of isotopic signals in human hair and nails","volume":"20","author":"Fraser","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"2024051008283262900_bib27","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ajpa.21008","article-title":"Dietary and physiological controls on the hydrogen and oxygen isotope ratios of hair from mid-20th century indigenous populations","volume":"139","author":"Bowen","year":"2009","journal-title":"Am. J. Phys. Antropol."},{"key":"2024051008283262900_bib28","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/ajpa.21162","article-title":"Stable isotope analysis of modern human hair collected from Asia (China, India, Mongolia, and Pakistan)","volume":"141","author":"Thompson","year":"2010","journal-title":"Am. J. Phys. Antropol."},{"key":"2024051008283262900_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0304-4165(70)90092-9","article-title":"Isotope biology of 13C extensive incorporation of highly enriched 13C in the alga Chlorella vulgaris","volume":"215","author":"Flaumenhaft","year":"1970","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Genomics, Proteomics &amp; Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S167202291160003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S167202291160003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/9\/1-2\/15\/57483600\/gpb_9_1-2_15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gpb\/article-pdf\/9\/1-2\/15\/57483600\/gpb_9_1-2_15.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T08:31:07Z","timestamp":1715329867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gpb\/article\/9\/1-2\/15\/7221882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,1]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,4,1]]}},"URL":"https:\/\/doi.org\/10.1016\/s1672-0229(11)60003-x","relation":{},"ISSN":["1672-0229","2210-3244"],"issn-type":[{"value":"1672-0229","type":"print"},{"value":"2210-3244","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,4]]},"published":{"date-parts":[[2011,4,1]]}}}