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Until now, little is known about their roles in plant drought resistance. Physcomitrella patens is highly tolerant to drought; however, it is not clear about the basic biology of the traits that contribute P. patens this important character. In this work, we discovered 16 drought stress-associated miRNA (DsAmR) families in P. patens through computational analysis. Due to the possible discrepancy of expression periods and tissue distributions between potential DsAmRs and their targeting genes, and the existence of false positive results in computational identification, the prediction results should be examined with further experimental validation. We also constructed an miRNA co-regulation network, and identified two network hubs, miR902a-5p and miR414, which may play important roles in regulating drought-resistance traits. We distributed our results through an online database named ppt-miRBase, which can be accessed at http:\/\/bioinfor.cnu.edu.cn\/ppt_miRBase\/index.php. Our methods in finding DsAmR and miRNA co-regulation network showed a new direction for identifying miRNA functions.<\/jats:p>","DOI":"10.1016\/s1672-0229(11)60006-5","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T11:56:12Z","timestamp":1308916572000},"page":"37-44","source":"Crossref","is-referenced-by-count":26,"title":["Computational Analysis of Drought Stress-Associated miRNAs and miRNA Co-Regulation Network in <i>Physcomitrella Patens<\/i>"],"prefix":"10.1093","volume":"9","author":[{"given":"Ping","family":"Wan","sequence":"first","affiliation":[{"name":"College of Life Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junshu","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weizhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanglong","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University , Beijing, 100048 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Informatics, Indiana University-Purdue University Indianapolis , IN, 46202 , USA"},{"name":"Department of Computer & Information Science, Purdue University , IN, 47907 , USA"},{"name":"Indiana Center for Systems Biology and Personalized Medicine , IN, 46202 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"2024051008282287300_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1046\/j.1365-313X.2002.01359.x","article-title":"Monitoring the expression profiles of 7,000 Arabidopsis genes under drought, cold and high-salinity stresses using a full-length cDNA microarray","volume":"31","author":"Seki","year":"2002","journal-title":"Plant J."},{"key":"2024051008282287300_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1469-8137.2007.02187.x","article-title":"Microarray analysis of transcriptional responses to abscisic acid and osmotic, salt, and drought stress in the moss, Physcomitrella patens","volume":"176","author":"Cuming","year":"2007","journal-title":"New Phytol."},{"key":"2024051008282287300_bib3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00036962","article-title":"Common amino acid sequence domains among the LEA proteins of higher plants","volume":"12","author":"Dure","year":"1989","journal-title":"Plant Mol. 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