{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:05:18Z","timestamp":1771470318921,"version":"3.50.1"},"reference-count":30,"publisher":"Medical Association of Pharmacopuncture Institute","issue":"1","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":1813,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Korea Pharmacopuncture Institute and the Blue-Bio Industry RIC at Dongeui University as a RIC","award":["08-06-07"],"award-info":[{"award-number":["08-06-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Acupuncture and Meridian Studies"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/s2005-2901(10)60004-0","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T00:36:16Z","timestamp":1270600576000},"page":"24-31","source":"Crossref","is-referenced-by-count":51,"title":["Induction of Apoptosis by Ethanol Extracts of Ganoderma lucidum in Human Gastric Carcinoma Cells"],"prefix":"10.51507","volume":"3","author":[{"given":"Kyung-Jun","family":"Jang","sequence":"first","affiliation":[]},{"given":"Min-Ho","family":"Han","sequence":"additional","affiliation":[]},{"given":"Byung-Hoon","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Byung-Woo","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Cheol-Hong","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Hyun-Min","family":"Yoon","sequence":"additional","affiliation":[]},{"given":"Yung-Hyun","family":"Choi","sequence":"additional","affiliation":[]}],"member":"28906","reference":[{"key":"10.1016\/S2005-2901(10)60004-0_bib1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3322\/canjclin.55.3.178","article-title":"Targeting apoptosis pathways in cancer therapy","volume":"55","author":"Ghobrial","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/S2005-2901(10)60004-0_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5483\/BMBRep.2008.41.1.001","article-title":"Role of apoptotic and necrotic cell death under physiologic conditions","volume":"41","author":"Han","year":"2008","journal-title":"BMB Rep"},{"key":"10.1016\/S2005-2901(10)60004-0_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4161\/cbt.4.2.1508","article-title":"Overview of cell death signaling pathways","volume":"4","author":"Jin","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/S2005-2901(10)60004-0_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5483\/BMBRep.2008.41.1.011","article-title":"The role of mitochondria in apoptosis","volume":"41","author":"Jeong","year":"2008","journal-title":"BMB Rep"},{"key":"10.1016\/S2005-2901(10)60004-0_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/138945007780362764","article-title":"The apoptotic pathway as a therapeutic target in sepsis","volume":"8","author":"Wesche-Soldato","year":"2007","journal-title":"Curr Drug Targets"},{"key":"10.1016\/S2005-2901(10)60004-0_bib6","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1038\/sj.onc.1209598","article-title":"Mitochondria as therapeutic targets for cancer chemotherapy","volume":"25","author":"Galluzzi","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/S2005-2901(10)60004-0_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000103747","article-title":"Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection","volume":"20","author":"Javadov","year":"2007","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/S2005-2901(10)60004-0_bib8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1101\/gad.11.6.701","article-title":"The PI3-kinase\/Akt signaling pathway delivers an anti-apoptotic signal","volume":"11","author":"Kennedy","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/S2005-2901(10)60004-0_bib9","first-page":"1250","article-title":"Targeting the phosphatidylinositol-3 kinase\/Akt pathway for the treatment of cancer","volume":"6","author":"Kim","year":"2005","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/S2005-2901(10)60004-0_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/01635580802379323","article-title":"Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum","volume":"61","author":"Mahajna","year":"2009","journal-title":"Nutr Cancer"},{"key":"10.1016\/S2005-2901(10)60004-0_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1387-2656(07)13010-6","article-title":"Ganoderma lucidum and its pharmaceutically active compounds","volume":"13","author":"Boh","year":"2007","journal-title":"Biotechnol Annu Rev"},{"key":"10.1016\/S2005-2901(10)60004-0_bib12","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.phytochem.2006.07.004","article-title":"Ganoderma: a therapeutic fungal biofactory","volume":"67","author":"Paterson","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/S2005-2901(10)60004-0_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1207\/s15327914nc5301_2","article-title":"Anticancer effects of Ganoderma lucidum: a review of scientific evidence","volume":"53","author":"Yuen","year":"2005","journal-title":"Nutr Cancer"},{"key":"10.1016\/S2005-2901(10)60004-0_bib14","first-page":"7891","article-title":"Gene expression and mitotic exit induced by microtubule-stabilizing drugs","volume":"63","author":"Chen","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/S2005-2901(10)60004-0_bib15","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1016\/j.bmc.2004.08.004","article-title":"Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56 + NK-cell cytotoxicity in cord blood","volume":"12","author":"Chien","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/S2005-2901(10)60004-0_bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1254\/jphs.CRJ05008X","article-title":"Cellular and molecular mechanisms of immunomodulation by Ganoderma lucidum","volume":"99","author":"Lin","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/S2005-2901(10)60004-0_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ijc.10707","article-title":"Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell","volume":"102","author":"Hu","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/S2005-2901(10)60004-0_bib18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0006-291X(02)02496-8","article-title":"Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells","volume":"298","author":"Sliva","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S2005-2901(10)60004-0_bib19","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/S0024-3205(03)00124-3","article-title":"Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogenactivated protein kinases and G2-phase cell cycle arrest","volume":"72","author":"Lin","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/S2005-2901(10)60004-0_bib20","first-page":"1093","article-title":"Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3","volume":"24","author":"Jiang","year":"2004","journal-title":"Int J Oncol"},{"key":"10.1016\/S2005-2901(10)60004-0_bib21","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/ptr.1495","article-title":"Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells","volume":"18","author":"Hong","year":"2004","journal-title":"Phytother Res"},{"key":"10.1016\/S2005-2901(10)60004-0_bib22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2005.02.116","article-title":"Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-a1 from prostate cancer cells","volume":"330","author":"Stanley","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S2005-2901(10)60004-0_bib23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.leukres.2005.12.004","article-title":"Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells","volume":"30","author":"M\u00fcller","year":"2006","journal-title":"Leuk Res"},{"key":"10.1016\/S2005-2901(10)60004-0_bib24","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1021\/jf900011f","article-title":"Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines","volume":"57","author":"Liu","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.1016\/S2005-2901(10)60004-0_bib25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.canlet.2008.12.009","article-title":"Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells","volume":"277","author":"Sadava","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/S2005-2901(10)60004-0_bib26","doi-asserted-by":"crossref","first-page":"9893","DOI":"10.1073\/pnas.93.18.9893","article-title":"Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria","volume":"93","author":"Murphy","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S2005-2901(10)60004-0_bib27","first-page":"1","article-title":"Specific alteration of the Bax\/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons","volume":"23","author":"Thees","year":"2005","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/S2005-2901(10)60004-0_bib28","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.embor.7400795","article-title":"Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family","volume":"7","author":"Eckelman","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1016\/S2005-2901(10)60004-0_bib29","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s10495-007-0087-3","article-title":"The inhibitors of apoptosis (IAPs) as cancer targets","volume":"12","author":"Hunter","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/S2005-2901(10)60004-0_bib30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/371346a0","article-title":"Cleavage of polyADP-ribose polymerase by a proteinase with properties like ICE","volume":"371","author":"Lazebnik","year":"1994","journal-title":"Nature"}],"container-title":["Journal of Acupuncture and Meridian Studies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2005290110600040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2005290110600040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T21:10:35Z","timestamp":1610485835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2005290110600040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S2005290110600040"],"URL":"https:\/\/doi.org\/10.1016\/s2005-2901(10)60004-0","relation":{},"ISSN":["2005-2901"],"issn-type":[{"value":"2005-2901","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}