{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:47:32Z","timestamp":1788320852915,"version":"build-2803163510"},"reference-count":96,"publisher":"Elsevier","isbn-type":[{"value":"9780323988377","type":"print"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/bs.acc.2021.09.004","type":"book-chapter","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T04:14:06Z","timestamp":1644466446000},"page":"67-89","source":"Crossref","is-referenced-by-count":5,"title":["Metabolomics of peripheral artery disease"],"prefix":"10.1016","member":"78","reference":[{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0010","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a000588","article-title":"Metabolomics: an emerging but powerful tool for precision medicine","volume":"1","author":"Clish","year":"2015","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"issue":"2784","key":"10.1016\/bs.acc.2021.09.004_bb0015","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.107.2784.481","article-title":"Paper chromatography using capillary ascent","volume":"107","author":"Williams","year":"1948","journal-title":"Science"},{"issue":"5481","key":"10.1016\/bs.acc.2021.09.004_bb0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/252285a0","article-title":"Observation of tissue metabolites using P-31 nuclear magnetic-resonance","volume":"252","author":"Hoult","year":"1974","journal-title":"Nature"},{"issue":"5216","key":"10.1016\/bs.acc.2021.09.004_bb0025","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.7770779","article-title":"Chemical characterization of a family of brain lipids that induce sleep","volume":"268","author":"Cravatt","year":"1995","journal-title":"Science"},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/metabo9040076","article-title":"Systems biology and multi-omics integration: viewpoints from the metabolomics research community","volume":"9","author":"Pinu","year":"2019","journal-title":"Metabolites"},{"issue":"D1","key":"10.1016\/bs.acc.2021.09.004_bb0035","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: The human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"Database issue","key":"10.1016\/bs.acc.2021.09.004_bb0040","first-page":"D801","article-title":"HMDB 3.0\u2014The Human Metabolome Database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/bs.acc.2021.09.004_bb0045","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.ftd.0000179845.53213.39","article-title":"METLIN: a metabolite mass spectral database","volume":"27","author":"Smith","year":"2005","journal-title":"Ther. Drug Monit."},{"issue":"Database issue","key":"10.1016\/bs.acc.2021.09.004_bb0050","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the human metabolome database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/bs.acc.2021.09.004_bb0055","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpba.2014.12.020","article-title":"Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery","volume":"107","author":"Patel","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"9","key":"10.1016\/bs.acc.2021.09.004_bb0060","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1161\/CIRCRESAHA.117.311002","article-title":"Cardiovascular metabolomics","volume":"122","author":"McGarrah","year":"2018","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/bs.acc.2021.09.004_bb0065","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/ac051437y","article-title":"XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification","volume":"78","author":"Smith","year":"2006","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0070","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0731-7085(03)00410-2","article-title":"A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects","volume":"33","author":"Lenz","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0075","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.cbpa.2003.08.008","article-title":"Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis","volume":"7","author":"Griffin","year":"2003","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/bs.acc.2021.09.004_bb0080","first-page":"790132","article-title":"Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases","volume":"2011","author":"Barderas","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"issue":"2","key":"10.1016\/bs.acc.2021.09.004_bb0085","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0003-2697(89)90153-X","article-title":"Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry","volume":"179","author":"Loo","year":"1989","journal-title":"Anal. Biochem."},{"issue":"11","key":"10.1016\/bs.acc.2021.09.004_bb0090","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s13361-012-0462-3","article-title":"Application of probe electrospray ionization mass spectrometry (PESI-MS) to clinical diagnosis: solvent effect on lipid analysis","volume":"23","author":"Mandal","year":"2012","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0095","doi-asserted-by":"crossref","DOI":"10.1088\/1752-7155\/5\/1\/016002","article-title":"Secondary electrospray ionization-mass spectrometry: breath study on a control group","volume":"5","author":"Martinez-Lozano","year":"2011","journal-title":"J. Breath Res."},{"issue":"2","key":"10.1016\/bs.acc.2021.09.004_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1021\/cr990091m","article-title":"Separations combined with mass spectrometry","volume":"101","author":"Tomer","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/bs.acc.2021.09.004_bb0105","first-page":"1","article-title":"Selection of analytical methodology for metabolomics","volume":"18","author":"Wiedmer","year":"2013","journal-title":"Chromatogr. Methods Metabolom."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0110","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.semnephrol.2010.07.007","article-title":"Analytical approaches to metabolomics and applications to systems biology","volume":"30","author":"Wang","year":"2010","journal-title":"Semin. Nephrol."},{"issue":"6","key":"10.1016\/bs.acc.2021.09.004_bb0115","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/COH.0b013e32833ed177","article-title":"What are biomarkers?","volume":"5","author":"Strimbu","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0120","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1038\/s41467-019-11311-9","article-title":"A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals","volume":"10","author":"Deelen","year":"2019","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/bs.acc.2021.09.004_bb0125","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.dld.2019.01.012","article-title":"Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection","volume":"51","author":"Farowski","year":"2019","journal-title":"Digest. Liv. Dis."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/metabo8010011","article-title":"Metabolomics and biomarkers for drug discovery","volume":"8","author":"Yeung","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/bs.acc.2021.09.004_bb0135","first-page":"354671","article-title":"Metabolomics for biomarker discovery: moving to the clinic","volume":"2015","author":"Zhang","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"9","key":"10.1016\/bs.acc.2021.09.004_bb0140","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMcp1507631","article-title":"Clinical practice. Peripheral artery disease","volume":"374","author":"Kullo","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"5I","key":"10.1016\/bs.acc.2021.09.004_bb0145","article-title":"Disease location is associated with survival in patients with peripheral arterial disease","volume":"2","author":"Chen","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"10190","key":"10.1016\/bs.acc.2021.09.004_bb0150","doi-asserted-by":"crossref","first-page":"E44","DOI":"10.1016\/S0140-6736(19)31429-1","volume":"393","author":"Roberts","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/bs.acc.2021.09.004_bb0155","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2018.05.033","article-title":"Update on peripheral artery disease: epidemiology and evidence-based facts","volume":"275","author":"Shu","year":"2018","journal-title":"Atherosclerosis"},{"issue":"Suppl S","key":"10.1016\/bs.acc.2021.09.004_bb0160","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-society consensus for the management of peripheral arterial disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J. Vasc. Surg."},{"issue":"13","key":"10.1016\/bs.acc.2021.09.004_bb0165","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1161\/CIR.0b013e31828b82aa","article-title":"Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF\/AHA guideline recommendations): a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"127","author":"Anderson","year":"2013","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/bs.acc.2021.09.004_bb0170","first-page":"e686","article-title":"2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"135","author":"Gerhard-Herman","year":"2017","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/bs.acc.2021.09.004_bb0175","doi-asserted-by":"crossref","first-page":"e980","DOI":"10.1016\/S2214-109X(19)30293-1","article-title":"Differential burden of peripheral artery disease","volume":"7","author":"Kengne","year":"2019","journal-title":"Lancet Glob. Health"},{"issue":"21","key":"10.1016\/bs.acc.2021.09.004_bb0180","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200105243442108","article-title":"Medical treatment of peripheral arterial disease and claudication","volume":"344","author":"Hiatt","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0185","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/1358863X10378376","article-title":"Sensitivity and specificity of the ankle\u2014brachial index to diagnose peripheral artery disease: a structured review","volume":"15","author":"Dachun","year":"2010","journal-title":"Vasc. Med."},{"issue":"3","key":"10.1016\/bs.acc.2021.09.004_bb0190","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11883-013-0393-x","article-title":"Ankle-brachial index and its link to automated carotid ultrasound measurement of intima-media thickness variability in 500 Japanese coronary artery disease patients","volume":"16","author":"Ikeda","year":"2014","journal-title":"Curr. Atheroscler. Rep."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0195","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jacc.2005.09.065","article-title":"Peripheral arterial disease in patients with diabetes","volume":"47","author":"Marso","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"16","key":"10.1016\/bs.acc.2021.09.004_bb0200","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.jacc.2013.01.054","article-title":"Association between advanced age and vascular disease in different arterial territories a population database of over 3.6 million subjects","volume":"61","author":"Savji","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/bs.acc.2021.09.004_bb0205","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jvs.2019.05.050","article-title":"Critical analysis and limitations of resting ankle-brachial index in the diagnosis of symptomatic peripheral arterial disease patients and the role of diabetes mellitus and chronic kidney disease","volume":"71","author":"AbuRahma","year":"2020","journal-title":"J. Vasc. Surg."},{"issue":"7","key":"10.1016\/bs.acc.2021.09.004_bb0210","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrcardio.2011.66","article-title":"Peripheral artery disease. Part 1: clinical evaluation and noninvasive diagnosis","volume":"8","author":"Lau","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1358836X0000500109","article-title":"Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease","volume":"5","author":"Brass","year":"2000","journal-title":"Vasc. Med."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2007.11.002","article-title":"Endothelial dysfunction: a key to the pathophysiology and natural history of peripheral arterial disease?","volume":"197","author":"Brevetti","year":"2008","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/bs.acc.2021.09.004_bb0225","article-title":"Oxidative stress and arterial dysfunction in peripheral artery disease","volume":"7","author":"Ismaeel","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"7","key":"10.1016\/bs.acc.2021.09.004_bb0230","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13650","article-title":"Oxidative stress and antioxidant treatment in patients with peripheral artery disease","volume":"6","author":"Koutakis","year":"2018","journal-title":"Physiol. Rep."},{"issue":"11","key":"10.1016\/bs.acc.2021.09.004_bb0235","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.2217\/bmm-2017-0110","article-title":"Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives","volume":"11","author":"Sinning","year":"2017","journal-title":"Biomark Med."},{"key":"10.1016\/bs.acc.2021.09.004_bb0240","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1479-5876-11-230","article-title":"Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease","volume":"11","author":"Weiss","year":"2013","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0245","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/eurheartj\/ehl533","article-title":"Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease","volume":"28","author":"Loffredo","year":"2007","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0250","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/joim.12102","article-title":"Medical management of critical limb ischaemia: where do we stand today?","volume":"274","author":"Lambert","year":"2013","journal-title":"J. Int. Med."},{"key":"10.1016\/bs.acc.2021.09.004_bb0255","first-page":"28","article-title":"Surveillance of peripheral arterial disease cases using natural language processing of clinical notes","volume":"2017","author":"Afzal","year":"2017","journal-title":"AMIA Jt. Summits Transl. Sci. Proc."},{"issue":"8","key":"10.1016\/bs.acc.2021.09.004_bb0260","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007332","article-title":"Frequency of care and mortality following an incident diagnosis of peripheral artery disease in the inpatient or outpatient setting: the ARIC (atherosclerosis risk in communities) study","volume":"7","author":"Kalbaugh","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"19","key":"10.1016\/bs.acc.2021.09.004_bb0265","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/archinte.163.19.2306","article-title":"Peripheral arterial disease: identification and implications","volume":"163","author":"Mohler","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/bs.acc.2021.09.004_bb0270","doi-asserted-by":"crossref","first-page":"2760272","DOI":"10.1155\/2018\/2760272","article-title":"Plasma energy-balance metabolites discriminate asymptomatic patients with peripheral artery disease","volume":"2018","author":"Hernandez-Aguilera","year":"2018","journal-title":"Mediators Inflamm."},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0275","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jvs.2013.04.022","article-title":"Plasma metabolomic profiles predict near-term death among individuals with lower extremity peripheral arterial disease","volume":"58","author":"Huang","year":"2013","journal-title":"J. Vasc. Surg."},{"issue":"12","key":"10.1016\/bs.acc.2021.09.004_bb0280","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/hr.2015.71","article-title":"Metabolomic signature of arterial stiffness in male patients with peripheral arterial disease","volume":"38","author":"Zagura","year":"2015","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0285","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.numecd.2017.07.011","article-title":"Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis","volume":"28","author":"Paapstel","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"9","key":"10.1016\/bs.acc.2021.09.004_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8091463","article-title":"Altered metabolomic profile in patients with peripheral artery disease","volume":"8","author":"Ismaeel","year":"2019","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/bs.acc.2021.09.004_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9061877","article-title":"Serum metabolic signatures of chronic limb-threatening ischemia in patients with peripheral artery disease","volume":"9","author":"Azab","year":"2020","journal-title":"J. Clin. Med."},{"issue":"20","key":"10.1016\/bs.acc.2021.09.004_bb0300","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1039\/C8AN01017J","article-title":"Multiple reaction monitoring (MRM)-profiling with biomarker identification by LC-QTOF to characterize coronary artery disease","volume":"143","author":"Yannell","year":"2018","journal-title":"Analyst"},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0305","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.jvs.2017.09.029","article-title":"Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes","volume":"68","author":"Cason","year":"2018","journal-title":"J. Vasc. Surg."},{"issue":"8","key":"10.1016\/bs.acc.2021.09.004_bb0310","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007546","article-title":"Metabolomic profiling in acute ST-segment-elevation myocardial infarction identifies succinate as an early marker of human ischemia-reperfusion injury","volume":"7","author":"Kohlhauer","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"7527","key":"10.1016\/bs.acc.2021.09.004_bb0315","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"issue":"18","key":"10.1016\/bs.acc.2021.09.004_bb0320","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.jacc.2011.09.083","article-title":"Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models","volume":"59","author":"Bodi","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/bs.acc.2021.09.004_bb0325","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/1538574407311106","article-title":"The myopathy of peripheral arterial occlusive disease: part 1. Functional and histomorphological changes and evidence for mitochondrial dysfunction","volume":"41","author":"Pipinos","year":"2007","journal-title":"Vasc. Endovasc. Surg."},{"key":"10.1016\/bs.acc.2021.09.004_bb0330","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/msb4100205","article-title":"1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death","volume":"4","author":"Makinen","year":"2008","journal-title":"Mol. Syst. Biol."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0335","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/MOL.0b013e32832fa22c","article-title":"Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans","volume":"20","author":"Santovito","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"issue":"Suppl B","key":"10.1016\/bs.acc.2021.09.004_bb0340","first-page":"72B","article-title":"Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk","volume":"22","author":"Anderson","year":"2006","journal-title":"Can. J. Cardiol."},{"issue":"21","key":"10.1016\/bs.acc.2021.09.004_bb0345","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur. Heart J."},{"issue":"10","key":"10.1016\/bs.acc.2021.09.004_bb0350","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/jch.12167","article-title":"Increased aortic stiffness and related factors in patients with peripheral arterial disease","volume":"15","author":"Catalano","year":"2013","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"issue":"13","key":"10.1016\/bs.acc.2021.09.004_bb0355","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jacc.2009.10.061","article-title":"Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis","volume":"55","author":"Vlachopoulos","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0360","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12868-016-0256-9","article-title":"Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia","volume":"17","author":"Zhang","year":"2016","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0365","doi-asserted-by":"crossref","first-page":"11742","DOI":"10.1038\/s41598-019-48227-9","article-title":"Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention","volume":"9","author":"Surendran","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.acc.2021.09.004_bb0370","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2164-7-142","article-title":"Centering, scaling, and transformations: improving the biological information content of metabolomics data","author":"van den Berg","year":"2006","journal-title":"BMC Genom."},{"issue":"8793","key":"10.1016\/bs.acc.2021.09.004_bb0375","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-Z","article-title":"Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure","volume":"339","author":"Vallance","year":"1992","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0380","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/bs.acc.2021.09.004_bb0385","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ahj.2012.02.005","article-title":"Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease","volume":"163","author":"Shah","year":"2012","journal-title":"Am. Heart J."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0390","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12031-015-0659-6","article-title":"Serum phenylalanine, tyrosine, and their ratio in acute ischemic stroke: on the trail of a biomarker?","volume":"58","author":"Ormstad","year":"2016","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0395","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1203\/00006450-199710000-00002","article-title":"Analysis of phenylalanine hydroxylase genotypes and hyperphenylalaninemia phenotypes using L-[1-13C]phenylalanine oxidation rates in vivo: a pilot study","volume":"42","author":"Treacy","year":"1997","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0400","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jvs.2004.03.043","article-title":"Nitric oxide and arterial disease","volume":"40","author":"Barbato","year":"2004","journal-title":"J. Vasc. Surg."},{"issue":"2","key":"10.1016\/bs.acc.2021.09.004_bb0405","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.niox.2011.04.004","article-title":"Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease","volume":"25","author":"Crabtree","year":"2011","journal-title":"Nitric Oxide"},{"issue":"6","key":"10.1016\/bs.acc.2021.09.004_bb0410","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00424-010-0808-2","article-title":"Nitric oxide and oxidative stress in vascular disease","volume":"459","author":"Forstermann","year":"2010","journal-title":"Pflugers Arch."},{"issue":"2","key":"10.1016\/bs.acc.2021.09.004_bb0415","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1074\/jbc.M805403200","article-title":"Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase I expression","volume":"284","author":"Crabtree","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/bs.acc.2021.09.004_bb0420","article-title":"The nitric oxide system in peripheral artery disease: connection with oxidative stress and biopterins","volume":"9","author":"Ismaeel","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0425","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1161\/01.CIR.84.4.1490","article-title":"Muscle carnitine deficiency in patients with severe peripheral vascular disease","volume":"84","author":"Brevetti","year":"1991","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/bs.acc.2021.09.004_bb0430","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1038\/s41598-017-06767-y","article-title":"Decreased long-chain acylcarnitines from insufficient beta-oxidation as potential early diagnostic markers for Parkinson's disease","volume":"7","author":"Saiki","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/bs.acc.2021.09.004_bb0435","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/sleep\/34.3.349","article-title":"Abnormally low serum acylcarnitine levels in narcolepsy patients","volume":"34","author":"Miyagawa","year":"2011","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/bs.acc.2021.09.004_bb0440","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.atherosclerosis.2013.10.029","article-title":"Metabolomics signature improves the prediction of cardiovascular events in elderly subjects","volume":"232","author":"Rizza","year":"2014","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/bs.acc.2021.09.004_bb0445","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3390\/ijms15022991","article-title":"Lipidomic analysis of serum from high fat diet induced obese mice","volume":"15","author":"Eisinger","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0450","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/j.1523-1755.2004.00914.x","article-title":"HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X","volume":"66","author":"Roberts","year":"2004","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/bs.acc.2021.09.004_bb0455","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.RES.0000147558.15554.67","article-title":"Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a: cholesterol acyltransferase 2 have opposite atherosclerotic potential","volume":"95","author":"Lee","year":"2004","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/bs.acc.2021.09.004_bb0460","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1161\/ATVBAHA.118.312236","article-title":"Metabolomic pattern predicts incident coronary heart disease","volume":"39","author":"Wang","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/bs.acc.2021.09.004_bb0465","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev-med-060513-093205","article-title":"The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases","volume":"66","author":"Brown","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/bs.acc.2021.09.004_bb0470","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52082-z","article-title":"Trimethylamine-N-oxide (TMAO) predicts cardiovascular mortality in peripheral artery disease","author":"Roncal","year":"2019","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/bs.acc.2021.09.004_bb0475","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004237","article-title":"Trimethylamine N-oxide and mortality risk in patients with peripheral artery disease","volume":"5","author":"Senthong","year":"2016","journal-title":"J. Am. Heart Assoc."},{"issue":"1-2","key":"10.1016\/bs.acc.2021.09.004_bb0480","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cca.2005.06.013","article-title":"Monitoring tryptophan metabolism in chronic immune activation","volume":"364","author":"Schrocksnadel","year":"2006","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/bs.acc.2021.09.004_bb0485","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/107999000312306","article-title":"Tumor necrosis factor-alpha and lipopolysaccharide enhance interferon-induced antichlamydial indoleamine dioxygenase activity independently","volume":"20","author":"Currier","year":"2000","journal-title":"J. Interferon Cytokine Res."}],"container-title":["Advances in Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065242321000780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065242321000780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:20:11Z","timestamp":1753363211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065242321000780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9780323988377"],"references-count":96,"URL":"https:\/\/doi.org\/10.1016\/bs.acc.2021.09.004","relation":{},"ISSN":["0065-2423"],"issn-type":[{"value":"0065-2423","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}