{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:35:31Z","timestamp":1781019331802,"version":"3.54.1"},"reference-count":231,"publisher":"Elsevier","isbn-type":[{"value":"9780443192883","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172370"],"award-info":[{"award-number":["82172370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["2019HQZX06"],"award-info":[{"award-number":["2019HQZX06"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2020jcyj-msxmX0173"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0173"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.acc.2023.02.004","type":"book-chapter","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T16:47:09Z","timestamp":1679417229000},"page":"109-150","source":"Crossref","is-referenced-by-count":5,"title":["Advances in liquid biopsy\u2013based markers in NSCLC"],"prefix":"10.1016","member":"78","reference":[{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA. Cancer J. Clin."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.21037\/tlcr.2016.06.07","article-title":"Non-small cell lung cancer: current treatment and future advances","volume":"5","author":"Zappa","year":"2016","journal-title":"Transl. Lung Cancer Res"},{"issue":"18","key":"10.1016\/bs.acc.2023.02.004_bib3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.21037\/atm-20-5952","article-title":"Unique genomic features and prognostic value of COSMIC mutational signature 4 in lung adenocarcinoma and lung squamous cell carcinoma","volume":"8","author":"Cai","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hoc.2016.08.006","article-title":"Wistuba, II, lung cancer biomarkers","volume":"31","author":"Villalobos","year":"2017","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00408-020-00407-5","article-title":"Update 2020: management of non-small cell lung cancer","volume":"198","author":"Alexander","year":"2020","journal-title":"Lung"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.thorsurg.2020.01.001","article-title":"Adjuvant and neoadjuvant immunotherapy in non-small cell lung cancer","volume":"30","author":"Broderick","year":"2020","journal-title":"Thorac. Surg. Clin."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jmoldx.2021.02.002","article-title":"KRAS G12C-mutant non-small cell lung cancer: biology, developmental therapeutics, and molecular testing","volume":"23","author":"Veluswamy","year":"2021","journal-title":"J. Mol. Diagn."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J. Thorac. Oncol"},{"issue":"Pt 1","key":"10.1016\/bs.acc.2023.02.004_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.semcancer.2017.11.019","article-title":"Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): moving from targeted therapy to immunotherapy","volume":"52","author":"Osmani","year":"2018","journal-title":"Semin. Cancer Biol."},{"issue":"8","key":"10.1016\/bs.acc.2023.02.004_bib10","doi-asserted-by":"crossref","DOI":"10.1097\/JTO.0b013e3181e0b977","article-title":"Screening for lung cancer with low-dose computed tomography: a systematic review and meta-analysis of the baseline findings of randomized controlled trials","volume":"5","author":"Gopal","year":"2010","journal-title":"J. Thorac. Oncol"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/thx.2007.087015","article-title":"Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas","volume":"63","author":"Zhang","year":"2008","journal-title":"Thorax"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib12","doi-asserted-by":"crossref","first-page":"P7","DOI":"10.1164\/rccm.19010P7","article-title":"Lung cancer prevention","volume":"190","author":"Slatore","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/bs.acc.2023.02.004_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2019.102862","article-title":"Diagnosis and treatment of early and locally advanced non-small-cell lung cancer: the 2019 AIOM (Italian Association of Medical Oncology) clinical practice guidelines","volume":"148","author":"Passiglia","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/bs.acc.2023.02.004_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ypmed.2016.04.015","article-title":"Screening for lung cancer: a systematic review and meta-analysis","volume":"89","author":"Usman Ali","year":"2016","journal-title":"Prev. Med."},{"key":"10.1016\/bs.acc.2023.02.004_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lungcan.2021.11.015","article-title":"A risk prediction model for selecting high-risk population for computed tomography lung cancer screening in China","volume":"163","author":"Guo","year":"2022","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.21037\/tlcr.2017.02.05","article-title":"Risk assessment in relation to the detection of small pulmonary nodules","volume":"6","author":"Field","year":"2017","journal-title":"Transl. Lung Cancer Res"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1373\/clinchem.2012.194258","article-title":"Circulating tumor cells: liquid biopsy of cancer","volume":"59","author":"Alix-Panabi\u00e8res","year":"2013","journal-title":"Clin. Chem"},{"key":"10.1016\/bs.acc.2023.02.004_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.nbt.2019.09.006","article-title":"The pre-analytical phase of the liquid biopsy","volume":"55","author":"Salvianti","year":"2020","journal-title":"N. Biotechnol."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4132\/jptm.2020.02.27","article-title":"Current status and future perspectives of liquid biopsy in non-small cell lung cancer","volume":"54","author":"Chang","year":"2020","journal-title":"J. Pathol. Transl. Med"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00595-020-02148-7","article-title":"Liquid biopsy as a perioperative biomarker of digestive tract cancers: review of the literature","volume":"51","author":"Shoda","year":"2021","journal-title":"Surg. Today"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib23","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.7150\/ijbs.44024","article-title":"Circulating tumor DNA as an emerging liquid biopsy biomarker for early diagnosis and therapeutic monitoring in hepatocellular carcinoma","volume":"16","author":"Wu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12943-019-1043-x","article-title":"Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA","volume":"18","author":"Ye","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib25","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3389\/fgene.2019.01150","article-title":"DNA methylation cancer biomarkers: translation to the clinic","volume":"10","author":"Locke","year":"2019","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40246-019-0220-8","article-title":"Next-generation sequencing in liquid biopsy: cancer screening and early detection","volume":"13","author":"Chen","year":"2019","journal-title":"Hum. Genomics"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/annonc\/mdx504","article-title":"Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer","volume":"29","author":"Siena","year":"2018","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1159\/000499337","article-title":"Liquid biopsy: general concepts","volume":"63","author":"Poulet","year":"2019","journal-title":"Acta Cytol"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ccell.2017.07.004","article-title":"Swarm intelligence-enhanced detection of non-small-cell lung cancer using tumor-educated platelets","volume":"32","author":"Best","year":"2017","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/bs.acc.2023.02.004_bib30","article-title":"The analysis of platelet-derived circRNA repertoire as potential diagnostic biomarker for non-small cell lung cancer","volume":"13","author":"D'Ambrosi","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/bs.acc.2023.02.004_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.735682","article-title":"Cell-free DNA as a diagnostic and prognostic biomarker in dogs with tumors","volume":"8","author":"Kim","year":"2021","journal-title":"Front. Vet. Sci."},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib32","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1158\/1541-7786.MCR-16-0044","article-title":"Cell-free DNA (cfDNA): clinical significance and utility in cancer shaped by emerging technologies","volume":"14","author":"Volik","year":"2016","journal-title":"Mol. Cancer Res"},{"key":"10.1016\/bs.acc.2023.02.004_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.gpb.2018.06.002","article-title":"5-Hydroxymethylome in circulating cell-free DNA as a potential biomarker for non-small-cell lung cancer","author":"Zhang","year":"2018","journal-title":"Genom. Proteom.\u00a0Bioinformat."},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib34","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.jtho.2019.08.003","article-title":"Monitoring therapeutic response and resistance: analysis of circulating tumor DNA in patients with ALK+ lung cancer","volume":"14","author":"Horn","year":"2019","journal-title":"J. Thorac. Oncol"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001942","article-title":"Cell-free DNA copy number variations predict efficacy of immune checkpoint inhibitor-based therapy in hepatobiliary cancers","volume":"9","author":"Yang","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib36","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.2147\/OTT.S100901","article-title":"Cell-free DNA as a diagnostic marker for cancer: current insights","volume":"9","author":"Salvi","year":"2016","journal-title":"Onco. Targets Ther."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib37","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/cas.13972","article-title":"Clinical utility of circulating tumor DNA for colorectal cancer","volume":"110","author":"Osumi","year":"2019","journal-title":"Cancer Sci"},{"issue":"16","key":"10.1016\/bs.acc.2023.02.004_bib38","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1002\/cncr.33571","article-title":"High concordance of actionable genomic alterations identified between circulating tumor DNA-based and tissue-based next-generation sequencing testing in advanced non-small cell lung cancer: the Korean Lung Liquid Versus Invasive Biopsy Program","volume":"127","author":"Park","year":"2021","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/bs.acc.2023.02.004_bib39","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1111\/1759-7714.13201","article-title":"Detection of EGFR gene mutation status from pleural effusions and other body fluid specimens in patients with lung adenocarcinoma","volume":"10","author":"Zhang","year":"2019","journal-title":"Thorac Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2018.03.009","article-title":"Urine proteome profiling predicts lung cancer from control cases and other tumors","volume":"30","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.currproblcancer.2021.100722","article-title":"EGFR mutation testing on plasma and urine samples: A pilot study evaluating the value of liquid biopsy in lung cancer diagnosis and management","volume":"45","author":"Satapathy","year":"2021","journal-title":"Curr Probl Cancer"},{"issue":"16","key":"10.1016\/bs.acc.2023.02.004_bib42","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1158\/1078-0432.CCR-19-2896","article-title":"Detection of promoter DNA methylation in urine and plasma aids the detection of non-small cell lung cancer","volume":"26","author":"Liu","year":"2020","journal-title":"Clin. Cancer Res"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cllc.2021.09.002","article-title":"Genetic profiling of cell-free DNA from pleural effusion in advanced lung cancer as a surrogate for tumor tissue and revealed additional clinical actionable targets","volume":"23","author":"Tu","year":"2022","journal-title":"Clin. Lung Cancer"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib44","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.21037\/tlcr-20-882","article-title":"A multicenter real-world study of tumor-derived DNA from pleural effusion supernatant in genomic profiling of advanced lung cancer","volume":"9","author":"Jin","year":"2020","journal-title":"Transl. Lung Cancer Res"},{"issue":"19","key":"10.1016\/bs.acc.2023.02.004_bib45","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.7150\/thno.34070","article-title":"Tumor-derived DNA from pleural effusion supernatant as a promising alternative to tumor tissue in genomic profiling of advanced lung cancer","volume":"9","author":"Tong","year":"2019","journal-title":"Theranostics"},{"issue":"2020","key":"10.1016\/bs.acc.2023.02.004_bib46","first-page":"2950751","article-title":"Malignant pleural effusion: diagnosis and management","author":"Ferreiro","year":"2020","journal-title":"Can. Respir. J."},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib47","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1007\/s11033-020-05869-7","article-title":"Liquid biopsy approaches for pleural effusion in lung cancer patients","volume":"47","author":"Baburaj","year":"2020","journal-title":"Mol Biol Rep"},{"issue":"22","key":"10.1016\/bs.acc.2023.02.004_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225701","article-title":"Current approaches in NSCLC targeting K-RAS and EGFR","volume":"20","author":"Aran","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib49","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.7150\/jca.49647","article-title":"Combined assay of circulating tumor DNA and protein biomarkers for early noninvasive detection and prognosis of non-small cell lung cancer","volume":"12","author":"Yin","year":"2021","journal-title":"J. Cancer"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14020296","article-title":"Aberrant methylation of SLIT2 gene in plasma cell-free DNA of non-small cell lung cancer patients","volume":"14","author":"Kim","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib52","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13148-018-0527-7","article-title":"Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer","volume":"10","author":"Peng","year":"2018","journal-title":"Clin. Epigenetics"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.gpb.2018.06.002","article-title":"5-Hydroxymethylome in circulating cell-free DNA as a potential biomarker for non-small-cell lung cancer","volume":"16","author":"Zhang","year":"2018","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib54","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s11255-013-0491-2","article-title":"Plasma cell-free DNA and its DNA integrity as biomarker to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate-specific antigen","volume":"45","author":"Feng","year":"2013","journal-title":"Int. Urol. Nephrol."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib55","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1038\/s41598-021-84507-z","article-title":"Cell-free DNA concentration and fragment size as a biomarker for prostate cancer","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib56","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/bjc.2015.225","article-title":"Cell-free DNA levels in plasma of patients with non-small-cell lung cancer and inflammatory lung disease","volume":"113","author":"Szpechcinski","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib57","first-page":"45","article-title":"Serum circulating cell free DNA as potential diagnostic and prognostic biomarker in non small cell lung cancer","volume":"15","author":"Soliman","year":"2018","journal-title":"Biochem. Biophys. Rep."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/14737159.2020.1860021","article-title":"Concentration of cell-free DNA in different tumor types","volume":"21","author":"Bryzgunova","year":"2021","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib59","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2014.222679","article-title":"Circulating tumor DNA as a liquid biopsy for cancer","volume":"61","author":"Heitzer","year":"2015","journal-title":"Clin. Chem"},{"key":"10.1016\/bs.acc.2023.02.004_bib60","article-title":"Current treatments for non-small cell lung cancer","volume":"12","author":"Guo","year":"2022","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib61","article-title":"Liquid biopsy in lung cancer: clinical applications of circulating biomarkers (CTCs and ctDNA)","volume":"9","author":"Lim","year":"2018","journal-title":"Micromachines (Basel)"},{"key":"10.1016\/bs.acc.2023.02.004_bib62","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fonc.2014.00281","article-title":"Clinical utility of circulating tumor cells in ALK-positive non-small-cell lung cancer","volume":"4","author":"Faugeroux","year":"2014","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib63","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/17476348.2020.1714441","article-title":"Targeted therapy of oncogenic-driven advanced non-small cell lung cancer: recent advances and new perspectives","volume":"14","author":"Genova","year":"2020","journal-title":"Expert Rev. Respir. Med"},{"key":"10.1016\/bs.acc.2023.02.004_bib64","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.lungcan.2020.07.033","article-title":"Retrospective analysis of real-world data to determine clinical outcomes of patients with advanced non-small cell lung cancer following cell-free circulating tumor DNA genomic profiling","volume":"148","author":"Madison","year":"2020","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib65","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2014.222679","article-title":"Circulating tumor DNA as a liquid biopsy for cancer","volume":"61","author":"Heitzer","year":"2015","journal-title":"Clin. Chem"},{"issue":"15","key":"10.1016\/bs.acc.2023.02.004_bib66","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1158\/1078-0432.CCR-19-0624","article-title":"Clinical utility of comprehensive cell-free DNA analysis to identify genomic biomarkers in patients with newly diagnosed metastatic non-small cell lung cancer","volume":"25","author":"Leighl","year":"2019","journal-title":"Clin. Cancer Res"},{"issue":"19","key":"10.1016\/bs.acc.2023.02.004_bib67","doi-asserted-by":"crossref","first-page":"1900721","DOI":"10.1002\/advs.201900721","article-title":"Circulating DNA-based sequencing guided anlotinib therapy in non-small cell lung cancer","volume":"6","author":"Lu","year":"2019","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/bs.acc.2023.02.004_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00318","article-title":"Use of low-frequency driver mutations detected by cell-free circulating tumor DNA to guide targeted therapy in non-small-cell lung cancer: a multicenter case series","volume":"2","author":"Jacobs","year":"2018","journal-title":"JCO Precis. Oncol"},{"issue":"14","key":"10.1016\/bs.acc.2023.02.004_bib69","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1002\/cncr.32876","article-title":"Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: analysis of over 8000 cases","volume":"126","author":"Mack","year":"2020","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib70","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41571-018-0081-4","article-title":"Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?","volume":"15","author":"Recondo","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib71","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12943-018-0793-1","article-title":"EGFR-TKIs resistance via EGFR-independent signaling pathways","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib72","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41416-019-0573-8","article-title":"Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer","volume":"121","author":"Leonetti","year":"2019","journal-title":"Br. J. Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.722078","article-title":"Whole-exome sequencing on circulating tumor cells explores platinum-drug resistance mutations in advanced non-small cell lung cancer","volume":"12","author":"Chang","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/bs.acc.2023.02.004_bib74","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.semcancer.2020.07.009","article-title":"Precision medicine in non-small cell lung cancer: Current applications and future directions","volume":"84","author":"Yang","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib75","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/1878-0261.12983","article-title":"Mutated circulating tumor DNA as a liquid biopsy in lung cancer detection and treatment","volume":"15","author":"Filipska","year":"2021","journal-title":"Mol. Oncol."},{"issue":"14","key":"10.1016\/bs.acc.2023.02.004_bib76","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1002\/cam4.3948","article-title":"Next-generation sequencing of tissue and circulating tumor DNA: Resistance mechanisms to EGFR targeted therapy in a cohort of patients with advanced non-small cell lung cancer","volume":"10","author":"Zhang","year":"2021","journal-title":"Cancer Med"},{"key":"10.1016\/bs.acc.2023.02.004_bib77","article-title":"The potential use of dynamics changes of ctDNA and cfDNA in the perioperative period to predict the recurrence risk in early NSCLC","volume":"11","author":"Zhao","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/bs.acc.2023.02.004_bib78","doi-asserted-by":"crossref","first-page":"31985","DOI":"10.1038\/srep31985","article-title":"Circulating tumor DNA detection in early-stage non-small cell lung cancer patients by targeted sequencing","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/bs.acc.2023.02.004_bib79","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3390\/cells10081912","article-title":"Liquid biopsy for disease monitoring in non-small cell lung cancer: the link between biology and the clinic","volume":"10","author":"Fernandes","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib80","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cllc.2020.06.015","article-title":"Duration of targeted therapy in patients with advanced non-small-cell lung cancer identified by circulating tumor DNA analysis","volume":"21","author":"Reckamp","year":"2020","journal-title":"Clin. Lung Cancer"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib81","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001504","article-title":"Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)","volume":"9","author":"Ricciuti","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040947","article-title":"Genomic profiling of circulating tumor DNA predicts outcome and demonstrates tumor evolution in ALK-positive non-small cell lung cancer patients","volume":"12","author":"Madsen","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib83","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00280-021-04230-4","article-title":"Monitoring of EGFR mutations in circulating tumor DNA of non-small cell lung cancer patients treated with EGFR inhibitors","volume":"87","author":"Verheijen","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib84","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/ijc.30650","article-title":"Analysis of ctDNA to predict prognosis and monitor treatment responses in metastatic pancreatic cancer patients","volume":"140","author":"Cheng","year":"2017","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib85","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1158\/0008-5472.CAN-18-1127","article-title":"Dynamics of tumor and immune responses during immune checkpoint blockade in non-small cell lung cancer","volume":"79","author":"Anagnostou","year":"2019","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib86","first-page":"242","article-title":"Recurrence after surgery in patients with NSCLC","volume":"3","author":"Uramoto","year":"2014","journal-title":"Transl. Lung Cancer Res"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib87","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/j.cllc.2017.01.014","article-title":"Definitive radiotherapy for local recurrence of NSCLC after surgery","volume":"18","author":"Wu","year":"2017","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.561598","article-title":"Circulating tumor DNA as a prognostic biomarker in localized non-small cell lung cancer","volume":"10","author":"Peng","year":"2020","journal-title":"Front. Oncol."},{"issue":"23","key":"10.1016\/bs.acc.2023.02.004_bib89","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.1002\/cam4.4339","article-title":"Potential utility of longitudinal somatic mutation and methylation profiling for predicting molecular residual disease in postoperative non-small cell lung cancer patients","volume":"10","author":"Li","year":"2021","journal-title":"Cancer Med"},{"issue":"15","key":"10.1016\/bs.acc.2023.02.004_bib90","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1158\/1078-0432.CCR-21-3044","article-title":"Perioperative ctDNA-based molecular residual disease detection for non-small cell lung cancer: a prospective multicenter cohort study (LUNGCA-1)","volume":"28","author":"Xia","year":"2022","journal-title":"Clin. Cancer Res"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib91","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/1878-0261.13116","article-title":"Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer","volume":"16","author":"Waldeck","year":"2022","journal-title":"Mol. Oncol."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib92","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.annonc.2022.02.007","article-title":"Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer","volume":"33","author":"Gale","year":"2022","journal-title":"Ann. Oncol."},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib93","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1111\/cas.14155","article-title":"Genomic profile of urine has high diagnostic sensitivity compared to cytology in non-invasive urothelial bladder cancer","volume":"110","author":"Hirotsu","year":"2019","journal-title":"Cancer Sci"},{"issue":"12","key":"10.1016\/bs.acc.2023.02.004_bib94","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1016\/j.ejso.2021.07.017","article-title":"Detection of KRAS mutations in circulating tumour DNA from plasma and urine of patients with colorectal cancer","volume":"47","author":"Ohta","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"issue":"8","key":"10.1016\/bs.acc.2023.02.004_bib95","article-title":"Detection of CTNNB1 hotspot mutations in cell-free DNA from the urine of hepatocellular carcinoma patients","volume":"11","author":"Lin","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"D1","key":"10.1016\/bs.acc.2023.02.004_bib96","doi-asserted-by":"crossref","first-page":"D40","DOI":"10.1093\/nar\/gkz715","article-title":"CFEA: a cell-free epigenome atlas in human diseases","volume":"48","author":"Yu","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib97","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1002\/ijc.32356","article-title":"Noninvasive diagnosis of urothelial cancer in urine using DNA hypermethylation signatures-Gender matters","volume":"145","author":"K\u00f6hler","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib98","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13148-021-01073-x","article-title":"A urine-based DNA methylation assay to facilitate early detection and risk stratification of bladder cancer","volume":"13","author":"Ruan","year":"2021","journal-title":"Clin. Epigenetics"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031117","article-title":"ITIH5 and ECRG4 DNA methylation biomarker test (EI-BLA) for urine-based non-invasive detection of bladder cancer","volume":"21","author":"Rose","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.acc.2023.02.004_bib100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13148-018-0524-x","article-title":"A panel of DNA methylation markers for the detection of prostate cancer from FV and DRE urine DNA","volume":"10","author":"Brikun","year":"2018","journal-title":"Clin. Epigenetics"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib101","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2217\/pme-2020-0019","article-title":"Concentration and integrity indexes of urine cell-free DNA as promising biomarkers for early lung cancer diagnosis","volume":"18","author":"Ren","year":"2021","journal-title":"Per. Med."},{"issue":"8","key":"10.1016\/bs.acc.2023.02.004_bib102","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23321","article-title":"Urine cell-free DNA as a promising biomarker for early detection of non-small cell lung cancer","volume":"34","author":"Ren","year":"2020","journal-title":"J. Clin. Lab. Anal"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib103","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/ijc.27369","article-title":"ALU and LINE-1 hypomethylations in multistep gastric carcinogenesis and their prognostic implications","volume":"131","author":"Bae","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib104","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.canep.2016.02.004","article-title":"Hypomethylation of repetitive elements in blood leukocyte DNA and risk of gastric lesions in a Chinese population","volume":"41","author":"Chen","year":"2016","journal-title":"Cancer Epidemiol"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib105","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1038\/s41467-018-04745-0","article-title":"Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract","volume":"9","author":"Burnham","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib106","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s12094-017-1669-3","article-title":"Utility of urinary circulating tumor DNA for EGFR mutation detection in different stages of non-small cell lung cancer patients","volume":"19","author":"Li","year":"2017","journal-title":"Clin. Transl. Oncol."},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib107","first-page":"2318","article-title":"Clinical applications of urinary cell-free DNA in cancer: current insights and promising future","volume":"7","author":"Lu","year":"2017","journal-title":"Am. J. Cancer Res."},{"issue":"7","key":"10.1016\/bs.acc.2023.02.004_bib108","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.21037\/jtd.2018.06.50","article-title":"Urinary circulating DNA profiling in non-small cell lung cancer patients following treatment shows prognostic potential","volume":"10","author":"Hu","year":"2018","journal-title":"J. Thorac. Dis"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib109","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3233\/CBM-181511","article-title":"Comparison of circulating DNA from plasma and urine for EGFR mutations in NSCLC patients","volume":"23","author":"Zhang","year":"2018","journal-title":"Cancer Biomark"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/CBM-182344","article-title":"Circulating tumor cell free DNA from plasma and urine in the clinical management of colorectal cancer","volume":"27","author":"Yu","year":"2020","journal-title":"Cancer Biomark"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib111","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jtho.2016.05.035","article-title":"A highly sensitive and quantitative test platform for detection of NSCLC EGFR mutations in urine and plasma","volume":"11","author":"Reckamp","year":"2016","journal-title":"J. Thorac. Oncol."},{"issue":"14","key":"10.1016\/bs.acc.2023.02.004_bib112","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1158\/1078-0432.CCR-16-2592","article-title":"Mutation-enrichment next-generation sequencing for quantitative detection of KRAS mutations in urine cell-free DNA from patients with advanced cancers","volume":"23","author":"Fujii","year":"2017","journal-title":"Clin. Cancer Res"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib113","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41551-021-00837-3","article-title":"Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics","volume":"6","author":"Song","year":"2022","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib114","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.amjms.2018.10.006","article-title":"Urinary and plasma cell-free DNA comparison for lung cancer patients treated with epidermal growth factor receptor-thyroxine kinase inhibitors","volume":"357","author":"Yu","year":"2019","journal-title":"Am. J. Med. Sci."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib115","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12094-016-1534-9","article-title":"Urinary circulating DNA detection for dynamic tracking of EGFR mutations for NSCLC patients treated with EGFR-TKIs","volume":"19","author":"Chen","year":"2017","journal-title":"Clin. Transl. Oncol."},{"issue":"1\u20132","key":"10.1016\/bs.acc.2023.02.004_bib116","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cell.2018.11.046","article-title":"Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding","volume":"176","author":"Gkountela","year":"2019","journal-title":"Cell"},{"key":"10.1016\/bs.acc.2023.02.004_bib117","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.lungcan.2019.06.016","article-title":"Circulating tumor cell clusters are a potential biomarker for detection of non-small cell lung cancer","volume":"134","author":"Yma","year":"2019","journal-title":"Lung Cancer"},{"issue":"24","key":"10.1016\/bs.acc.2023.02.004_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13246362","article-title":"Sequential isolation and characterization of single CTCs and large CTC clusters in metastatic colorectal cancer patients","volume":"13","author":"Francescangeli","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"jan.","key":"10.1016\/bs.acc.2023.02.004_bib119","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.snb.2016.05.163","article-title":"An integrated microfluidic chip for one-step isolation of circulating tumor cells","volume":"238","author":"Lee","year":"2017","journal-title":"Sensor. Actuat. B-chem."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib120","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.21873\/invivo.11571","article-title":"Circulating tumor cells in diagnosis and treatment of lung cancer","volume":"33","author":"Maly","year":"2019","journal-title":"In Vivo"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib121","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.7150\/thno.18588","article-title":"Circulating tumor cells: moving biological insights into detection","volume":"7","author":"Chen","year":"2017","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib122","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12010127","article-title":"High-throughput label-free isolation of heterogeneous circulating tumor cells and CTC clusters from non-small-cell lung cancer patients","volume":"12","author":"Zeinali","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib123","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13045-019-0735-4","article-title":"Technologies for circulating tumor cell separation from whole blood","volume":"12","author":"Bank\u00f3","year":"2019","journal-title":"J. Hematol. Oncol"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib124","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Dagogo-Jack","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib125","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2741\/4893","article-title":"EMT imparts cancer stemness and plasticity: new perspectives and therapeutic potential","volume":"26","author":"Roy","year":"2021","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"12","key":"10.1016\/bs.acc.2023.02.004_bib126","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.21037\/jtd.2017.11.106","article-title":"Association of epithelial-to-mesenchymal transition circulating tumor cells in non-small cell lung cancer (NSCLC) molecular subgroups","volume":"9","author":"Messaritakis","year":"2017","journal-title":"J. Thorac. Dis"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092158","article-title":"Clinical relevance of mesenchymal- and stem-associated phenotypes in circulating tumor cells isolated from lung cancer patients","volume":"13","author":"Pantazaka","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib128","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s00432-020-03244-4","article-title":"Correlations between circulating tumor cell phenotyping and 18F-fluorodeoxyglucose positron emission tomography uptake in non-small cell lung cancer","volume":"146","author":"Bian","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/bs.acc.2023.02.004_bib129","first-page":"3506874","article-title":"Molecular detection of EMT markers in circulating tumor cells from metastatic non-small cell lung cancer patients: potential role in clinical practice","volume":"2018","author":"Milano","year":"2018","journal-title":"Anal. Cell. Pathol. (Amst)"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib130","doi-asserted-by":"crossref","first-page":"486","DOI":"10.21037\/tlcr.2017.05.07","article-title":"Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer","volume":"6","author":"Gallo","year":"2017","journal-title":"Transl. Lung Cancer Res"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib131","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1593\/tlo.13535","article-title":"Folate receptor-positive circulating tumor cells as a novel diagnostic biomarker in non-small cell lung cancer","volume":"6","author":"Yu","year":"2013","journal-title":"Transl. Oncol."},{"key":"10.1016\/bs.acc.2023.02.004_bib132","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2147\/OTT.S241956","article-title":"Circulating tumor cells as a screening and diagnostic marker for early-stage non-small cell lung cancer","volume":"13","author":"Duan","year":"2020","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/bs.acc.2023.02.004_bib133","doi-asserted-by":"crossref","first-page":"5727815","DOI":"10.1155\/2017\/5727815","article-title":"Circulating tumor cells were associated with the number of T lymphocyte subsets and NK cells in peripheral blood in advanced non-small-cell lung cancer","volume":"2017","author":"Ye","year":"2017","journal-title":"Dis. Markers"},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib134","first-page":"3799","article-title":"Isolation of circulating tumor cells and detection of EGFR mutations in patients with non-small-cell lung cancer","volume":"17","author":"Zhang","year":"2019","journal-title":"Oncol. Lett."},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib135","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s12094-017-1652-z","article-title":"Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer","volume":"19","author":"Li","year":"2017","journal-title":"Clin. Transl. Oncol."},{"issue":"7","key":"10.1016\/bs.acc.2023.02.004_bib136","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8071011","article-title":"Prognostic relevance of circulating tumor cells and circulating cell-free DNA association in metastatic non-small cell lung cancer treated with nivolumab","volume":"8","author":"Alama","year":"2019","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib137","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.21037\/tcr.2019.09.43","article-title":"Identification of plasma exosomes long non-coding RNA HAGLR and circulating tumor cells as potential prognosis biomarkers in non-small cell lung cancer","volume":"8","author":"Rao","year":"2019","journal-title":"Transl. Cancer Res."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib138","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s40425-019-0649-2","article-title":"Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors","volume":"7","author":"Tamminga","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib139","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.21037\/tlcr-20-841","article-title":"Enumeration and molecular characterization of circulating tumor cells enriched by microcavity array from stage III non-small cell lung cancer patients","volume":"9","author":"Cohen","year":"2020","journal-title":"Transl. Lung Cancer Res"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib140","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1007\/s00259-021-05260-z","article-title":"18F-FDG PET\/CT and circulating tumor cells in treatment-naive patients with non-small-cell lung cancer","volume":"48","author":"Zhang","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"17","key":"10.1016\/bs.acc.2023.02.004_bib141","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13174488","article-title":"Subpopulations of circulating cells with morphological features of malignancy are preoperatively detected and have differential prognostic significance in non-small cell lung cancer","volume":"13","author":"Fina","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib142","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cllc.2021.03.005","article-title":"PD-L1 expression in circulating tumor cells as a promising prognostic biomarker in advanced non-small-cell lung cancer treated with immune checkpoint inhibitors","volume":"22","author":"Dall'Olio","year":"2021","journal-title":"Clin. Lung Cancer"},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib143","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/clinchem\/hvab131","article-title":"Programmed cell death ligand 1-expressing circulating tumor cells: a new prognostic biomarker in non-small cell lung cancer","volume":"67","author":"Sinoquet","year":"2021","journal-title":"Clin. Chem"},{"key":"10.1016\/bs.acc.2023.02.004_bib144","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.2147\/IJGM.S330361","article-title":"Aneuploid circulating tumor cells as a predictor of response to neoadjuvant chemotherapy in non-small cell lung cancer","volume":"14","author":"Huang","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/bs.acc.2023.02.004_bib145","article-title":"Evaluation of cell surface vimentin positive circulating tumor cells as a diagnostic biomarker for lung cancer","volume":"11","author":"Xie","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib146","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2012228118","article-title":"Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients","volume":"118","author":"Yang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib147","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrclinonc.2016.144","article-title":"Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape","volume":"14","author":"Mohme","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib148","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cllc.2019.04.011","article-title":"Early detection of recurrence in patients with locally advanced non-small-cell lung cancer via circulating tumor cell analysis","volume":"20","author":"Chinniah","year":"2019","journal-title":"Clin. Lung Cancer"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib149","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1158\/1078-0432.CCR-19-2158","article-title":"Circulating tumor cells are associated with recurrent disease in patients with early-stage non-small cell lung cancer treated with stereotactic body radiotherapy","volume":"26","author":"Frick","year":"2020","journal-title":"Clin. Cancer Res"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib150","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cllc.2018.11.014","article-title":"Dynamic monitoring and predictive value of circulating tumor cells in EGFR-mutated advanced non-small-cell lung cancer patients treated with first-line EGFR tyrosine kinase inhibitors","volume":"20","author":"Jiang","year":"2019","journal-title":"Clin. Lung Cancer"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib151","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.21037\/jtd-20-1636","article-title":"Circulating tumor cells detected only after surgery for non-small cell lung cancer: is it a predictor of recurrence","volume":"12","author":"Sawabata","year":"2020","journal-title":"J. Thorac. Dis"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib152","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00280-017-3339-0","article-title":"Prognostic value of chemotherapy-resistant CK19mRNA-positive circulating tumor cells in patients with advanced\/metastatic non-small cell lung cancer","volume":"80","author":"Milaki","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/bs.acc.2023.02.004_bib153","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.641978","article-title":"Evaluation of monocarboxylate transporter 4 (MCT4) expression and its prognostic significance in circulating tumor cells from patients with early stage non-small-cell lung cancer","volume":"9","author":"Markou","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib154","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180914","article-title":"The prognostic roles of circulating ALDH1(+) tumor cell in the patients with non-small cell lung cancer","volume":"38","author":"Tian","year":"2018","journal-title":"Biosci. Rep"},{"key":"10.1016\/bs.acc.2023.02.004_bib155","article-title":"Preoperative folate receptor-positive circulating tumor cell level is a prognostic factor of long term outcome in non-small cell lung cancer patients","volume":"10","author":"Li","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/bs.acc.2023.02.004_bib156","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.2147\/CMAR.S245425","article-title":"Detection of PD-L1 expression and its clinical significance in circulating tumor cells from patients with non-small-cell lung cancer","volume":"12","author":"Cheng","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib157","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211036856","article-title":"Prediction of preeclampsia using a combination of serum micro RNA-210 and uterine artery Doppler ultrasound","volume":"104","author":"Trongpisutsak","year":"2021","journal-title":"Sci. Prog."},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib158","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/clinchem\/hvab116","article-title":"Single cell and plasma RNA sequencing for RNA liquid biopsy for hepatocellular carcinoma","volume":"67","author":"Vong","year":"2021","journal-title":"Clin. Chem"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib159","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1038\/s41598-020-60616-z","article-title":"Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/bs.acc.2023.02.004_bib160","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/resp.13749","article-title":"Sputum transcriptomics implicates increased p38 signalling activity in severe asthma","volume":"25","author":"Baines","year":"2020","journal-title":"Respirology"},{"key":"10.1016\/bs.acc.2023.02.004_bib161","doi-asserted-by":"crossref","first-page":"6124106","DOI":"10.1155\/2020\/6124106","article-title":"Detection of ALK gene rearrangement in cell-free RNA from lung cancer malignant pleural effusion","volume":"2020","author":"Chu","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"7898","key":"10.1016\/bs.acc.2023.02.004_bib162","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41586-022-04410-z","article-title":"Early prediction of preeclampsia in pregnancy with cell-free RNA","volume":"602","author":"Moufarrej","year":"2022","journal-title":"Nature"},{"key":"10.1016\/bs.acc.2023.02.004_bib163","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fgene.2019.00496","article-title":"Coding or noncoding, the converging concepts of RNAs","volume":"10","author":"Li","year":"2019","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib164","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-020-01185-7","article-title":"Noncoding RNAs in gastric cancer: implications for drug resistance","volume":"19","author":"Wei","year":"2020","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib165","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.rpor.2020.07.007","article-title":"cfRNAs as biomarkers in oncology - still experimental or applied tool for personalized medicine already?","volume":"25","author":"Kolenda","year":"2020","journal-title":"Rep. Pract. Oncol. Radiother."},{"issue":"7","key":"10.1016\/bs.acc.2023.02.004_bib166","first-page":"1354","article-title":"Emerging roles of lncRNA in cancer and therapeutic opportunities","volume":"9","author":"Jiang","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/bs.acc.2023.02.004_bib167","doi-asserted-by":"crossref","first-page":"6218353","DOI":"10.1155\/2017\/6218353","article-title":"Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers","volume":"2017","author":"Bolha","year":"2017","journal-title":"Int J Genomics"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/genes12060835","article-title":"Circulating RNA in kidney cancer: what we know and what we still suppose","volume":"12","author":"Cinque","year":"2021","journal-title":"Genes (Basel)"},{"issue":"24","key":"10.1016\/bs.acc.2023.02.004_bib169","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246249","article-title":"Deciphering miRNAs\u2019 action through miRNA editing","volume":"20","author":"Correia de Sousa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.acc.2023.02.004_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2019.10.005","article-title":"Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics","volume":"72","author":"Geeurickx","year":"2020","journal-title":"Mol. Aspects Med."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib171","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4251\/wjgo.v13.i5.332","article-title":"Liquid biopsy in cholangiocarcinoma: current status and future perspectives","volume":"13","author":"Rompianesi","year":"2021","journal-title":"World J. Gastrointest. Oncol"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib172","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41571-018-0035-x","article-title":"Clinical utility of circulating non-coding RNAs - an update","volume":"15","author":"Anfossi","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib173","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3233\/CBM-171082","article-title":"RRM1 gene expression evaluated in the liquid biopsy (blood cfRNA) as a non-invasive, predictive factor for radiotherapy-induced oral mucositis and potential prognostic biomarker in head and neck cancer patients","volume":"22","author":"Mlak","year":"2018","journal-title":"Cancer Biomark"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib174","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/humupd\/dmu031","article-title":"Cell-free nucleic acids as non-invasive biomarkers of gynecological cancers, ovarian, endometrial and obstetric disorders and fetal aneuploidy","volume":"20","author":"Traver","year":"2014","journal-title":"Hum. Reprod. Update"},{"issue":"7","key":"10.1016\/bs.acc.2023.02.004_bib175","first-page":"11295","article-title":"Diagnostic value of Cyfra21-1, SCC and CEA for differentiation of early-stage NSCLC from benign lung disease","volume":"8","author":"Chen","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/bs.acc.2023.02.004_bib176","article-title":"Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients","volume":"28","author":"de Kock","year":"2021","journal-title":"Cancer Treat. Res. Commun."},{"key":"10.1016\/bs.acc.2023.02.004_bib177","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cca.2017.10.027","article-title":"Circulating long non-coding RNA AFAP1-AS1 is a potential diagnostic biomarker for non-small cell lung cancer","volume":"475","author":"Li","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/bs.acc.2023.02.004_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.537120","article-title":"Circulating long noncoding RNAs act as diagnostic biomarkers in non-small cell lung cancer","volume":"10","author":"Yuan","year":"2020","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib179","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3233\/CBM-201616","article-title":"intergenic noncoding RNA LINC00173 as a potential serum biomarker for diagnosis of non-small-cell lung cancer","volume":"29","author":"Yang","year":"2020","journal-title":"Cancer Biomark"},{"key":"10.1016\/bs.acc.2023.02.004_bib180","article-title":"Comprehensive assessment of serum hsa_circ_0070354 as a novel diagnostic and predictive biomarker in non-small cell lung cancer","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib181","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/1759-7714.13800","article-title":"Plasma miR-1247-5p, miR-301b-3p and miR-105-5p as potential biomarkers for early diagnosis of non-small cell lung cancer","volume":"12","author":"Dong","year":"2021","journal-title":"Thorac. Cancer"},{"key":"10.1016\/bs.acc.2023.02.004_bib182","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71035","article-title":"Serum RNAs can predict lung cancer up to 10 years prior to diagnosis","volume":"11","author":"Umu","year":"2022","journal-title":"Elife"},{"key":"10.1016\/bs.acc.2023.02.004_bib183","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.lfs.2016.03.002","article-title":"A circulating non-coding RNA panel as an early detection predictor of non-small cell lung cancer","volume":"151","author":"Peng","year":"2016","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib184","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12943-016-0520-8","article-title":"Small non-coding RNA biomarkers in sputum for lung cancer diagnosis","volume":"15","author":"Su","year":"2016","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib185","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3892\/ijo.2017.3925","article-title":"Identification of circulating long non-coding RNA GAS5 as a potential biomarker for non-small cell lung cancer diagnosisnon-small cell lung cancer, long non-coding RNA, plasma, GAS5, biomarker","volume":"50","author":"Tan","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib186","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4103\/jcrt.JCRT_733_17","article-title":"Expression level of long noncoding RNA H19 in plasma of patients with nonsmall cell lung cancer and its clinical significance","volume":"14","author":"Luo","year":"2018","journal-title":"J. Cancer Res. Ther."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib187","first-page":"2597","article-title":"The diagnostic and prognostic role of circulating miR-141 expression in non-small-cell lung cancer patients","volume":"11","author":"Zhao","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"4","key":"10.1016\/bs.acc.2023.02.004_bib188","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/bab.1764","article-title":"Circulating long non-coding RNA GAS5 and SOX2OT as potential biomarkers for diagnosis and prognosis of non-small cell lung cancer","volume":"66","author":"Kamel","year":"2019","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/bs.acc.2023.02.004_bib189","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2147\/CMAR.S237024","article-title":"Plasma long non-coding RNA RP11-438N5.3 as a novel biomarker for non-small cell lung cancer","volume":"12","author":"Chen","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib190","doi-asserted-by":"crossref","first-page":"652","DOI":"10.20892\/j.issn.2095-3941.2020.0063","article-title":"Serum miR-339-3p as a potential diagnostic marker for non-small cell lung cancer","volume":"17","author":"Trakunram","year":"2020","journal-title":"Cancer Biol. Med."},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib191","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/cancers12020353","article-title":"Plasma next generation sequencing and droplet digital-qPCR-based quantification of circulating cell-free RNA for noninvasive early detection of cancer","volume":"12","author":"Metzenmacher","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib192","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4103\/lungindia.lungindia_100_20","article-title":"The diagnostic role of microRNA 21 in patients with nonsmall cell lung cancer: An exploratory study","volume":"37","author":"Rai","year":"2020","journal-title":"Lung India"},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib193","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3892\/ol.2021.12471","article-title":"Downregulation of long non-coding RNA LINC-PINT serves as a diagnostic and prognostic biomarker in patients with non-small cell lung cancer","volume":"21","author":"Zhang","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/bs.acc.2023.02.004_bib194","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2147\/CMAR.S320965","article-title":"High expression of lncRNA HEIH is helpful in the diagnosis of non-small cell lung cancer and predicts poor prognosis","volume":"14","author":"He","year":"2022","journal-title":"Cancer Manag. Res."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/17246008211073151","article-title":"CircFOXP1: a novel serum diagnostic biomarker for non-small cell lung cancer","volume":"37","author":"Luo","year":"2022","journal-title":"Int. J. Biol. Markers"},{"issue":"6\u20137","key":"10.1016\/bs.acc.2023.02.004_bib196","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/07357907.2021.1928167","article-title":"Circulating long non-coding RNA GAS5: a non-invasive molecular marker for prognosis, response to treatment and survival in non-small cell lung cancer","author":"Al Mourgi","year":"2021","journal-title":"Cancer Invest. 39"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib197","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3892\/ol.2021.12781","article-title":"Potential of the cell-free blood-based biomarker uroplakin 2 RNA to detect recurrence after surgical resection of lung adenocarcinoma","volume":"22","author":"Zhu","year":"2021","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib198","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12885-017-3151-6","article-title":"A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis","volume":"17","author":"Wang","year":"2017","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib199","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2217\/bmm.13.63","article-title":"Exosomes: the future of biomarkers in medicine","volume":"7","author":"Properzi","year":"2013","journal-title":"Biomark. Med."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib200","doi-asserted-by":"crossref","first-page":"1750202","DOI":"10.1080\/20013078.2020.1750202","article-title":"A circulating extracellular vesicles-based novel screening tool for colorectal cancer revealed by shotgun and data-independent acquisition mass spectrometry","volume":"9","author":"Zheng","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/bs.acc.2023.02.004_bib201","article-title":"Naturally occurring exosome vesicles as potential delivery vehicle for bioactive compounds","volume":"3","author":"Akuma","year":"2019","journal-title":"Front. Sustain. Food S"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib202","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11912-018-0720-z","article-title":"The present and future of liquid biopsies in non-small cell lung cancer: combining four biosources for diagnosis, prognosis, prediction, and disease monitoring","volume":"20","author":"Bracht","year":"2018","journal-title":"Curr. Oncol. Rep."},{"issue":"19","key":"10.1016\/bs.acc.2023.02.004_bib203","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1002\/cam4.3379","article-title":"Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer","volume":"9","author":"Wu","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/bs.acc.2023.02.004_bib204","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4939-9769-5_4","article-title":"Exosomes extraction and identification","volume":"2054","author":"Wu","year":"2019","journal-title":"Methods Mol. Biol"},{"key":"10.1016\/bs.acc.2023.02.004_bib205","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2019.07.021","article-title":"New insight into isolation, identification techniques and medical applications of exosomes","volume":"308","author":"Yang","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/bs.acc.2023.02.004_bib206","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13578-019-0282-2","article-title":"Exosomes: biogenesis, biologic function and clinical potential","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci"},{"issue":"9","key":"10.1016\/bs.acc.2023.02.004_bib207","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1007\/s11033-020-05715-w","article-title":"Advances of exosome isolation techniques in lung cancer","volume":"47","author":"Mahgoub","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib208","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12943-022-01505-z","article-title":"Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring","volume":"21","author":"Li","year":"2022","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/bs.acc.2023.02.004_bib209","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/CBM-170955","article-title":"Plasma exosome levels in non-small-cell lung cancer: Correlation with clinicopathological features and prognostic implications","volume":"22","author":"Liu","year":"2018","journal-title":"Cancer Biomark"},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib210","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1039\/C4LC00136B","article-title":"Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes","volume":"14","author":"Kanwar","year":"2014","journal-title":"Lab Chip"},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib211","doi-asserted-by":"crossref","first-page":"20721","DOI":"10.1002\/jcp.28678","article-title":"Tumor-derived exosomal lncRNA GAS5 as a biomarker for early-stage non-small-cell lung cancer diagnosis","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/bs.acc.2023.02.004_bib212","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fgene.2020.00258","article-title":"Non-invasive detection of exosomal MicroRNAs via tethered cationic lipoplex nanoparticles (tCLN) biochip for lung cancer early detection","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/bs.acc.2023.02.004_bib213","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.aca.2018.02.051","article-title":"Exosomal lipids for classifying early and late stage non-small cell lung cancer","volume":"1037","author":"Fan","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/bs.acc.2023.02.004_bib214","article-title":"Tumor-derived exosomal miRNAs as diagnostic biomarkers in non-small cell lung cancer","volume":"10","author":"Zhang","year":"2020","journal-title":"Front. Oncol."},{"issue":"16","key":"10.1016\/bs.acc.2023.02.004_bib215","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1177\/1535370220945987","article-title":"Circulating serum exosomal miR-20b-5p and miR-3187-5p as efficient diagnostic biomarkers for early-stage non-small cell lung cancer","volume":"245","author":"Zhang","year":"2020","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib216","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/cas.13862","article-title":"Tumor-derived exosomal proteins as diagnostic biomarkers in non-small cell lung cancer","volume":"110","author":"Niu","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/bs.acc.2023.02.004_bib217","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nano.2018.11.008","article-title":"Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer","volume":"16","author":"Carmicheal","year":"2019","journal-title":"Nanomedicine"},{"issue":"12","key":"10.1016\/bs.acc.2023.02.004_bib218","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.1021\/acs.analchem.7b00911","article-title":"Exosome classification by pattern analysis of surface-enhanced raman spectroscopy data for lung cancer diagnosis","volume":"89","author":"Park","year":"2017","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib219","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1021\/acsnano.9b09119","article-title":"Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes","volume":"14","author":"Shin","year":"2020","journal-title":"ACS nano"},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib220","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jtho.2016.05.034","article-title":"Exosomal proteins as diagnostic biomarkers in lung cancer","volume":"11","author":"Sandfeld-Paulsen","year":"2016","journal-title":"J. Thorac. Oncol."},{"issue":"6","key":"10.1016\/bs.acc.2023.02.004_bib221","first-page":"712","article-title":"Upregulated expression of serum exosomal microRNAs as diagnostic biomarkers of lung adenocarcinoma","volume":"48","author":"Feng","year":"2018","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"2020","key":"10.1016\/bs.acc.2023.02.004_bib222","first-page":"6691211","article-title":"Tumor-derived exosomal miR-620 as a diagnostic biomarker in non-small-cell lung cancer","author":"Tang","year":"2020","journal-title":"J. Oncol."},{"issue":"3","key":"10.1016\/bs.acc.2023.02.004_bib223","doi-asserted-by":"crossref","first-page":"471","DOI":"10.7150\/ijbs.39123","article-title":"Exploration of serum exosomal LncRNA TBILA and AGAP2-AS1 as promising biomarkers for diagnosis of non-small cell lung cancer","volume":"16","author":"Tao","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"8","key":"10.1016\/bs.acc.2023.02.004_bib224","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jmoldx.2020.05.011","article-title":"Identification of three circular RNA cargoes in serum exosomes as diagnostic biomarkers of non-small-cell lung cancer in the chinese population","volume":"22","author":"Xian","year":"2020","journal-title":"J. Mol. Diagn."},{"issue":"10","key":"10.1016\/bs.acc.2023.02.004_bib225","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.7150\/ijms.43500","article-title":"Tumor-derived circulating exosomal miR-342-5p and miR-574-5p as promising diagnostic biomarkers for early-stage Lung Adenocarcinoma","volume":"17","author":"Han","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"11","key":"10.1016\/bs.acc.2023.02.004_bib226","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23979","article-title":"Increased serum exosomal long non-coding RNA SNHG15 expression predicts poor prognosis in non-small cell lung cancer","volume":"35","author":"Han","year":"2021","journal-title":"J. Clin. Lab. Anal"},{"key":"10.1016\/bs.acc.2023.02.004_bib227","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.4788","article-title":"Integration of bioinformatics analysis and experimental validation identifies plasma exosomal miR-103b\/877-5p\/29c-5p as diagnostic biomarkers for early lung adenocarcinoma","author":"Wu","year":"2022","journal-title":"Cancer Med."},{"issue":"7","key":"10.1016\/bs.acc.2023.02.004_bib228","first-page":"1601","article-title":"Early diagnostic and prognostic value of serum exosomal miR-1246 in non-small cell lung cancer","volume":"13","author":"Huang","year":"2020","journal-title":"Int. J Clin. Exp. Pathol."},{"issue":"5","key":"10.1016\/bs.acc.2023.02.004_bib229","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000487006","article-title":"Usefulness of plasma exosomal microRNA-451a as a noninvasive biomarker for early prediction of recurrence and prognosis of non-small cell lung cancer","volume":"94","author":"Kanaoka","year":"2018","journal-title":"Oncology"},{"issue":"1","key":"10.1016\/bs.acc.2023.02.004_bib230","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12935-021-02075-8","article-title":"Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer","volume":"21","author":"Li","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/bs.acc.2023.02.004_bib231","first-page":"5893981","article-title":"Circulating exosomal miR-96 as a novel biomarker for radioresistant non-small-cell lung cancer","author":"Zheng","year":"2021","journal-title":"J. Oncol."}],"container-title":["Advances in Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006524232300029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006524232300029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T07:54:30Z","timestamp":1753689270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S006524232300029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780443192883"],"references-count":231,"URL":"https:\/\/doi.org\/10.1016\/bs.acc.2023.02.004","relation":{},"ISSN":["0065-2423"],"issn-type":[{"value":"0065-2423","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}