{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:00Z","timestamp":1791081960018,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier","isbn-type":[{"value":"9780443297007","type":"print"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.acc.2024.03.003","type":"book-chapter","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T15:53:12Z","timestamp":1713455592000},"page":"145-168","source":"Crossref","is-referenced-by-count":9,"title":["Advances in periodontal biomarkers"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.acc.2024.03.003_bib1","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1038\/s41598-019-40463-3","article-title":"Forceful mastication activates osteocytes and builds a stout jawbone","volume":"9","author":"Inoue","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.acc.2024.03.003_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial signatures of health, gingivitis, and periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bdj.2016.865","article-title":"The oral microbiome\u2013an update for oral healthcare professionals","volume":"221","author":"Kilian","year":"2016","journal-title":"Br. Dent. J."},{"key":"10.1016\/bs.acc.2024.03.003_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/omi.2015.0146","article-title":"Biofilms as \u201cconnectors\u201d for oral and systems medicine: a new opportunity for biomarkers, molecular targets, and bacterial eradication","volume":"20","author":"Sintim","year":"2016","journal-title":"OMICS."},{"key":"10.1016\/bs.acc.2024.03.003_bib5","doi-asserted-by":"crossref","first-page":"2197779","DOI":"10.1080\/20002297.2023.2197779","article-title":"Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis","volume":"15","author":"Abdulkareem","year":"2023","journal-title":"J. Oral. Microbiol."},{"key":"10.1016\/bs.acc.2024.03.003_bib6","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/jcpe.12939","article-title":"Plaque\u2010induced gingivitis: case definition and diagnostic considerations","volume":"45","author":"Trombelli","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib7","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/jcm8081135","article-title":"Periodontitis: a multifaceted disease of tooth-supporting tissues","volume":"8","author":"K\u00f6n\u00f6nen","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/bs.acc.2024.03.003_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/prd.12426","article-title":"Fusobacterium nucleatum and cancer","volume":"89","author":"Alon\u2010Maimon","year":"2022","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/prd.12486","article-title":"Periodontal diseases and adverse pregnancy outcomes. Present and future","author":"Bobetsis","year":"2023","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/bs.acc.2024.03.003_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.anaerobe.2013.09.010","article-title":"Oral microbiota and systemic disease","volume":"24","author":"Kumar","year":"2013","journal-title":"Anaerobe"},{"key":"10.1016\/bs.acc.2024.03.003_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/prd.12304","article-title":"Mechanisms underlying the association between periodontitis and atherosclerotic disease","volume":"83","author":"Schenkein","year":"2020","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri\u2010implant diseases and conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/prd.12487","article-title":"Clinical periodontal diagnosis","author":"Salvi","year":"2023","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib15","doi-asserted-by":"crossref","first-page":"6S","DOI":"10.14219\/jada.archive.2012.0341","article-title":"Salivary diagnostics for periodontal diseases","volume":"143","author":"Giannobile","year":"2012","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/bs.acc.2024.03.003_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/jre.12713","article-title":"To what extent does smoking affect gingival bleeding response to supragingival plaque? Site\u2010specific analyses in a population\u2010based study","volume":"55","author":"Holde","year":"2020","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00784-001-0141-4","article-title":"The influence of gingival dimensions on bleeding upon probing in young adults with plaque-induced gingivitis","volume":"6","author":"M\u00fcller","year":"2002","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/bs.acc.2024.03.003_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0300-5712(95)00095-X","article-title":"The effect of subgingival calculus on the validity of clinical probing measurements","volume":"24","author":"Clerehugh","year":"1996","journal-title":"J. Dent."},{"key":"10.1016\/bs.acc.2024.03.003_bib19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1067\/mcp.2001.113989","article-title":"Biomarkers and surrogate endpoints: preferred definitions and conceptual framework","volume":"69","author":"Group","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/bs.acc.2024.03.003_bib20","first-page":"303","article-title":"Biomarkers in clinical medicine","volume":"163","author":"Chen","year":"2011","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/bs.acc.2024.03.003_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/jcpe.13617","article-title":"Molecular biomarker research in periodontology: a roadmap for translation of science to clinical assay validation","volume":"49","author":"G\u00fcrsoy","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3389\/fimmu.2020.00511","article-title":"The nexus between periodontal inflammation and dysbiosis","volume":"11","author":"Van Dyke","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.acc.2024.03.003_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/prd.12371","article-title":"Polymicrobial communities in periodontal disease: their quasi\u2010organismal nature and dialogue with the host","volume":"86","author":"Hajishengallis","year":"2021","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/bs.acc.2024.03.003_bib26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/bs.acc.2024.03.003_bib27","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/JPER.21-0120","article-title":"Dysbiosis revisited: understanding the role of the oral microbiome in the pathogenesis of gingivitis and periodontitis: a critical assessment","volume":"92","author":"Scannapieco","year":"2021","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1399-302X.2009.00544.x","article-title":"Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque","volume":"24","author":"Byrne","year":"2009","journal-title":"Oral. Microbiol. Immunol."},{"key":"10.1016\/bs.acc.2024.03.003_bib29","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1128\/JCM.02560-06","article-title":"Population-based study of salivary carriage of periodontal pathogens in adults","volume":"45","author":"K\u00f6n\u00f6nen","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/bs.acc.2024.03.003_bib30","doi-asserted-by":"crossref","first-page":"1653123","DOI":"10.1080\/20002297.2019.1653123","article-title":"Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis","volume":"11","author":"Damgaard","year":"2019","journal-title":"J. Oral. Microbiol."},{"key":"10.1016\/bs.acc.2024.03.003_bib31","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/jcpe.13697","article-title":"Toll\u2010like receptor\u20101,\u20102, and\u20106 genotypes in relation to salivary human beta\u2010defensin\u20101,\u20102,\u20103 and human neutrophilic peptide\u20101","volume":"49","author":"G\u00fcrsoy","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imr.13152","article-title":"Neutrophils in the periodontium: interactions with pathogens and roles in tissue homeostasis and inflammation","volume":"314","author":"Uriarte","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/bs.acc.2024.03.003_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/prd.12490","article-title":"The role of the host\u2014neutrophil biology","author":"Chapple","year":"2023","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"64","author":"Cekici","year":"2014","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12331","article-title":"Current understanding of periodontal disease pathogenesis and targets for host\u2010modulation therapy","volume":"84","author":"Hajishengallis","year":"2020","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib36","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00784-020-03411-4","article-title":"Salivary and serum markers of angiogenesis in periodontitis in relation to smoking","volume":"25","author":"Y\u0131lmaz \u015ea\u015ft\u0131m","year":"2021","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/bs.acc.2024.03.003_bib37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/jre.12738","article-title":"Salivary Del\u20101, IL\u201017, and LFA\u20101 levels in periodontal health and disease","volume":"55","author":"In\u00f6n\u00fc","year":"2020","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib38","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/jre.12995","article-title":"Gingival crevicular fluid lipocalin\u20102 and semaphorin3A in stage III periodontitis: non\u2010surgical periodontal treatment effects","volume":"57","author":"Ceylan","year":"2022","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib39","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/jre.13124","article-title":"Salivary levels of BAFF, TWEAK, and soluble CD163 and salivary arginase activity before and after periodontal treatment","volume":"58","author":"Yilmaz","year":"2023","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/jre.12957","article-title":"Is TIMP\u20101 a biomarker for periodontal disease? A systematic review and meta\u2010analysis","volume":"57","author":"de Brouwer","year":"2022","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib41","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s00784-023-05010-5","article-title":"Localization and expression profiles of gingival monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1)","volume":"27","author":"Yu","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/bs.acc.2024.03.003_bib42","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/JPER.20-0051","article-title":"Periodontal inflammation and distinct inflammatory profiles in saliva and gingival crevicular fluid compared with serum and joints in rheumatoid arthritis patients","volume":"92","author":"Arvikar","year":"2021","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib43","article-title":"The role of MIF in periodontitis: a potential pathogenic driver, biomarker, and therapeutic target","author":"Fang","year":"2023","journal-title":"Oral. Dis."},{"key":"10.1016\/bs.acc.2024.03.003_bib44","article-title":"Regulation of matrix metalloproteinases-8,-9 and endogenous tissue inhibitor-1 in oral biofluids during pregnancy and postpartum","volume":"124","author":"\u00d6zt\u00fcrk","year":"2021","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/bs.acc.2024.03.003_bib45","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/odi.13030","article-title":"Understanding the pathophysiology behind chairside diagnostics and genetic testing for IL\u20101 and IL\u20106","volume":"25","author":"Rudick","year":"2019","journal-title":"Oral. Dis."},{"key":"10.1016\/bs.acc.2024.03.003_bib46","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-0765.2011.01445.x","article-title":"Bone remodeling\u2010associated salivary biomarker MIP\u20101\u03b1 distinguishes periodontal disease from health","volume":"47","author":"Al\u2010Sabbagh","year":"2012","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib47","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jcpe.13218","article-title":"Diagnostic sensitivity and specificity of host\u2010derived salivary biomarkers in periodontal disease amongst adults: systematic review","volume":"47","author":"Kc","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12101","article-title":"Analysis of matrix metalloproteinases, especially MMP\u20108, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases","volume":"70","author":"Sorsa","year":"2016","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib49","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3390\/pathogens9090751","article-title":"Elevated baseline salivary protease activity may predict the steadiness of gingival inflammation during periodontal healing: a 12-week follow-up study on adults","volume":"9","author":"G\u00fcrsoy","year":"2020","journal-title":"Pathogens."},{"key":"10.1016\/bs.acc.2024.03.003_bib50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12447","article-title":"Risk factors for periodontitis & peri\u2010implantitis","volume":"90","author":"Darby","year":"2022","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00508798","article-title":"Inhibition of lactate dehydrogenase in cultured SIRC cells by cigarette smoke","volume":"55","author":"Fleming","year":"1978","journal-title":"Histochemistry"},{"key":"10.1016\/bs.acc.2024.03.003_bib52","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/JPER.18-0545","article-title":"Smoking confounds the periodontal diagnostics using saliva biomarkers","volume":"90","author":"Lahdentausta","year":"2019","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib53","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1902\/jop.2009.090510","article-title":"Salivary interleukin\u20106, matrix metalloproteinase\u20108, and osteoprotegerin in patients with periodontitis and diabetes","volume":"81","author":"Costa","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/jre.13127","article-title":"Biomarker panel discriminates diabetics with and without periodontitis pre\u2010and post\u2010therapy","volume":"58","author":"Miller","year":"2023","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib55","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1902\/jop.2009.080480","article-title":"Identification of pathogen and host\u2010response markers correlated with periodontal disease","volume":"80","author":"Ramseier","year":"2009","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib56","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/jcpe.12538","article-title":"Host\u2010derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta\u2010analysis","volume":"43","author":"de Lima","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib57","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/biom10030395","article-title":"An oral rinse active matrix metalloproteinase-8 point-of-care immunotest may be less accurate in patients with crohn\u2019s disease","volume":"10","author":"Rautava","year":"2020","journal-title":"Biomolecules."},{"key":"10.1016\/bs.acc.2024.03.003_bib58","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/odi.14335","article-title":"Oral active matrix metalloproteinase-8 immunotest may be less accurate in haemato-oncologic patients","volume":"30","author":"Mauramo","year":"2022","journal-title":"Oral. Dis."},{"key":"10.1016\/bs.acc.2024.03.003_bib59","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/jre.12795","article-title":"Expression of inflammatory biomarkers and growth factors in gingival crevicular fluid at different healing intervals following non\u2010surgical periodontal treatment: a systematic review","volume":"55","author":"Koidou","year":"2020","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib60","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jre.13093","article-title":"Accuracy of a MMP\u20108 point\u2010of\u2010care test in indicating periodontal treatment outcomes in stage III\/IV periodontitis: a 24\u2010week follow\u2010up study","volume":"58","author":"Yilmaz","year":"2023","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-051X.2011.01810.x","article-title":"The RANKL\u2010OPG system in clinical periodontology","volume":"39","author":"Belibasakis","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib62","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1600-051X.2008.01310.x","article-title":"Saliva concentrations of RANKL and osteoprotegerin in smoker versus non\u2010smoker chronic periodontitis patients","volume":"35","author":"Buduneli","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib63","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1600-051X.2010.01563.x","article-title":"Salivary MMP\u20108, TIMP\u20101, and ICTP as markers of advanced periodontitis","volume":"37","author":"Gursoy","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib64","first-page":"39","article-title":"Periodontal disease activity","volume":"2","author":"Lamster","year":"1992","journal-title":"Curr. Opin. Dent."},{"key":"10.1016\/bs.acc.2024.03.003_bib65","doi-asserted-by":"crossref","DOI":"10.1902\/jop.2013.120637","article-title":"Mathematical modeling suggests that periodontitis behaves as a non\u2010linear chaotic dynamical process","volume":"84","author":"Papantonopoulos","year":"2013","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/prd.12473","article-title":"Periodontal microbiology and microbial etiology of periodontal diseases: historical concepts and contemporary perspectives","author":"Belibasakis","year":"2023","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib67","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1155\/2011\/621484","article-title":"Use of host-and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach","volume":"30","author":"Gursoy","year":"2011","journal-title":"Dis. Markers"},{"key":"10.1016\/bs.acc.2024.03.003_bib68","doi-asserted-by":"crossref","first-page":"49396","DOI":"10.1080\/00016357.2018.1441436","article-title":"Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds","volume":"76","author":"G\u00fcrsoy","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/bs.acc.2024.03.003_bib69","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1902\/jop.2017.170187","article-title":"Investigation of a novel predictive biomarker profile for the outcome of periodontal treatment","volume":"88","author":"Gul","year":"2017","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib70","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jcpe.12234","article-title":"Salivary biomarkers of bacterial burden, inflammatory response, and tissue destruction in periodontitis","volume":"41","author":"Salminen","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib71","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3390\/diagnostics10080560","article-title":"Immunological and microbiological profiling of cumulative risk score for periodontitis","volume":"10","author":"Liukkonen","year":"2020","journal-title":"Diagnostics."},{"key":"10.1016\/bs.acc.2024.03.003_bib72","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/jcpe.13854","article-title":"Accuracy of periodontitis diagnosis obtained using multiple molecular biomarkers in oral fluids: a systematic review and meta\u2010analysis","volume":"50","author":"Blanco\u2010Pintos","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib73","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1034\/j.1600-0757.2003.03101.x","article-title":"Gingival crevice fluid\u2013an introduction","volume":"31","author":"Uitto","year":"2003","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/prd.12107","article-title":"Gingival crevicular fluid as a source of biomarkers for periodontitis","volume":"70","author":"Barros","year":"2016","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib75","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-0757.2003.03102.x","article-title":"Structure and function of the tooth\u2013epithelial interface in health and disease","volume":"31","author":"P\u00f6ll\u00e4nen","year":"2003","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib76","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1902\/jop.1996.67.5.472","article-title":"pH changes observed in the inflamed gingival crevice modulate human polymorphonuclear leukocyte activation in vitro","volume":"67","author":"Leblebicioglu","year":"1996","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib77","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0765.1980.tb00269.x","article-title":"Sulcular polymorphonuclear leucocytes and gingival exudate during experimental gingivitis in man","volume":"15","author":"Kowashi","year":"1980","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib78","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1902\/jop.2007.060465","article-title":"Periodontal disease at the biofilm\u2013gingival interface","volume":"78","author":"Offenbacher","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib79","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1902\/jop.2009.090374","article-title":"Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis","volume":"81","author":"Reinhardt","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib80","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-051X.2007.01190.x","article-title":"Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase\u201013, periodontal pathogens and inflammatory cells","volume":"35","author":"Silva","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib81","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/prd.12109","article-title":"Clinical and technical considerations in the analysis of gingival crevicular fluid","volume":"70","author":"Wassall","year":"2016","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib82","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12116","article-title":"The physiology of salivary secretion","volume":"70","author":"Proctor","year":"2016","journal-title":"Periodontol. 2000"},{"key":"10.1016\/bs.acc.2024.03.003_bib83","first-page":"1","article-title":"Biosensors for saliva biomarkers","volume":"113","author":"Ayd\u0131n","year":"2022","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/bs.acc.2024.03.003_bib84","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cden.2021.06.006","article-title":"Biomarkers and periodontal regenerative approaches","volume":"66","author":"G\u00fcrsoy","year":"2022","journal-title":"Dent. Clin. N. Am."},{"key":"10.1016\/bs.acc.2024.03.003_bib85","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/jre.12999","article-title":"Diagnostic accuracy of active matrix metalloproteinase\u20108 point\u2010of\u2010care test for the discrimination of periodontal health status: comparison of saliva and oral rinse samples","volume":"57","author":"Deng","year":"2022","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib86","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/14728222.2023.2240014","article-title":"An MMP-8 point-of-care-diagnostic methods and treatment modalities in periodontitis and peri-implantitis","volume":"27","author":"L\u00e4hteenm\u00e4ki","year":"2023","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/bs.acc.2024.03.003_bib87","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1007\/s00784-023-05122-y","article-title":"Characterization of the soft-tissue wall lining residual periodontal pockets and implications in periodontal wound healing","volume":"27","author":"Gousopoulou","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/bs.acc.2024.03.003_bib88","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jcpe.13227","article-title":"Gingival tissue human beta\u2010defensin levels in relation to infection and inflammation","volume":"47","author":"\u00d6zdemir","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib89","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1902\/jop.2013.130030","article-title":"Combining salivary pathogen and serum antibody levels improves their diagnostic ability in detection of periodontitis","volume":"85","author":"Liljestrand","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib90","doi-asserted-by":"crossref","first-page":"2106115","DOI":"10.1902\/jop.2005.76.11-S.2106","article-title":"Systemic markers of inflammation in periodontitis","volume":"76","author":"Loos","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib91","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1007\/s00784-023-05169-x","article-title":"Biomarkers for diagnosis of stage III, grade C with molar incisor pattern periodontitis in children and young adults: a systematic review and meta-analysis","volume":"27","author":"Alamri","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/bs.acc.2024.03.003_bib92","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/jcpe.13188","article-title":"Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: a systematic review and meta\u2010analysis","volume":"46","author":"Arias\u2010Bujanda","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib93","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jcpe.13202","article-title":"Accuracy of single molecular biomarkers in saliva for the diagnosis of periodontitis: a systematic review and meta\u2010analysis","volume":"47","author":"Arias\u2010Bujanda","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib94","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jre.12872","article-title":"Metabolomics of gingival crevicular fluid to identify biomarkers for periodontitis: a systematic review with meta\u2010analysis","volume":"56","author":"Baima","year":"2021","journal-title":"J. Periodontal Res."},{"key":"10.1016\/bs.acc.2024.03.003_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286079","article-title":"A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis","volume":"18","author":"S\u00e1nchez-Medrano","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/bs.acc.2024.03.003_bib96","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1600-051X.2009.01480.x","article-title":"Salivary interleukin\u20101\u03b2 concentration and the presence of multiple pathogens in periodontitis","volume":"36","author":"Gursoy","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib97","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1902\/jop.2016.160146","article-title":"Salivary concentrations of interleukin (IL)\u20101\u03b2, IL\u201017A, and IL\u201023 vary in relation to periodontal status","volume":"87","author":"Liukkonen","year":"2016","journal-title":"J. Periodontol."},{"key":"10.1016\/bs.acc.2024.03.003_bib98","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00784-023-04878-7","article-title":"Precision periodontal care: from omics discoveries to chairside diagnostics","volume":"27","author":"Bostanci","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/bs.acc.2024.03.003_bib99","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.tibtech.2018.05.013","article-title":"Point-of-care periodontitis testing: biomarkers, current technologies, and perspectives","volume":"36","author":"He","year":"2018","journal-title":"Trends Biotechnol."},{"key":"10.1016\/bs.acc.2024.03.003_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.588480","article-title":"Biosensor and lab-on-a-chip biomarker-identifying technologies for oral and periodontal diseases","volume":"11","author":"Steigmann","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/bs.acc.2024.03.003_bib101","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1177\/00220345211014432","article-title":"The human salivary proteome wiki: a community-driven research platform","volume":"100","author":"Lau","year":"2021","journal-title":"J. Dent. Res."}],"container-title":["Advances in Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006524232400060X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006524232400060X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T17:47:31Z","timestamp":1753724851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S006524232400060X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443297007"],"references-count":101,"URL":"https:\/\/doi.org\/10.1016\/bs.acc.2024.03.003","relation":{},"ISSN":["0065-2423"],"issn-type":[{"value":"0065-2423","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}