{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:11:30Z","timestamp":1750824690631,"version":"3.41.0"},"reference-count":68,"publisher":"Elsevier","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.acc.2025.04.004","type":"book-chapter","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:49:30Z","timestamp":1750794570000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolomics of nephrotic syndrome"],"prefix":"10.1016","author":[{"given":"Shereen M.","family":"Aleidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Malkawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba","family":"Al Fahmawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas M.","family":"Abdel Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/bs.acc.2025.04.004_bib1","article-title":"Nephrotic syndrome: a review","volume":"16","author":"Verma","year":"2024","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/bs.acc.2025.04.004_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1542\/pir.2020-001230","article-title":"Nephrotic syndrome","volume":"43","author":"Rodriguez-Ballestas","year":"2022","journal-title":"Pediatr. Rev."},{"issue":"8","key":"10.1016\/bs.acc.2025.04.004_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12081860","article-title":"Endocrine disorders in nephrotic syndrome\u2014A comprehensive review","volume":"12","author":"Mizdrak","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/bs.acc.2025.04.004_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2016.00039","article-title":"Ethnic differences in childhood nephrotic syndrome","volume":"4","author":"Chanchlani","year":"2016","journal-title":"Front. Pediatr"},{"key":"10.1016\/bs.acc.2025.04.004_bib5","series-title":"Nephrotic Syndrome","author":"Tapia","year":"2024"},{"issue":"6","key":"10.1016\/bs.acc.2025.04.004_bib6","first-page":"479","article-title":"Diagnosis and management of nephrotic syndrome in adults","volume":"93","author":"Kodner","year":"2016","journal-title":"Am. Fam. Physician"},{"issue":"5","key":"10.1016\/bs.acc.2025.04.004_bib7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1681\/ASN.2012070734","article-title":"The treatment of minimal change disease in adults","volume":"24","author":"Hogan","year":"2013","journal-title":"J. Am. Soc. Nephrol"},{"issue":"5","key":"10.1016\/bs.acc.2025.04.004_bib8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.kint.2018.04.024","article-title":"Acute kidney injury complicating nephrotic syndrome of minimal change disease","volume":"94","author":"Meyrier","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/bs.acc.2025.04.004_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/IJNRD.S351053","article-title":"Disease-associated systemic complications in childhood nephrotic syndrome: a systematic review","volume":"15","author":"Hilmanto","year":"2022","journal-title":"Int. J. Nephrol. Renovasc Dis."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pcl.2018.08.006","article-title":"Nephrotic syndrome","volume":"66","author":"Wang","year":"2019","journal-title":"Pediatr. Clin. North. Am."},{"issue":"9","key":"10.1016\/bs.acc.2025.04.004_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/jcm7090265","article-title":"Idiopathic nephrotic syndrome: characteristics and identification of prognostic factors","volume":"7","author":"Dumas De La Roque","year":"2018","journal-title":"J. Clin. Med."},{"issue":"12","key":"10.1016\/bs.acc.2025.04.004_bib12","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1007\/s00467-022-05639-6","article-title":"Clinical practice guidelines for nephrotic syndrome: consensus is emerging","volume":"37","author":"Sinha","year":"2022","journal-title":"Pediatr. Nephrol."},{"issue":"6","key":"10.1016\/bs.acc.2025.04.004_bib13","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.ekir.2023.03.015","article-title":"Multiomics analysis of plasma proteomics and metabolomics of steroid resistance in childhood nephrotic syndrome using a \u201cpatient-specific\u201d approach","volume":"8","author":"Bhayana","year":"2023","journal-title":"Kidney Int. Rep."},{"issue":"4","key":"10.1016\/bs.acc.2025.04.004_bib14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00467-019-04225-7","article-title":"Treatment of nephrotic syndrome: going beyond immunosuppressive therapy","volume":"35","author":"Zhao","year":"2020","journal-title":"Pediatr. Nephrol."},{"issue":"2","key":"10.1016\/bs.acc.2025.04.004_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.ajkd.2023.02.003","article-title":"KDOQI US commentary on the 2021 KDIGO clinical practice guideline for the management of glomerular diseases","volume":"82","author":"Beck","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/bs.acc.2025.04.004_bib16","series-title":"Biomarkers of Kidney Disease","first-page":"33","article-title":"Chapter three - the role of metabolomics in the study of kidney diseases and in the development of diagnostic tools","author":"Christians","year":"2017"},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib17","first-page":"7","article-title":"Dyslipidaemia in nephrotic syndrome: mechanisms and treatment","volume":"14","author":"Agrawal","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"3","key":"10.1016\/bs.acc.2025.04.004_bib18","first-page":"182","article-title":"Progress of research on dyslipidemia accompanied by nephrotic syndrome","volume":"6","author":"Tao","year":"2020","journal-title":"Chron. Dis. Transl. Med."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.kint.2016.02.026","article-title":"Disorders of lipid metabolism in nephrotic syndrome: mechanisms and consequences","volume":"90","author":"Vaziri","year":"2016","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/bs.acc.2025.04.004_bib20","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s40620-023-01697-7","article-title":"Nephrotic syndrome: pathophysiology and consequences","volume":"36","author":"Claudio","year":"2023","journal-title":"J. Nephrol."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12882-020-02003-4","article-title":"Protein energy-wasting associated with nephrotic syndrome \u2013 the comparison of metabolic pattern in severe nephrosis to different stages of chronic kidney disease","volume":"21","author":"Matyjek","year":"2020","journal-title":"BMC Nephrol."},{"issue":"3","key":"10.1016\/bs.acc.2025.04.004_bib22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/biomedicines12030569","article-title":"Nephrotic syndrome: from pathophysiology to novel therapeutic approaches","volume":"12","author":"Fr\u0103til\u0103","year":"2024","journal-title":"Biomedicines"},{"issue":"20","key":"10.1016\/bs.acc.2025.04.004_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012614","article-title":"Metabolomics profiling of nephrotic syndrome towards biomarker discovery","volume":"23","author":"Jacob","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/bs.acc.2025.04.004_bib24","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1152\/ajpendo.2001.280.4.E591","article-title":"Plasma protein synthesis in patients with low-grade nephrotic proteinuria","volume":"280","author":"Zanetti","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"issue":"5","key":"10.1016\/bs.acc.2025.04.004_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrneph.2017.30","article-title":"Metabolomics for clinical use and research in chronic kidney disease","volume":"13","author":"Hocher","year":"2017","journal-title":"Nat. Rev. Nephrol"},{"issue":"6","key":"10.1016\/bs.acc.2025.04.004_bib26","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/ndt\/gfn739","article-title":"Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms","volume":"24","author":"Schefold","year":"2009","journal-title":"Nephrol, Dialysis, Transpl."},{"key":"10.1016\/bs.acc.2025.04.004_bib27","first-page":"334","article-title":"Application of metabolomics in establishing primary nephrotic syndrome diagnosis model","author":"Zhang","year":"2016","journal-title":"Chin. J. Nephrol."},{"issue":"3","key":"10.1016\/bs.acc.2025.04.004_bib28","first-page":"415","article-title":"Biochemical markers of endothelial dysfunction in pediatric nephrotic syndrome","volume":"5","author":"Shouman","year":"2009","journal-title":"Arch. Med. Sci."},{"issue":"3","key":"10.1016\/bs.acc.2025.04.004_bib29","first-page":"169","article-title":"Oxidative stress status in adults with nephrotic syndrome","volume":"53","author":"Bulucu","year":"2000","journal-title":"Clin. Nephrol."},{"key":"10.1016\/bs.acc.2025.04.004_bib30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12291-010-0017-y","article-title":"Role of reactive oxygen species in pathogenesis of nephrotic syndrome","volume":"25","author":"Ghodake","year":"2010","journal-title":"Indian. J. Clin. Biochem."},{"issue":"15","key":"10.1016\/bs.acc.2025.04.004_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153711","article-title":"Oxidative stress in the pathogenesis and evolution of chronic kidney disease: untangling ariadne\u2019s thread","volume":"20","author":"Duni","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1-2","key":"10.1016\/bs.acc.2025.04.004_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0009-8981(02)00294-2","article-title":"Oxidative stress in pediatric nephrotic syndrome","volume":"325","author":"Kamireddy","year":"2002","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.kint.2016.08.021","article-title":"An overview of renal metabolomics","volume":"91","author":"Kalim","year":"2017","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/bs.acc.2025.04.004_bib34","doi-asserted-by":"crossref","first-page":"690","DOI":"10.2215\/CJN.05230513","article-title":"Clinical correlates of insulin sensitivity and its association with mortality among men with CKD stages 3 and 4","volume":"9","author":"Xu","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/bs.acc.2025.04.004_bib35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/metabo9020034","article-title":"Metabolomics approaches for the diagnosis and understanding of kidney diseases","volume":"9","author":"Abbiss","year":"2019","journal-title":"Metabolites"},{"issue":"6","key":"10.1016\/bs.acc.2025.04.004_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.14740\/jocmr4913","article-title":"Metabolomics in acute kidney injury: the experimental perspective","volume":"15","author":"Patschan","year":"2023","journal-title":"J. Clin. Med. Res."},{"issue":"29","key":"10.1016\/bs.acc.2025.04.004_bib37","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011495","article-title":"Nephrotic syndrome with acute pulmonary embolism in young adults: two case reports","volume":"97","author":"Song","year":"2018","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/bs.acc.2025.04.004_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000447954","article-title":"Metabolomics in diabetic kidney disease: unraveling the biochemistry of a silent killer","volume":"44","author":"Darshi","year":"2016","journal-title":"Am. J. Nephrol."},{"issue":"4","key":"10.1016\/bs.acc.2025.04.004_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000538051","article-title":"Deliverables from metabolomics in kidney disease: adenine, new insights, and implication for clinical decision-making","volume":"55","author":"Ragi","year":"2024","journal-title":"Am. J. Nephrol."},{"issue":"51","key":"10.1016\/bs.acc.2025.04.004_bib40","doi-asserted-by":"crossref","first-page":"18645","DOI":"10.1021\/acs.analchem.3c02924","article-title":"Current practices in LC-MS untargeted metabolomics: a scoping review on the use of pooled quality control samples","volume":"95","author":"Broeckling","year":"2023","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-64561-z","article-title":"Untargeted metabolomics reveal signatures of a healthy lifestyle","volume":"14","author":"Pathmasiri","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.acc.2025.04.004_bib42","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fped.2019.00404","article-title":"The search for biomarkers to aid in diagnosis, differentiation, and prognosis of childhood idiopathic nephrotic syndrome","volume":"7","author":"Stone","year":"2019","journal-title":"Front. Pediatr."},{"key":"10.1016\/bs.acc.2025.04.004_bib43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jpba.2018.08.046","article-title":"Metabolomics in chronic kidney disease: strategies for extended metabolome coverage","volume":"161","author":"Gagnebin","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"8","key":"10.1016\/bs.acc.2025.04.004_bib44","article-title":"Metabolomics profiling of cystic renal disease towards biomarker discovery","volume":"10","author":"Sriwi","year":"2021","journal-title":"Biol. (Basel)"},{"key":"10.1016\/bs.acc.2025.04.004_bib45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chroma.2016.05.058","article-title":"Systematic biomarker discovery and coordinative validation for different primary nephrotic syndromes using gas chromatography-mass spectrometry","volume":"1453","author":"Lee","year":"2016","journal-title":"J. Chromatogr. A"},{"issue":"7","key":"10.1016\/bs.acc.2025.04.004_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8070222","article-title":"Amino acid metabolites associated with chronic kidney disease: an eight-year follow-up korean epidemiology study","volume":"8","author":"Lee","year":"2020","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/bs.acc.2025.04.004_bib47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11306-021-01788-1","article-title":"Metabolomics analysis of serum in pediatric nephrotic syndrome based on targeted and non-targeted platforms","volume":"17","author":"Guo","year":"2021","journal-title":"Metabolomics"},{"key":"10.1016\/bs.acc.2025.04.004_bib48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aca.2018.03.058","article-title":"A targeted metabolomics approach for clinical diagnosis of inborn errors of metabolism","volume":"1025","author":"Jacob","year":"2018","journal-title":"Anal. Chim. Acta."},{"key":"10.1016\/bs.acc.2025.04.004_bib49","first-page":"1","article-title":"Targeted metabolomics","author":"Roberts","year":"2012","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/bs.acc.2025.04.004_bib50","first-page":"1","article-title":"Targeted metabolomics","author":"Roberts","year":"2012","journal-title":"Curr. Protoc. Mol. Biol."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2014.08.016","article-title":"Label-free mass spectrometric profiling of urinary proteins and metabolites from paediatric idiopathic nephrotic syndrome","volume":"452","author":"Sedic","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.acc.2025.04.004_bib52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.toxlet.2019.11.020","article-title":"Elucidating the time-dependent changes in the urinary metabolome under doxorubicin-induced nephrotoxicity","volume":"319","author":"Li","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/bs.acc.2025.04.004_bib53","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2017.10.027","article-title":"Metabolomics and gene expression analysis reveal down-regulation of the citric acid (TCA) cycle in non-diabetic CKD patients","volume":"26","author":"Hallan","year":"2017","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/bs.acc.2025.04.004_bib54","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13978","article-title":"Metabolomic profiles in serum and urine uncover novel biomarkers in children with nephrotic syndrome","volume":"53","author":"Hu","year":"2023","journal-title":"Eur. J. Clin. Invest."},{"issue":"12","key":"10.1016\/bs.acc.2025.04.004_bib55","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","article-title":"Untargeted metabolomics strategies-challenges and emerging directions","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J. Am. Soc. Mass. Spectrom."},{"issue":"29","key":"10.1016\/bs.acc.2025.04.004_bib56","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1007\/s00216-016-9974-1","article-title":"Evaluation of dilution and normalization strategies to correct for urinary output in HPLC-HRTOFMS metabolomics","volume":"408","author":"Vogl","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"issue":"7","key":"10.1016\/bs.acc.2025.04.004_bib57","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/bs.acc.2025.04.004_bib58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibtech.2004.03.007","article-title":"Metabolomics by numbers: acquiring and understanding global metabolite data","volume":"22","author":"Goodacre","year":"2004","journal-title":"Trends Biotechnol."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s43586-023-00203-4","article-title":"Mass spectrometry using electrospray ionization","volume":"3","author":"Prabhu","year":"2023","journal-title":"Nat. Rev. Meth Primers"},{"key":"10.1016\/bs.acc.2025.04.004_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340711","article-title":"From fundamentals in calibration to modern methodologies: a tutorial for small molecules quantification in liquid chromatography\u2013mass spectrometry bioanalysis","volume":"1240","author":"Visconti","year":"2023","journal-title":"Anal. Chim. Acta."},{"issue":"19","key":"10.1016\/bs.acc.2025.04.004_bib61","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.scib.2023.08.047","article-title":"Advances in mass spectrometry-based multi-scale metabolomic methodologies and their applications in biological and clinical investigations","volume":"68","author":"Wang","year":"2023","journal-title":"Sci. Bull."},{"key":"10.1016\/bs.acc.2025.04.004_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.705932","article-title":"A metabolic pattern in healthy subjects given a single dose of metformin: a metabolomics approach","volume":"12","author":"Dahabiyeh","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/bs.acc.2025.04.004_bib63","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/metabo9110274","article-title":"Metabolomics distinguishes DOCK8 deficiency from atopic dermatitis: towards a biomarker discovery","volume":"9","author":"Jacob","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/bs.acc.2025.04.004_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.882487","article-title":"Studying metabolism by NMR-based metabolomics","volume":"9","author":"Moco","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"5","key":"10.1016\/bs.acc.2025.04.004_bib65","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1742-4658.2007.05675.x","article-title":"Recent applications of NMR spectroscopy in plant metabolomics","volume":"274","author":"Ward","year":"2007","journal-title":"FEBS J."},{"issue":"11","key":"10.1016\/bs.acc.2025.04.004_bib66","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1074\/mcp.O113.030239","article-title":"An introduction to biological NMR spectroscopy","volume":"12","author":"Marion","year":"2013","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/bs.acc.2025.04.004_bib67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fbioe.2015.00023","article-title":"Analytical methods in untargeted metabolomics: state of the art in 2015","volume":"3","author":"Alonso","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/bs.acc.2025.04.004_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/tjb-2023-0095","article-title":"Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications","volume":"49","author":"Do\u011fan","year":"2024","journal-title":"Turkish J. Biochem."}],"container-title":["Advances in Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065242325000435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065242325000435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:49:40Z","timestamp":1750794580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065242325000435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":68,"URL":"https:\/\/doi.org\/10.1016\/bs.acc.2025.04.004","relation":{},"ISSN":["0065-2423"],"issn-type":[{"value":"0065-2423","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}